CHINESE JOURNAL OF POLYMER SCIENCE
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2025
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IF 4
Deng Xiao-Bo,Wei Hong-Xiu,Yang Lin,Luo Feng,Li Zhen,Tan Hong,Wang Yan-Chao,Li Jie-Hua
Enhancing the lubricating properties and antibacterial adhesion resistance of implantable medical materials is critical to prevent soft tissue injury during implantation and the formation of bacterial biofilms. Prior studies may have exhibited limitations in the preparation methodologies and long-term stability of coatings for implantable medical materials. In this study, we developed a multilayered hybrid hydrogel coating method based on the rate difference of polymerization initiation on the material surface. The acquired coating with persistent lubrication capability retained its functionality after 2×10 4 cycles of friction and 21 days of PBS immersion. A quaternary ammonium salt coating with antibacterial properties was introduced to further functionalize the coating. Animal experiments demonstrated that this coating exhibited remarkable effects on delaying encrustation and bacterial colonization. These studies indicate that this simple method of introducing lubricating and antibacterial coatings on catheters is likely to enhance the biocompatibility of medical devices and has broad application prospects in this field of medical devices.
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Nano-Micro Letters
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2023
·Vol. 15
·期 1
·1-13
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IF 26.6
Liu Liming,Ma Yajie,Wang Yousheng,Ma Qiaoyan,Wang Zixuan,Yang Zigan,Wan Meixiu,Mahmoudi Tahmineh,Hahn Yoon-Bong,Mai Yaohua
A graded inverted solar cell configuration is developed by hole-transport management aiming to suppress interface defects-induced non-radiative recombination for efficient hole transport.
NiO x -based inverted PSCs present a power-conversion-efficiency over 23% with a high fill factor of 0.84 and open-circuit voltage of 1.162 volts, one of the best performances reported so far for 1.56-electron volt bandgap formamidinium-based triple-halide perovskites.
Devices show high operational stability over 1,200 h during T 90 lifetime measurement under 1-sun illumination in ambient-air conditions.
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Bratislava Medical Journal-Bratislavske Lekarske Listy
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2026
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IF 1.4
Jiao Yuxin,Mu Shengzhi,Kang Bei
Objective Post-stroke depression (PSD), a common stroke complication, negatively impacts physical function, cognition, and quality of life. Edaravone dexborneol (ED), a combination agent, helps alleviate ischemia-induced damage to neuro-motor and cognitive functions. This study aims to evaluate the neuroprotective effects of ED in a rat model of PSD. Methods The PSD model was established via filament inserting through the internal carotid artery and chronic unpredictable mild stress stimulation. After the model was established, ED treatment was given for 14 days ( i.p. at a dose of 3mg/kg). Subsequently, the therapeutic effects of ED on behavioral parameters and inflammatory biomarkers in the PSD rats were analyzed. Results ED has a tendency to increase the percentage of sucrose preference in PSD rats. ED could significantly shorten the forced swimming time of PSD rats ( P < 0.05). ED significantly increased the level of 5-hydroxytryptamine in the brain tissue of PSD rats ( P < 0.05) and reduced the expression of inflammatory markers interleukin-6 and tumor necrosis factor-α ( P < 0.05). Conclusion ED demonstrates potential therapeutic efficacy in mitigating depressive-like behaviors in a PSD rat model, reducing neuroinflammation, minimizing brain tissue damage, and conferring neuroprotective benefits.
