SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xin Li,Xinghua Yang,Rui Wang,Pingping Teng,Shuai Gao,Nan Lu,Xiaoyu Li,Adam Jones,Kang Li
Surface-enhanced Raman scattering (SERS) is a promising tool for sweat analysis, but signal noise, nonlinear responses, and spectral overlap limit its quantitative accuracy in complex samples. In this work, an intelligent SERS sensing strategy was developed by combining an Ag NP fractal substrate with a Gradient Kernel Size Convolutional Neural Network (GKS-CNN). The self-assembled Ag NP substrate provided abundant electromagnetic hotspots, enabling sensitive detection of lactate (LA) and glucose (Glu) from 10 −4 to 10 1 mM, with limits of detection of 108 nM and 224 nM, respectively. PCA results showed that the preprocessed SERS spectra contained distinguishable concentration-related information. Compared with linear regression, traditional machine learning methods, and standard CNNs, GKS-CNN achieved better prediction performance by extracting multi-scale features from nonlinear and overlapping spectra. For pure-component samples, the R 2 values of LA and Glu reached 0.99 and 0.98, respectively; for the joint dataset containing pure and mixed samples, the R 2 values were 0.98 and 0.97, respectively. In real sweat analysis, sample-level splitting was used to reduce data leakage, and the model classified four exercise-related states with an independent test accuracy of 95.00%. The average accuracies of 20 repeated random splits and 5-fold cross-validation were 94.50% and 93.50%, respectively. These results suggest that the proposed SERS-GKS-CNN strategy has potential for non-invasive sweat metabolite analysis and preliminary physiological-state recognition.
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PubMed
高影响因子
TALANTA
·
2026
·
IF 6.7
Chenglong Chen,Qiaoxia Zhang,Xiajuan Wang,Ran Miao,Tiesheng Shi,Qingyun Liu
To resolve the conflict between multidimensional interferences derived from complex matrices and the stringent requirements for trace-level detection sensitivity, a novel electrochemical aptasensor was constructed for highly sensitive kanamycin (KANA) detection based on a split aptamer engineering strategy. Ag–Ti 3 C 2 T x MXene, synthesized via in-situ reduction of silver nanoparticles onto the surface of two-dimensional MXene nanosheets, is employed for electrode decoration. This composite possesses abundant binding sites for aptamer 1 (Apt1) immobilization and exhibits outstanding catalytic performance in the reduction of H 2 O 2 . Signal acquisitions were performed under reductive potential conditions, endowing the sensor with superior anti-interference capability. Upon KANA addition, aptamer 2 (Apt2) can assemble into a ternary structure with the target and Apt1, leading to the displacement of cDNA and triggering a signal-down response. Under optimized conditions, the fabricated aptasensor presents a broad linear range of 1∼20000 nM with a limit of detection (LOD) of 0.12 nM, and exhibits excellent selectivity, reproducibility, and strong stability. In addition, the aptasensor demonstrates satisfactory recovery rates in real sample analysis, indicating its great potential for practical applications. The combination of Ag–Ti 3 C 2 T x MXene nanocomposite and split aptamer engineering technology provides a feasible strategy for highly sensitive detections of trace-level antibiotic residues in complex food matrices.
