Eye and Vision
·
2021
·Vol. 8
·期 1
·22
·
IF 3.257
Meng Jiaqi,Wei Ling,He Wenwen,Qi Jiao,Lu Yi,Zhu Xiangjia
Background To evaluate the distribution of lens thickness (LT) and its associations with other ocular biometric factors among cataract patients in Shanghai. Methods Twenty-four thousand thirteen eyes from 24,013 cataract patients were retrospectively included. Ocular biometric factors including LT, central corneal thickness (CCT), anterior chamber depth (ACD), white-to-white (WTW) distance, anterior corneal curvature, and axial length (AL) were obtained using the IOLMaster700. The associations between LT and general or ocular factors were assessed. Results The mean age was 62.5 ± 13.6 years and 56.1% were female. The mean LT was 4.51 ± 0.46 mm. The LT was greater in older patients ( P < 0.001). LT was positively correlated with CCT, while negatively correlated with ACD, WTW, and anterior corneal curvature ( P < 0.001). Multivariate analysis revealed that increased LT was associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature ( P < 0.001). LT changed with a variable behavior according to AL. In short eyes LT increased as AL increased, then decreased with longer AL in normal eyes and moderate myopic eyes, but increased again as AL increased in highly myopic eyes. Thickest LT was found in the 20.01–22 mm AL group. The correlation between LT and other biometric factors remained significant when stratified by ALs. Conclusions In a large Chinese cataractous population, we found that the thicker lens may be associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature. As AL increased, the change of LT was nonlinear, with the thickest lens seen in the 20–22 mm AL group.
研究领域:
眼科
·
生物医学工程
·
临床眼科学
·
屈光手术
·
白内障研究
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 41
·19642-19650
·
IF 3.5
Chu Yican,Yao Zhendong,Liu Min,Li Wenqing,Gu Jing,Huang Zhenguang,Xie Jiaxing,Li Chao,Cui Yongfu,Li Yun,Fan Meiqiang
The hydrolysis of silicon and its compounds to produce hydrogen for fuel cell remains a major problem. The main obstacle is the weak hydrolytic activity and slow kinetics of silicon. In this work, the alloying properties of Si and Ca to improve its hydrolytic activity, and studied the film breaking effect of different metals and halogen ions on its passivation layer. The results show that the hydrogen production of the alloy is still determined by its phase composition. Among the common metal (Ni, Bi, Sn) and halogen ions (F – , Cl – ) catalyzed by hydrolysis, Ni and F – showed a good synergistic effect, resulting in a hydrogen yield of 269 mL/g at room temperature without alkali. Graphical
The effects of metal ions and halogens on the hydrolytic properties of Ca–Si alloy were investigated, and Ni 2+ and F — showed good synergistic effect.
研究领域:
材料化学
·
能源材料
·
无机化学
·
氢能源
·
金属合金
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DOI
高影响因子
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2015
·Vol. 31
·期 4
·585-589
·
IF 0.875
Wei Qi,Wang Liyuan
Molecular glass resist has been considered as one of the best choices for a new generation of lithography. In this work, a new type of photoactive compound was obtained by the esterification of tannic acid with 2-diazo-1-naphthoquinone-4-sulfonyl chloride(2,1,4-DNQ-Cl) and ditertbutyl dicarbonate. The new obtained compound possessed both a photosensitive group of diazonaphthoquinone sulfonate(2,1,4-DNQ) and a group of acidolytic protection. Upon the irradiation of the compound under 365 nm light, the former group was photolyzed and converted into indene carboxylic acid along with a small amount of sulfonic acid, which could lead to the deprotection of the latter group. As a result, a novel i-line molecular glass photoresist was formed with the chemical modification of tannic acid. The experimental results show that the modificated compound had a fair solubility in many organic solvents. The lithographic performance of the resist was evaluated on an i-line exposure system with high photosensitivity and resolution as well.
