INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Lin Lin,Huiyan Cheng,Qun Cheng,Changzhu Li,Fahad Al-Asmari,Manal Y. Sameeh,Haiying Cui
Listeria monocytogenes ( L. monocytogenes ) is a foodborne pathogen often found in ready-to-eat (RTE) foods, posing significant threats to human health. In this study, an active film based on cross-linking via Schiff base and electrostatic interaction to inactivate L. monocytogenes on RTE foods was constructed. Zinc-casein hydrolysate chelates (Zn-HCas) was prepared and blended with cationic starch (CSt) to form the substrates of the film. Then, Citral (CI) with excellent antibacterial properties was added to enhance the biological and packaging properties of the film through covalent cross-linking (Schiff base). Based on the zinc ion-activated metalloproteinases produced by L. monocytogenes , the cross-linked film could be disrupted and the release of CI was accelerated. The variation in color, FTIR, and amino group content proved that Schiff base reaction had taken place. Enhanced mechanical properties, barrier properties, thermal stability and antimicrobial activity against L. monocytogenes (exceed 99.99 %) were obtained from the CI/Zn-HCas/CSt film. The application on RTE cheese results demonstrated that the cross-linked film could be employed in active packaging field with the ability in maintaining the original chroma and texture properties of RTE cheese. In summary, the prepared cross-linked film could be used as an active packaging against L. monocytogenes contamination with great potential.
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高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
·
IF 4.6
Linze Liu,Yawen Deng,Hangqi Ren,Ying Ren,Taizheng Tang,Eerdun bayaer,Shaobo Li,Tungalag Dong,Xueyan Yun
Plant extracts with antioxidant activity are frequently employed to inhibit acrylamide (AM) production, but there has been limited focus on their inhibitory effects on AM during the extended storage of foods. In this study, impregnation solutions were prepared using Hippophae rhamnoides L (Hp) and Alkekengi officinarum Moench (Ak) fruits extracts to investigate their protective effects on roasted chicken breasts (RCB) during processing and storage (vacuum packed at 4°C and stored at 25°C for 90 days). In a 90-day storage experiment with RCB, these extracts also slowed the increase of AM in RCB. However, these extracts exhibit inadequate protective effects on RCB during long-term storage. It is needed to develop new methods for monitoring and inhibiting AM formation in RCB.
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Foods
·
2025
·Vol. 14
·期 10
·1796
·
IF 5.1
Ziyan Hua,Yunfan Lv,Han Zhang,Tianyi Mao,Ruyu Xv,Mingxuan Pan,Yadong Hu,Shu Liu,Yaowei Fang
The gut microbiota plays important functions in human health and influences immune responses, metabolic processes, and several physiological activities. The modulation of the gut microbiota through dietary interventions has emerged as a promising approach, leading to significant interest in the development of functional foods that provide health benefits. In this context, our study investigated the effects of raspberry juice fermented byLimosilactobacillus fermentumFUA033 on the structure and metabolism of the gut microbiota. We performed 16S rRNA gene sequencing and nontargeted metabolomics analyses to evaluate changes in the microbial composition and metabolite profiles resulting from fermentation. Our findings revealed that fermented raspberry juice considerably increased the gut microbial diversity and promoted the abundance of beneficial genera. Fermentation substantially increased the production of short-chain fatty acids, such as acetate and butyrate, which increased from 30.09 ± 5.23 mmol/L to 43.07 ± 3.31 mmol/L, and from 7.72 ± 1.72 mmol/L to 15.01 ± 1.26 mmol/L, respectively. Metabolomic analyses also showed significant enhancements in amino acid metabolism pathways, particularly those involving tyrosine, arginine, and proline. These results highlight the potential of fermented raspberry juice as a functional food to improve gut health and metabolic functions.