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PubMed
高影响因子
RARE METALS
·
2026
·Vol. 45
·期 6
·e70345
·
IF 12.1
Zhizhong Sun,Yifei Wang,Yi Zheng,Minying Li,Longbao Feng,Ziwei Jiang,Hengrui Liu,Rui Guo,Weipeng Sun
en This link goes to a English section zh This link goes to a Chinese section Bone restoration is often hindered by the spatiotemporal dysregulation of immune and regenerative signals. Conventional bio-inert implants, providing only passive support, fail to modulate this microenvironment, leading to infections and poor healing. To achieve proactive regulation of the osteo-immune niche alongside robust antimicrobial defense, we developed a novel 3D-printed, high-strength hydrogel composed of methacrylated silk fibroin (SFMA), copper-epigallocatechin gallate (Cu-EGCG), and silver nanoparticles (AgNPs), characterized by dual-ion release kinetics. A sophisticated staged-release strategy was engineered wherein the rapid initial burst of Cu 2+ establishes an immediate antimicrobial barrier and initiates early immunomodulation, whereas the sustained, long-term release of Ag + ensures continuous pathogen suppression. This “fast-and-slow” synergistic release profile effectively bridges the gap between acute-phase infection control and the requirement for a stable environment during chronic tissue maturation. In vitro studies confirmed that the hydrogel possesses superior mechanical integrity, biocompatibility, and potent antibacterial activity, significantly promoting the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs). In vivo results demonstrated robust new bone formation, with near-complete anatomical restoration of critical-size bone defects achieved within 4 weeks in the experimental group. Transcriptomic analysis further elucidated the underlying mechanism, revealing that the SFMA/Cu-EGCG/AgNPs hydrogel significantly reshaped gene expression profiles associated with immunity and osteogenesis. By activating immune-regulatory pathways—specifically IL-17 and TGF-β—the hydrogel successfully orchestrated a pro-regenerative immune microenvironment. Simultaneously, the significant enrichment of Wnt signaling and ossification-related pathways confirmed its dual-functional role in accelerating bone regeneration at the molecular level. In summary, this hydrogel facilitates a synergistic “infection control-immunomodulation-osteogenesis” tripartite repair strategy, offering a highly promising biomimetic approach for the clinical management of complex bone defects. 摘要 en This link goes to a English section zh This link goes to a Chinese section 骨缺损修复过程常受到免疫反应与再生信号时空失调的显著制约。传统生物惰性植入材料仅提供被动结构支撑,难以有效调控局部微环境,易导致感染发生及组织修复不良。针对上述问题,该研究构建了一种新型3D打印高强度水凝胶体系,由甲基丙烯酰化丝素蛋白(SFMA)、铜-表没食子儿茶素没食子酸酯复合物(Cu-EGCG)及银纳米颗粒(AgNPs)组成,具有双离子协同释放特性。通过构建分阶段释放策略,实现了Cu 2+ 与Ag + 的“快-慢协同”调控:初期快速释放的Cu 2+ 可迅速建立抗菌屏障并启动早期免疫调节,而Ag + 的持续释放则维持长期抗菌效应,从而有效衔接急性感染控制与后期组织稳定再生过程。体外实验表明,该水凝胶具有优异的力学性能与生物相容性,并表现出显著的抗菌活性,同时能够促进骨髓间充质干细胞(BMSCs)的增殖与成骨分化。体内实验结果显示,实验组在4周内实现了临界尺寸骨缺损的近完全结构修复。转录组分析进一步揭示其作用机制:SFMA/Cu-EGCG/AgNPs水凝胶显著重塑了与免疫调控及成骨相关的基因表达谱,通过激活IL-17与TGF-β信号通路,构建促再生免疫微环境; 同时,Wnt信号通路及骨形成相关通路的显著富集,证实其在分子水平上具有促进骨再生的双重功能。综上,该水凝胶通过构建“抗感染—免疫调控—成骨再生”协同修复策略,为复杂骨缺损的临床治疗提供了一种具有重要应用前景的仿生材料新方案。
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Chen Lin,Jiabin Lu,Qiyuan Wu,Xiaolan Xiao
Fabricated a broad-spectrum responsive AgCl@Ag photocatalyst with SPRE. • AgCl@Ag exhibits 2.4-fold higher MRR than TiO 2 under visible light. • Revealed SPRE-enhanced ·OH generation and synergistic removal mechanism. To overcome the ultraviolet (UV) light limitation of conventional TiO 2 -based photocatalysis-assisted polishing, AgCl@Ag composite particles with surface plasmon resonance effect (SPRE) were prepared via a precipitation-chemical reduction method. Their morphology, phase composition, surface chemistry, and optical absorption were characterized by SEM, XRD, XPS, and UV–Vis. Photocatalytic activity and polishing performance on single-crystal SiC were systematically compared with commercial TiO 2 under both UV and visible light. The AgCl@Ag particles showed uniform size, regular morphology, no surface impurities, and broad-spectrum absorption. Under UV light, both AgCl@Ag and TiO 2 achieved >90% methyl orange degradation within 30 min, with comparable polishing performance: AgCl@Ag yielded an MRR of 86.7 nm·h −1 and a surface roughness Sa of 3.25 nm, versus 77.0 nm·h −1 and 3.28 nm for TiO 2 . Under visible light, significant differences emerged. TiO 2 degraded only 13% of methyl orange in 30 min, with an MRR of 22.8 nm·h −1 and Sa of 6.78 nm. In contrast, AgCl@Ag achieved >55% degradation, an MRR of 55.0 nm·h −1 , and Sa of 4.93 nm under the same conditions. The SPRE of AgCl@Ag promotes photogenerated charge carrier separation, enabling ·OH radical generation that synergistically forms and mechanically removes the surface oxide layer on SiC. Download: Download high-res image (250KB) Download: Download full-size image
