CHEMISTRY-A EUROPEAN JOURNAL
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2021
·Vol. 27
·期 42
·10966-10972
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IF 5.236
Lanqing Li,Wei Gao,Min Lei,Dan Wen
Graphical A simple ex situ wet chemical transformation method of alkali treatment was proposed to prepare Ni(OH) 2 nanostructured flowers with large specific surface areas from Ni-MOF-74. The relationship between concentration of alkali and the structure properties of corresponding Ni(OH) 2 was uncovered. As the results, the catalyst of Ni(OH) 2 -0.25 performed remarkably catalytic properties with lower potential, higher current density and excellent durability towards MOR among various samples. Post treatment of metal-organic frameworks (MOFs) is widely employed to develop efficient electrocatalysts with better catalytic properties. But the complex processes of post treatment generally led to the collapse of the original structures of MOFs, making the preservation of their pristine hierarchical porous structure a great challenge. Herein, we propose the strategy of alkali treatment of Ni-MOF to transform it into Ni(OH) 2 with similar morphology and enhanced electrocatalytic properties for methanol oxidation reaction (MOR). The structure and electrocatalytic properties of as-obtained Ni(OH) 2 nanostructured flowers were seriously depended on the alkali concentrations. As the result, Ni(OH) 2 obtained from Ni-MOF treated by 0.25 M NaOH (noted as Ni(OH) 2 -0.25) performs 1.5 and 2.5 times larger current density than those of Ni(OH) 2 -0.025 and Ni(OH) 2 -0.5 for MOR. Moreover, the electrocatalytic process and mechanism of MOR on the catalyst of Ni(OH) 2 -0.25 are also revealed. Hence, this ex situ conversion strategy of alkali treatment for Ni-MOF uncovered the transformation of MOFs in alkaline solution and develops robust electrocatalyst for practical application of methanol fuel cells.
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CHEMICO-BIOLOGICAL INTERACTIONS
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2021
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IF 5.194
Min Wang,Longji Fang,Tongtong Liu,Xuejie Chen,Yan Zheng,Yilong Zhang,Shiming Chen,Zeng Li
The development of multi-target-directed ligands (MTDLs) may improve complex central nervous system diseases such as Alzheimer's disease (AD). Here, a series of 7-O-1, 2, 3-triazole hesperetin derivatives was evaluated for their inhibition of cholinesterase , anti-neuroinflammatory, and neuroprotective activity. Among the hesperetin derivatives, compound a8 (7-O-((1-(3-chlorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)hesperetin) possessed excellent anti-butyrylcholinesterase activity (IC 50 = 3.08 ± 0.29 μM) and exhibited good anti-neuroinflammatory activity (IC 50 = 2.91 ± 0.47 μM) against NO production through remarkably blocking the NF-κB signaling pathway and inhibiting the phosphorylation of P65. In addition, a8 showed a remarkable neuroprotective effect and lacked neurotoxicity up to 50 μM concentration. Furthermore, possessing significant self-mediated Aβ 1-42 aggregation inhibitory activity, chelated biometals and reduced ROS production were found in compound a8 . In the bi-directional transport assay, a8 exhibited a blood–brain barrier penetrating ability. In this study, the Morris water maze task showed that compound a8 significantly improved the learning and memory impairment of the scopolamine-induced AD mice model. Results highlighted the potential of compound a8 to be a potential MTDL for the development of anti-AD agents.
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Energy Storage Materials
·
2021
·
IF 17.789
Pan Xu,Xinyu Hu,Xiaoyu Liu,Xiaodong Lin,Xiaoxiang Fan,Xueyang Cui,Cui Sun,Qihui Wu,Xiaobing Lian,Ruming Yuan,Mingsen Zheng,Quanfeng Dong
ABSTRACT Lithium dendrites, “dead lithium”, infinite volume change and fragile solid electrolyte interphase (SEI) appear indefinitely during Li plating/stripping process, which severely resist the practical application of lithium metal batteries (LMBs). Herein, by a functionalized framework, a phosphorized copper mesh as support skeleton, the lithium plating/stripping has been gridded into zoning effect, thus a desired lithium anode with excellent performance and practical application significance can be achieved. The framework-based lithium anode showed multi-functions with many advantages: enhancing lithium affinity, mitigating volume expansion, improving the current distributions, and inducing uniform deposition of Li + . Thus, a highly reversible and dendrite-free lithium anode under large capacity could be successfully realized, which has been verified by operando optical dynamic test and COMSOL simulation. As expected, symmetric-cell displays low overpotential (~210 mV) at ultra-high current density of 20 mA cm −2 and long lifespan (>1600 h) at ultra-high areal capacity of 50 mAh cm −2 , moreover, full-cell delivers high cycling stability (2 C, 500 cycles) and outstanding rate performance with a lower polarization.
