Nature Communications
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2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Zhang Xiaotan,Li Jiongxian,Wang Tianqi,Gong Yuxiang,Zhou Jiang
Conventional lattice orientation modulation of metal negative electrodes typically aims to expose low-surface-energy crystal planes, which, due to their high thermodynamic stability and low migration barrier, promote planar electrodeposition behavior. However, we demonstrate that a single [11 \(\bar{2}\) 0]-oriented Zn metal negative electrode with higher surface energy can also achieve uniform Zn deposition. Advanced atomic-level transmission electron microscopy reveals the crystallographic orientation of Zn deposits along the growth direction, showing zero lattice mismatch at the epitaxial interface. The [11 \(\bar{2}\) 0]-oriented Zn electrode shows high reversibility over 4000 cycles in Zn| |Cu cells at 40.0 mA/cm 2 and 4.0 mAh/cm 2 and enhanced cycling stability over 2600 cycles with 94.7% capacity retention in Zn| |NH 4 V 4 O 10 cells at 2.0 A/g. This concept is further expanded to other Zn metal negative electrodes with any single lattice orientation, with growth rates and grain boundary (GB) characteristics elucidated through simulated calculations and crystallographic characterizations. Grains within a single-oriented metal negative electrode exhibit uniform growth rates, superior GB stability, and an ordered atomic arrangement, promoting spontaneous dislocation-free homoepitaxy. Our study deepens the understanding of lattice modulation and provides valuable insights for engineering other high-reversibility metal negative electrodes.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Kim Baekmin Q.,Lee Jaehong,Kim Hanul,Kim Subeen,Lee Kyoungmun,Koh Dong-Yeun,Choi Siyoung Q.
Despite significant advances in membrane technology, achieving efficient separation in organic solvent nanofiltration (OSN) remains a major challenge in the chemical and pharmaceutical industries, particularly when dealing with multicomponent molecular mixtures. To address this, in this study, we develop a biphasic column for organic solvent membrane extraction, which consists of closely packed micron-sized water droplets covered by sub-nanometer-thick ion-ligand complexes that serve as size-exclusive membranes. Molecular mixtures dissolved in an organic solvent can be selectively extracted into the droplets through the interfacial complexes based on their sizes, while the solvent flows through the micron-scale interstices between the droplets. This solute-solvent dual pathway design minimizes resistance in solvent convection, resulting in high productivity, while simultaneously achieving a high separation factor through the monodisperse nanopores of the interfacial complexes. Using aluminum ion-carboxylate terminated polydimethylsiloxane complexes as a representative, the column demonstrates a controllable, high separation factor of 600 with a productivity of 1100 L·m − 2 ·hour −1 ·bar −1 in cyclohexane, significantly outperforming conventional membrane OSN.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Li Yuheng,Li Lin,Zeng Haipeng,Lan Chunxiang,Yang Shaomin,Zheng Ziwei,Zeng Miaomiao,Shi Yingying,Gao Kai,Cui Lianmeng,Guo Rui,Guo Jing,Hu Bin,Rong Yaoguang,Xie Haibing,Li Xiong