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ELECTROCHIMICA ACTA
·
2026
·
IF 5.8
Jingli Tang,Yichao Wang,Jiayu Ma,Yuanyuan Zhang,Liqian Huang,Xueli Wang,Jianyong Yu
Asymmetric electrode reactivity confines viologen redox to ITO interface. • Ag/TiO₂ conduction band edge prevents electron transfer to viologen. • Voltage polarity reversal achieves electrochemically controlled bleaching. • Textile-based planar device design suits wearable electrochromic applications. This study addresses the key challenge of slow bleaching kinetics in conventional viologen-based electrochromic devices (ECDs) employing solid/gel electrolytes by proposing a novel electrode engineering strategy based on differentiated electrode reactivity. The Ag/TiO₂ fabric electrode, due to the semiconducting properties of its TiO₂ coating, exhibits insufficient reducing power to drive the reduction and coloration of dissolved viologen cations. Leveraging this principle, an asymmetric planar ECD with reaction "directionality" was constructed, consisting of an ITO electrode paired with an Ag/TiO₂ fabric electrode in a side-by-side configuration. In this design, the viologen coloration/bleaching reactions are effectively "confined" to the ITO electrode interface. Simply switching the polarity of the applied voltage (±1.0 V) enables controllable coloration (7.4 s) and active bleaching (16.5 s), which is over 98% faster than the natural diffusion-driven bleaching observed under open-circuit conditions (>900 s). Unlike conventional approaches that require complementary electroactive layers or immobilized redox species, this strategy circumvents the slow spontaneous back-reaction solely through electrode-level thermodynamic control. Furthermore, by patterning the ITO electrode, its potential for applications in flexible displays was demonstrated. This work provides a novel and effective electrode engineering strategy for developing high-performance, rapidly switchable, and designable wearable electrochromic devices. Download: Download high-res image (182KB) Download: Download full-size image
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高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Quan Luo,Jiayi Wang,Baixin Zhang,Qiaoqiao Wei,Jiahao Chen,Lijuan Wang,Xiaolu Wang,Wenzhong Wang
The light collection ability, surface oxidation reaction kinetics, bulk charge carrier separation efficiency, and surface charge injection efficiency play a crucial role in hydrogen production through solar-driven water splitting of semiconductor photoanodes in photoelectrochemical (PEC) system. Surface plasmon resonance (SPR) effect of plasmonic metals exhibits a potential to simultaneously boost the aforementioned performances of semiconductor photoanodes. Herein, the SPR effect of plasmonic Ag nanoparticles is exploited to augment PEC performance of BiVO 4 photoanode. The modification and SPR effect of Ag nanoparticles not only substantially accelerates the reaction kinetics of surface water oxidation but also enhances surface charge injection and bulk charge separation efficiencies of BiVO 4 nanostructure photoanode, leading to 361% enhancement in injection efficiency of surface charges and 126% enhancement in separation efficiency of bulk charges compared with those of pristine BiVO 4 photoanode. As a result, the optimized BiVO 4 /Ag nanostructure photoanode exhibits significantly enhanced PEC performance in Na 2 SO 4 electrolyte without sacrificial agent, and achieves a photocurrent density of 2.3 mA cm −2 at 1.23 V vs. reversible hydrogen electrode, 5 times of unmodified BiVO 4 nanostructure photoanode. This wok offers valuable insights into boosting PEC performance of wide bandgap semiconductor photoanodes through utilizing SPR effect of metals to simultaneously improve surface oxidation reaction kinetics, bulk charge separation and surface charge injection. Download: Download high-res image (131KB) Download: Download full-size image We demonstrate for the first time a novel plasmonic BiVO 4 nanostructure photoanode modified by Ag nanoparticles to achieve solar-driven efficient PEC water splitting by plasmon-induced acceleration of surface reaction kinetics, injection of energetic hot electrons and separation of bulk and surface charges.
