JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-25
·
IF 12.6
Han Yuhan,Gu Jiacheng,Xu Miaomiao,Ma Yufei,Weng Weiji,Feng Qiyuan,He Zhenghui,Qi Wenlan,Mao Qing,Jiang Jiyao,Feng Junfeng
Microglia play a critical role in neuroinflammation, a key secondary injury mechanism following traumatic brain injury (TBI). The colony-stimulating factor 1 receptor (CSF-1R) inhibitor PLX5622 has shown promise in suppressing neuroinflammation by depleting microglia, but it lacks specificity in targeting microglia at the injury site. To overcome this limitation, we developed PLX5622 nanoparticles functionalized with the CAQK peptide for lesion-specific targeting and combined them with a hydrogel (GelMA-PPS) that possesses potent reactive oxygen species (ROS) scavenging capabilities. This nanoparticle-hydrogel drug delivery system (GelMA-PPS/P) significantly enhanced the delivery efficiency and therapeutic efficacy of PLX5622 in TBI treatment. Localized administration of this system effectively depleted microglia at the injury site, suppressed neuroinflammation, and reduced the release of inflammatory cytokines. Its ROS scavenging ability was also validated in vitro and in vivo. Together, these effects synergistically improved neurological function recovery in TBI mouse models. This innovative strategy offers a comprehensive and targeted approach to managing neuroinflammation after TBI, providing a promising avenue for advancing TBI therapies.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-23
·
IF 12.6
Fei Weidong,Xin Yu,Qian Wenqiang,Liu Mingqi,Zheng Caihong,Liu Yunxi,Chen Danfei,Zhou Ying,Xu Shanshan,Wu Xiaodong,Zhao Mengdan
Due to the insidious onset of ovarian cancer, the majority of patients are diagnosed at advanced stages, often presenting with extensive pelvic and abdominal metastasis. A significant proportion of these patients exhibit primary or acquired drug resistance, limiting improvements in the five-year survival rate. In this study, an analysis of patient-derived samples demonstrated a strong correlation between cholesterol levels and ovarian cancer progression. Membrane lipid therapy, a strategy that targets the composition, structure, and function of the cell membrane, has demonstrated notable potential in tumor therapy. Subsequently, a novel cholesterol oxidation-mediated membrane lipid therapy employing PLGA microspheres co-loaded with miriplatin (MiR) and cholesterol oxidase (COD) was proposed for drug-resistant advanced ovarian cancer therapy. The microspheres had a particle size of approximately 2.58 μm, with encapsulation efficiencies of 82.98 ± 0.09% for MiR and 32.83 ± 4.30% for COD. In vitro experiments demonstrated that COD-induced cholesterol oxidation modulated the membrane rigidity and fluidity of SKOV3-TR cells, thereby compromising membrane structural integrity and attenuating tumor cell migration. Additionally, the reactive oxygen species generated during cholesterol oxidation disrupted mitochondrial membrane potential and adenosine triphosphate production. The resulting energy deficiency and compromised membrane integrity reduced the expression and function of drug resistance-associated proteins, thereby enhancing chemosensitivity. Moreover, the combined effects of reactive oxygen species and MiR drove resistant cells towards apoptosis. In vivo studies demonstrated that the large-particle PLGA formulation effectively resided in the peritoneal cavity, resulting in superior therapeutic outcomes against drug-resistant metastatic ovarian tumor, as evidenced by fewer peritoneal metastatic nodules and diaphragmatic colonization sites, more extensive tumor tissue destruction, and prolonged survival. More importantly, PLGA encapsulation significantly decreased the toxic side effects associated with continuous platinum-based chemotherapy. Overall, cholesterol oxidation-mediated membrane lipid therapy represented a promising approach for treating advanced ovarian cancer. Graphical abstract
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EMBO Molecular Medicine
·
2025
·
IF 8.3
FengShengyong,MaEnhao,NaXiaona,WangZongmei,TaiWanbo,BaoXinhui,WangMao,ChangHan,WuBaolei,LiuMiaoxi,LiJuzhen,ShiHuicheng,YangCeli,XiMenglu,YangHaibing,LiYuhan,ZhuYibin,WangPenghua,ZhaoLing,ZhaoAi,ChengGong
Vaccination offers the most effective protection against contagious infectious diseases primarily by inducing humoral immunity. Vaccination efficacy is influenced by various factors. We report that dietary administration of arachidonic acid (ARA) significantly boosts rabies vaccine-induced production of neutralizing antibodies and protection against lethal rabies virus (RABV) infection in mice. In human volunteers, oral supplementation of ARA accelerates the expression of neutralizing antibodies to the levels sufficient for protection against RABV as early as one week after primary immunization. Mechanistically, ARA is enriched in lymph nodes and metabolized into immune modulators there. One of the ARA metabolites, prostaglandin I2 (PGI2), via the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) axis, upregulates the expression of costimulatory molecule CD86, and activates activation-induced cytidine deaminase (AID) in B cells. These results suggest that ARA can be a potent dietary adjuvant to foster germinal center (GC) B cell response and humoral immunity.