Addressing the stability challenges induced by the chemical interactions between metal electrodes and perovskite components is essential for high-performance perovskite solar cells (PSCs). Herein, we design a bilayer multifunctional polymer buffer composed of polyethyleneimine (PEI) and 2-((2-methyl-3-(2-((2-methylbutanoyl)oxy)ethoxy)−3-oxopropyl)thio)−3-(methylthio)succinic acid (PDMEA), inserting into the interface of metal electrode/transporting layer. This buffer mitigates metal atom diffusion by forming thioether-metal-carboxyl chelation rings between the metal layer and PDMEA. Additionally, it facilitates efficient electron transport and suppresses interfacial recombination through an in-situ cross-linking between the carboxyl groups of PDMEA and the amine groups of PEI based on Lewis acid-base reaction. Consequently, this design effectively reduces undesirable metal/ion interdiffusion during device fabrication and operation. The resulting PSCs with the PEI/PDMEA buffer achieve certified power conversion efficiencies (PCEs) of 26.46% (0.1 cm 2 ) and 24.70% (1.01 cm 2 ), demonstrating enhanced thermal and operational stability. We anticipate that this buffer design strategy, which forms bilayer polymer buffers via cross-linking of polymers with distinct functionalities, will inspire the rational design of robust buffers for highly efficient and stable PSCs and other electronic devices.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Zhang Fanxing,Cao Ning,Wang Chentao,Wang Shengxiang,He Yi,Shi Yao,Yan Mi,Bao Ying,Li Zhenglong,Xie Pengfei
Electrochemical CO 2 -to-ethanol conversion is challenged by sluggish C-C coupling kinetics and wide products distribution. Although Cu + has been demonstrated to enhance multi-carbon (C 2+ ) formation, the stabilization of Cu + under reduction conditions is difficult. Here, we report a hydrogen-ethanol pretreatment strategy to obtain Cu nanoparticles covered by highly dispersed and disordered ZnO 1- x clusters. Ethanol-induced ZnO 1- x redispersion gives rise to abundant Cu + on the subsurface. The optimal catalyst delivers a 73.0% ethanol Faradaic efficiency (FE) and 86.0% total C 2+ FE at −0.9 V, with a 2.3 mmol cm −2 h −1 ethanol formation rate and single-pass ethanol yield of 18.0%. The catalyst also exhibits stability beyond 500 h, attributed to the stabilization of Cu + by the ZnO 1- x shield that requires a high energy barrier for lattice oxygen removal. In situ X-ray spectroscopy and calculations reveal a volcano relationship between Cu + ratio in Cu species and ethanol FE. Optimal Cu + density not only facilitates *OC-COH coupling but also optimizes the adsorption energy of *CH 2 CH 2 O on catalyst for ethanol electrosynthesis.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-10
·
IF 15.7
Wei Fen,Zhao Jiwu,Liu Yu-Chun,Hsu Yung-Hsi,Hung Sung-Fu,Fu Junwen,Liu Kunlong,Lin Wei,Yu Zhiyang,Tan Li,Lu Xue Feng,Feng Chengyang,Zhang Huabin,Wang Sibo
Lattice oxygen-mediated photocatalytic ethane dehydrogenation represents a sustainable strategy for ethylene production, yet achieving a balance between high productivity, selectivity, and durability remains challenging. Here, we report a defective NiO-300 catalyst, where precisely engineered Ni vacancies activate lattice oxygen by weakening Ni–O bond and improving lattice oxygen mobility. This promotes efficient ethane activation and C–H bonds cleavage through photoinduced hole capture, intensifying ethane dehydrogenation via a light-boosted Mars-van Krevelen mechanism. The NiO-300 catalyst manifests a high ethylene yield of 604.5 μmol g −1 h −1 with 100% selectivity and stability over 200 cycles. In situ spectroscopic and theoretical studies elucidate the generation of active oxygen species, the evolution of Ni coordination, the formation of key intermediates, and the underlying photocatalytic mechanism. Our findings highlight cation vacancy engineering as a powerful tactic to fully activate lattice oxygen for solar-driven alkene production from alkane dehydrogenation over oxide photocatalysts.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Marks Joshua H.,Bai Xilin,Nikolayev Anatoliy A.,Gong Qi’ang,McAnally Mason,Wang Jia,Pan Yang,Fortenberry Ryan C.,Mebel Alexander M.,Yang Tao,Kaiser Ralf I.
