SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xing Lai,Chun Wang,Huaiyin Chen,Tianxue Zhu,Jianying Huang,Changfa Xiao,Yuekun Lai,Weilong Cai
Organic solvent nanofiltration (OSN) is a green, energy-saving, and highly efficient emerging membrane separation technology, and there is an urgent need for robust, easy-to-process OSN membranes with high permeance and small solute selectivity for industrial applications. Herein, we propose a new strategy for accurately designing novel OSN membranes. Specifically, a polyamide (PA) interlayer was synthesized in-situ on the surface of homogeneous reinforced poly(p-phenylene terephthamide) (PPTA) hollow fiber membrane by interfacial polymerization (IP) using both ultra-low concentrations piperazine (PIP, 0.05 wt%) and trimesoyl chloride (TMC, 0.005 wt%), and then a defect-free and dense PPy layer was deposited on top of the hydrophilic PA interlayer by chemical vapor deposition (CVD) process to prepare PA/PPy composite membranes with spherical cluster or strip cluster “Turing-like” structure. The resulting PA/PPy composite membranes presented an excellent high selective permeability, the dimethylacetamide (DMAc) permeability was 21.1 L·m −2 ·h −1 ·MPa −1 , and the molecular weight cut-off (MWCO) was as low as 185 Da. A 30-hour OSN test at elevated temperatures (80 °C) and in organic solvent (DMAc), as well as a one-month immersion test in ethanol and DMAc at room temperature, demonstrated superior separation performance and structural stability of the membranes, indicating their application potential in harsh solvent systems. Our novel method for developing nanoscale ordered structured PA/PPy composite membranes offers great potential for the development of multilevel structural designs in the preparation of high-performance OSN membranes with potential industrial applications.
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高影响因子
JOURNAL OF ETHNOPHARMACOLOGY
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2025
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IF 5.4
Junying Li,Xiaoxiao Shan,Yu Gao,Haizhou Zhu,Hongyan Cheng,Chengjie Xing,Lele Zhou,Wenkang Tao,Yangyang Li,Baoqi Yin,Caiyun Zhang
Ethnopharmacological relevance Kai-Xin-San (KXS) has a significant effect therapeutic on Alzheimer's disease (AD) in clinical practice. According to the compatibility theory of traditional Chinese medicine, Acori Tatarinowii Rhizoma (ATR) serves as the guiding drug in the KXS formulation and is believed to enhance the bioavailability and brain tissue distribution of the other drugs. However, the mechanism underlying the “guiding medicine upwards” effect of ATR in KXS remains unexplored. Aim of the study The aim of this study is to investigate the role of ATR in the efficacy of KXS on amyloid precursor protein/presenilin 1 (APP/PS1) mice, as well as its impact on the brain tissue distribution of other active ingredients in the KXS formula, and to elucidate the mechanism of ATR's “guiding medicine upwards” effect in KXS. Materials and methods The pharmacodynamic effects of ATR in KXS were assessed through behavioral tests, immunohistochemical staining, and Nissl staining. Additionally, the levels of inflammatory factors, as well as the activities of malondialdehyde, superoxide dismutase, and acetylcholinesterase, were measured using enzyme-linked immunosorbent assay kits. Subsequently, the effect of ATR on the ultrastructure of the blood-brain barrier (BBB) in APP/PS1 mice was observed using transmission electron microscopy (TEM), and the pharmacodynamic components of KXS in cerebrospinal fluid were quantified by ultra-high-performance liquid chromatography-triple quadrupole mass spectrometry (UPLC-MS/MS). Furthermore, Western blot (WB) analysis was used to quantitatively assess