Journal of Physical Chemistry C
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2024
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IF 3.3
Qi Liu,Wenrou Yu,Anping Liu,Zhaoxian Chen,Xuliang Xia,Yingzhou Huang,Haiyang Shi
By harnessing the capture of target molecules at the metal surface via a highly confined electromagnetic field induced by surface plasmons, surface-enhanced Raman spectroscopy (SERS) has emerged as a sensitive technique for spectral analysis. However, the precise identification of biomarkers in urine using SERS remains a formidable challenge due to the low concentration of biomarkers and the complex nature of the urine composition. In this investigation, we developed an optoplasmonic film SERS substrate comprising silver nanowires (AgNWs) and silicon dioxide (SiO2) to tackle this issue. The AgNWs produce robust SERS signals, while SiO2 enhances laser focusing, facilitating the efficient detection of levothyroxine sodium (LS) in urine with an ultralow detection limit of 1 × 10–9 M. Leveraging artificial intelligence (AI) algorithms, this optoplasmonic substrate achieved precise LS identification in urine with a remarkable accuracy rate. This pioneering substrate holds substantial promise for the noninvasive, swift detection of target molecules in biofluids, heralding advancements in disease diagnostics and health monitoring.
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Journal of Materials Chemistry B
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2024
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IF 6.1
Wan-Chun Luo,Li-N Bao,Yu Zhang,Zi-Tong Zhang,xi li,Mengmeng Pan,Jingtao Zhang,Kun Huang,Yu Xu,Li Xu
Alzheimer’s Disease (AD) heavily impacts human lives, and is becoming serious with the aging society. Inhibiting and disaggregating β-amyloid aggregates is a possible solution for AD therapy. In this study, a novel type of nanozymes based on Ru3+ chelated nanoscale metal organic frameworks (Ru3+-NMOFs), displaying strong peroxidase-like activity, was proposed as an inhibitor and disaggregater for β-amyloid aggregates. As a high concentration of hydrogen peroxide was present at the sites of β-amyloid aggregates, Ru3+-NMOFs could catalyze hydrogen peroxide to hydroxyl radicals. Thus, hydroxyl radical would attack the β-amyloid chain for oxidation, enhancing its hydrophilicity, and resulting in a decreased hydrophobic interaction and reduced aggregation degree. Ru3+-NMOFs behaved effective in inhibiting as well as disaggregating β-amyloid fibrils both in vitro and in vivo. Additionally, the reduction of β-amyloid aggregates and the attenuation of reactive oxygen species transfer led to lower levels of inflammatory factors, which would be beneficial in alleviating AD symptom. In a typical application, Ru3+-NMOFs could mitigate the paralysis of C. elegans CL2120 and increase survival rates. This study opens a new avenue for MOFs based nanozymes as a potential treatment agent for AD therapy.
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Gels
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2024
·Vol. 10
·期 2
·93
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IF 5
Cheng Wang,Jinsheng Sun,Yifu Long,Hongjun Huang,Juye Song,Ren Wang,Yuanzhi Qu,Zexing Yang
Lost circulation control remains a challenge in drilling operations. Self-healing gels, capable of self-healing in fractures and forming entire gel block, exhibit excellent resilience and erosion resistance, thus finding extensive studies in lost circulation control. In this study, layered double hydroxide, Acrylic acid, 2-Acrylamido-2-methylpropane sulfonic acid, and CaCl2were employed to synthesize organic-inorganic nanocomposite gel with self-healing properties. The chemical properties of nanocomposite gels were characterized using X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscope, X-ray photoelectron spectroscopy and thermogravimetric analysis. layered double hydroxide could be dispersed and exfoliated in the mixed solution of Acrylic acid and 2-Acrylamido-2-methylpropane sulfonic acid, and the swelling behavior, self-healing time, rheological properties, and mechanical performance of the nanocomposite gels were influenced by the addition of layered double hydroxide and Ca2+. Optimized nanocomposite gel AC6L3, at 90 °C, exhibits only a self-healing time of 3.5 h in bentonite mud, with a storage modulus of 4176 Pa, tensile strength of 6.02 kPa, and adhesive strength of 1.94 kPa. In comparison to conventional gel, the nanocomposite gel with self-healing capabilities demonstrated superior pressure-bearing capacity. Based on these characteristics, the nanocomposite gel proposed in this work hold promise as a candidate lost circulation material.