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Scientific Reports
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2026
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IF 4.9
Niu Jiale,Liu Guangxia,He Guangyao,Zhang Xiaomeng,Bai Huihui,Lu Yamin
To investigate the role of IL-17 in macrophage M1 polarization within a type 2 diabetic (T2DM) milieu and to evaluate the therapeutic potential of its neutralizing antibody. PMA-differentiated THP-1 macrophages were polarized to M1 state. Under high glucose, cells were treated with IL-17 and an IL-17 neutralizing antibody. Inflammatory cytokines (IL-1β, IL-6, TNF-α) were measured; mRNA levels of TNF-α, HIF-1α, and NLRP3 were assessed by qPCR; and protein expression related to the NF-κB, mTOR/HIF-1α axis and pyroptosis (NLRP3, Caspase-1, GSDMD) was analyzed by Western Blot. High glucose and IL-17 synergistically promoted M1 polarization, enhancing proinflammatory cytokine secretion. This was associated with activation of the NF-κB, mTOR/HIF-1α signaling axis and induction of pyroptosis, evidenced by NLRP3 inflammasome assembly, Caspase-1 activation, and GSDMD cleavage. The IL-17 neutralizing antibody effectively suppressed these pathological processes. IL-17 acts as a key immunological amplifier in diabetes, driving M1 polarization, oxidative stress, and pyroptosis via the NF-κB, mTOR/HIF-1α axis and NLRP3 inflammasome. Treatment with an αIL-17 effectively reversed the aberrant activation of the aforementioned cellular phenotypes and signaling pathways, partially restoring macrophage functional balance. This finding provides preliminary experimental support for further exploration of IL-17-targeted immunomodulatory strategies to ameliorate diabetes-associated metabolic inflammation.
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Journal of Ovarian Research
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2026
·Vol. 19
·期 1
·52
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IF 4.2
Ying Zhu,Hongqiu Zhu,Junjie Li,Peijuan Wu,qian Zhang,Mengxue Duan,Yan Li
Objectives The current treatments of polycystic ovarian syndrome (PCOS) have limited selectivity and effectiveness. Zishen Yutai Wan (ZSYTW) has shown therapeutic effects on patients with PCOS. This study aims to discover potential therapeutic targets and molecular mechanisms based on network pharmacology and molecular docking. Methods A disease gene set related to PCOS was collected from three public databases, a ZSYTW target gene set was established using the Traditional Chinese Medicine Systems Pharmacology database and Traditional Chinese Medicine and Chemical Components Database, and an intersection of two gene sets to obtain intersecting genes. Protein-protein interaction (PPI) network were performed on intersecting genes. Molecular docking further confirmed the high affinity and stability between the active compounds of ZSYTW and core targets. Finally, PCOS model mice were used to verify the results. Results Network pharmacology showed that AKT1 , TNF , IL6 , TP53 , and ESR1 were the key targets of ZSYTW against PCOS. Molecular docking demonstrated beta-sitosterol and stigmasterol exhibit strong binding affinities and binding stability with core targets, and p53 has the highest affinity with core components of ZSYTW. Mice experiment showed that compared with the control group, the expression of p53 protein and total apoptosis rate of ovarian granulosa cells in PCOS group were significantly increased ( P < 0.001). And ZSYTW could decrease the increased expression of P53 protein and total apoptosis rate of granulosa cells ( P < 0.001). Conclusion ZSYTW could effectively improve PCOS by regulating p53 and apoptosis of ovarian granulosa cells.
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Food Science of Animal Resources
·
2026
·Vol. 46
·期 1
·11
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IF 4.9
Zhao Shengming,Chen Xiang,Zhai Ligong,Zhao Yanyan,Ma Hanjun,Xiong Guoyuan
In this research, low-frequency alternating magnetic field (LF-AMF, 5 mT, 1–5 h) was used to investigate the effect on the structural, rheological, and gel properties of porcine myofibrillar protein (MP) under low-salt condition (0.3 M NaCl). The solubility, surface hydrophobicity, active sulfhydryl content, intrinsic fluorescence intensity, water holding capacity (WHC), and gel strength of low-salt porcine MP exhibited a trend of initial increase followed by a subsequent decrease as the LF-AMF processing time extended ( P < 0.05). Furthermore, LF-AMF treatment could induce an elevated β-sheet proportion, G’ value and a reduced α-helix proportion, suggesting that LF-AMF facilitated the improvement of gel attributes in low-salt porcine MP. Meanwhile, LF-AMF could trigger the construction of a homogeneous and tight MP gel network, resulting in bounding of more water molecules, which elevated the percentage of immobilized water and diminished the percentage of free water. Thus, an appropriate LF-AMF processing time can effectively improve the gel characteristics of low-salt porcine MP.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 3
·146
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IF 5.4
Li Ruiwen,Shen Hao,Shi Dandan,Yu Shaoning,Qian Guoqing