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高影响因子
Journal of Optics
·
2015
·Vol. 17
·期 7
·075003
·
IF 2.059
Yongan Yang,Yuyang Wang,Xiaoyong Zhang,Guohua Qi,Shuping Xu,Weiqing Xu
Ag nanoparticles and nanostructured surfaces have been widely used as surface-enhanced Raman scattering (SERS) substrates, which can enhance the Raman signals when molecules are adsorbed on the surface of Ag by the effect of Ag-thiol bonds. In this paper, we propose an efficient method to remove the molecules adsorbed on Ag with sodium borohydride solution, providing a protocol to realize a reproducible and practicable Ag SERS substrate. A theoretical density function theory approach has been used to explain the mechanism of desorption.
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Fang Miao,Mingquan Jiang,Jing Yu,Yiyan Wang,Jiehong Lei
Dual-layer Ag 0 -HA@ACF enables rapid iodine capture and durable immobilization. • HA-driven in situ reduction achieved 21.58 wt% uniformly dispersed Ag 0 loading. • Ag 0 -HA@ACF achieves 1934.7 mg/g iodine uptake, surpassing most Ag-based adsorbents. • DFT revealed strong chemisorption of I 2 on Ag 0 (−3.880 eV) with AgI formation. A dual-layer active interface synergistic strategy was innovatively developed to address the critical challenge of efficient capture and immobilization of radioactive iodine vapor during spent fuel reprocessing. Humic acid (HA)-grafted activated collagen fiber (ACF) was constructed as a rapid induced adsorption layer, while nanoscale zero-valent silver (21.58 wt%) was in situ immobilized through HA-assisted chelation/double reduction combined with NaBH 4 reduction, forming a specific chemical immobilization layer. The resulting Ag 0 -HA@ACF composite exhibited an outstanding iodine-vapor uptake of 1934.7 mg/g and achieved 81.2% of its saturated capacity within 6 h, outperforming most reported silver-based adsorbents. FT-IR, XPS, and DFT analyses systematically revealed the synergistic “induced adsorption–specific immobilization” mechanism, where phenolic hydroxyl and amino groups promoted rapid I 3 ⁻ formation, while nanoscale Ag 0 converted iodine into thermally stable AgI. Moreover, DFT calculations revealed a strong chemisorption interaction between Ag 0 and I 2 , with an adsorption energy of − 3.880 eV. Owing to its facile preparation and scalability, this material provides a promising strategy for radioactive iodine management. Download: Download high-res image (124KB) Download: Download full-size image
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高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·Vol. 65
·期 33
·17553-17569
·
IF 3.9
Shi Ketao,Tang Ningjing,Xu Zhen,Zhu Youbing,Gong Ruidi,Jiao Nianming,Wang Hui
Bifunctional dehydrogenation-cracking
metal/zeolite catalysts
are
promising for the production of light olefins from alkanes, but their
activation commonly relies on high-temperature calcination. This conventional
activation can induce metal migration and aggregation, damage the
zeolite framework, reduce micropore accessibility, and alter the acid-site
distribution, thereby compromising the dehydrogenation-cracking synergy.