the expression of tight junction proteins (Claudin-5, Occludin, and ZO-1) and transporters (OCT3, OATP2, P-gp, and MRP1) in the BBB. Finally, bEND.3 cells and astrocyte cells were co-cultured to validate the effect of ATR on KXS. The expressions of OCT3/OATP2 and P-gp/MRP1 in BBB cell model were determined by WB and the content of pharmacodynamic components in the lower chamber of the transwell were also analyzed by UPLC-MS/MS. Results Behavioral test results suggest that KXS significantly improved the learning and memory capacities of APP/PS1 mice compared to the ATR-free KXS group. Furthermore, KXS was more effective in reducing amyloid-β protein deposition in the brain and repairing damaged neurons in the CA1 and CA3 regions than ATR-free KXS. Notably, KXS significantly reversed the pathological biochemical indices compared to the ATR-free KXS group. These results indicate that ATR has a positive effect on the pharmacodynamics of KXS in treating AD. Most importantly, TEM results revealed that KXS repaired the damaged BBB in AD mice, and ATR contributed to the improvement of BBB integrity. Furthermore, KXS and ATR increased the expression levels of Claudin-5, Occludin, and ZO-1 proteins in AD mice. Meanwhile, the levels of ginsenoside Rg1, ginsenoside Rb1, and polygalaxanthone III in the cerebrospinal fluid of the KXS group were 1.47, 1.39, and 2.02 times higher than those in the ATR-free KXS group, respectively. WB results showed that ATR and KXS significantly upregulated the expression of OCT3/OATP2 uptake transporters and downregulated the expression of P-gp/MRP1 efflux transporters compared to ATR-free KXS. Concurrently, in vitro BBB cell experimental results suggest that ATR promoted the transport of ginsenoside Rg1, ginsenoside Rb1, and polygalaxanthone III across BBB cells in KXS, and the regulation of OCT3/OATP2 and P-gp/MRP1 expression was consistent with the in vivo trends observed in AD mice. Conclusions ATR plays a critical role in enhancing the efficacy of KXS in treating AD and facilitates the entry of other pharmacodynamic components into the brain. The mechanism underlying the “guiding medicine upwards” effect of ATR may involve the regulation of OCT3/OATP2 and P-gp/MRP1 transporters.
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高影响因子
ORGANOMETALLICS
·
2024
·
IF 2.5
Hong Chen,Weiwei Zuo
Asymmetric transfer hydrogenation (ATH) of ketones is an efficient method for constructing chiral alcohols that are widely used in synthesizing various fine chemicals. Currently, most of the existing catalysts contain precious metals that are highly toxic and scarce, which limits industrial application and sustainability. Therefore, the development of catalysts based on earth-abundant and environmentally friendly 3d metals is an important research topic. We previously reported that amido-ene(amido)diphosphine Ni(II) catalysts exhibited promising reactivities. However, the enantioselectivity of the catalytic system was not satisfactory. Here, we report (primary amido)-ene(amido)Ni(II)diphosphine catalyst 2n containing a P-chirogenic substituted ferrocene moiety in the ligand backbone and its analogue (2m). 2n was used for ATHs of a range of ketones with improved enantioselectivity, affording secondary alcohols of the (S)-configuration with up to 98% enantiomeric excess (e.e.). Computational results indicated that in the reaction system of catalyst 2n, the (S)-configuration of the phosphine kept the (S)-planar chiral ferrocene moiety far from the reacting site in the transition state that produced the (S)-configured alcohol. This created space for the aryl ring of the substrate and the ene(amido) moiety of the catalyst to approach each other and form a strong π–π interaction that enhanced the enantioselectivity.