An aptamer-gated metal-organic framework-based biosensing platform for highly sensitive detection of multidrug-resistant bacteria (MDRB) has been developed. This biosensing platform utilizes aptamers as specific “gated” switches, which are integrated with the UiO-66-NH₂ MOFs to construct a “gated” sensing system loaded with 3,3′,5,5′-tetramethylbenzidine (TMB). The entry of target bacteria induces specific dissociation of sDNA/Apt, forming an aptamer-bacteria complex on the UiO-66-NH₂ surface while releasing TMB into the solution. Subsequently, the PCN-224-Mn nanozyme catalyzes the oxidation of TMB, generating a colorimetric signal. This biosensing platform demonstrates a broad linear range for detecting New Delhi metallo-β-lactamase-1 Klebsiella pneumoniae (NDM-1 KP) and multidrug-resistant Acinetobacter baumannii (MDR-AB), achieving ultra-high sensitivity with detection limits of 5 CFU/mL and 7 CFU/mL, respectively. The practical performance of this biosensing platform was evaluated through spiked recovery experiments. Its excellent recovery demonstrates that the method maintains high reliability and stability even when applied to complex real-world samples, providing an effective technical solution for addressing challenges in microbial detection in practical scenarios. Graphical
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Nature Communications
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2026
·Vol. 17
·期 1
·1663
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IF 18.1
Zhang Yan,Liu Zhiqiang,Kong Wenyu,Ao Yanxiao,Zhang Rui,Du Yanan
CAR-macrophage (CAR-M) therapy holds promise for the treatment of tumor and fibrotic diseases, yet genetic engineering remains the main efficacy-enhancing approach. Here we develop a non-genetic strategy using viscoelastic hydrogel to mechanically prime CAR-Ms. CAR-Ms exhibit potent phagocytosis of activated fibroblasts and collagen-degradation capacity, and hydrogel priming further enhances their cytotoxicity. Mechanistically, viscoelastic hydrogel priming reduces CAR-M membrane tension, which triggers membrane CAR to disassemble from clusters into dispersed monomers and dimers, leading to enhanced downstream signaling. In pulmonary fibrosis models, hydrogel-primed CAR-Ms demonstrate superior therapeutic outcomes, showing fibrosis reduction and microenvironment improvement. This study highlights CAR-M therapy’s potential for pulmonary fibrosis treatment and offers a distinct approach to improve CAR-M efficacy by physical stimuli.
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MICROCHIMICA ACTA
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2026
·Vol. 193
·期 3
·134
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IF 5.4
Wu Jiayi,Li Chengwei,Zhao Jingwen,Liu Jiyang
A Mn-doped Fe 3 O 4 (Mn-Fe 3 O 4 ) nanozyme was synthesized using a one-step solvothermal method. Compared to pristine Fe 3 O 4 , Mn-Fe 3 O 4 exhibits unique oxidase (OXD)-like activity and enhanced peroxidase (POD)-like activity. The superior catalytic performance arises from the incorporated Mn species and the associated oxygen vacancies facilitate oxygen adsorption and activation, establishing an efficient self-cascade catalytic system. In this system, hydrogen peroxide (H 2 O 2 ) generated in-situ through OXD-like catalysis can trigger mimic-POD reactions. A dual-mode antioxidant detection platform was subsequently constructed using melatonin (MT) as a proof of concept, with 3,3’,5,5’-tetramethylbenzidine (TMB) serving as the substrate for the Mn-Fe 3 O 4 nanozyme. The colorimetric mode enables rapid visual screening by monitoring the oxidation of TMB to a blue-colored product, achieving a detection limit of 0.13 µM. The electrochemical mode features the novel utilization of mesoporous silica nanochannels for the selective enrichment of oxidized TMB (oxTMB), enabling highly sensitive quantification of MT with a detection limit as low as 0.6 nM. The assay applied to commercial tablets shows excellent recovery and reproducibility. This work combines engineered nanozymes with nanofilm-modified electrodes, offering an innovative approach for constructing advanced multimodal sensing systems. Graphical
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Nature Communications
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2026
·
IF 18.1
Guo Jiaxin,Wang Ruguang,Yang Yuting,Zhang Qinhao,Cao Fahe,Zhao Jiong,Pan Caofeng,Ling Tao
Anion exchange membrane water electrolyser is a highly promising electrolyser technology, but its performance in pure water is severely limited by the unsatisfactory OH − conductivity of the membrane. To overcome this critical challenge, we develop a local alkalinity engineering strategy that employs TiO 2 nanoparticles in catalyst layers. These nanoparticles enrich OH − in the electric double layer at both electrodes, creating self-sustaining alkaline microenvironments (pH ~ 14), as confirmed by a scanning electrochemical microscopy technique integrating pH microelectrodes. As a result, the engineered electrolyser achieves a high current density of 3.0 A cm −2 at 2.08 V, approaching that of the precious-metal-based proton exchange membrane water electrolyser under identical conditions. In addition, the local alkalinity alleviates the degradation of non-noble metal catalysts and membrane, thus enabling the electrolyser to realise long-term stability of ~ 1400 h at 1.0 A cm −2 . We also demonstrate that this local alkalinity strategy can be readily extended to different types of membranes and scaled up, providing a universal tactic to boost the performance of anion exchange membrane water electrolysers.
