ANALYST
·
2019
·Vol. 145
·期 3
·1025-1032
·
IF 4.019
Hui Xu,Zijie Feng,Yingxiang Du
Recently, ionic liquids have been widely used for chiral separation. However, several papers have reported the use of ionic liquids as the sole chiral selector. In this work, a novel capillary electrophoresis method using the ionic liquid 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate (MSI-LA) as a chiral selector was developed for the enantioseparation of propranolol, metoprolol, bisoprolol, esmolol, atenolol, sotalol, terbutaline and clenbuterol. Method optimization was conducted and the optimized method (40 mM borax buffer, v/v 30% methanol, pH 8.5, 160 mM MSI-LA; +10 kV voltage; capillary temperature, 15 °C; 50 mbar/5 s injection; detection wavelength, 230 nm) was successful for the baseline separation of the eight basic drugs. The LA (lactobionic acid) system was compared. The possible mechanisms of enantioseparation were investigated using molecular modeling. Both the cation and anion of MSI-LA provided interactions between the chiral selector and analytes, and finally enhanced chiral recognition capability compared with LA.
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PubMed
高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2017
·Vol. 40
·期 12
·2565-2574
·
IF 2.557
Senlin Li,Sainan Li,Yu Huang,Chunming Liu,Lina Chen,Yuchi Zhang
The separation of a compound of interest from its structurally similar homologues to produce high-purity natural products is a challenging problem. This work proposes a novel method for the separation of iristectorigenin A from its structurally similar homologues by ionic-liquid-based ultrasound-assisted extraction and the subsequent screening and isolation of potential α-glucosidase inhibitors via ultrafiltration and semipreparative high-performance liquid chromatography. Ionic-liquid-based ultrasound-assisted extraction was successfully applied to the extraction of tectorigenin, iristectorigenin A, irigenin, and irisflorentin from Belamcanda chinensis . The optimum conditions for the efficient extraction of isoflavones were determined as 1.0 M 1-ethyl-3-methylimidazolium tetrafluoroborate with extraction time of 30 min and a solvent to solid ratio of 30 mL/g. Ultrafiltration with liquid chromatography and mass spectrometry was applied to screen and identify α-glucosidase inhibitors from B. chinensis , followed by the application of semipreparative high-performance liquid chromatography to separate and isolate the active constituents. Four major compounds including tectorigenin, iristectorigenin A, irigenin, and irisflorentin were screened and identified as α-glucosidase inhibitors, and then the four active compounds abovementioned were subsequently isolated by semipreparative high-performance liquid chromatography (99.89, 88.97, 99.79, and 99.97% purity, respectively). The results demonstrate that ionic liquid extraction can be successfully applied to the extraction of isoflavones from B. chinensis .
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高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 7
·1532-1542
·
IF 1.915
Lianfei Zhao,Hua Wang,Huiyan Gu,Lei Yang
Rapid and efficient solvent extraction of syringin and oleuropein from Syringa reticulata var. mandshurica branch bark was achieved using microwave-assisted ionic liquid–lithium salt pretreatment, followed by ultrasonic breakdown of the plant cell walls. The conditions for this novel sample treatment method, including microwave pretreatment time and power, ultrasound irradiation extraction time and power, types and concentrations of ionic liquid and lithium salt, and the liquid–solid ratio, were optimized using a dual response surface methodology. The proposed approach under optimal conditions was compared with conventional extraction methods. No degradation of syringin and oleuropein was observed in stability studies performed with a reference standard. The experimental results indicate that the proposed approach is a simple and efficient sample preparation technique that has strong potential for application in the field of sample analysis.