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JOURNAL OF MEDICINAL CHEMISTRY
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2024
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IF 6.8
Chao Zhao,Wanlu Sun,Yanyan Zhu,Xiaoyan Huang,Ye Sun,Hai-Yan Wang,Yi Pan,Yi Liu
Photodynamic therapy (PDT) is an innovative and promising method for treating tumors that has attracted significant interest but still faces several challenges, such as a lack of selectivity, deep penetration of light, and efficient ROS generation. To address these challenges, we optimized and synthesized a series of photosensitizers and successfully developed a heavy-atom-free near-infrared FUCL photosensitizer NFh-NMe-2. This photosensitizer can generate singlet oxygen (1O2) and induce cellular apoptosis under 808 nm light. For the safe ablation of microtumors in vivo, an activatable FUCL photosensitizer NFh-NTR was developed based on the overexpression of nitroreductase (NTR). NFh-NTR could be activated by NTR, leading to the release of the photosensitizer NFh-NMe-2, restoring the fluorescence signal, and effectively killing tumor cells under 808 nm light irradiation. This work opens new possibilities in the chemical design of an FUCL photosensitizer for cancer treatment.
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Heliyon
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2024
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IF 3.4
Feifei Sun,Yao Xiao,Lili Kong,Haibo Mu,Xing Wang,Jinyou Duan
The consequences caused by bacterial resistance are becoming more and more serious. The rate of antibiotic development is far behind the rate of bacterial resistance, so it is urgent to develop a new drug system. In this study, photoresponsive nanogels based on hyaluronic acid were prepared and loaded with ciprofloxacin as a model molecule. The results showed that the nanogels had the advantages of high stability and good cytocompatibility. The inhibition effect of drug-loaded nanogels after light irradiation on the growth of Staphylococcus aureus and Salmonella typhimurium was significantly better than that before light irradiation, and ciprofloxacin could be released on demand and in control. This strategy is of great significance to reduce the unnecessary use of antibiotics and weaken bacterial resistance.
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CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Kai Han,Jian Liu,Fukang Hao,Jianlong Wang,Jinfeng Yuan,Zhicheng Pan,Mingwang Pan
Waterborne fluorocarbon coatings are gaining popularity as a more environmentally friendly replacement for traditional solvent-based coatings because of its corrosion resistance and antibiofouling properties. However, the environmental unfriendliness of small molecular emulsifiers used, the occurrence of flash rusting, and the inability to self-repair after accidental damage restrict its application in the marine industry. Here, a redox-responsive copolymer (PM x ) was synthesized by the amphiphilic nature of waterborne polyurethane as microreactors, which was employed as coatings (PM x /WPU) with anti-flashing rust, antibiofouling, and self-repairing functions. The copolymer was polymerized from chlorotrifluoroethylene (CTFE), vinyl acetate (VA), and a special monomer conjugated to the corrosion inhibitor 2-benzothiazolethiol (MBT) through disulfide bonds, in which MBT can be released through disulfide bond breaking in a reducing environment, effectively preventing the occurrence of flash rusting. The combination of the repelling properties of the fluorinated groups and the bactericidal action of the MBT results in PM x /WPU coatings with excellent antibiofouling properties. Additionally, the reversible hydrogen bonds in the polyurethane provide the PM x /WPU coatings with excellent self-repairing ability (93.9%). Our study presents a new approach to polymerize fluoro-substituted ethylene monomers using polyurethane as microreactors, enabling the preparation of waterborne fluorocarbon coatings with anti-flashing rust, antibiofouling, and self-repairing properties for practical applications.
