Nature Communications
·
2025
·Vol. 16
·期 1
·9451
·
IF 15.7
Bai Ju,Xiao Luqi,Zhang Xiangping,Liu Hongyan,Wang Can,Gong Lili,Luo Shuangjiang,Zhu Yihan,Shan Linglong,Fan Hongwei,Zhang Suojiang
Oriented metal-organic framework (MOF) membranes hold significant promise for advanced helium (He) separation, but their synthesis remains a challenging task. We report the preparation of an oriented MOF membrane using metal-organic polyhedra (MOP) fragment as metallocene-anchor. The metallocene-anchor induces the growth of homoligand Zr-MOF along the c-axis, resulting in the {001}-oriented structure. This orientation increases the transition energy barrier of methane (CH 4 ), enabling precise He/CH 4 separation with a selectivity of 77.3 and a He permeance of 695.1 GPU. The membrane exhibits exceptional robustness, demonstrating resistance to high-pressure conditions (up to 40 bar), thermal shock (−25 °C to 85 °C), and long-term stability (1000 h). The separation performance surpasses that of existing MOF membranes and exceeds the Robeson upper bound. Additionally, a three-stage membrane process enables the concentration of low He concentrations of 0.3% up to 99.9%, highlighting the potential of membranes for helium extraction. The successful fabrication of various oriented MOF membranes indicates the universality of this strategy.
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Communications Materials
·
2025
·Vol. 6
·期 1
·233
·
IF 9.6
Wang Ruoming,Yang Guangping,Yang Tianxiang,Lu Yuzheng,Raza Rizwan,Zhu Bin,Lund Peter D.,Yun Sining
High ionic conductivity at reduced temperatures may allow electrochemical cell applications to be efficiently scaled up. Herein, we introduce an approach that exploits electrode-electrode synergy and in situ structural transformation to increase the ionic conductivity of an electrolyte within the electrochemical cell. This transformation is based on the formation of a Li 2 TiO 3 -Li 2 CO 3 heterostructure electrolyte via the combination of a TiO 2 semiconductor precursor, polystyrene spheres as the soft skeleton, and the lithium-based electrode LiNi 0.8 Co 0.15 Al 0.05 O 2 . The unique surface and interface of the heterostructure electrolyte enable the formation of long-range ion transport channels that lower electrode impedance, resulting in a superior ionic conductivity of 0.23 S cm −1 at 550 °C and a high-power density of 1239 mW cm −2 . Our general method to form superionic electrolytes shows potential in fuel cell technologies.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 237
·期 1
·8
·
IF 3
Li Xiaoya,Zheng Ru,Duan Guangyu,Cao Zhanfang,Han Kai,Zhong Hong,Ma Xin,Wang Shuai
A poly( N -vinylpyrrolidone)-graphene oxide (NVP-GO) composite with high adsorption capacity for methylene blue (MB) was synthesized and comprehensively characterized using SEM, XRD, FT-IR, TG, elemental analysis, nitrogen physical adsorption, and XPS. The adsorption of MB onto NVP-GO was examined in relation to several variables, including contact time, adsorption temperature, initial concentration of MB, and pH. Adsorption kinetics, isotherms, and thermodynamics were thoroughly investigated. The adsorption kinetics followed the pseudo-second-order model, and the Langmuir isotherm model indicated a monolayer adsorption pattern of MB onto NVP-GO, with the maximum adsorption capacities ranging from 116.6 to 161.3 mg·g −1 at temperatures between 25 and 45 °C. Thermodynamic assessments and activation energy calculations demonstrated that the adsorption process was spontaneous, endothermic, and controlled by chemical activation. XPS analysis highlighted the significance of electrostatic interactions, n–π interactions, π–π stacking, and hydrogen bonding in mediating the adsorption mechanisms between NVP-GO and MB. Notably, NVP-GO maintained stable adsorption efficiency over three consecutive adsorption–desorption cycles, highlighting its potential as a promising adsorbent for wastewater treatment. Graphical
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 3
·3032-3044
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IF 2.195
Zhao Rongjun,Wang Zhezhe,Zou Tong,Wang Zidong,Xing Xinixn,Yang Yue,Wang Yude
One-dimensional fiber-like SnO 2 nanomaterials (SnO 2 nanofibers) were prepared by ‘green’ preparation approach that using shaddock peels as bio-templates via a facile hydrothermal method for the first time. The microstructure, morphology, chemical states and specific surface areas were characterized by X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and N 2 adsorption–desorption, respectively. Results indicating the as-synthesized SnO 2 are fiber-like structures and composed of numerous nanoparticles, and with large specific surface areas (36.50 m 2 g −1 ). The XPS spectra confirms that the existence of adsorbed oxygen (O ads ) on the surface of product, which may lead to the response of gas sensor. The gas-sensing properties of the sensor based on SnO 2 nanofibers for volatile organic compounds (VOCs) were investigated, such as methanol, ethanol, isopropanol, acetone, formaldehyde and n-butanol. The sensor showed high gas response, low detection limit and fast response towards various VOCs gases at the optimal operating temperature of 260 °C. These results demonstrated the potential of using as-synthesized SnO 2 nanofibers for VOCs gases detection. In addition, the possible formation mechanism and the gas-sensing mechanism were also discussed.