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Guang-En Yuan,Yan-Ge Ma,Kangning Huangfu,Yunbei Li,Xin Zhang,Fenglin Yang
Advanced oxidation processes based on the combination of zero-valent iron (ZVI) and S(IV) have been extensively investigated for oxidative degradation of organic pollutants, but little attention has been paid to their reducing capacities in the presence of oxygen. This work found bisulfite (BS) could greatly enhance the degradation of p-nitrophenol (PNP) by ZVI under oxic conditions and PNP was only reduced to p-aminophenol without further degradation. A combination of indirect reduction by superoxide radical (O 2 •– ) and direct reduction by ZVI was verified as the mechanism of PNP degradation. Highly oxidizing species, such as hydroxyl radical (HO • ) and sulfate radical (SO 4 •− ), were also produced in the ZVI/BS system under oxic conditions but did not contribute to pollutant degradation perhaps due to the rapid consumption by reducing substances like BS ions and the released Fe 2+ . BS concentration, ZVI dosage, initial solution pH and coexisting anions (CO 3 2– , PO 4 3– and Cl – ) affected the degradation of PNP. ZVI lost the reactivity after used for three times because of the production of goethite and lepidocrocite covered on its surface. This study will provide a new insight into degradation of organic pollutants in ZVI/BS system under oxic conditions.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2024
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IF 8.1
Qihang He,Lei Wang,Feng Xiao,Rong Su,Yu Jiang,Lichuan Chen,Zeyi Wang,Bin Jia,Ping He,Chao Chen,Yali Zeng,Yun Zhou,Bin Tang
The design of advanced noble-metal-free electrocatalysts with high activity and good stability for the hydrogen evolution process (HER) is both appealing and challenging. Herein, cauliflower-like Co–B–P nanoparticles anchored on multi-layered g-C 3 N 4 nanosheets (Co–B–P/g-C 3 N 4 ) are fabricated by a facile electroless deposition method at room temperature . The effect of P/B ratios on electrocatalytic performance of ternary Co–B–P/g-C 3 N 4 catalysts for HER is fully investigated in 1.0 M KOH solution. Due to both the synergetic effect among P, B and Co, and the support of multi-layered g-C 3 N 4 nanosheets , ternary Co–B–P/g-C 3 N 4 catalyst exhibits satisfactory electrocatalytic HER performances. The onset overpotential for the best ternary Co–B–P/g-C 3 N 4 catalyst is only 93 mV, whereas it is 173 mV for binary Co–B/g-C 3 N 4 catalyst. When current density achieves 10 mA cm −2 and 40 mA cm −2 , the required overpotentials for ternary Co–B–P/g-C 3 N 4 catalyst are 174 mV and 226 mV, respectively, which are much lower than those of binary Co–B/g-C 3 N 4 catalyst (261 mV and 327 mV). Furthermore, the stability test indicates that ternary Co–B–P/g-C 3 N 4 catalyst possesses a favorable long-term electrochemical stability under alkaline condition. The satisfactory electrocatalytic performances of as-prepared ternary Co–B–P/g-C 3 N 4 catalyst suggest that it is a promising candidate to substitute noble-metal based catalysts for HER.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 7
·3294-3303
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IF 2.7
Xiaobo Li,Kaifeng Yang,Fangming Han,Yafeng Jin,Haonan Zhang,Heng Gao
The coexistence of dopamine (DA) and acetaminophen (AC) in living organisms leading to an unexpected mutual interference in electrochemical detection techniques demands a simultaneous, selective as well as simple and cost-effective approach for DA and AC. Herein, a novel nanocomposite was fabricated by integrating carbonized ZIF-67 (C-ZIF-67) with carbon black Super P (SP) and introduced onto a glassy carbon electrode (GCE) to form a highly sensitive electrochemical sensor (C-ZIF-67/SP/GCE) for the simultaneous determination of DA and AC. The well-prepared nanomaterial presents a polyhedral morphology interlaced on a reticulated chain. C-ZIF-67/SP/GCE shows excellent electrocatalytic activity towards the redox reactions of DA and AC in a dynamic linear range up to 100 μM, which could be attributed to the synergistic effect of the large specific surface area of C-ZIF67 and the excellent conductivity of SP. The limits of detection (LODs, S/N = 3) of 0.58 μM and 0.27 μM were obtained for DA and AC, respectively. Moreover, the developed sensor exhibited good reproducibility and long-term stability. The C-ZIF-67/SP/GCE was employed to analyze DA and AC biomedical samples and satisfactory recoveries were achieved. This approach provides a simple, easy and sensitive method to detect DA and AC simultaneously and selectively.