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JOURNAL OF SURFACTANTS AND DETERGENTS
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2021
·Vol. 24
·期 2
·199-208
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IF 1.902
Yun Bai,Chunsheng Pu,Shuai Liu,Xiang Gao,Gang Chen
The purpose of this paper is to comprehend in-depth the effect of the surfactant structure on its and physicochemical properties such as surface/interfacial properties, foam stability, wettability, and biodegradability. To this end, quaternary ammonium Gemini surfactants, alkanediyl-α,ω-bis[(2-hydroxypropyl)dodecylammonium] dibromide (abbreviated as C m -n-C m [iso-Pr(OH)] 2 with m = 12, 14 and n = 2, 3, 4) were synthesized via substitution and quaternization reactions, and their chemical structures were characterized by Fourier transform infrared (FT-IR) and nuclear magnetic resonance ( 1 HNMR) spectroscopies. The results showed that with the decrease of the spacer length, the surface tension was reduced more strongly, and with the increase of the alkyl tail length, micelles were more easily formed. Besides, the highest surface activity of C 14 -2-C 14 [iso-Pr(OH)] 2 was observed by increasing NaCl concentration to 200 g L −1 . The temperature had a great influence on thermodynamic parameters of the adsorption and micellization. The interfacial tension between 0.26 g L −1 C 14 -2-C 14 [iso-Pr(OH)] 2 solution and oil could reach 0.022 mN m −1 . An elongation of the spacer chain in C 14 -n-C 14 [iso-Pr(OH)] 2 was unfavorable to foam stability. Besides, the oil-wetted core, which was aged in 0.6 g L −1 C 14 -2-C 14 [iso-Pr(OH)] 2 solution, exhibited more hydrophilicity. C m -n-C m [iso-Pr(OH)] 2 surfactants produced higher biodegradable rates in river water (≥ 90% after 28 days) than the biodegradable surfactant of international recommendation (71% after 28 days) at 30 °C.
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CHEMICAL ENGINEERING JOURNAL
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2021
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IF 13.273
Jingwen Zhang,Chuchu Cheng,FangShu Xing,Cheng Chen,Caijin Huang
Engineering semiconductor materials with vacancies and co-catalysts is a valid method to improve their photocatalytic performance. Herein, we prepared S vacancies-rich Mn 0.3 Cd 0.7 S nanorods modified with β-Ni(OH) 2 nanoparticles through solvothermal and co-precipitation strategies. The as-obtained 0D/1D β-Ni(OH) 2 /Mn 0.3 Cd 0.7 S nanorods exhibit excellent visible-light H 2 -production activity up to 71.09 mmol g −1 h −1 , 5.23 times higher than pure Mn 0.3 Cd 0.7 S and better than 1 wt% Pt/Mn 0.3 Cd 0.7 S and most reported Mn x Cd 1−x S-based catalysts. The apparent quantum yield reaches 46.68% at λ = 420 nm. We found that the presence of S vacancies and β-Ni(OH) 2 enhances the transfer/separation of photogenerated carriers and increases reaction sites, which is beneficial to photocatalytic H 2 -production reaction. This work proposes a new idea for the application of metal hydroxide co-catalysts and S vacancies in sulfide materials for photocatalytic H 2 production.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Feiwei Cao,Mingming Liang,Jianxin Liu,Yu Liu,John A. Renye,Phoebe X. Qi,Daxi Ren
Yak yogurt, one of the naturally fermented dairy products prepared by local herdsmen in the Qinghai-Tibet Plateau, contains a diverse array of microorganisms. We isolated and identified a novel Streptococcus thermophilus strain, ZJUIDS-2-01, from the traditional yak yogurt. We further purified and carried out detailed structural, physiochemical, and bioactivity studies of an exopolysaccharide (EPS-3A) produced by S. thermophilus ZJUIDS-2-01. The weight-average molecular weight (Mw) of EPS-3A was estimated to be 1.38 × 10 6 Da by High-Performance Gel Permeation Chromatography (HPGPC). The monosaccharide analysis established its composition to be glucose, galactose, N -acetyl-D-galactosamine, and rhamnose in a ratio of 5.2:2.5:6.4:1.0. The molecular structure of EPS-3A was determined by the combination of permethylation analysis, FT-IR, and NMR spectroscopic techniques. The ζ-potential measurements indicated that EPS-3A had a p K a value of ~4.40. The DSC yielded a melting point (T m ) of 80.4 °C and enthalpy change (ΔH) of 578 J/g for EPS-3A, comparable to those of the xanthan gum (XG), a commercial EPS. EPS-3A exhibited better O/W emulsion stability and flocculating capacity than XG. Furthermore, it also demonstrated similar antioxidant activity to XG and promising in vitro antibacterial properties. This work evidenced that EPS-3A derived from S. thermophilus ZJUIDS-2-01 holds the potential for food and industrial applications.