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Nature Communications
·
2026
·
IF 18.1
Wu Xinya,Pang Chunlin,Li Qikai,Huang Yu-Ting,Wang Sijia,Cheng Chun,Li Wei,He Chuan,Deng Qiyu,Zhu Hengjia,Ni Meng,Chi Yun,Wang Liqiu,Feng Shien-Ping
Ionic thermocells offer a compelling route for converting low-grade heat into electricity, yet their real-world deployment is hindered by performance decay under fluctuating conditions and limited synergistic pathways. Herein, we introduce polyethyleneimine as a self-limiting sacrificial additive in a K 3 Fe(CN) 6 /K 4 Fe(CN) 6 thermocell. During initial operation, only a fraction of amine groups in polyethyleneimine engages in redox with Fe(CN) 6 3- /Fe(CN) 6 4- , while the remaining amine groups mediate thermally induced adsorption-desorption, selective condensation, and homogeneous catalysis. These cascaded effects boost the thermopower from 1.4 mV K -1 to 7.76 mV K -1 . Crucially, the self-limiting nature and temperature-dependent reactivity of polyethyleneimine-Fe(CN) 6 3- reaction not only generates solvation-perturbing species but also ensures long-term functional stability (>1000 hours). A proof-of-concept panel delivers over 5 V and 7.5 mW under a 50 K temperature difference, demonstrating system scalability. This work highlights the potential of sacrificial additive engineering to enable durable and high-performance thermocells for sustainable heat-to-electricity conversion.
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Nature Communications
·
2026
·
IF 18.1
Peng Xiaoyan,Han Liwei,Wu Xuanhao,Keok Hong Ling,Zhang Wanglin,Mao Min,Zhu Haiyun,Liu Lingmei,Yang Hao,Yang Aijun,Chu Jifeng,Li Yi,Xiao Song,Buenconsejo Pio John S.,Zhang Mingming,Zhao Dan,Yuan Hongye
Precise control over the stacking of two-dimensional (2D) metal-organic framework (MOF) nanosheets enables the fabrication of MOF films or membranes with adjustable interlayer spacing and/or pore size, offering great potential for numerous applications, yet remains highly challenging. We herein propose a postsynthetic modification strategy to functionalize solution-processable NUS-8 nanosheets with photo-responsive monodentate carboxylic acids undergoing a “trans-cis” conformational change upon irradiation or with non-responsive counterparts. This yields azobenzene-functionalized NUS-8 (designated as NUS-8-Azobenzene) and/or tetra-phenylethylene-functionalized NUS-8 (NUS-8-TPE). The 2D nature and excellent solution processability of resultant NUS-8-Azobenzene and NUS-8-TPE facilitate the fabrication of large-area, highly homogeneous films/membranes with (00l) preferential orientation. Responsive interlayer spacing was observed in the NUS-8-Azobenzene stacked membranes, confirmed by multiple characterizations. Subtle variations in interlayer spacing of NUS-8-Azobenzene stacked membranes under irradiation enable a certain control over the ubiquitous trade-off between membrane selectivity and permeability. This study presents a strategy for fabricating 2D MOF membranes with scalable production and new functionalities, even for rigid and non-responsive MOFs, holding significant potential for practical applications in separation.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2026
·Vol. 37
·期 1
·42
·
IF 4.7
Xiaomei Ye,Shuzhen Lu,Hao Peng,Zhirong Huang,Chunyu Pan,Yayan Huang,Kangrui Yuan,Youfa Qin
Mesoporous metal-organic frameworks (MOFs) have the advantages of high specific surface area, tunable pore size, and favorable biocompatibility, making them promising candidates for drug delivery in cancer therapy. In this study, a series of mesoporous zinc-based MOF, constructed using cyclopentane dicarboxylic acid as the organic linker, was successfully synthesized via a surfactant-assisted solvothermal method. Surface characterization revealed that MOF-2 exhibited high surface area (1325 m 2 /g), pore volume (0.273 cm 3 /g), and average pore diameter (5.69 nm). UV-Vis analysis showed that MOF-2 demonstrated improved drug loading (18% w/w), encapsulation efficiency (86%), and cumulative release (96%), along with both pH-responsive degradation and drug release properties. Furthermore, cisplatin-loaded MOF-2 exhibited potent antitumor activity against A549 cells and effectively inhibited cell migration and invasion, while maintaining minimal cytotoxicity toward LO2 normal hepatic cells. These findings suggest MOF-2 as a promising nanocarrier for pH-responsive anticancer drug delivery.
