MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 11
·740
·
IF 5.4
Lai Huasheng,Fu Fangsi,Zhu Siyu,Xu Meng
Au nanoparticle-loaded mixed-valence MnOₓ nanosheets were prepared as an oxidase-like nanozyme for colorimetric determination of leucomalachite green (LMG). The nanozyme oxidized colorless LMG to the strongly absorbing malachite green (MG) chromophore using dissolved molecular oxygen without externally added H 2 O 2 . The resulting MG produced a characteristic absorption band at 620 nm. Electron microscopy, elemental mapping, X-ray diffraction, and X-ray photoelectron spectroscopy confirmed crystalline Au nanodomains dispersed on a low-crystallinity mixed-valence MnO x matrix. The catalytic response was maximal at pH 3.0 and reached a stable value within approximately 60 s. Initial-rate measurements showed apparent Michaelis–Menten behavior, with an apparent K m of 39.2 µM and V max of 0.0345 µM s⁻¹. Radical-scavenging and electron paramagnetic resonance experiments supported a multistep reactive-oxygen-species pathway involving hydroxyl radicals and singlet oxygen. The analytical response was linear over 30–1000 µg L⁻¹, with a detection limit of 2.1 µg L⁻¹. This corresponds to a theoretical fish-sample equivalent of 0.42 µg kg⁻¹ after sample concentration. Recoveries of 81.6–110.2% were obtained for fish and water samples. A positive fish sample gave 25.4 µg kg⁻¹ by the Au–MnO x assay, in reasonable agreement with the HPLC result of 23.4 µg kg⁻¹. Graphical abstract
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry A
·
2014
·Vol. 2
·期 33
·13682-13690
·
IF 0
Shengjie Xu,Peiyi Wu
In this work, a well-dispersed Au cluster/reduced graphene oxide (RGO) composite was synthesized using citric acid (CA) as a reducing and binding agent. The as-prepared composite was systemically characterized by TEM, XPS, TGA and FTIR. TEM image showed Au clusters uniformly distributed on the RGO sheet with an average size of 1.8 nm. The Au clusters/RGO composite exhibited excellent catalytic performance for the oxygen reduction reaction (ORR). Moreover, the electrocatalytic comparison indicated that the long-term durability and methanol tolerance of this composite was superior to the commercial Pt/C catalyst. Therefore, such a composite might be an alternative and more promising non-Pt electrocatalyst for fuel cells.
✓ 已验证
DOI
Advanced Materials Interfaces
·
2021
·Vol. 8
·期 18
·2101055
·
IF 6.147
Changchang Xing,Shichuan Zhong,Dilong Liu,Tao Zhang,An Cao,Pan Zeng,Dandan Men,Cuncheng Li,Weiping Cai,Yue Li
A facile route to fabricate the hydrogel film@Au nanoparticle array composite for a surface-enhanced Raman scattering (SERS) substrate with high signal sensitivity and signal uniformity based on self-assembly co-assisted by electrostatic reaction and hydrogel-shrinkage is developed. First, the positive-charged Au nanoparticles (NPs) are self-assembled on the hydrogel film with opposite charges due to electrostatic attraction to obtain non-close-packed Au NP films on both surface sides of the hydrogel film. Then, the non-close-packed Au NP films are densified to further form hexagonal close-packed Au NP arrays on both surfaces due to the principle of minimum free energy during the hydrogel-shrinkage process. The shrinkage of hydrogel film is proved to be a key process to form hexagonal close-packed Au NP arrays by densifying the non-closely packed Au NPs achieved by electrostatically self-assembled on the hydrogel film. Constructed SERS substrate exhibits high signal sensitivity, colorant molecule amaranth with a concentration as low as 10 −8 m can be detected. This is caused by the uniform array structure with active gaps between neighboring NPs on a large area. Overall, this work paves a way to fabricate functional NP arrays on soft hydrogel, which will be highly helpful to prepare the micro/nano-structured devices.