The rapid dissociation of methanetetrol (C(OH) 4 ) has been suggested as an impediment to its observation, despite the stability of its substituted derivative orthocarbonates (C(OR) 4 ). Here, the tunability of synchrotron-generated vacuum ultraviolet light and the sensitivity of photoionization are exploited to probe the exotic chemistry of the interstellar medium toward the discovery of this molecule. Laboratory-made model ices simulate the composition of astrophysical ices under conditions mimicking those found in dense interstellar molecular clouds with low temperature (5–10 K) and low pressure (<10 −10 Torr). High-energy irradiation simulates secondary electrons produced by galactic cosmic rays, one of few sources of energy that penetrate to the icy cloud interior. The reaction mechanism that yields methanetetrol is conclusively revealed by the simultaneous production and detection of key intermediates: carbonic acid (HOCOOH) and the recently reported methanetriol. State-of-the-art electronic structure calculations support the experimental observations and results suggest that if carbonic acid is sufficiently abundant in space, then methanetetrol may be waiting to be observed. The detection of methanetetrol in space-simulation experiments demonstrates that the interstellar medium is host to an unanticipated and counterintuitive chemistry that demands scientific attention.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-18
·
IF 15.7
Li Wanqian,Whiteway Malcolm,Hang Sijin,Yu Jinhua,Lu Hui,Jiang Yuanying
Azole effectiveness against candidiasis can be compromised by Candida albicans resistance and tolerance, and unfortunately, few clinically useful compounds can enhance azole antifungal activities. We find that the amino acids V234, F235 and L238 of Erg11 are critical for its interaction with Ncp1, and the Ncp1-Erg11 association is important in azole response. Ellipticine and its analog phiKan 083 block this Erg11-Ncp1 interaction by targeting Ncp1, and boost antifungal effects of fluconazole in vitro and in vivo. A series of steps influencing this process—an initial elevation in reactive oxygen species, leading to protein oxidation and misfolding in the endoplasmic reticulum (ER) that causes ER stress. This stress leads to Ca 2+ release from the ER, mitochondrial Ca 2+ accumulation and dysfunction, increased ROS production, and apoptosis of C. albicans cells. Overall, disrupting the Erg11-Ncp1 interaction in C. albicans can serve as a useful approach to enhancing the antifungal properties of azoles.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Zhang Xiuxiu,Zhang Yuhao,Protsenko Bogdan O.,Soldatov Mikhail A.,Zhang Jing,Yang Chenyu,Bo Shuowen,Wang Huijuan,Chen Xin,Wang Chao,Cheng Weiren,Liu Qinghua
The development of non-iridium-based oxygen evolution reaction (OER) catalysts is crucial for proton exchange membrane water electrolysis (PEMWE), but hydrogen production remains a great challenge because of sluggish OER kinetics and severe catalyst dissolution. Here, we present a 4 f -induced covalent polarity modulation strategy for the construction of 4 f -orbital-modified RuO 2 (4 f -RuO 2 ) nanocatalysts with tunable Ru–O polarity. We find that the OER activity of 4 f -RuO 2 shows a volcano shape as a function of the polarity of Ru–O bond. Consequently, the best 4 f -Nd-RuO 2 catalyst possesses an ultra-low overpotential of 214 mV at 10 mA cm −2 and robust electrochemical stability in 0.1 M HClO 4 . Theoretical calculations coupled with in situ synchrotron infrared and X-ray absorption spectroscopy analyses reveal that the modulation of Ru–O polarity in RuO 2 by the valence f − p − d gradient orbital coupling can modify the adsorption energy of the reaction intermediates and suppress the participation of lattice oxygen to avoid over-oxidation of Ru, which can thus serve as an effective descriptor for fine tuning the activity and durability of acidic OER nanocatalysts.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Chen Zhong,Weng Hao,Chu Chengcheng,Yao Ducheng,Li Qiuju,Zhang Chen,Mao Shun
Nitrogen heterocyclic covalent organic frameworks offer great potential for H 2 O 2 production due to their unique optical and electrical properties. Herein, we design four photocatalysts with varying nitrogen atom configurations to tune their electronic and energy-band structures. Among them, the covalent organic frameworks with pyrimidine achieves an efficient H 2 O 2 production rate of 17014 μmol g −1 h −1 and a solar-to-chemical conversion efficiency of 1.84% in pure water without sacrificial agent or oxygen aeration. The theoretical calculation and experimental study confirm that it owns superior photoelectrochemical properties, oxygen reduction reaction activity, and the lowest reaction potential barrier, enabling dual channel H 2 O 2 production via 2e − oxygen reduction reaction and 4e − water oxidation reaction. To explore the application potential of the photocatalytic system, a panel reactor (20 × 20 cm) under natural sunlight demonstrates continuous H 2 O 2 generation for antibiotic degradation and long-lasting water disinfection. This work presents an advanced photocatalytic H 2 O 2 synthesis system with high efficiency and environmental remediation potential.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Zhuoting Lu,Tong Wang,Xiangchi Xu,Qinglian Hu,Lei Wang,Yuanxiang Jin