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Journal of Physical Chemistry C
·
2021
·
IF 4.126
Jian He,Huining Zhao,Xinru Hu,Zhiyong Fang,Jilin Wang,Rui Zhang,Guoyuan Zheng,Bing Zhou,Fei Long
In this study, a new type of 0-dimensional organic–inorganic hybrid perovskite single crystal (2-5-py)2MnBr4 was synthesized using 2-amino-5-methylpyridine (2-5-py) as the organic ligand. The crystal is a center-symmetric P-1 space group with a grain size of 20 mm, which belongs to the triclinic crystal system. It has a strong absorption of violet and blue light as well as excellent thermal stability. Its optical band gap is 2.38 eV, which is in good agreement with the theoretical band gap (2.39 eV) calculated by density functional theory. Under the excitation of a suitable light source, it can emit 526 nm pure bright green lights, which are confirmed by the main peaks to be almost in the green range with a full width at half maximum of 45 nm. As a result, the quantum efficiency and fluorescence lifetime reached a high level of 44.2% and 117 μs, respectively. Based on the good fluorescence performance of the crystal, a white LED with a color rendering index of 97 was finally successfully fabricated, realizing the leap from basic materials to optoelectronic devices.
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Food & Function
·
2021
·Vol. 12
·期 8
·3572-3585
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IF 5.396
Qifang Wu,Siya Wu,Yang Cheng,Zhongshan Zhang,Genxiang Mao,Shijun Li,Yue Yang,Xu Zhang,Mingjiang Wu,Haibin Tong
Type 2 diabetic mellitus (T2DM) is a complicated metabolic disorder that is now considered as a major global public health problem. Fucoidan exhibits diverse biological activities, especially prevention of metabolic diseases. In this regard, we herein aimed to reveal the beneficial effect of Sargassum fusiforme fucoidan (SFF) on high-fat diet (HFD) and streptozotocin (STZ) induced T2DM mice. We noted that on the one hand, SFF significantly decreased fasting blood glucose, diet and water intake, and hyperlipidemia, while on the other hand, it improved glucose tolerance. Furthermore, SFF reduced epididymal fat deposition, attenuated the pathological changes in heart and liver tissues, and decreased oxidative stress in diabetic mice. To explore the underlying mechanisms of these ameliorative effects, the gut microbiota was analyzed. Notably, SFF highly enriched benign microbes including Bacteroides, Faecalibacterium and Blautia, as well as increased levels of (R)-carnitine and choline in the colon of diabetic mice. This may be a potential mechanism for alleviating T2DM, thus implying the benefits of SFF as an adjuvant agent for T2DM treatment. Taken together, this study demonstrated a promising application of fucoidan as one of the adjuvant agents for the management of T2DM in the future.
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CERAMICS INTERNATIONAL
·
2021
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IF 4.527
Rui Yun,Jingqi He,Li Luo,Xiaohua Liu,Zhaogang Nie,Weiren Zhao,Hongli Wen
Upconverting materials excited by near-infrared light are getting attention due to their biological applications in cancer treatment. Er 3+ , Yb 3+ and Nd 3+ tri-doped LiLn(WO 4 ) 2 (Ln = Y/La/Gd) phosphors were synthesized via the typical solid-state method. LiGd(WO 4 ) 2 : Er 3+ , Yb 3+ , Nd 3+ (LGW) phosphors exhibit the most intense green emission under 785 nm excitation among the three doped host materials, which is ascribed to their lowest phonon density and the strong absorption properties. Nd 3+ and Yb 3+ concentration effect on its luminescent properties and the energy transfer of Nd 3+ →Yb 3+ →Er 3+ under 785 nm excitation are discussed. The ratio of integrated intensity from the 4 S 3/2 / 2 H 11/2 → 4 I 15/2 transition of Er 3+ is characteristic of the optical temperature sensing based on fluorescence intensity ratio (FIR). LGW shows high absolute sensitivity about 0.0070 K −1 at 439 K and broad temperature sensing ranging from 200 K to 600 K under the excitation of 785 nm compared with systems doped with Er 3+ . Our significant results predicate the potential applications of this lanthanum-doped tungstate in optical thermometers.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2021
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IF 5.279
Haihong Chen,Qixing Nie,Jielun Hu,Xiaojun Huang,Junyi Yin,Shaoping Nie
Type 2 diabetes (T2D) is a worldwide epidemic associated with metabolic disorders and intestinal microbiota alterations. Polysaccharides have been considered to be beneficial to the prevention and alleviation of T2D. In the present study, ultra-performance liquid chromatography–triple-time-of-flight-based metabolomics and proteomics and 16S rRNA sequencing methods were employed to evaluate the effects of glucomannans from Dendrobium officinale stem, konjac, and Aloe vera leaves on host metabolism and intestinal microbiota regulation in type 2 diabetic rats and potential mechanisms. The metabolism of amino acids was significantly disturbed in the type 2 diabetic rats, especially the upregulated branched-chain amino acid (BCAA) metabolism. Host-derived BCAA metabolism was significantly decreased in type 2 diabetic rats. However, the levels of BCAAs in host circulation and gene abundance of BCAA biosynthesis in gut microbiota were significantly increased in diabetic rats, which suggested that the disturbed intestinal microbiota might be responsible for the increased circulation of BCAAs in T2D. Glucomannan treatment decreased the abundance of microbial BCAA biosynthesis-related genes and ameliorated the host BCAA metabolism. Also, glucomannan with a higher molecular weight and a lower ratio of mannose/glucose possessed better antidiabetic effects. In summary, the antidiabetic effects of glucomannans might be associated with the amelioration of BCAA metabolism by modulating intestinal microbiota.
