JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.262
Xiaojuan Wang,Hanqing Gu,Guolin Wu
A series of poly (amino acid) with zwitterionic character was prepared for surface coating to avoid protein adsorption, by modifying the poly (aspartic acid) side chain with tertiary amine groups. An interesting and facile procedure is described with starts with polysuccinic acid which is followed by ring-opening with amino functions and finally hydrolysis of the remaining succinic acid groups achieving the polyaspartic acid structure as backbone. The degree of cationic tertiary amino group was easily varied by the degree of ring-opening with amines. The materials show isoelectric point between pH 4 and 9, have a typical zwitterionic character, and can be used to coat negatively as well as positively charged surfaces, depending on composition. The protein adsorption behavior is thus pH dependent and was studied with various proteins mainly available in blood. The adsorption test proved that a significant reduction of protein adsorption could be found for fibrinogen and albumin, and this protein-repellent behavior is strongly dependent on the amount of the absorbed polymer (adsorbed at pH = 7.4). This is a nice additional contribution to polymers with zwitterionic character used as coating reducing nonspecific protein adsorption.
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Zhentao Li,Changjun Hu,Zhuang Hu,Yuanyuan Fu,Zilin Chen
Here, a novel multifunctional β-cyclodextrin microporous organic network (CD-MON) has been successfully synthesized and used to remove bisphenol A (BPA) from water. The morphology and composition of the synthesized CD-MON were confirmed. The combination of hydrophobic interaction, π-π interaction inclusion mechanism and hydrogen bonding endowed CD-MON to exhibit superior adsorption capacity toward BPA. The adsorption kinetics and isotherms of BPA and other four model aromatic pollutants on CD-MON were studied. CD-MON could maintain adsorption efficiency toward BPA over wide pH ranges and without being affected by the ionic strengths , co-existing inorganic ions and humic acid. The optimal conditions and removal efficiency of BPA were screened by response surface analysis . In addition, nearly unchanged in the adsorption efficiency toward BPA was observed after five regeneration cycles on CD-MON. CD-MON can adsorb about 80% of five model aromatic pollutants from the water within 40 s in the flow-through experiments. This novel adsorbent gives great promise for practical wastewater remediation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Jian Gao,Yuezhong Mao,Chuyue Xiang,Mengna Cao,Gerui Ren,Kuiwu Wang,Xiangjuan Ma,Di Wu,Hujun Xie
In this work, the β-lactoglobulin/gum arabic (β-Lg-GA) complexes were prepared to encapsulate epigallocatechin gallate (EGCG), forming β-Lg-GA-EGCG complex nanoparticles with an average particle size of 133 nm. The β-Lg-GA complexes exhibited excellent encapsulation efficiency (84.5%), and the antioxidant performance of EGCG in vitro was improved after encapsulation. It was recorded that 86% of EGCG could be released in simulated intestinal fluid after 3 h of digestion, much faster than that in simulated gastric fluid, indicating that the β-Lg-GA complexes were effective in enhancing EGCG stability, which was confirmed using SDS-PAGE and SEM. Further spectrum results demonstrated that various intramolecular interactions including electrostatic, hydrophobic and hydrogen bonding interactions contribute to the formation of β-Lg-GA-EGCG complex nanoparticles. Also, XRD experiments indicated that EGCG was successfully encapsulated by β-Lg-GA complexes. Therefore, the β-Lg-GA complexes hold great potentials in the protective delivery of sensitive bioactives.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2021
·
IF 7.491
Qiaozhi Zhang,Huatao Li,Congnan Cen,Jie Zhang,Shunyu Wang,Yanbo Wang,Linglin Fu