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Journal of Materials Chemistry A
·
2025
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IF 9.5
Xiaoyan Lu,Xinhui Jiang,Jindou Hu,Junhong Li,Anjie Liu,Zhenjiang Lu,Jing Xie,Yali Cao
The p–n type charge transfer pathway plays an active role in efficient carrier separation and enhancement of photocatalytic activity, but it will also reduce the redox ability of photogenerated carriers. Herein, the anchored amino molecular layer acts as a heterojunction conversion switch to transform Cu2O/T-N from a p–n to an S-scheme heterojunction. Following this transformation, the redox ability of carriers can be dramatically enhanced: the reduction potential of photogenerated electrons increases from −0.49 eV to −1.68 eV, and the oxidation potential of photogenerated holes increases from 0.32 eV to 2.33 eV. Therefore, the optimized Cu2O/T-N S-scheme heterojunction photocatalyst exhibits superior photocatalytic performance for hydrogen evolution (up to 41.85 mmol g−1, 64 times higher than that of pure TiO2) and nitrogen fixation (as high as 18 mmol gCu2O−1 h−1). Moreover, the post-conversion carrier transfer pathway also prevents the accumulation of holes on Cu2O, alleviating the photocorrosion caused by hole oxidation. Hence, the catalytic activity remains stable during photocatalytic cycling for up to 50 h. This study provides a straightforward and practical method for enhancing the redox capacity of photocatalysts.
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BIOMACROMOLECULES
·
2024
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IF 5.5
Yuhan Yang,Yangyi Chen,Yue Wei,Wei Wu,Qing Wang,Tianyun Xue,Xiaoyan Zhang,Wei Chen,Wei Zhang
A drug delivery system based on silybin-conjugated chitosan (CS-SB) polymeric micelles was developed to improve the oral absorption of doxorubicin (DOX). SB was grafted to CS via succinic acid, and CS-SB was identified by 1H NMR and FT-IR. The DOX-loaded micelles were prepared by self-assembly, and the characteristics of micelles, including a small particle size of 167.8 ± 2.3 nm, a high drug loading capacity of 8.59%, and a low critical micelle concentration of 1.3 × 10–5 g/mL, were demonstrated. The micelles showed oral bioavailability of up to 193% versus DOX·HCl. The cytotoxicity test showed the biosafety of CS-SB and the potential of reductive DOX-induced cardiotoxicity. The inhibition of P-gp efflux and CYP3A4 enzyme in CS-SB micelles was confirmed by cellular uptake and enzyme activity inhibition tests. The endocytosis process of micelles was revealed by an endocytosis inhibition test. The findings exhibited the potential of CS-SB micelles in drug delivery.
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ACS Catalysis
·
2025
·
IF 13.1
Hongzhong Wang,Kai Chen,Junheng Huang,Chengchao He,Qinlong Zhang,Junwei Li,Zhifang Zhang,Zhenhai Wen
4-Nitrophenol (4-NP), a toxic and recalcitrant pollutant, necessitates effective remediation strategies. Here, a noble metal-free NiCu-NC electrocatalyst is developed, where dual atomic Ni–Cu sites are elegantly anchored on a rhombic dodecahedral nitrogen-doped carbon matrix, enabling selective electrochemical reduction of 4-NP into value-added p-aminophenol (4-AP). This catalyst achieves a low overpotential and a high Faradaic efficiency of 95.7% for 4-AP production. Density functional theory (DFT) calculations reveal that the NiCu dual-atom configuration minimizes the energy barrier for the rate-determining step, thereby enhancing catalytic performance. Furthermore, a hybrid acid/alkali flow electrolysis cell is designed to couple the cathodic 4-NP reduction with the anodic oxygen evolution. This system maintains stable operation for over 400 h while maintaining a high Faradaic efficiency (>91%) and near-complete conversion (99%) for valorization of 4-NP. This work demonstrates a practical electrocatalytic approach for pollutant transformation and chemical production with potential implications for wastewater treatment and resource utilization.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2024
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IF 5.8
Jiahuan Cao,Yujia Wu,Yinghuan Fu,Yu Song,Guowen Wang,Hongchao Ma