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yudie Sun,Aobo Feng,Ruilai Zhang,Kehong Quan,Zefeng Hua,Kui Zhang
Bacterial contamination is a very serious health and environmental problem, with the main source of toxicity being lipopolysaccharides in the cell walls of Gram-negative bacteria. Therefore, the development of effective analytical methods is crucial for the detection of lipopolysaccharide content. This work facilitates the efficient generation of precisely adjustable dual-mode signals for LPS detection in surface-enhanced Raman spectroscopy (SERS) and electrochemiluminescence (ECL) by inducing anisotropic morphological evolution of Au@Ag nanocubes (Au@AgNCs) through poly-cytosine (poly-C) DNA. In the presence of LPS, the released probe triggers rolling circle amplification (RCA) and generates cyclic poly-C DNA, which subsequently induces the etching of Ag composites on Au@AgNCs. This etching process leads to changes in both the morphology and composition of Au@AgNCs composite materials, resulting in a decrease in SERS signals. The poly-C DNA was subsequently adsorbed with Ag + and then reduced to silver nanoclusters (AgNC) by NaBH 4 , serving as an ECL signal source. Under optimal experimental conditions, both SERS and ECL demonstrated linear ranges spanning from 1 fg/mL to 1 ng/mL, with detection limits of 0.29 fg/mL and 0.14 fg/mL, respectively. Moreover, the SERS-ECL dual-mode sensor facilitates the accurate discrimination of Gram-negative bacteria in diverse real samples. It demonstrates promising applications in the areas of food safety, water quality monitoring, and clinical bacterial detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xue-Hui Shi,Wei Zhao,Zhimou Yang,Lei Wang,Wenjie Ren
The development of sophisticated nanomaterials with synergistically enhanced functionalities and applications has been greatly promoted via the construction of Janus nanoparticles with controlled compositions. In this work, we described and demonstrated the formation of Janus Au-PbS nanoparticles (NPs) by Au NPs-mediated spontaneous epitaxial nucleation and growth. The mechanism of formation of Janus Au-PbS NPs was investigated in detail. Then, we also found that there was a strong electronic interaction between the Au NPs and PbS quantum dots (QDs) in Janus Au-PbS NPs, where electrons were transferred from the Au NPs domain to the PbS QDs domain. Moreover, the Janus Au-PbS NPs integrated the high-brightness tunable second near-infrared (NIR-II) photoluminescence emission and surface-enhanced Raman scattering (SERS), which achieved good intraoperative tumor resection. This complementary dual-functional imaging had the potential to enable more accurate tumor imaging and resection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMISTRY OF MATERIALS
·
2024
·
IF 7.2
Xue-Hui Shi,Leiming Tao,Lei Wang,Xing Liu,Shu-Lin Liu,Zhi-Gang Wang
In recent years, the application of both fluorescence and photothermal systems in one system has received great attention in the biomedical field. Yet, synthesizing a nanomaterial with both fluorescence (radiative decay) and a photothermal effect (nonradiative decay) is rarely reported. Here, we proposed novel plasmonic-fluorescent Janus Au-PbS nanoparticles (NPs) with tunable near-infrared II (NIR-II) fluorescence and photothermal effect to be used as a highly effective nanotheranostic for dual-modal NIR-IIb fluorescence imaging (FI)/computed tomography imaging (CT)-guided photothermal therapy. In addition, we investigated the equilibrium mechanism between the fluorescence and photothermal effects to guide the synthesis of this type of nanomaterial and found that the fluorescent semiconductor PbS quantum dots (QDs) receive electrons from Au NPs in Janus Au-PbS NPs, which could maintain the good fluorescence properties of Janus Au-PbS NPs. In addition, the alteration of electron and hole recombination between PbS QDs and Au NPs in Janus Au-PbS NPs increased nonradiative decay, leading to enhanced photothermal effects of Janus Au-PbS NPs. The electron receiver and electron–hole interactions in Janus Au-PbS NPs offered a fundamentally new means of engineering materials with fluorescence and photothermal properties through tailoring electron redistribution in Janus NPs.
✓ 已验证
产品关联
DOI
高影响因子
Carbon Energy
·
2024
·
IF 19.5
Hongyu Gong,Guanliang Sun,Wenhua Shi,Dongwei Li,Xiangjun Zheng,Huan Shi,Xiu Liang,Ruizhi Yang,Changzhou Yuan
Enhancing both the number of active sites available and the intrinsic activity of Co-based electrocatalysts simultaneously is a desirable goal. Herein, a ZIF-67-derived hierarchical porous cobalt sulfide decorated by Au nanoparticles (NPs) (denoted as HP-Au@Co x S y @ZIF-67) hybrid is synthesized by low-temperature sulfuration treatment. The well-defined macroporous–mesoporous–microporous structure is obtained based on the combination of polystyrene spheres, as-formed Co x S y nanosheets, and ZIF-67 frameworks. This novel three-dimensional hierarchical structure significantly enlarges the three-phase interfaces, accelerating the mass transfer and exposing the active centers for oxygen evolution reaction. The electronic structure of Co is modulated by Au through charge transfer, and a series of experiments, together with theoretical analysis, is performed to ascertain the electronic modulation of Co by Au. Meanwhile, HP-Au@Co x S y @ZIF-67 catalysts with different amounts of Au were synthesized, wherein Au and NaBH 4 reductant result in an interesting “competition effect” to regulate the relative ratio of Co 2+ /Co 3+ , and moderate Au assists the electrochemical performance to reach the highest value. Consequently, the optimized HP-Au@Co x S y @ZIF-67 exhibits a low overpotential of 340 mV at 10 mA cm –2 and a Tafel slope of 42 mV dec –1 for OER in 0.1 M aqueous KOH, enabling efficient water splitting and Zn–air battery performance. The work here highlights the pivotal roles of both microstructural and electronic modulation in enhancing electrocatalytic activity and presents a feasible strategy for designing and optimizing advanced electrocatalysts.