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Microbiome
·
2026
·
IF 14.9
Guanjing Cai,Yingying Wu,Ziming Chen,Xiaoyu Yang,Xue Jiang,Qingshuang Wang,Runlin Cai,Hui Wang
Background Marine algae represent major producers of complex polysaccharides and serve as hosts for diverse microbial communities in the phycosphere. Flavobacteriaceae are among the key bacterial taxa involved in polysaccharide degradation and carbon remineralization in this environment. However, the extent to which algal hosts drive the divergence of polysaccharide utilization profiles in these bacteria remains unclear. Results We conducted a genome-resolved analysis of 103 cultured Flavobacteriaceae strains isolated from red, green, and brown macroalgae, as well as from diatoms and dinoflagellates. We found that macroalga-associated strains generally harbored more abundant and diverse CAZyme-encoding genes than their microalga-associated counterparts. Moreover, strains associated with different algal phyla showed distinct metabolic specializations that aligned with the typical polysaccharides of their respective hosts, strongly supporting host-specific adaptation. In four widely distributed genera ( Maribacter , Flagellimonas , Polaribacter , Winogradskyella ), CAZyme profile dissimilarity and key glycoside hydrolase gene divergence exhibited phylogenetic congruence with algal host phylogeny (Mantel r up to 0.76 and 0.85, respectively), indicative of host-associated functional adaptation. Using Maribacter as a model, cultivation experiments and transcriptome characterization demonstrated that polysaccharide utilization efficiency is not solely linked to the organization of genes into polysaccharide utilization loci (PULs), but also associated with the expression dynamics of key transcription factors (TFs), particularly those from AraC and DeoR families, whose expression patterns were coordinated with laminarin degradation. Notably, these two TF families also exhibited host-associated divergence patterns similar to those of CAZyme-encoding genes. Furthermore, analysis of the Tara Oceans metagenomic data indicated that, within the AraC and DeoR families, a higher proportion of genes were positively correlated with chlorophyll a content compared to other TF families, reinforcing their specialized roles in alga-associated bacterial lifestyles. Conclusions Our integrative genomic and transcriptomic analyses reveal evolutionary and regulatory adaptation of marine Flavobacteriaceae to distinct algal hosts. These findings highlight algae-derived habitats as specialized niches that shape microbial metabolic potential, and suggest that carbohydrate metabolism plays a key role in host-driven bacterial evolution across global oceans. Your browser is not supporting the HTML5
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INFLAMMATION
·
2026
·Vol. 49
·期 1
·92
·
IF 5.4
Shiying Lin,Xin Liu,Jian Jiang,Wenqiang Ge,Qingxiao Tao,Suwen Liu,Ouyang Zhanmu,Yang Yang,Man Li,Hongxiang Chen
The endogenous cannabinoid system, comprising endocannabinoids, cannabinoid receptors, and enzymes responsible for synthesis and degradation of endocannabinoids, is integral to the regulation of skin inflammation. However, the precise contributions of cannabinoid-metabolizing enzymes including fatty acid amide hydrolase and monoacylglycerol lipase (MAGL) remain poorly defined in psoriatic pathogenesis. In this study, we demonstrated the significant MAGL upregulation in psoriatic lesions and established that pharmacological inhibition of MAGL markedly reduced psoriasiform inflammation and pruritus in imiquimod-challenged C57BL/6 mice. Mechanically, inhibition of MAGL decreased the expression of 12-lipoxygenase (ALOX12), subsequently reducing the synthesis of 12-hydroxyeicosatetraenoic acid (12-HETE), which is the principal metabolite of ALOX12. Importantly, these effects were reversed by cannabinoid receptor 2 (CB2R) antagonism or knockout, establishing a signaling axis in which MAGL inhibition activates CB2R to suppress ALOX12. Collectively, our findings identified MAGL as a potentially targetable nexus in psoriasiform inflammation and itch.