研究领域:
材料科学
·
微纳加工
·
高分子化学
·
光电子学
·
半导体工艺
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DOI
高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2016
·Vol. 31
·期 1
·157-163
·
IF 0.4
Liu Rongpeng,Wan Liqiang,Huang Farong,Du Lei
The reaction kinetics between diazide(4,4’-biphenyl dibenzyl azide) and different diynes (dipropargyl bisphenol A and 1,3-diethynylbenzene) were studied by means of differential scanning calorimetry (DSC) and nuclear magnetic resonance spectroscopy ( 1 H-NMR). DSC was adopted to analyze the reactions under bulk polymerization condition, while 1 H-NMR for solution reaction polymerization was conducted. The apparent activation energies ( E
α ) calculated by Kissinger’s method were 77.96, 81.24 kJ/mol, which were confirmed by Friedman’s method, and 65.45, 69.36 kJ/mol by 1 H-NMR for dispropargyl bisphenol A/4,4’-biphenyl dibenzyl azide and 1,3-diethynylbenzene/4,4’-biphenyl dibenzyl azide, respectively. The polymerizations between the diazide and diynes were first-order reactions based on calculation from both DSC and 1 H-NMR. The results showed that the reaction between dipropargyl bisphenol A and 4,4’-biphenyl dibenzyl azide was easier than that between 1,3-diethynylbenzene and 4,4’-biphenyl dibenzyl azide, verifying that the reactivity of aliphatic alkyne was higher than that of aromatic alkyne.
研究领域:
高分子化学
·
物理化学
·
材料科学
·
有机化学
·
反应动力学
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DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2016
·Vol. 122
·期 7
·678
·
IF 1.444
Yin Xin,Song Lixin,Xie Xueyao,Zhou Yangyang,Guan Yingli,Xiong Jie
The flexible ZrO 2 /C composite nanofibrous film was fabricated by electrospinning and thermal treatment. Field-emission scanning electron microscopy, transmission electron microscopy, X-ray diffractometer, and Fourier transform infrared spectra were used to characterize the morphology and microstructure of the ZrO 2 /C composite nanofibrous film. The ZrO 2 /C nanofibers exhibited rough surface and had the average diameter of about 230 ± 35 nm. And the ZrO 2 nanoparticles were incorporated in carbon matrix and in tetragonal and monoclinic. The flexural property of the ZrO 2 /C composite nanofibrous film was investigated in detail. The results showed that the flexural property of the nanofibrous film was greatly improved with addition of the ZrO 2 nanoparticles. Besides, with the increase of the contents of ZrO 2 nanoparticles, the flexural modulus of the nanofibrous film decreased, reached a lowest value, and then increased. The lowest flexural modulus of the ZrO 2 /C composite nanofibrous film in precursor concentration of 7.0 wt% was 8.55 ± 0.06 MPa.
研究领域:
材料科学
·
纳米科技
·
复合材料
·
功能材料
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 22
·19940-19947
·
IF 2.195
He Zhen,Cao Di,Qiao Yanxin,Hayat Muhammad D.,Singh Harshpreet,Wang Yuxin
Chromium coatings are largely restricted in electrical and electronic industries due to the environmental concerns. To address these concerns, a cobalt–phosphorus–titanium oxide (Co–P–TiO 2 ) nanocomposite coating is developed in this study using a nanoparticle-reinforced electrodeposition process. The effects of TiO 2 nanoparticles on the properties of co-deposited Co–P–TiO 2 nanocomposite coatings are investigated. The surface characterisation is carried out by scanning electron microscopy and atomic force microscopy, while the crystal structure is studied using X-ray diffraction. The mechanical properties of nanocomposite coatings including microhardness and wear resistance are also determined. To study the electrochemical behaviour of the coatings, the potentiodynamic polarisation analysis combined with electrochemical impedance spectroscopy is performed. The Co–P–TiO 2 coating at 1 g/L TiO 2 addition displays the best physicochemical performance. Compared to Co–P coating, the mechanical properties of the nanocomposite coating are significantly improved by the strengthening effects of the well-dispersed TiO 2 particles. Excellent corrosion resistance is also achieved for the Co–P–TiO 2 at proper TiO 2 addition due to its smooth and defect-free microstructure. However, it is found that the excessive addition of TiO 2 decreases the coating quality, resulting in an unfavourable microstructure and properties.