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BIOTECHNOLOGY AND BIOENGINEERING
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2024
·
IF 3.5
Chunyu Han,Zhenxu Wu,Yuqi Gao,Shuang Yang,Yu Wang,Min Guo,Yueyue Li,Wanzhong Yin,Ling Liu,Wenzhi Song,Peibiao Zhang,Liqiang Wang
The repair process of bone tissue includes the early inflammatory response period and the late tissue repair period. It has been widely approved to be beneficial to the repair of bone injury by procedurally inhibiting the inflammatory response in the early stage and promoting bone regeneration in the late stage. In this study, the nano-hydroxyapatite/Poly(glycolide-co-caprolactone) (n-HA/PGCL) scaffold loaded with icariin was fabricated by fused deposition modeling technique, and the quercetin-loaded GelMA was further filled into the scaffold pores via light-curing methods to form a biphasic scaffold loaded with dual molecules (PHI + GQ scaffold). The releases of icariin and quercetin were sequential due to different degradation rates of GelMA and PGCL. In vitro, the scaffold not only scavenged reactive oxygen species production, but also promoted osteogenic differentiation of the MC-3T3-E1 cells. Furthermore, in vivo bone reconstruction of PHI + GQ scaffold was better than other groups by assessment of micro-CT data. In addition, the immunofluorescence staining of Arg-1 and iNOS indicated that PHI + GQ scaffold created an immune microenvironment conducive to bone repair due to the release of quercetin in the early stage, and HE and Masson staining suggested that PHI + GQ scaffold induced more new bone formation. These results demonstrated that the biphasic scaffold loaded with icariin and quercetin had both antioxidants in the early stage and osteogenesis properties in the late stage, obtaining satisfactory bone repair outcomes. Thus, the biphasic scaffold loaded with icariin and quercetin for sequential release could provide a promising solution for the restoration of bone defects and represent a potential strategy for bone regeneration.
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Acta Pharmaceutica Sinica B
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2024
·
IF 14.7
Yongkang Lai,Tinglin Zhang,Xiaojing Yin,Chunping Zhu,Yiqi Du,Zhaoshen Li,Jie Gao
Helicobacter pylori ( H. pylori) infection remains the leading cause of gastric adenocarcinoma, and its eradication primarily relies on the prolonged and intensive use of two antibiotics. However, antibiotic resistance has become a compelling health issue, leading to H. pylori eradication treatment failure worldwide. Additionally, the powerlessness of antibiotics against biofilms, as well as intracellular H. pylori and the long-term damage of antibiotics to the intestinal microbiota, have also created an urgent demand for antibiotic-free approaches. Herein, we describe an antibiotic-free, multifunctional copper-organic framework (HKUST-1) platform encased in a lipid layer comprising phosphatidic acid (PA), rhamnolipid (RHL), and cholesterol (CHOL), enveloped in chitosan (CS), and loaded in an ascorbyl palmitate (AP) hydrogel: AP@CS@Lip@HKUST-1. This platform targets inflammatory sites where H. pylori aggregates through electrostatic attraction. Then, hydrolysis by matrix metalloproteinases (MMPs) releases CS-encased nanoparticles, disrupting bacterial urease activity and membrane integrity. Additionally, RHL disperses biofilms, while PA promotes lysosomal acidification and activates host autophagy, enabling clearance of intracellular H. pylori . Furthermore, AP@CS@Lip@HKUST-1 alleviates inflammation and enhances mucosal repair through delayed Cu 2+ release while preserving the intestinal microbiota. Collectively, this platform presents an advanced therapeutic strategy for eradicating persistent H. pylori infection without inducing drug resistance.
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GREEN CHEMISTRY
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2024
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IF 9.3
Yunjian Wu,Yiran Hu,Hui Lin,Xiaoxing Zhang
Anhydride-cured epoxy is a common insulating material used in electrical equipment, but recycling it effectively is difficult, which results in the overall abandonment of the equipment after decommissioning and serious environmental pollution. In order to make anhydride cured epoxy degradable while maintaining its electrical performance, we synthesized a high-performance epoxy insulating material that can be recycled and reused using triethanolamine as a transesterification catalyst co-accelerator. Results show that the new epoxy has the lowest dielectric loss of 0.0012, the highest breakdown strength of 42.26 kV mm−1, and the highest tensile strength of 93.7 MPa. The degradable epoxy can be recovered via mechanical hot pressing and regenerated through chemical degradation. Degradation products can be directly used as curing accelerators to complete the re-preparation of the insulating material. Even after recovery, the properties of the epoxy resin meet the application requirements of insulating materials.