A key challenge in clinical anticancer treatments is metastasis and recurrence, to address this challenge, it is crucial to develop combination treatment strategies that target different molecular pathways, considering the high complexity of tumors, as well as to create efficient drug delivery systems that enhance therapeutic efficacy and minimize systemic toxicity. Herein, two clinical small molecular drugs indocyanine green (ICG) and paclitaxel (PTX) were self-assembled into relatively stable, carrier-free nanoparticles (IP NPs) through a simple one-step nanoprecipitation method. The spherical IP NPs demonstrate excellent aqueous stability, tumor-targeted accumulation, and potent apoptosis induction. Combined with AKT inhibitor MK-2206, they effectively modulate survival pathways, suppress metastasis, and prevent tumor recurrence in rechallenge models. This synergistic approach achieves equivalent therapeutic efficacy at reduced doses, enhancing treatment safety. Encouraged by its effective therapy and sensitivity-enhancing properties, this study might show significant potential for malignant tumor synergistic therapy. Carrier-free nano-integrated strategy for combination therapy
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Human Cell
·
2025
·Vol. 38
·期 2
·1-16
·
IF 3.1
Zhang Lexi,Ye Jianfeng,Qiu Cheng
Renal ischemia–reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Twist-related protein 2 (Twist2) is a basic helix/loop/helix transcription factor. However, the underlying effects of Twist2 in IRI remain to be elucidated. Herein, we found that the expression of Twist2 was significantly upregulated in renal tissues of mice induced by ischemia/reperfusion (I/R) and in human renal tubular epithelial cell HK-2 exposed to hypoxia–reoxygenation. We silenced Twist2 with RNAi technology. Twist2 knockdown alleviated renal pathological damage in mice. Twist2 depletion ameliorated IRI-induced mitochondrial dysfunction, such as increasing ATP content and mitochondrial DNA copy number and restoring mitochondrial membrane potential in the kidneys of mice , and similar results were observed in in vitro experiments. Twist2 interference increased the expression of LC3B and decreased the expression of p62 and mitochondrial membrane proteins TIMM23 and TOMM20 both in vivo and in vitro. Electron microscope and the co-localization of LC3B and mitotracker DsRed suggested the induction of autophagy and mitophagy after Twist2 knockdown in kidneys or cells. Mechanism studies revealed that Twist2 exerted a direct inhibitory effect on BCL2 interacting protein 3 (Bnip3) transcriptional activity by targeting the Bnip3 promoter. In hypoxia/reoxygenation-induced renal tubular epithelial cells, the interference of Bnip3 reversed the effect of Twist2 depletion on mitochondrial function and mitophagy. In conclusion, our findings suggest that the depletion of Twist2 exerts renoprotective effect in I/R-induced AKI. Twist2 regulates mitochondrial function and mitophagy in part by targeting and downregulating Bnip3. Our study provides new insights into the pathological mechanisms of I/R-induced AKI.
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CELLULOSE
·
2024
·
IF 4.9
Xing Tian-Qing,Zhao Teng-Fei,Hu Chen-Sheng,Cao Xue-Fei,Sun Shao-Ni,Shen Xiao-Jun,Wen Jia-Long,Yuan Tong-Qi,Sun Run-Cang
Cellulose is the most abundant and renewable biopolymers on earth. The hydrophilic nature of cellulose endows cellulosic materials with good compatibility with polar matrices, but it also leads to their poor dispersion in non-polar matrices. Regulating the surface hydrophobicity of cellulosic materials via surface esterification can greatly extend their applications. However, the existing surface esterification methods for cellulosic materials are time-consuming and costly, which makes them less attractive for practical application. Here we found that when vinyl esters were used as esterifying agents, various alkalis can be used to catalyze the ultrafast surface esterification of cellulose materials in aqueous media at room temperature within seconds or minutes, which is highly attractive for the surface esterification of nanocellulose in suspension state. Surface acetylated cellulose nanofibers (ACNF) and surface acetylated cellulose nanocrystals (ACNC) with acetyl group content (Ac%) up to 10.7% and 6.5%, respectively, were successfully prepared within 5 min in aqueous diethylamine solution. Additionally, this method can also be used to achieve the rapid acetylation of phenol hydroxy group in aqueous media.
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