研究领域:
材料科学
·
表面工程
·
纳米技术
·
电化学
·
腐蚀科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 27
·期 10
·11118-11125
·
IF 1.798
Liu Shuping
Construction of a nanocomposite WO 3 film has been considered to be an important way to enhance electrochromic performance of the material. Herein, we fabricated a nanocomposite film containing WO 3 nanoparticles, tungstophosphate clusters K 6 P 2 W 18 O 62 (P 2 W 18 ) and poly(ethylene imine) by the layer-by-layer method. The fabrication and morphology of composite materials were investigated by UV–Vis spectra and scanning electron microscopy. The electrochemical and electrochromic properties were also examined and compared with P 2 W 18 –WO 3 composite film as well as individual P 2 W 18 and WO 3 thin film. The composite film supported a greater number of sites for Li + ion intercalation and extraction due to its large active surface area. As a result, the composite film displays enhanced optical contrast (48.4 %) and coloration efficiency (46.1 cm 2 C −1 ) by incorporation of P 2 W 18 into the WO 3 film. The enhanced electrochromic performances can be attributed to the composite structure, which provides large active surface area for electrochemical reactions and electrochromic performances. These results demonstrate that enhanced electrochromic properties could be achieved using the WO 3 and P 2 W 18 composite structure.
研究领域:
材料科学
·
纳米科技
·
电化学
·
功能材料
·
表面科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 17
·1363
·
IF 2.8
Liu Lin,Dong Xi,Jiang Chuanjian,Xu Xiye,Lai Rixin,Zhang Wenfeng
Doping heteroatoms into graphene is effective to open the energy bandgap and increase the free carrier density, thereby improving its electronic and electrochemical properties. In this paper, CO was selected as the carbon source for the preparation of graphene through the self-propagating reaction. During the reaction, a variety of hexamethyltetramine were used to dope N atoms into the graphene when different ratios of MgO/Mg were compared. Microstructural and electrochemical characterizations were conducted to study the effects of nitrogen doping as well as MgO/Mg ratio on the performance of the graphene as supercapacitor electrode. The Raman spectra show the presence of graphene after self-propagating reaction. The graphene doped from hexamethyltetramine shows the existence of pyridinic-N, pyrrolic-N, and graphitic-N. In general, the percentages of pyridinic-N in the materials increased with the usage of hexamethyltetramine. Given the same condition, the pyridinic-N content of the samples based on MgO/Mg ratio of 8 was higher than that of the samples using MgO/Mg ratio of 4. Besides, the specific surface areas of the samples increase as MgO/Mg increased. The introduction of nitrogen atoms in the graphene increased the active sites on its surface and consequently, the specific capacity, capacity retention rate and energy density of the supercapacitor. At the current density of 1Ag −1 , the specific capacity of N-SHS-8-3 was 153 Fg −1 and the capacity retention rate was 60% as the current density increased to 20Ag −1 .
研究领域:
材料科学
·
电化学
·
纳米材料
·
能源存储
·
功能材料
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2013
·Vol. 24
·期 12
·4862-4867
·
IF 1.486
Dou S. Y.,Yan L. T.,Liu Y. C.,Du G.,Zhou P.
Layered organic–inorganic perovskites have potential application in solar cells because of their unique electrical and optical properties. These materials can also overcome the instability of organic sensitizers and the disorder of metal oxides. A preliminary study on the preparation of organic–inorganic halide perovskites (CH 3 NH 3 PbI
x
Cl 3− x
) was conducted in this paper. The synthesis temperature and thermal stability in air were analyzed by thermogravimetric analysis and differential scanning calorimetry. The structure and morphology of the products were investigated by X-ray diffraction and scanning electron microscopy. UV–visible spectroscopy revealed that the material had good absorption within the range of 350–750 nm and can be used as the active light-absorbing layer of solar cells. Hybrid solar cells of FTO/TiO 2 –CH 3 NH 3 PbI
x
Cl 3− x
/Spiro-MeOTAD/Ag were found to have a high fill factor of 0.5 but low power conversion efficiency of 0.28 %.