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CHEMICAL ENGINEERING JOURNAL
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2024
·
IF 13.3
Na Wang,Kai Liu,Anran Xu,Hong Li,Zhenyu Zhao,Xiaolei Fan,Xin Gao
Biorefinery of lignocellulosic biomass to produce biofuels for replacing fossil resources is a major topic of energy conservation and carbon reduction. The efficiency of such biorefinery processes relies on the pretreatment of biomass, which is, however, the most energy-consuming step in the bio-conversion processes. To answer the demand of clean and efficient production in modern era, this study proposed a microwave (MW)-assisted route to pretreat corn stover (for fractionation) using a green cosolvent system consisting of ethyl lactate (EL) and water, and sulfonated activated carbon particles (AC-SO 3 H) were used to improve the MW absorbing ability and process efficiency. Based on the systematic investigation of the effect of operating parameters on fractionation of corn stover, 81.7 % of hemicellulose and 85.3 % of lignin were separated from the raw corn stover with 80.9 % of cellulose retained under optimal conditions of 160 ℃ for 40 min with 0.3 g AC-SO 3 H catalyst in EL/H 2 O cosolvent (EL/H 2 O = 3/2). The proposed EL/water cosolvent showed much higher efficiency than that using either pure EL or water, and in situ production of lactic acid (LA) and ethanol (EtOH) (via EL hydrolysis under acid environment) can benefit the pretreatment process. Compared to conventional heating, the MW method shortened the treatment time by half to obtain similar separation results. The improvement of the MW absorption ability and catalytic activity for this proposed pretreatment method was proven by control experiments, achieving effective disruption of the biomass structure and the accessibility of solvents to hemicellulose and lignin.
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ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Anamika Kushwaha,Lalit Goswami,Beom Soo Kim
In this study, we established an innovative and integrated chemical/biological methodology for the complete poly(ethylene terephthalate) (PET) degradation and biopolyol production using cerium–iron oxide nanoparticles (CeFeNPs). Initially, three nanoparticles, i.e., CeNPs, FeNPs, and CeFeNPs, were synthesized and evaluated for PET glycolysis. CeFeNPs demonstrated the best catalytic performance for PET depolymerization to bis(2-hydroxyethyl) terephthalate (BHET) and were further recovered from the PET depolymerized slurry to be reutilized again. BHET was further biodegraded using the hydrocarbonoclastic bacterium Pseudomonas aeruginosa PR3 under the batch modes using a shake flask and a stirred tank bioreactor. To elucidate the fate of BHET biodegradation under aerobic conditions, identification of various BHET degraded metabolites was carried out using liquid chromatography–mass spectrometry analysis. The strain could produce an extracellular diol synthase enzyme, which transforms oleic acid into the biopolyol, 7,10-dihydroxy-8(E)-octadecenoic acid (DOD). CeFeNPs were further supplemented to enhance DOD production via whole cell and cell-free approaches.
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Small
·
2024
·
IF 13
Xiuli Chen,Yusheng Gong,Min Li,Qi Zeng,Rengui Xu,Xiaolong Li,Xiang Lu,Shang Gong,Jiarong Xu,Guanyue Li,Jingwen Yang,Wenhao Jiao,Jiajing Liu,Yuan Liu,Xinting Liang,Linxi He,Fei Xiao,Wei Chen
Anastomotic leakage (AL) is a pervasive and risky postoperative complication that presently features inaccessible prevention, delayed diagnosis, and intractable remediation, resulting in distressing morbidity and mortality. Herein an interior/exterior collaboration-enhanced neoteric intestinal anastomosis (IECIA) is developed, which consists of an interior hydrogel-based protective barrier adhering to mucosa, and exterior synergistic leakage-prevention safeguard sutured to serosa, for multi-tiered leakage complication management. Noticeably, the hydrogel barrier protects anastomosis stoma against injurious stimulation from digestive liquid, consequently reducing leakage risk effectively and comfortably in place of painful gastric tube insertion. The exterior safeguard encompassing fluorescein-loaded hydrogel and electrospun film functions as a secondary defense, exhibiting critical leakage-prevention capability to refrain from lethal intra-abdominal infection. Meanwhile, fluorescein is released to the enteric cavity for following detection within the excrement in case anastomotic leakage occurs, achieving presymptomatic alarming in providing valuable prompts for timely clinical intervention. Importantly, IECIA has been investigated in realistic in vivo end-to-end intestinal anastomosis scenarios as well as simulated leakage models, which present satisfactory postoperative recovery of gastrointestinal functions and systematic indexes. Moreover, the IECIA system is endowed with guaranteed biocompatibility, effective durability, comprehensibility for surgical operation, comfort, and compliance for patients, which demonstrates precious value for clinical translation.
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