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Nature Communications
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2026
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IF 18.1
Peng Jiaxing,Wu Taizheng,Zeng Liang,Liu Zhou,Li Shiqi,Feng Guang
Amorphous porous carbons have been widely used as electrodes for energy storage. However, due to their structural heterogeneity and complex pore topology, the absence of reliable atomic carbon models hinders understanding energy storage mechanisms through molecular simulations. Here, we develop a modeling approach capturing the rich experimental information of small angle X-ray scattering, gas adsorption, and material density, integrating three-dimensional morphology construction with atomic structure generation. Using the built atomic model, constant-potential molecular simulations are performed to investigate the capacitive behavior of amorphous porous carbons, well-validated by experimental measurements of capacitance and impedance. Voronoi sphere analyses uncover the interplay between pore structure and charge storage: ultramicropores (< 0.7 nm) are found to enhance the capacitance through ion exchange, while large micropores (> 0.7 nm) exhibit lower capacitance with negligible ion number change. The charging dynamics are quantified by the proposed multi-scale impedance model, bridging microscopic simulations and macroscopic experiments. This modeling framework paves the way toward molecular understanding of energy storage in amorphous porous materials.
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Cell Death & Disease
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2026
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IF 12.2
Yang Dian,Liu Yichao,Hong Yueshun,Miao Enming,Wang Peng,Sun Yuming,Zhou Lina,Liu Shuyan,Zhang Yingqiu,Qin Hongqiang,Ye Mingliang,Liu Han
Stress granules (SGs) are membrane-less organelles formed through liquid-liquid phase separation of proteins and RNAs, serving as temporary repositories for biomacromolecules to protect cells under stress conditions. Impaired SG disassembly is closely implicated in neurodegenerative diseases and aging, yet the mechanisms regulating SG dynamics are incompletely investigated. The constituents of heterogenous SGs are complicated and broadly categorized as core and shell components. In contrary to the relatively stable core components, our understanding of the diverse SG shell is deficient. By combining interactomic and proximity proteomic approaches, we reveal that the deubiquitinating enzyme OTUD6B is associated with SG-related functions. Immunofluorescence assays showed that OTUD6B localized to SGs, as well as regulated their early assembly and clearance, partially dependent on its enzymatic activity. Further proximity proteomics and interactomics results uncover the ATPase VCP/p97, a key SG disassembly factor, as an OTUD6B-associated protein. OTUD6B and VCP association is governed through their disordered regions normally participated in biomolecular condensation. VCP knockdown or pharmacological inhibition phenocopied OTUD6B silencing by leading to defects in SG dynamics. Mechanistically, SG coalescence of VCP incurred by OTUD6B in a partially enzymatic activity-dependent manner functions to accelerate not only the early assembly, but also SG clearance following stress removal. Therefore, our findings establish OTUD6B as a critical modulator of SG dynamics, linking its function to stress responses and potential disease mechanisms.
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