研究领域:
材料科学
·
光伏技术
·
纳米技术
·
无机化学
·
光电子学
✓ 已验证
DOI
高影响因子
Frontiers of Materials Science
·
2025
·Vol. 19
·期 2
·1-11
·
IF 2.3
Luo Qisheng,Li Delin,Tang Zhaoyang,Zhou Cheng,Yang Xiaoge,Di Ningyu,Ling Bin,Li Yao,Kong Xiangdong
Reactive oxygen species (ROS) are highly prevalent in skin-related impairments and accelerate chronic ulcer progression. The routine subcutaneous administration approaches combining drug delivery with microenvironment intervention are widely developed for skin-related treatment but lack effective outcomes. Herein, we present a cuttlefish ink-derived nanoparticles (CNPs)-integrated microneedles patch, silk fibroin and cuttlefish ink-derived melanin nanoparticles (SC-MNs), that can easily be inserted into the skin and alleviate ROS. The microneedle tips, formed from silk fibroin and treated with methanol vapor annealing, turn to increased β-sheet and enhanced mechanical strength. Meanwhile, the tips can rapidly detach from SC-MNs in mildly acidic conditions due to the introduction of NaHCO 3 . SC-MNs also exhibited a unique ROS obliteration capacity. Furthermore, under near-infrared irradiation, SC-MNs triggered photothermal performance, which elicited reliable tumor cell-killing effects. Collectively, these SC-MN patches described here can provide a promising platform for combined ROS-scavenging and photothermal therapy, which makes them a potential candidate in skin-related disease management.
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DOI
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2026
·
IF 8.4
Li Shuo,Xu Bing,Lu Ming-jun,Wu Qian-wen,Qin Wen-qing,Dai Zi-qi,Li Xiao-jiao-yang,Bai Jin-zhao,Lei Hai-min,Liu Run-ping
The severe inflammation associated with infectious or inflammatory diseases significantly contributes to mortality. Interferon regulatory factor 3 (IRF3) represents a potential anti-inflammatory target, but the development of IRF3 inhibitors has not yielded satisfactory results to date. In this study, we established a phenotype-based high-throughput screening system to conduct activity-guided hierarchical screening of clinical frequently used anti-inflammatory and anti-rheumatic herbal extracts and compounds. Employing a Gaussia-luciferase reporter system driven by the IFNB1 promoter, we identified sinomenine as a potent type I interferon (IFN) inhibitor from a set of 28 anti-inflammatory herbal products. Furthermore, among 24 synthesized sinomenine derivatives modified by various electrophilic groups, Sim-9 (2.5–10 μM) dose-dependently inhibited IFN responses triggered by TLRs, RLRs, and STING activation in mouse RAW264.7 cells and in human THP-1 cells, HT-29 cells and A549 cells. We demonstrated that Sim-9, by covalently binding to Cys222, induced a conformational change in the p LxIS motif-binding surface of IRF3, thus blocking its interaction with upstream adapters, including TRIF, MAVS and STING, and subsequent homodimerization of IRF3 itself, which were all essential for activation of type I IFN responses. In in vivo experiments, we showed that injection of Sim-9 (30, 60 mg/kg, i.p.) effectively protected against devastating inflammation in cecal ligation and puncture (CLP)-induced sepsis in mice, and improved cerulein-induced pancreatitis by inhibiting IRF3. Our study discovers Sim-9 as a novel covalent allosteric inhibitor of IRF3 and reveals that the p LxIS motif binding surface represents a previously uncharacterized druggable target for IRF3 activation, providing a promising therapeutic strategy for the treatment of severe inflammatory injuries.
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 15.7
Liu Xiaojing,Ye Yuanxin,Li Zhonghan,Liao Li,Wei Qiang
Bone aging compromises skeletal integrity and increases vulnerability to osteoporosis and other age-related disorders, underscoring the need for new therapeutic strategies. Although pharmacological and genetic approaches have been widely explored, how cellular mechanical remodeling contributes to bone aging remains unclear. Here, we find that senescent bone marrow stem cells show markedly reduced intracellular force and impaired mechanical behavior. Moderate mechanical stimulation in cell culture and in mice restores cellular force, increases chromatin accessibility at the FOXO1 locus, activates its expression, and reverses cellular senescence and bone aging. These mechanical interventions also improve physical performance in aged female mice and show a tendency to reduce systemic inflammation, whereas excessive force induces chromatin overextension and DNA damage, indicating the necessity of precise force control. In this work, we show that optimized mechanical stimulation provides a simple and effective strategy to counteract age-related bone deterioration and systemic inflammation, offering potential for clinical translation.
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）