✓ 已验证
DOI
高影响因子
Nanoscale Advances
·
2025
·
IF 4.6
Mengting Tong,Guangpeng Chen,Yong Dong,Yubin Pan,Yanan Xue,Da Li
Despite the progress made in novel immunotherapy for hepatocellular carcinoma (HCC), drug resistance remains a challenging problem. In this study, we developed a stepwise nanodrug delivery system, known as Au-SS-PEG/Sor/ATP aptamer /LHRH-MPG ΔNLS , to adapt to the high concentrations of glutathione (GSH) and adenine nucleoside triphosphate/adenosines (ATP/ADO) found in cancer cells and the tumor microenvironment (TME). This system utilizes novel Au nanoclusters conjugated with disulfide-linked PEG as vectors to transport sorafenib (Sor) and an ATP-binding nucleic acid aptamer (ATP apt ). It can enter HCC cells through luteinizing hormone-releasing hormone (LHRH)-MPG ΔNLS (LM). Within the cells, the disulfide bonds of the nanoclusters are cleaved by the high levels of GSH, leading to the release of Sor/ATPapt. This release can be further triggered by ATP/ADO, resulting in a stepwise drug release mechanism. Furthermore, this nanodrug system has exhibited the ability to overcome αPD-1 resistance in HCC tumors. In summary, our novel drug delivery system demonstrates a dramatic anti-HCC effect and holds great potential for treating HCC patients. Synthesis and mechanistic illustration of Au-SS-PEG/Sor/ATP apt /LM nanoclusters for the treatment of hepatocellular carcinoma (HCC).
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2022
·
IF 6.443
Meiting Guo,Fang Wang,Wang Guo,Run Tian,Tingtiao Pan,Ping Lu
Pymetrozine is widely used in agriculture to control pests, and its residue may pose a threat to humans. In this study, the adsorption behavior of pymetrozine on Au@AgNPs surfaces in different solutions was investigated by calculation of ACD/Labs, density functional theory, UV–vis spectra, zeta potential and surface-enhanced Raman scattering. Then, a SERS method for detection of pymetrozine residues in apples was established based on the adsorption study. The results showed that pymetrozine was adsorbed on Au@AgNPs surface in different forms in various solutions and high SERS sensitivity of pymetrozine was obtained by the synergistic effect of pymetrozine, Au@AgNPs and NaOH. A simple SERS method has been established to detect pymetrozine in apples with a LOD of 0.038 mg/kg, linear range of 0.05–1.00 mg/kg, recovery of 71.93–117.49 % and RSD low than 11.70 %. This study provides a reference for rapid detection of pymetrozine in agricultural products.