Photocathodic protection is a promotion strategy for the corrosion protection of metallic materials, and the selection of photocathodic materials is a critical factor in improving the performance of photocathodic protection of metallic materials. Herein, a Ti-P-V-O composite semiconductor photoelectrode with an adjustable porous structure was prepared by the micro-arc oxidation (MAO) method using titanium alloy (TC 4 ) as the matrix and ammonium metavanadate (NH 4 VO 3 ) as the additive. The photogenerated open circuit potential, instantaneous photocurrent density response value, electrochemical impedance spectroscopy, and Tafel curve of as-prepared Ti-P-V-O photo-electrodes were measured after coupling with 304SS to clarify the cathodic protection effect for 304 stainless steel (304SS). It is found that the as-prepared Ti-P-V-O coating photoelectrode has a more negative open circuit potential, a more significant photocurrent density response, more effective interface carrier transport ability, lower resistance, lower compounding efficiency of photogenerated electron/hole pairs, and more negative conduction band level, as compared with that of TiO 2 coatings. Moreover, the optimized Ti-P-V-O photoelectrode (Ti-P-V-O&300 V) exhibited the maximum negative shift of the corrosion potential (410 mV vs. SCE) for coupling with 304 stainless steel. This work presents a new strategy for constructing an efficient coating photo-electrode for photocathodic protection of metallic materials.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Yue Sun,Chenrui Zhao,Jin Xu,Yazi Liu,Huan He,Feihu Mu,Wei Zhao,Dan Sun,Shaogui Yang,Cheng Sun
The construction of built-in electric field (BIEF) in heterojunction is an effective strategy to enhance solar-driven hydrogen (H 2 ) production by minimizing charge carrier recombination and improving transport kinetics. Herein, p-type ternary sulfide CuGaS 2 (CGS) and n-type g-C 3 N 4 nanosheets (CN) are integrated to construct a p-n heterojunction through a simple co-precipitation method for photocatalytic hydrogen evolution reaction (HER). In situ X-ray photoelectron spectroscopy (in situ XPS), in situ electron paramagnetic resonance (EPR) and density functional theory (DFT) calculations revealed that differences in Fermi levels and carrier concentrations between CGS and CN induce charge migration following an S-scheme mechanism, which aligned well with the intrinsic p-n junction field. The escalated BIEF effect enhances interfacial band bending, drives efficient charge separation, and promotes directional charge transfer. As a result, the optimized 20CN/CGS photocatalyst achieves a high H 2 evolution rate of 563 ± 5 μmol g cat −1 , approximately 3.3 times that of CGS. Additionally, the 20CN/CGS exhibits photothermal properties with further boosted HER rate of 732 ± 6 μmol g cat −1 at 35 °C, achieving a photothermal conversion efficiency (PCE) of 11 ± 2 %. This indicates its potential for exploitation of thermal heat from solar spectrum. This work provides a promising strategy for designing high-performance p-n heterojunction governed by S-scheme charge transfer to boost solar energy conversion.
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JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
·
2025
·Vol. 29
·期 14
·e70659
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IF 4.2
Hao Wang,Chi Zhang,Jinyue He,Zhuoen He,Shihua Yan,Yuan Zhang,Shiyin Huang,Yangtian Yan,Yuchi Chen,Zhiqiang Xian,Rong Hu,Yanjing Wang,Wei Xiao,Mingqing Wang
Skeletal muscle atrophy is a prevalent complication in chronic kidney disease (CKD), and its pathogenesis is closely related to inflammation and oxidative stress. P-Coumaric acid (PCA) is a phenolic acid with anti-inflammatory and antioxidant pharmacological actions. This research aims to investigate the effect of PCA on CKD-induced muscle atrophy and its underlying mechanism. In our study, in vivo and in vitro models were established by using 5/6 nephrectomized rats and LPS-induced C2C12 myoblasts. The experimental results showed that PCA ameliorated kidney injury in CKD rats and increased skeletal muscle weight and the cross-sectional area of muscle fibres. In both CKD rats and LPS-induced C2C12 myoblasts, PCA also exhibited anti-inflammatory and antioxidant effects, reduced the levels of pro-inflammatory cytokines and enhanced the activity of antioxidant enzymes. Network pharmacology studies have identified 165 common targets between PCA and skeletal muscle atrophy. Furthermore, the experimental results also demonstrated that PCA decreased the expression of TLR4, MyD88, NF-κB p65, MurF1 and MAFbx at both the protein and mRNA levels. Additionally, in vitro experiments showed that the use of TLR4 agonists could reverse the muscle-protective effect of PCA. In summary, this study illustrated that PCA ameliorated skeletal muscle atrophy in CKD rats by inhibiting the TLR4/MyD88/NF-κB pathway.
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