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Scientific Reports
·
2025
·Vol. 15
·期 1
·1-13
·
IF 3.9
Yang Le,Wang Jie,Li Peng,Guo Yuxi,Li Siyuan,Liu Shuangyu,Lou Yingying,Qi Jinlong,Yang Qian
Gastric cancer (GC) is a severe malignancy characterized by late diagnosis, poor prognosis, and low survival rates. Its progression is often linked to chronic non-atrophic gastritis (CNAG) and chronic atrophic gastritis (CAG), which show atypical symptoms. Identifying biomarkers for CNAG, CAG, and GC progression is crucial for earlier diagnosis and prevention. This study conducted non-targeted metabolomics on 81 clinical samples (17 controls; 23, 23, and 18 from CNAG, CAG, and GC patients, respectively) using ultra-high-performance Liquid chromatography and high-resolution mass spectrometry. A total of 763 metabolites were identified, of which eight metabolic pathways were in dysregulation at different disease stages. Disease progression showed pronounced disruptions in amino acid, Lipid, and microbial metabolism. Targeted metabolomics identified 56 metabolites, with significant differences in O-(4,8-dimethylnonanoyl) carnitine and dehydroepiandrosterone sulfate (DHEAS). DHEAS and L-threonic acid (L-TA) were validated as biomarkers, with detection methods developed and applied to confirm their clinical significance. These findings enhance understanding of CNAG, CAG, and GC progression and provide validated biomarkers for potential clinical application in GC diagnosis and treatment.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Wang Sikai,Liu Weiping,Wang Lei,Lv Lin,Liu Xiangqin,Luo Xiaojun,Zhang Guoqi,Zhao Yan
d -Galactose (D-Gal), an essential monosaccharide, plays multiple physiological roles in living organisms. Abnormal fluctuations in its concentration are closely associated with various genetic metabolic disorders, such as galactosemia and galactose deficiency. Therefore, the development of an efficient, sensitive, and accurate method for D-Gal detection is critical for disease diagnosis and treatment. In this study, a ratiometric fluorescence-based sensing platform was constructed for the quantitative detection of D-Gal. Galactose oxidase can catalyze the oxidation of D-Gal, resulting in the generation of hydrogen peroxide (H 2 O 2 ). When combined with WSe 2 nanosheets prepared via liquid-phase exfoliation and functioning as nanozymes, in the presence of H 2 O 2 , the substrate o -phenylenediamine (OPD) undergoes oxidation to generate 2,3-diaminophenazine (DAP), which exhibits a fluorescence peak at 570 nm. Simultaneously, DAP quenches the fluorescence of carbon dots (CDs) at 430 nm via an inner filter effect, thereby enabling ratiometric detection with enhanced accuracy and sensitivity. The method exhibits a Limit of detection of 0.004 mM, Linear ranges spanning from 0.01 to 1 mM and from 1 to 300 mM, with recoveries ranging between 91.0 and 100.4%. Furthermore, the proposed method was effectively utilized for the detection of D-Gal in human serum specimens, demonstrating excellent selectivity and reliability. This research presents a novel method for D-Gal detection based on WSe 2 nanosheets and CDs, offering potential applications in the biomedical and biosensing fields. Graphical abstract
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Light-Science & Applications
·
2024
·Vol. 13
·期 1
·1-11
·
IF 20.6
Li Shi-Long,Chen Zhao-Yi,Chen Peng,Hu Wei,Huang Chaohong,Li Sen-Sen,Hu Xuejia,Lu Yan-Qing,Chen Lu-Jian
Liquid crystals are a vital component of modern photonics, and recent studies have demonstrated the exceptional sensing properties of stimuli-responsive cholesteric liquid crystals. However, existing cholesteric liquid crystal-based sensors often rely on the naked eye perceptibility of structural color or the measurement of wavelength changes by spectrometric tools, which limits their practical applications. Therefore, developing a platform that produces recognizable sensing signals is critical. In this study, we present a visual sensing platform based on geometric phase encoding of stimuli-responsive cholesteric liquid crystal polymers that generates real-time visual patterns, rather than frequency changes. To demonstrate this platform’s effectiveness, we used a humidity-responsive cholesteric liquid crystal polymer film encoded with a q -plate pattern, which revealed that humidity causes a shape change in the vortex beam reflected from the encoded cholesteric liquid crystal polymers. Moreover, we developed a prototype platform towards remote humidity monitoring benefiting from the high directionality and long-range transmission properties of laser beams carrying orbital angular momentum. Our approach provides a novel sensing platform for cholesteric liquid crystals-based sensors that offers promising practical applications. The ability to generate recognizable sensing signals through visual patterns offers a new level of practicality in the sensing field with stimuli-responsive cholesteric liquid crystals. This platform might have significant implications for a broad readership and will be of interest to researchers working in the field of photonics and sensing technology.