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JOURNAL OF SEPARATION SCIENCE
·
2016
·Vol. 39
·期 22
·4415-4421
·
IF 2.741
Long Pang,Rong Pang,Liming Ge,Liqing Zheng,Jihong Zhao,Hongzhong Zhang
Organophosphate esters, widely used as flame retardants and plasticizers, are regarded as a class of emerging pollutants. In this work, a novel approach was developed for the fabrication of a solid-phase microextraction fiber by using hybrid silica-based materials with immobilized ionic liquids with sol–gel technology, and the prepared solid-phase microextraction fiber was then coupled with gas chromatography and flame photometric detection for the analysis of six organophosphate esters. The high loading of 1-hexadecyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide was confined within the hybrid network. The developed solid-phase microextraction fiber possesses a coating thickness of ∼35 μm with good thermal stability and long lifetime. The parameters affecting the extraction efficiency such as extraction time, temperature, pH, and ionic strength of the sample solution were optimized. Under the optimized conditions, the limits of detection were in the range of 0.04−0.95 μg L −1 , and the precision of the method assessed with repeatability and reproducibility of (RSD%) ˂13 and ˂29%, respectively. The proposed method was successfully applied to determine the six organophosphate esters in three real water samples, with recoveries in the range of 64.8−125.4% at two different spiking concentration levels. As a result, the proposed method demonstrated its potential for application in trace determination of organophosphate esters in actual water samples.
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高影响因子
LANGMUIR
·
2024
·
IF 3.7
Jie Chen,Huiyao Huang,Wangquan Gong,Yi Chen,Rong Dong,Limei Ren,Ting Qiu
Ethyl methyl carbonate (EMC) is a crucial solvent extensively utilized in lithium-ion battery electrolytes; the transesterification of dimethyl carbonate (DMC) with ethanol is a pivotal reaction for EMC production. However, this reaction faces challenges due to the trade-off between catalytic activity and selectivity from the basic catalysts. In this issue, we report an innovative strategy through fine-tuning the electron-donor capability of the basic phenolate anion ([PhO]) in a novel poly(ionic liquid) (PIL) framework, as synthesized via an alkylation reaction between 1,3,5-tris(bromomethyl)benzene, biphenyldiimidazole, and N,N′-carbonyldiimidazole (CDI) to trigger targeted basicity that can directionally catalyze the transesterification of DMC with ethanol, so as to achieve both ultrahigh catalytic activity and selectivity toward EMC. By varying the substituent groups with electron-withdrawing and electron-donating effects on the phenolate anion, the PILs show expected changes in the catalytic performance, following well with the trend of charge density on these substituted phenolate anions. The optimized catalyst [CPIL-CDI][MeOPhO], induced by p-methoxyphenolate anions, allows an extraordinary EMC yield of 72.19% and an EMC selectivity of 91.48% under mild conditions without any process intensifications, suppressing all of the reported catalysts reported to date. Outcomes and approaches shown in this work have the potential to expedite the systematic design of cations and anions within PILs for industrial-scale EMC production through environmentally friendly transesterification processes.
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高影响因子
JOURNAL OF SEPARATION SCIENCE
·
2025
·Vol. 48
·期 3
·e70116
·
IF 2.8
Jinghui Li,Yan Kang,Ying Wang,Jiaxin Liu,Yingting Wang,Sitong Liu,Yunxi Bu,Xiangqun Li,Jiahan Xie,Zhibing Wang
A simple, green, and efficient ultrasound-assisted deep eutectic solvents (DESs) extraction followed by high-performance liquid chromatography-diode array detector was established to detect four liposoluble anthraquinones in Salvia miltiorrhiza Bge. root. In this study, a series of polarity-adjustable DESs were prepared using n -hexanol and tetrabutylammonium chloride, and their structure, density, viscosity, pH, and thermal stability were determined. The conditions for extraction were optimized through single-factor experiments and response surface methodology. The kinetic and thermodynamic properties associated with the ultrasound-assisted extraction of anthraquinones were investigated. The results showed that the standard curves for anthraquinones showed excellent linearity from 0.018 to 150 µg mL −1 ( r > 0.9998). The detection and quantification limits varied from 5.04 to 5.60 ng mL −1 and 16.81 to 18.67 ng mL −1 , respectively. The recoveries were measured as 84.1%–95.1%, and the relative standard deviations were not exceeded 4.6%.