✓ 已验证
DOI
高影响因子
Journal of Advanced Research
·
2026
·
IF 17.1
Sumei Ling,Yang Xu,ZhouJie Xu,Xiaoli Li,Linfang Lu,Menghan Sun,Wenjun Yang,Yuxuan Liu,Jun Yuan,Shihua Wang
Introduction Sulfamethazine (SM2) antibiotic residues in food pose a significant risk to human health, including pathogenic bacterial resistance, allergic reactions, and carcinogenicity. Current lateral flow immunoassay (LFIA) typically employing colloidal gold (AuNP) as a signal reporter exhibits unsatisfactory sensitivity. Recently, metal–organic frameworks (MOFs) nanomaterial as a supporting matrix for loading nanoparticles provides a powerful tool to improve the performance of LFIA. Objectives This study aims to develop an enhanced immunosensor based on antibody labeled Au/Ir@Cu/Zn-MOF signal amplification nano-composite for sensitive and point-of-care monitoring of SM2 antibiotic residues. Methods Firstly, the highly specific monoclonal antibody (mAb) against SM2 belonging to the IgG1 subclass was screened. Subsequently, the Au/Ir@Cu/Zn-MOF nanocomposite was synthesized by incorporating Au/Ir bimetallic nanoparticles into the previously prepared Cu/Zn-MOF composite. The anti-SM2 mAb was then conjugated to Au/Ir@Cu/Zn-MOF nanocomposite via a co-precipitation method to fabricate the mAb-Au/Ir@Cu/Zn-MOF probe. Finally, a lateral flow immunoassay was constructed for the detection of SM2 residues. Results The vLOD the Au/Ir@Cu/Zn-MOF-based LFIA for SM2 detection was approximately 2.5 ng/mL, which was at least 600 times greater than that of the AuNP-based LFIA (with the vLOD of 1563 ng/mL). Average recovery rates were 80.08–90.8% in milk sample, 88–89.3% in eel sample and 85.3–95.2% in pork sample, respectively. Conclusion The Au/Ir@Cu/Zn-MOF nanocomposite utilized as signal amplification probe demonstrated remarkable sensitivity for the detection of SM2. The developed Au/Ir@Cu/Zn-MOF-based LFIA exhibits significant potential for the rapid and sensitive detection of contaminants in environmental monitoring and food safety.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xinyuan Zhao,Hui Pan,Wenwen Chen,Wei Zhang,Chuanxi Liu,Mengjie Wang,Ming Shang,Cuijuan Wang
High index facets of Au TOHs/ZIF-67/PTFE enables good sensitivity. • Supports air sampling and testing suitable for on-site settings. • Applicable to both airborne and aqueous samples for versatile monitoring. • Rapid detection (<5 min) for practical use. Monitoring of pesticides in air and water is essential for assessing occupational exposure and ensuring environmental safety. In this study, an integrated point-of-use (POU) surface-enhanced Raman scattering (SERS) platform based on a high-index Au trisoctahedrons (Au TOHs)/zeolitic imidazolate framework-67 (ZIF-67)-decorated polytetrafluoroethylene (PTFE) membrane was developed for the rapid sampling and in situ detection of carbaryl (CBR), diquat (DQ), and paraquat (PQ) in air and water. The high-index facets of Au TOHs generate abundant plasmonic “hot spots”, thereby enhancing the sensitivity of SERS, while the porous PTFE film and ZIF-67 provide efficient analyte enrichment. The entire detection process was completed within 5 min. The bifunctional SERS-active substrate exhibited good thermal stability, spatial uniformity, reproducibility, and long-term stability. Strong linear relationships between SERS intensity of characteristic peaks and logarithmic analyte concentrations were obtained for CBR, DQ, and PQ in airborne and aqueous environments, with detection limits of 0.0044–0.94 ppb. In addition, the platform demonstrated good selectivity against interfering pesticides and satisfactory recovery rates. The results were consistent with conventional analytical methods, confirming the reliability of the proposed approach. This work provides a promising strategy for rapid on-site monitoring of pesticide contaminants in environmental media. Download: Download high-res image (620KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
Food Bioscience
·
2026
·
IF 6.2
Xifan Zhan,Xinying Wang,Md Mehedi Hassan,Fangling Jiang,Jiaying Xu,Yuan Zhang,Shanghua Li,Sha Zou,Hongfa Liu,Yi Xu,Quansheng Chen
Pesticide residues in tea pose significant health risks to consumers. This research focuses on developing a surface-enhanced Raman scattering (SERS) sensor using a solid-phase substrate made of Au@Ag@PVP nanoparticles (NPs), combined with machine learning chemometric techniques, for the rapid detection of trichlorfon, carbendazim, and clothianidin in tea. Au@Ag@PVP NPs were immobilized onto anodic aluminum oxide (AAO) filter membranes via vacuum filtration, yielding densely packed NPs that generate strong electromagnetic hot spots, thereby increasing SERS sensitivity. Raman spectra of tea infusions containing different concentrations of pesticides were acquired and analyzed using three machine-learning algorithms. Among these models, competitive adaptive reweighted sampling-partial least squares (CARS-PLS) demonstrated superior predictive performance, with Rc = 0.9950, Rp = 0.9942, and RPD = 9.2893 for trichlorfon; Rc = 0.9955, Rp = 0.9942, and RPD = 9.1010 for carbendazim; and Rc = 0.9981, Rp = 0.9957, and RPD = 9.7523 for clothianidin. This approach enables the rapid, quantitative detection of pesticide residues with minimal sample preparation and high sensitivity, representing a practical method for monitoring tea safety.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）