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高影响因子
POLYMER
·
2020
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IF 4.231
Xiangli Li,Dongsheng Yang,Youbo Zhao,Xingyuan Diao,Hongwei Bai,Qin Zhang,Qiang Fu
Stereoblock copolymerization is regarded an appealing strategy to substantially enhance the melt stability (i.e., the survival ability of the intermolecular collaboration between poly( l -lactide) (PLLA) and poly( d -lactide) (PDLA) upon melting) of high-molecular-weight (high-MW) stereocomplex-type polylactide (SC-PLA), however it usually suffers from complicated synthetic procedures and even impaired sustainability. Herein, solid-state transesterification (SST) has been devised as a facile and robust route to prepare unique multi-stereoblock PLA copolymers with outstanding melt stability and unexpectedly strong crystallizability from commercial available linear high-MW PLLA/PDLA (50/50) blends. The SST was performed through low-temperature (i.e., 180 °C) melt-blending of PLLA and PDLA in the presence of trace amounts (0.03–0.035 wt%) of catalysts, where the enantiomeric PLA chains could rapidly co-crystallize into solid-state SC crystallites upon melting and subsequently the hetero-chain transesterification reaction occurs exclusively in the mobile amorphous phase of the pre-formed SC crystallites. As a result, multiblock-like PLLA- b -PDLLA- b -PDLA copolymers with long crystallizable PLLA and PDLA blocks are in-situ generated. The results show that high-content SC crystallites can be exclusively formed in the melt-crystallization of the copolymers even at high cooling rates (e.g., 40 °C/min) and low temperatures (e.g., 140 °C). More interestingly, the presence of the non-crystallizable PDLLA blocks not only does not disturb the SC crystallizability of the enantiomeric PLA blocks, as evidenced by the same high crystallinity and melting temperature as those of starting PLLA/PDLA blends, but also increase the crystallization rate by stabilizing the clusters of ordered PLLA/PDLA segments in the copolymer melt. Overall, these findings could open a new pathway to develop melt-processible all SC-PLA for engineering applications.
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高影响因子
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
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2013
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IF 2.207
Feng Xu,Ting-Ting Yan,Yan-Ling Luo
Novel amphiphilic block copolymers consisting of hydrophobic poly(D,L-lactide) segments and hydrophilic poly(N-isopropylacrylamide-co-N, N-dimethylacrylamide) blocks were designed and synthesized through a simple free radical copolymerization route based on a bifunctional initiator, followed by the ring-opening polymerization of D,L-lactide. The copolymers self-assembled into thermosensitive spherical-nanosized core–shell micelles in aqueous solution in the presence or the absence of the model drug prednisone. The chemical and physical characterizations of drug-loaded and unloaded micelles revealed a lower critical solution temperature of 40°C–47°C, and a critical micelle concentration less than 7.20 mg L−1, a transmission electron microscope mean particle size from 50 to 75 nm, and a narrow dynamic light scattering diameter below 180 nm. The prepared blank and drug-loaded micellar nanoparticles were thermodynamically stabile and employed in targeted drug delivery by responding to the higher temperature of the local microenvironment. Based on prednisone release kinetic studies, structural changes of the self-assembled micelles as well as temperature- or environment-induced diffusion controlled drug release and improved bioavailability. The copolymer micelles exhibited good biocompatibility as established by the MTT cytotoxicity assay. Therefore, an effective target therapy against lesion tissues is feasible using these polymeric micelles.
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高影响因子
Frontiers of Materials Science
·
2023
·Vol. 17
·期 2
·1-13
·
IF 2.7
Fan Yongyong,Yin Anlin,Li Yunhuan,Gu Qi,Zhou Yan,Zhou Junlong,Zhao Ruibo,Zhang Kuihua
In order to provide a biomimetic natural extracellular matrix microenvironment with excellent mechanical capacity for tissue regeneration, a novel porous hybrid glycidyl methacrylate-modified silk fibroin/poly(L-lactic acid-ε-caprolactone)-polyethylene glycol diacrylate (SFMA/P(LLA-CL)-PEGDA) hybrid three-dimensional (3D) nanofibrous scaffolds was successfully fabricated through the combination of 3D nanofibrous platforms and divinyl PEGDA based photocrosslinking, and then further improved water resistance by ethanol vapor post-treatment. Scanning electron microscopy and micro-computed tomography results demonstrated significant PEGDA hydrogel-like matrices bonded nanofibers, which formed a 3D structure similar to that of “steel bar (nanofibers)–cement (PEGDA)”, with proper pore size, high porosity, and high pore connectivity density. Meanwhile, the hybrid 3D nanofibrous scaffolds showed outstanding swelling properties as well as improved compressive and tensile properties. Furthermore, these hybrid 3D nanofibrous scaffolds could provide a biocompatible microenvironment, capable of inducing the material–cell hybrid and regulating human umbilical vein endothelial cells proliferation. They thus present significant potential in tissue regeneration.