Herein, ion-exchanged Ag/ZSM-5 catalysts were activated by dielectric
barrier discharge (DBD) plasma as a mild alternative to thermal calcination
for nitrate removal and Ag-site reconstruction. Plasma activation
could effectively remove nitrate precursors while better preserving
the crystallinity, micropore accessibility, and acidity of ZSM-5.
More importantly, it suppressed Ag migration and aggregation, increased
the fraction of highly dispersed Ag + species associated
with exchange sites, and promoted a more favorable Brønsted/Lewis
acid balance. As a result, the plasma-activated Ag/ZSM-5 catalysts
exhibited enhanced catalytic performance in n -hexane
cracking, with higher selectivity to light olefins. At a low Ag loading,
the plasma-activated catalyst delivered a light-olefin selectivity
of 50.7% after 6 h of reaction, higher than those of the calcined
counterpart (46.8%) and parent ZSM-5 (34.7%). Meanwhile, it showed
slower deactivation during the 6 h fixed-bed reaction, together with
lower tendencies toward hydrogen transfer, aromatics formation, and
coke deposition.
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高影响因子
Surfaces and Interfaces
·
2026
·
IF 6
Xun Wang,Yan Yang,Hanhui Xie,Kai Xu,Xinlei Yao,Li Liang,Biyun Shi,Weidong Dou
Surface Enhanced Raman Scattering (SERS) substrates with high sensitivity and uniformity have been achieved using metallic plasmonic nanostructure arrays. There is a growing demand for cost-effective, ordered SERS-active nanostructures in portable detection. This study presents an efficient strategy for scalable fabricating low-cost, highly sensitive SERS substrates through a hot-electron-assisted reduction mechanism. Two sequential steps are involved: first, depositing an Au film onto an anodic aluminum oxide (AAO) template to create a 3D plasmonic nanostructure; second, in situ formation of Ag nanoparticles on the Au-coated AAO via plasmon-induced hot-electron reduction of silver nitrate under light excitation, eliminating the need for additional heating. The composite substrate demonstrates a 10⁴-fold Raman enhancement for low-concentration Rhodamine B detection, with a relative standard deviation of merely 2.3–4.7%. Moreover, a favorable linear relationship between the logarithm of SERS intensity (LogI) and logarithm of Rhodamine 6 G concentration (LogC) is observed with the Coefficient of Determination (R 2 ) reaching 0.99. It also serves as an effective catalytic template for 4-nitrobenzenethiol photoreactions, monitored via SERS spectral changes. Benefiting from distinct plasmonic signal enhancement, the Ag–Au/AAO substrate is competent for diverse analytical tasks, ranging from standard dye probes and trace paraquat pesticides to clinical clozapine pharmaceuticals, demonstrating broad applicability in environmental and biomedical sensing. Download: Download high-res image (298KB) Download: Download full-size image
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高影响因子
SOLID STATE SCIENCES
·
2026
·
IF 3.6
Yingxia Ma,Shuo Zhou,Tianze Li,Miaoshi Li,Wenhui Han
A superparamagnetic Fe 3 O 4 @Zn-AST nanocomposite was constructed. • The Fe 3 O 4 @Zn-AST had abundant N, S-containing functional groups. • The Fe 3 O 4 @Zn-AST exhibits a saturation magnetization of 61.29 emu/g. • The maximum adsorption capacity of Fe 3 O 4 @Zn-AST for Ag(I) was 1410.68 mg/g. Silver as a precious metal, is extensively utilized in jewelry, electronics and some other fields due to its excellent conductivity and ductility. With the growing demand for silver, excessive exploitation of silver ore resources has generated large volumes of Ag(I)-containing wastewater. The direct release of untreated Ag(I)-containing wastewater contaminates ecosystems and poses risks to human health. Metal-Organic Frameworks (MOFs) exhibit a notably specific surface area, ample unsaturated metal sites, ease of functionalization, and tunable pore size and structure, which make them highly promising materials for effective adsorption of pollutants from