There is a need to understand the ultrasound-induced changes in the interactions between proteins and phenolic compounds at different pH. This study systematically explored the role of high-intensity ultrasound pre-treatment on the binding mechanisms of β-lactoglobulin (β-LG) to two common phenolic compounds, i.e. , (−)-epigallocatechin-3-gallate (EGCG) and chlorogenic acid (CA) at neutral and acidic pH (pH 7.2 and 2.4). Tryptophan fluorescence revealed that compared to proteins sonicated at 20% and 50% amplitudes, 35%-amplitude ultrasound pre-treatment (ULG-35) strengthened the binding affinities of EGCG/CA to β-LG without altering the main interaction force. After phenolic addition, ULG-35 displayed a similar but a greater extent of protein secondary and tertiary structural changes than the native protein, ascribed to the ultrasound-driven hydrophobic stacking among interacted molecules. The dominant form of β-LG (dimer/monomer) played a crucial role in the conformational and interfacial properties of complexes, which can be explained by the distinct binding sites at different pH as unveiled by molecular docking. Combining pre-ultrasound with EGCG interaction notably increased the foaming and emulsifying properties of β-LG, providing a feasible way for the modification of bovine whey proteins. These results shed light on the understanding of protein–phenolic non-covalent binding under ultrasound and help to develop complex systems with desired functionality and delivery.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2021
·
IF 5.279
Xu-mei Wang,Yun-hua Ye,Zong-cai Tu,Yue-ming Hu,Hui Wang,Tao Huang
Glycation between proteins and reducing sugars is the common chemical modification in food protein, and many studies have focused on the allergenicity of the glycated protein. However, a systemic study on the allergenicity change of its digests is lacking. In this work, we explored the change rule of the digestibility and allergenicity of glycated β-Lg during invitro gastrointestinal digestion and interpreted the mechanism using high-resolution mass spectrometry. Glycation with arabinose increased the resistance of β-Lg to digestive enzyme, with a low hydrolysis value. Indirect competitive ELISA showed that the IgG/IgE binding rates of β-Lg were reduced after glycation and further reduced after digestion, in comparison with the digests of unglycated β-Lg. There are two reasons for this phenomenon. On the one hand, 11 glycated sites were determined in the lowest allergenicity arabinose-β-Lg conjugation (Ara-β-Lg), which was distributed in the IgG and IgE linear allergic epitopes of β-Lg. On the other hand, glycation masking linear allergenic epitopes had a more significant effect on reducing allergenicity in comparison to digestive enzyme hydrolysis. These results indicated that the allergenicity of Ara-β-Lg in the human body might be lower than that of unglycated β-Lg.
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2021
·
IF 5.875
Yeli Wang,Zian Deng,Xinmiao Wang,Yugang Shi,Ying Lu,Sheng Fang,Xianrui Liang
Improving solubility and administration route of isoflavone formononetin (FMN) are critical factors to improve its bioavailability in the oral cavity. This study fabricated fast-dissolving nanofibers containing FMN/methyl- β -cyclodextrin (FMN/Me- β -CD) inclusion complex. The solubility of FMN could be increased by approximately 50 times at 20 mM aqueous Me- β -CD. Interactions and thermodynamic parameters of the host-guest inclusion complex were studied by a fluorescence quenching method. The structure and mechanisms of the complex were further studied by molecular docking and molecular dynamics. Finally, polyvinyl-alcohol (PVA) nanofibrous webs containing the FMN/Me- β -CD inclusion complex were fabricated by electrospinning. The dissolution test demonstrated that the FMN/Me- β -CD/PVA nanofibers can be dissolved in artificial saliva within approximately 2 s. This study shows the potential of Me- β -CD inclusion and electrospinning to improve solubility and administration route of isoflavones.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Xuze Hu,Changjun Zou,Hanxiang Huang