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高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 43
·9031-9040
·
IF 6.331
Jilin Zheng,Peng Zhao,Shiying Zhou,Sha Chen,Yi Liang,Fengchun Tian,Jun Zhou,Danqun Huo,Changjun Hou
Integrating metal–organic frameworks (MOFs) of different components or structures together and exploiting them as electrochemical sensors for electrochemical sensing has aroused great interest. Furthermore, the incorporation of noble metals with MOFs is conducive to the improvement of catalytic performance. In this work, Pd@UiO-66-on-ZIF-L nanomaterials were successfully synthesised onto a self-supported flexible carbon cloth (Pd@UiO-66-on-ZIF-L/CC) through a novel strategy called MOF-on-MOF. Then, Au nanoparticles were electrodeposited onto Pd@UiO-66-on-ZIF-L/CC to obtain Au–Pd@UiO-66-on-ZIF-L/CC, which can serve as an excellent electrocatalyst for the reduction of hydrogen peroxide (H2O2). The obtained flower-like Pd@UiO-66-on-ZIF-L/CC hybrid MOF changes the structure of the monomeric MOF alone and adds more attachment sites. The synergy of the bimetals greatly improved the catalytic performance of the as-developed sensor. Electrochemical experiment results show that the proposed sensor based on Au–Pd@UiO-66-on-ZIF-L/CC has an extended linear range from 1 μM to 19.6 mM with a sensitivity of 390 μA mM−1 cm−2, and a low limit of detection (LOD) of 21.2 nM (S/N = 3). Moreover, it has good anti-interference, reproducibility, repeatability and excellent stability. Furthermore, the real-time in situ detection of H2O2 secreted from human adenocarcinomic alveolar basal epithelial cells (A549 cells) was achieved by culturing cells on Au–Pd@UiO-66-on-ZIF-L/CC, which indicates the potential of the sensor for applications in cancer pathology. Both the synthesis strategy and the sensor design provide new methods and ideas for the production of ultrasensitive H2O2 electrochemical sensors.
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高影响因子
FOOD AND CHEMICAL TOXICOLOGY
·
2019
·
IF 3.775
Congyong Sun,Wenjing Li,Yingkun Liu,Wenwen Deng,Michael Adu-Frimpong,Huiyun Zhang,Qilong Wang,Jiangnan Yu,Ximing Xu
1-O-(4-hydroxymethylphenyl)-α-L-rhamnopyranoside (MPG) is a phenolic glycoside that exists in Moringa oleifera seeds with various health benefits, whereas its hepatoprotective effect is lacking clarification. Herein, MPG was isolated from Moringa oleifera seeds, and its hepatoprotection against CCl 4 -induced hepatotoxicity in L02 cells and ICR mice was investigated. Toxicity studies showed that MPG did not induce significant changes in organ coefficients and histological analysis, as well as exhibited no cytotoxicity. In vitro studies indicated that MPG substantially increased cell viability and intracellular SOD activities, and significantly inhibited LDH leakage in CCl 4 -treated cells. In vivo studies demonstrated that MPG significantly alleviated CCl 4 -induced hepatotoxicity in mice, as indicated by diagnostic indicators of hepatic injury, as well as the histopathological analysis. Moreover, MPG reduced the lipid peroxidation levels and regulated the inflammatory cytokines. Notably, MPG substantially suppressed the significant elevation of ROS production in hepatocytes of mice intoxicated with CCl 4 . Moreover, TUNEL assay demonstrated that MPG obviously inhibited hepatic apoptosis induced by CCl 4 . Altogether, these results suggested that MPG has excellent liver-protecting effects against hepatocytotoxicity induced by CCl 4 in mice and L02 cells, which can be further developed as a valuable functional food additive or drug for the treatment of hepatic injury.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Ying Luo,Jie Xu,Shuo Lv,De-Yang Li,Yuan-Yuan Hu,Xiao-Yang Liu,Fa-Wen Yin,Da-Yong Zhou
Ready-to-eat (RTE) oysters experience rapid and pronounced color deterioration, mainly attributable to lipid oxidation, phenolic oxidation, and Maillard/Maillard-like reactions. RTE oysters were treated with a combination of different color protection agents and packaging strategies to delay browning during storage. The color and associated color-change reactions of RTE oysters were evaluated to identify the optimal color-protection combination and elucidate its regulatory mechanisms. Results indicated that L-cysteine combined with light-proof nitrogen-filled packaging constituted the optimal color-protection strategy. This combination mitigated browning during storage by directly suppressing oxidation and the Maillard reaction. Furthermore, it indirectly inhibited both the Maillard reaction and lipid-mediated Maillard-like reactions by reducing the formation of free radicals and reactive carbonyl compounds. In summary, this study demonstrated that the integration of chemical color-protective agents with cost-effective physical methods effectively delayed the decline in color quality of RTE oysters throughout storage via multiple protective mechanisms.