wastewater. However, pure MOFs are typically in powder form, which are not easy to separate and recover after adsorption. In this work, using the zinc nitrate hexahydrate as the metal precursor along with 2-amino-5-sulfanyl-1,3,4-thiadiazole (AST) as the multi-dentate organic ligand, a superparamagnetic Fe 3 O 4 @Zn-AST nanocomposite was prepared via in-situ solvothermal method. The Fe 3 O 4 @Zn-AST exhibits a saturation magnetization of 61.29 emu/g, meeting the requirements for magnetic separation. The maximum Ag(I) adsorption capacity of Fe 3 O 4 @Zn-AST is 1410.68 mg/g, and adsorption process is mainly chemical adsorption, featured by endothermic, disordered, and spontaneous. Adsorption-desorption experiments prove that the removal efficiency can remain above 91% even after five cycles. From FT-IR and XPS, the Fe 3 O 4 @Zn-AST adsorbing Ag(I) was mainly through the synergistic effect of -SH, N-containing functional groups and electrostatic interactions. Given the magnetic separation advantage and superior Ag(I) adsorption, Fe 3 O 4 @Zn-AST could serve as a promising adsorbent. Download: Download high-res image (241KB) Download: Download full-size image
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高影响因子
ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xin Zhuang,Jing Lin,Jialun Lin,Ranxi Mo,Xinyan Zheng,Yiqing Chen,Yuhua Hu,Ruiyun You,Yudong Lu
Functionalized Au@Ag NRs were immobilized in a triple-network hydrogel for wearable SERS sweat sensing. • Three reporter-functionalized hydrogel channels enabled ratiometric SERS detection of azelaic acid, H 2 O 2 , and pH. • The ATPPZn hydrogel showed good signal uniformity, reproducibility, 100-day storage stability, and skin-contact adaptability. • Sensitive detection of azelaic acid and H 2 O 2 was achieved with detection limits of 7.8 × 10 −13 M and 66.1 μM, respectively. • Real sweat analysis confirmed the feasibility of the platform for monitoring skin-inflammation-related molecular changes. Skin inflammation is commonly accompanied by oxidative stress and changes in the local acid–base microenvironment, whereas molecular indicators reflecting inflammation-associated metabolic changes remain less explored in wearable sensing. Azelaic acid, a dicarboxylic acid associated with inflammatory skin conditions, represents a potential small-molecule target, yet its non-invasive analysis in sweat remains challenging. Herein, a wearable-compatible ratiometric surface-enhanced Raman scattering (SERS) platform was constructed by embedding functionalized Au@Ag nanorods into a TEMPO-oxidized cellulose nanofibers (TOCNF)/poly(vinyl alcohol) (PVA)/poly(acrylamide-co-acrylic acid) [P(AM-co-AA)]-Zn 2+ triple-network hydrogel. The hydrogel architecture promoted nanoprobe dispersion and immobilization while maintaining flexibility and signal stability, yielding a spatial SERS relative standard deviation (RSD) of 5.19% and 77% signal retention after 100 days. Using Au@4-ATP@Ag nanorods (NRs) containing 4-ATP as a Raman-responsive reporter, azelaic acid was quantified through the ratiometric I 1194 /I 1073 response over 1 × 10 −12 –1 × 10 −7 M, with a detection limit of 7.8 × 10 −13 M, and its analytical feasibility in sweat was further evaluated by spike-recovery analysis. To provide complementary information on inflammation-related microenvironmental changes, the same hydrogel architecture was further adapted for H 2 O 2 and pH sensing using Au@4-MPBA@Ag and Au@4-MBA@Ag NRs, respectively. The H 2 O 2 channel exhibited a concentration-dependent response over 1-500 μM, while the pH response agreed well with pH-meter measurements, with deviations within 0.07 pH units. These results demonstrate the analytical feasibility of azelaic acid as an underexplored inflammation-related sweat target and highlight the potential of the triple-network SERS hydrogel for integrating molecular and microenvironmental information in skin-related sweat analysis. Download: Download high-res image (313KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）