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高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Xiaopeng Hu,Yiwei Liu,Yide Xia,Faqiong Zhao,Baizhao Zeng
Citrinin can cause serious human diseases, thus its detection in foods is necessary. Herein, a molecularly imprinted polymer-based ratiometric electrochemical sensor (MIP-RECS) was presented for citrinin detection. The sensor was fabricated by electropolymerization, using thionine as monomer and citrinin as template. The ionic liquid decorated boron and nitrogen co-doped hierarchical porous carbon (BN-HPC) as supporter, provided large surface for anchoring thionine and citrinin. Poly(thionine) not only acted as MIP, but also acted as reference probe. When [Fe(CN) 6 ] 3-/4- was adopted as indicating probe, the resulting sensor demonstrated a wide linear detection range (i.e. 1 × 10 -3 –10 ng mL −1 ) and a low detection limit (i.e. 1 × 10 -4 ng mL −1 ).The sensor was applied to the detection of spiked citrinin in real samples, and satisfactory recovery (i.e. 97% – 110%) was obtained. Hence, it was promising for citrinin detection.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 27
·12294-12305
·
IF 2.7
Chang Bian,Yu Liu,Zhenghao Li,Xuedong Wang,Ming Gao
There are some notable drawbacks of ordinary magnetic effervescent tablets including their quick disintegration, hygroscopicity, and impracticability for field use. In order to solve the above problems for further extraction and preconcentration of three phenolic pesticides from crop flour samples, an effervescent tablet-assisted acidic ionic liquid-based in situ solvent formation magnetic solid-phase extraction (ETA-AIL-MSPE) technique was developed. In contrast to conventional imidazole ionic liquids, acidic ionic liquids can be employed as an acid source for effervescent processes in addition to being used as extractants. Not only does this reduce the need for organic solvents, but the production of CO2 by the effervescent tablet also provides a rapid dispersion effect, removing the requirement for further dispersion stages and streamlining the experiment. The magnetic effervescent tablet is made of Na2CO3 as an alkaline source, [BMIM][HSO4] as extractant and acidic sources, NaCl as a viscosity modifier, and Fe3O4 as magnetic nanoparticles. The Plackett–Burman design and the central composite design were used to screen and optimize three key variables (93 mg of Na2CO3, 451 mg of AIL, and 37 mg of Fe3O4), respectively. Through the integration of high-performance liquid chromatography-diode array detection (HPLC-DAD), the ETA-AIL-MSPE technique provided enhanced recoveries of 85.0–107.2% and limits of detection of 0.14–0.17 μg kg−1 for three representative species (ioxynil, bromoxynil, and dinoseb) in four different types of crop flour samples. For both intra-day and inter-day precision, the relative standard deviations were below 7.7%. Generally, the recently developed technique is convenient, efficient and environmental-friendly, and it has great potential for on-site sample preparation for the detection of phenolic pesticides in crop flour samples.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Zhuang Wang,Dongping Su,Ting Luo,Qiao Yu,Yiting Wang,Xingyue Liu,Xuanhao Huang,Songdong Ding
The separation of thorium from uranium and rare earths is of great significance for a thorium molten salt reactor nuclear energy system. Herein, a novel Aliquat 336@SiO2–P extraction resin, prepared by the in situ encapsulation of an amine-based ionic liquid (Aliquat 336) into a porous silica–polymer matrix at the same time as the polymerization, was developed for the highly selective separation of Th(IV) over U(VI) and rare earth ions. Batch adsorption studies showed that the prepared Aliquat 336@SiO2–P extraction resin has excellent selectivity, strong adsorption affinity, and high adsorption capacity for Th(IV). The adsorption process of Th(IV) follows pseudo-second-order kinetics and the Langmuir model, and the adsorption of Th(IV) is a monolayer-type, chemical, exothermic, and spontaneous process with increased entropy, achieving a maximum Th(IV) adsorption capacity (qmax) of 52.4 mg/g. Thorium is adsorbed as a complex anion in an HNO3 solution, and its adsorption conforms to the anion exchange mechanism. Furthermore, column experiments indicated that Th(IV) can be selectively separated from simulated monazite HNO3 leach liquor with a recovery rate as high as 97.7%, and the prepared extraction resin has good reusability. Compared to the conventional impregnation method, the Aliquat 336 extractant encapsulated in a porous silica–polymer matrix has significantly lower loss during the adsorption process. Overall, this new extraction resin demonstrates great application potential for the highly efficient separation and recovery of Th(IV) from monazite HNO3 leach liquor.