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ANTI-CANCER DRUGS
·
2021
·Vol. 33
·期 1
·19
·
IF 2.248
Liu Shengli,Liu Honglian,Sun Hao,Deng Shengming,Yue Ling,Weng Zhen,Yang Jianfeng,Zuo Bin,He Yang,Zhang Bin
Albendazole (ABZ), a clinical antiparasitic drug, has shown potential antitumor effects in various tumors. Herein, we prepared dimeric cRGD [(cRGD) 2 ] modified human serum albumin (HSA) nanosystem to co-delivery of albendazole (ABZ) and iodine-131 ( 131 I) for chemoradiotherapy of triple-negative breast cancer (TNBC). [email protected] NPs were synthesized by the self-assembly method. 131 I-(cRGD) 2 / [email protected] NPs were fabricated through covalently binding [email protected] NPs with (cRGD) 2 peptides, followed by chloramine T direct labeling with 131 I. In vitro therapeutic effects on TNBC (MDA-MB-231 and 4T1 cells) were determined using MTT assay, crystal violet assay, wound-healing assay and western blotting analysis. In vivo treatment was performed using 4T1-bearing mice, and the tumor-targeting efficacy was assessed by gamma imaging. The distribution of NPs was quantitatively analyzed by detecting the gamma counts in tumor and main organs. The nanoparticles possessed negative charge, moderate size and good polydispersity index. Dual responding to pH and redox, the in vitro release rate of ABZ was more than 80% in 72 h. In vitro, NPs inhibited the proliferation of TNBC cells in a concentration-dependent manner and decreased cell migration. Western blotting analysis showed that the NPs, as well as free ABZ, cell-dependently induced autophagy and apoptosis by restraining or promoting the expression of p-p38 and p-JNK MAPK. In vivo, gamma imaging exhibited an earlier and denser radioactivity accumulation in tumor of 131 I-(cRGD) 2 / [email protected] NPs compared to NPs free of (cRGD) 2 conjugating. Furthermore, 131 I-(cRGD) 2 / [email protected] NPs significantly suppressed tumor growth by restraining proliferation and promoting apoptosis in vivo. Our study suggested that the nanoparticles we developed enhanced tumor-targeting of ABZ and increased antitumor effects by combination of chemotherapy and radiotherapy.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2021
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IF 2.694
Wenju Liu,Yanmin Shen,Fankun Zeng,Shuanghui Lu,Jun Li,Jinjin Yang,Kewen Zhang
The solubility of 6-propyl-2-thiouracil was determined in DMF + water, DMF + methanol, DMF + ethanol, and DMF + 1-propanol mixture solvents by a gravimetric method in the temperature range from 278.15 to 323.15 K under atmospheric pressure. The results indicated that the solubility of 6-propyl-2-thiouracil in the (DMF + methanol) mixture is greater than that in (DMF + ethanol), (DMF + 1-propanol), and (DMF + water) at the same DMF composition and temperature, and that the solubility increased with increase in the mass fraction of DMF in mixture solvents. The modified Apelblat model, λh model, Van′t Hoff model, and Jouyban Acree-Apelblat model were employed to correlate well with the solubility of 6-propyl-2-thiouracil in four binary solvents using values of ARD% and RD, and the four models were considered to be the reliable methods for the solubility prediction of 6-propyl-2-thiouracil.
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