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Nature Communications
·
2026
·
IF 18.1
Xu Yinhan,Tian Meirong,Zhang Mengmeng,Hu Dengwen,Han Guoqiang,Zhu Jintao,Xu Jiangping,Kim Shin-Hyun
Responsive optical materials offer real-time visual feedback to external stimuli by converting them into visible light signals, holding great promise in display, sensing, and information encryption. Typically, heterogeneous Janus droplets can exhibit vivid coloration induced by total internal reflection and interference (TIRI) at concave liquid–liquid interfaces. Yet, achieving stimuli-responsive TIRI-based structural colors remains a challenge due to the difficulty in controlling interface curvature and reflective behavior under external stimuli. Here, we report the fabrication of Janus droplets with tunable TIRI structural colors that respond to both surfactant composition and temperature. By tailoring surfactant formulation, the droplet morphology and interface curvature can be adjusted, enabling reversible modulation of structural color appearance, including both iridescent and non-iridescent modes depending on incident light conditions. Furthermore, the structural color can be reversibly or irreversibly switched on/off in response to temperature changes, due to phase transitions that alter light reflection at the concave interface. Owing to their temperature-dependent optical response and real-time visual signaling, these droplets can serve as single-use security labels for monitoring freeze history of freeze-sensitive pharmaceuticals, providing reliable indication of product integrity.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Yu Jiang,Yaowu Zhang,Jingqi Hou,Heng Liu,Xianyu Dai,Yuchuan Hou
Characterizing the tumor immune microenvironment (TIME) to explore potential therapeutic targets is fundamental to advancing precision tumor immunotherapy. However, the immunosuppressive nature of “cold” tumors, notably prostate cancer, poses a significant barrier to immunotherapy, demanding new approaches to simultaneously reinvigorate anti-tumor immunity and modulate the molecular drivers of immune evasion. Here, we identified VSIG4 as a key regulator of prostate tumor-resident macrophage fate through single-cell sequencing analysis. Meanwhile, a shikonin (Shik)-mediated downregulation of VSIG4 in macrophages is verified, potentially attenuating its immunosuppressive effects. Building on these findings, cytosine guanine dinucleotide (CpG) oligodeoxynucleotide (ODN)-modified manganese (Mn)-Shik metal-polyphenol network nanodrugs (Mn/Shik@CpG NDs) are designed to reverse the “cold” immune environment of prostate tumor. In this scenario, Mn/Shik@CpG NDs release monomeric components under the stimulation of acidic and glutathione-rich tumor microenvironment (TME), thus exerting their immunomodulatory effects synergistically. Since the released Shik can induce DNA damage by necroptosis promoting reactive oxygen species production, cGAS-STING signaling pathway is initiated, which further activates interferon production in the TME. In addition, the necroptosis of Shik initiates immunogenic cell death, further activating innate immunity and promoting adaptive immune responses. Mn 2+ is a cGAS-STING sensitizer, which amplifies the intratumoral interferon response. As an immune adjuvant, CpG ODN effectively promotes the maturation of dendritic cells, as well as the helper T cell differentiation and pro-inflammatory cytokine secretion, thus activating both innate and adaptive immunity. In vivo studies suggest that Shik-mediated VSIG4 downregulation, combined with innate and adaptive immune activation, remodels the TIME to evoke a significant anti-tumor response. Furthermore, transcriptomic analysis of rechallenged tumors indicated this durable protection was driven by a genuine immune memory response, revealing a gene signature of T cell activation and immune reprogramming. Collectively, beyond presenting a novel therapeutic candidate for converting immunologically “cold” tumors into “hot” ones, our work validates a data-guided design pipeline, offering a conceptual blueprint to inform the precise engineering of future nanodrugs.
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Nature Communications
·
2026
·
IF 18.1
Wang Zhenhao,Yang Zhaoxiang,Ma Yingchao,Lyu Shanzhi,Hu Xiaohua,Wang Yapei
Phototherapy, valued for its non-toxicity, selectivity, and minimal trauma, is predominantly applied to treat superficial diseases due to the limited penetration of light through tissues. While optical-fiber-assisted interventional phototherapy addresses this limitation, it lacks an immediate mechanism to mitigate overheating of surrounding healthy tissues. To improve the biosafety of interventional phototherapy, we develop an adaptive optical waveguide system (AOWS) based on a negative feedback modulation mechanism. The AOWS employs a thermally responsive liquid as the waveguide gating material, characterized by a precisely tunable low critical solution temperature (LCST). When the temperature surpasses the LCST, one-dimensional light propagation is scattered, providing effective thermal regulation. Furthermore, the design supports adjustable optical fiber outlets, with convex or concave configurations and varied curvatures, enabling precise control of the divergence angle. Superior to conventional optical fibers with smaller divergence angles, the AOWS facilitates closer placement to the lesion site, delivering a larger illumination area while significantly reducing the light pathway through normal tissue. More importantly, it provides thermal protection almost like an “on-off” switch without relying on irradiation power, ensuring enhanced safety and efficacy.
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