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高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Tenghe Zhang,Wanhang Jiang,Yong Cao,Chanrong Zhu,Sara Toukouki,Shun Yao
Without inert gas protection and extra assistance by energy field, a green, facile, and catalyst-free strategy to synthesize ionic liquid@porous organic frameworks (IL@POFs) with high efficiency was developed for the first time. Besides, they have high specific surface area, stability and sustainability. As the brutal facts, many industrial crops are easily polluted and then cause safety risks. Among above IL@POFs, 1-butyl-3-methylimidazolium proline salt@porous organic framework ([C 4 mim][ L -pro]@POF) exhibits rapid removal performance for typical heavy metal ions from Poria cocos (removing 100% Pb 2+ within 5 min; 207.47 mg/g for Pb 2+ and 62.85 mg/g for Cu 2+ ). The separation mechanisms are coordination, accompanied by ion exchange and electrostatic interaction. Moreover, 1-butyl-3-methylimidazolium hexafluorophosphate@porous organic framework ([C 4 mim][PF 6 ]@POF) could remove 85% triazophos and 93% aflatoxin B 1 (AFB 1 ) effectively from Radices trichosanthis within 5 min, and multiple intermolecular interactions contribute to its adsorption capacity and selectivity. Above sorbents can be reused after effective elution. The proposed strategy not only provides valuable reference for the high-efficient synthesis of IL@POFs but also opens up a new pathway to recycling contaminated industrial crops.
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高影响因子
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
·
2017
·
IF 4.421
Li Yao,Xie Wang,Haitao Liu,Chaowen Lin,Liangyu Pang,Junwei Yang,Qingbin Zeng
A simple and efficient method for the determination of Cd and Pb in water samples was developed by ultrasound-assisted magnetic retrieval-linked ionic liquid dispersive liquid–liquid microextraction (UA-MR-IL-DLLME) preconcentration and graphite furnace atomic absorption spectrometry (GFAAS) detection. Ionic liquid (IL) [Hmim] [PF 6 ] was used as the extractant, ammonium pyrrolidine dithiocarbamate (APDC) as the complexing agent and Fe 3 O 4 nanoparticles as the sorbent, while ultrasound was applied to assist the dispersion of the extractant and accelerate the mass transfer process. The effect of different factors on the extraction efficiency including pH, IL volume, APDC amount, ultrasound extraction time, ultrasound desorption time and Fe 3 O 4 amount was studied by a fractional factorial design to screen for the most important factors. Then a central composite design was used to optimize the significant factors. Under the optimal conditions, the method has linear calibration curves over the range of 0.3–20 ng/mL for Cd and 0.5–40 ng/mL for Pb, with correlation coefficients (R) of 0.9990 and 0.9986 for Cd and Pb, respectively. The limits of detection were 0.1 ng/mL and 0.15 ng/mL with relative standard deviations of 3.4% and 2.8% for Cd and Pb, respectively. Finally, the method was successfully applied for the determination of Cd and Pb in the real water samples and satisfactory recoveries were achieved.
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高影响因子
RSC Advances
·
2019
·Vol. 9
·期 63
·36664-36669
·
IF 3.049
Liyan Jia,Jingrui Yang,Wenfei Zhao,Xu Jing
A simple, rapid, and environmentally friendly approach was introduced to determine triazole fungicides in water samples by air-assisted ionic liquid dispersive liquid–liquid microextraction based on solidification of the aqueous phase using high-performance liquid chromatography-diode array detection. Ionic liquid was applied as the extraction solvent rather than a high-toxicity extraction solvent. The air-assisted dispersion method induced a trace amount of the ionic liquid to disperse as small droplets in the water sample, which significantly increased the contact area between the organic phase and the aqueous phase for the rapid transfer of target fungicides without using a dispersion solvent or auxiliary extraction devices. The solidification of the aqueous phase facilitated the collection of extraction solvent. The type of extraction solvent, the volume ratio of the extraction solvent to the water sample, the number of extraction cycles, the addition of NaCl, and pH values were evaluated. The recoveries were 72.65–100.13% with a relative standard deviation of 0.92% to 5.99%. The limits of quantification varied from 0.65 ng mL−1 to 1.83 ng mL−1. This approach can be used to determine fungicides in ground, river, and lake water samples.
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