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高影响因子
Journal of Cleaner Production
·
2025
·
IF 10
Zhiheng Wang,Jingtao Hou,Khurram Shehzad,Shuanglian Xiong,Menghua Cao,Shuxin Tu
Organosilicon exhibits exceptional potential for reducing cadmium (Cd) uptake and accumulation in crops, owing to its molecular structure-endowed high membrane permeability and biocompatibility. However, the current understanding of the mechanisms by which organosilicon mitigates Cd toxicity in rice remains fragmented. We combined controlled hydroponic experiments and foliar organosilicon-sprayed field trials, integrating physiological, biochemical, transcriptomic, histochemical, and in vitro simulation analyses to clarify the underlying mechanisms. Results demonstrated that organosilicon reduces Cd uptake and accumulation and mitigates its toxicity through a synergistic triple mechanism: by reinforcing the root apoplastic barrier via enhanced lignification and suberization, by promoting vacuolar Cd compartmentalization in leaves, and by activating the plant defense system via potentiated glutathione-dependent antioxidant and glyoxalase pathways. Field trials revealed that foliar organosilicon application reduced Cd concentration in rice grains by 48.89 %–52.87 %, decreased Cd-associated health risks by 56.76 %–57.87 %, increased rice yield by 9.26 %–9.98 %, and enhanced grain nutritional quality. This study is the first to unveil the synergistic triple mechanism through which organosilicon mitigates rice Cd toxicity and accumulation. Given its low cost and high efficiency, this approach provides a practical and cost-effective strategy for using silicon-based materials in heavy metal-contaminated agricultural lands.
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高影响因子
Environmental Science-Nano
·
2023
·Vol. 10
·期 12
·3317-3328
·
IF 7.3
Baoyu Li,Wengui Duan,Guishan Lin,Yucheng Cui,Rongzhu Wen,Chuwen Liu,Yulu Xie
Natural product-based nanopesticide is an effective and sustainable approach for solving the environmental issues caused by the application of current commercial herbicides. In this study, 21 novel L-carvone-derived 4-methyl-1,2,4-triazole-thioether derivatives 5a–5u were rationally designed by transketolase-based in silicon virtual screening, synthesized, and structurally characterized using FT-IR spectroscopy, 1H/13C NMR spectroscopy, and HRMS technique. Besides, the herbicidal activity of the target compounds against Brassica campestris and Echinochloa crusgalli L. was evaluated, and the bioassay results revealed that compound 5a with the most significant herbicidal and TK-inhibition activities could serve as a potential TK inhibitor and could serve as a leading compound for further study of green herbicides. Subsequently, the molecular skeletons of chitosan and L-carvone were incorporated for developing high-efficiency nanopesticide carriers, and thus samples 7a–7d were synthesized by N-alkylation of chitosan and characterized using various methods. Compared with unmodified chitosan, L-carvone-derived nanochitosan carrier 7b with the micro-morphologies of nubby lumps and porous surfaces exhibited higher dispersibility and similar thermostability. Finally, L-carvone-derived 4-methyl-1,2,4-triazole-thioether/nanochitosan complexes 7b/5a, 7c/5a, and 7d/5a with better 5a-loading capacities and multi-stage sustained releasing performances were constructed, and the herbicidal activities of 7b/5a and 7d/5a against Brassica campestris were evaluated in the petri dish and greenhouse. It was found that 7b/5a and 7d/5a exhibited significant herbicidal activities. Among them, 7b/5a had great potential as a green and eco-friendly nanopesticide for weed control.
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高影响因子
ANALYTICAL LETTERS
·
2020
·
IF 1.467
CuiCui Liu,Xiaotong Bi,Ailin Zhang,Bin Qi,Shijie Yan
A typical l-cysteine functionalized magnetic mesoporous nanosorbent (Cys–Si–MNPs) was successfully synthesized and characterized by transmission electron microscopy, the nitrogen adsorption–desorption isotherm and X-ray photoelectron spectroscopy. The results showed that Fe3O4 magnetic core was shelled by mesoporous silica, and the capacity of thiol group with strong affinity to various heavy metal ions was as high as 238 mg g−1. Using the obtained l-cysteine functionalized magnetic nanoparticles as the adsorbent, a graphite furnace atomic absorption spectrometry (GFAAS) method was developed for the determination of Pb2+, Cd2+, Cu2+, Cr3+, and V5+ in food. The experimental parameters affecting the separation performance including the pH of the sample solution, adsorbent mass, contact time, and co-existing ions were investigated systematically. Using the optimized conditions, the detection limits were as low as from 0.006 to 0.36 μg L−1. The precision of the method was evaluated by the relative standard deviation (n = 11) at limit of quantification (LOQ) of each target ion and was less than 6.0%. The proposed method was further successfully applied for the determination of the target ions in certified reference materials including GBW10043 rice, GBW 10023 laver, and GBW 10050 shrimp. The obtained recoveries were in the range from 89% to 102% with relative standard deviations (n = 3) lower than 8%.
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高影响因子
危险品化学品经营许可证（带存储）