In this study, the nanocables were prepared by the supramolecular self-assembly interaction between polyaniline (PANI) and linear carboxymethyl-β-cyclodextrin polymer functionalized carbon nanotubes (L-CM-β-CD-P-CNTs). Its morphological, thermal, structural, and electrochemical properties were analyzed by using different instrumental techniques. As expected, the PANI/L-CM-β-CD-P-CNTs supramolecular nanocables exhibited excellent electrochemical performance and cycling stability. More importantly, the specific capacitance (SC) values for PANI/L-CM-β-CD-P-CNTs reached 996 F g −1 at a current density of 1 A g −1 . In addition, the PANI/L-CM-β-CD-P-CNTs supramolecular nanocables exhibited 90 % capacitance retention after 15,000 charge-discharge cycles.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Dongbo Wang,Xin Yu,Qingge Feng,Xianhao Lin,Ying Huang,Xianqing Huang,Xiang Li,Kao Chen,Bohan Zhao,Zhao Zhang
In order to construct tighter heterostructures , a novel Z-scheme β-Bi 2 O 3 /g-C 3 N 4 composite (xBC) was synthesized by in-situ growth method. The crystal phase, morphology, chemical composition, optical and photoelectrochemical properties of the composites were investigated by XRD , FT-IR, SEM, TEM, XPS, UV–vis DRS , EIS , etc. The characterizations verified that β-Bi 2 O 3 nanosheets grew uniformly on the surface of g-C 3 N 4 . Meanwhile, the photocatalytic performance of xBC composites were also evaluated by degrading Rhodamine B (RhB) and p -Nitrophenol (PNP) under visible-light irradiation. As a result, 0.5BC exhibited the most superior performance, the removal efficiencies reached 71.6% for PNP in 300min and 94.8% for RhB in 120 min, with a rate constant (0.0233min −1 ) of 7.1 and 5.8 times than that of g-C 3 N 4 and β-Bi 2 O 3 , respectively. Evidences that Z-scheme carries transfer path were strongly confirmed by XPS, PL and reactive species analysis.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2020
·Vol. 187
·期 8
·1-11
·
IF 6.232
Li Fang,Hu Yuting,Zhao Anqi,Xi Yachao,Li Zimu,He Jianbao
β -cyclodextrin-functionalized porous
Pd@Au nanostructures ( β -CD-Pd@Au) with intrinsic
and enhanced peroxidase-like activity were successfully synthesized by a two-step
method. The synthesized β -CD-Pd@Au can
efficiently catalyze the oxidation of various substrates, such as
3,3′,5,5′-tetramethylbenzidine (TMB), mixture of 4-amino antipyrine (4-AAP) and
3,5-dichloro-2-hydroxy acid sodium (DHBS) (4-AAP/DHBS), and mixture of 4-AAP and
N-Ethyl-N-(3-sulfopropyl)-3-methyl-aniline sodium salt (TOPS) (4-AAP/TOPS), by
H 2 O 2 to generate visual blue,
purple, and pink color, respectively. The UV-vis absorbance peak of the three β -CD-Pd@Au catalyzed the chromogenic reaction
system located at 650 nm, 510 nm, and 550 nm, respectively. The β -CD-Pd@Au-catalyzed
TMB-H 2 O 2 chromogenic reaction
exhibited higher absorbance intensity, catalytic efficiency, and color stability in
comparison to 4-AAP/DHBS-H 2 O 2 and
4-AAP/TOPS-H 2 O 2 chromogenic
reactions. The catalytic activity of β -CD-Pd@Au
was enhanced about 4-fold compared to that of Pd@Au in terms of
K cat for
H 2 O 2 . Using TMB as chromogenic
substrate, a colorimetric assay was fabricated for the determination of
H 2 O 2 with a detection limit of
2.78 μM (absorbance at 650 nm). The colorimetric determination of glucose with a
detection limit of 9.28 μM was further achieved by coupling with glucose oxidase
enzymatic reaction, indicating the versatility of the β -CD-Pd@Au-based detection strategy. A paper-based detection method
coupled with smartphone for fast visual and instrument-free detection of glucose was
further developed. Finally, the developed colorimetric assay and paper-based
detection method were successfully applied to the determination of glucose in human
serum sample.
Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2021
·
IF 5.876
Wei Zhang,Ping Sun,Desheng Liu,Quanlin Zhao,Binze Zou,Lincheng Zhou,Zhengfang Ye
Herein, a simple and green method to fabricate β-cyclodextrin (β-CD) porous cross-linked polymer modified poly(chloromethylstyrene) (PS-Cl) resin, namely, PS@CM-CDP, for ultrafast and efficient removal of heavy metal ions and organic pollutants from aqueous solution was reported. The selected (PS-Cl) was used as a matrix; meanwhile, the β-CD was formed on the surface of PS-Cl under a rigid cross-linking agent of tetrafluoroterephthalonitrile nitrile. The structure and surface elements distribution of PS@CM-CDP were characterized using FT-IR, TG, SEM, XPS, and BET. The resultant PS@CM-CDP with a relatively high maximum adsorption capacity for Cu(II) and BPA can reach 121.88 and 8.25 mg g −1 , respectively, and the spherical nature of the resin makes conventional β-CD polymers easy to recycle 6 times without significantly decreased. The possible adsorption mechanism was also proposed. Industrial wastewater adsorption methods have been used into practice, and the practice presents considerable prospects in the aspects of column for water treatment.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2020
·Vol. 25
·期 22
·5391
·
IF 3.267
Zheng Liu,Ming Bian,Qian-Qian Ma,Zhuo Zhang,Huan-Huan Du,Cheng-Xi Wei
A series of novel synthetic substituted benzo[d]oxazole-based derivatives (5a–5v) exerted neuroprotective effects on β-amyloid (Aβ)-induced PC12 cells as a potential approach for the treatment of Alzheimer’s disease (AD). In vitro studies show that most of the synthesized compounds were potent in reducing the neurotoxicity of Aβ25-35-induced PC12 cells at 5 μg/mL. We found that compound5cwas non-neurotoxic at 30 μg/mL and significantly increased the viability of Aβ25-35-induced PC12 cells at 1.25, 2.5 and 5 μg/mL. Western blot analysis showed that compound5cpromoted the phosphorylation of Akt and glycogen synthase kinase (GSK-3β) and decreased the expression of nuclear factor-κB (NF-κB) in Aβ25-35-induced PC12 cells. In addition, our findings demonstrated that compound5cprotected PC12 cells from Aβ25-35-induced apoptosis and reduced the hyperphosphorylation of tau protein, and decreased the expression of receptor for AGE (RAGE), β-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1), inducible nitric oxide synthase (iNOS) and Bcl-2-associated X protein/B-cell lymphoma 2 (Bax/Bcl-2) via Akt/GSK-3β/NF-κB signaling pathway. In vivo studies suggest that compound5cshows less toxicity than donepezil in the heart and nervous system of zebrafish.Keywords:synthesis;benzo[d]oxazol;thiadiazoles;Alzheimer’s disease;β-amyloid;Akt/GSK-3β/NF-κB signaling pathway
✓ 已验证
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2020
·
IF 4.3
John Michael Tesha,Derrick S. Dlamini,Saood Qaseem,Zhenyu Cui,Jianxin Li
Polysulfone–Styrene Maleic Anhydride (PSF/SMA) ultrafiltration (UF) membranes were prepared by the thermally induced phase separation (TIPS) method. The morphology of the UF membranes was fine tuned by varying the concentration of SMA. The surface of the membranes was then modified by dip-coating with β-cyclodextrin (β–CD) and Trimesoyl Chloride (TMC) to form tight UF membranes. The effects of β–CD on the separation performance, structure, and morphology of the flat sheet PSF/SMA membrane were examined. The tight UF membranes were characterized and then tested for the removal of Bovine Serum Albumin (BSA) and Congo red from water. The thickness was varied by increasing the concentration of β-CD. When increasing the concentration of β-CD from 2.0 % w/v to 8.0 % w/v, the thickness of the top layer increased from 8 μm to 18 μm, respectively. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) and X-Ray Photoelectron Spectroscopy (XPS) were used to confirm the successful deposition of the TMC and β-CD at the surface of the membrane. It was also established through Atomic Force Microscopy (AFM) that the roughness of membranes increases with an increase in β-CD concentration. The contact angle of the tight UF PSF/SMA blend membranes declined from 79.8° to 55.9° at the addition of β-CD implying that the hydrophilicity of the membranes improved. The lowest pure water flux of 40 Lm −2 h -1 was achieved by the membrane coated with 8.0 % w/v of β-CD. However, the highest pure water flux of 127 Lm −2 hr −1 was observed on the uncoated PSF/SMA UF membrane at 3 % wt/wt SMA. The highest BSA rejection (94 %) was recorded from PSF/SMA with a coating layer containing 8 % wt/v of β-CD concentration. Furthermore, the maximum Congo red dye rejection (96 %) was achieved by the tight UF membrane when β-CD concentration was 8 wt/v and the SMA was 3 % wt/wt.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）