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Light-Science & Applications
·
2024
·Vol. 13
·期 1
·1-12
·
IF 20.6
Liu Bo-Mei,Lin Yue,Liu Yingchun,Lou Bibo,Ma Chong-Geng,Zhang Hui,Wang Jing
Materials capable of dynamic persistent luminescence (PersL) within the visible spectrum are highly sought after for applications in display, biosensing, and information security. However, PersL materials with eye-detectable and excitation-wavelength-dependent characteristics are rarely achieved. Herein, a nonstoichiometric compound CaGa x O 4 :Bi ( x < 2) is present, which demonstrates ultra-long, color-tunable PersL. The persistent emission wavelength can be tuned by varying the excitation wavelength, enabling dynamic color modulation from the green to the orange region within the visible spectrum. Theoretical calculations, in conjunction with experimental observations, are utilized to elucidate the thermodynamic charge transitions of various defect states, thereby providing insights into the relationship between Bi 3+ emitters, traps, and multicolored PersL. Furthermore, the utility of color-tunable PersL materials and flexible devices is showcased for use in visual sensing of invisible ultraviolet light, multicolor display, information encryption, and anti-counterfeiting. These discoveries create new opportunities to develop smart photoelectric materials with dynamically controlled PersL for various applications.
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Nature Synthesis
·
2025
·
IF 20
Chen Cheng-Xia,Cui Xili,Xiong Yang-Yang,Lan Pui Ching,Tan Kui,Wei Zhang-Wen,Niu Zheng,Shan Chuan,Yang Lifeng,Ma Shengqian,Su Cheng-Yong
Dynamic chemistry offers opportunities for the design of smart materials that can self adapt or self repair to mediate their functionality. However, achieving anti-crack toughness using dynamic covalent bonds is often overlooked in crystalline porous solids such as metal–organic frameworks. Here we propose that crystalline dynamicity can be derived from bio-inspired disulfide metathesis, as demonstrated by a dynamic combinatorial library of isomeric metal–organic frameworks (LIFM-105, LIFM-105i, and LIFM-105a). Sulfur–sulfur bond breakage and regeneration facilitate stimuli-responsive interconversion between two-dimensional and three-dimensional frameworks, involving simultaneous layer rotation, component shift and linkage reorganization. The disulfide exchange-based crystal dynamics provides these porous solids with gas-induced adaptiveness and the gate effect, enabling pore tuning for efficient removal of C 2 H 2 from C 2 H 4 . Additionally, the guest-adaptation-motivated restoration and reorganization of the ‘damaged’ frameworks afford a promising protocol to apply radical-mediated dynamic solids as adaptive porous materials for durable separation and other applications.
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Light-Science & Applications
·
2023
·Vol. 12
·期 1
·1-9
·
IF 19.4
Liu Zhihao,Hu Guangwei,Ye Huapeng,Wei Miaoyang,Guo Zhenghao,Chen Kexu,Liu Chen,Tang Biao,Zhou Guofu
Microlens arrays (MLAs) based on the selective wetting have opened new avenues for developing compact and miniaturized imaging and display techniques with ultrahigh resolution beyond the traditional bulky and volumetric optics. However, the selective wetting lenses explored so far have been constrained by the lack of precisely defined pattern for highly controllable wettability contrast, thus limiting the available droplet curvature and numerical aperture, which is a major challenge towards the practical high-performance MLAs. Here we report a mold-free and self-assembly approach of mass-production of scalable MLAs, which can also have ultrasmooth surface, ultrahigh resolution, and the large tuning range of the curvatures. The selective surface modification based on tunable oxygen plasma can facilitate the precise pattern with adjusted chemical contrast, thus creating large-scale microdroplets array with controlled curvature. The numerical aperture of the MLAs can be up to 0.26 and precisely tuned by adjusting the modification intensity or the droplet dose. The fabricated MLAs have high-quality surface with subnanometer roughness and allow for record-high resolution imaging up to equivalently 10,328 ppi, as we demonstrated. This study shows a cost-effective roadmap for mass-production of high-performance MLAs, which may find applications in the rapid proliferating integral imaging industry and high-resolution display.
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Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-14
·
IF 23.655
Yang Zijie,Lv Siyuan,Zhang Yueying,Wang Jing,Jiang Li,Jia Xiaoteng,Wang Chenguang,Yan Xu,Sun Peng,Duan Yu,Liu Fangmeng,Lu Geyu
3D porous crumpled MXene spheres were synthesized by ultrasonic spray pyrolysis technology.
All-MXene transient sensors utilizing porous crumpled MXene sphere as sensing material and MXene films as electrodes were developed, which achieved excellent gas/pressure sensing performance.
Both gas and pressure sensors can achieve rapid and controllable degradation in medical-grade H 2 O 2 (2%) within 6 h.
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Light-Science & Applications
·
2025
·Vol. 14
·期 1
·1-11
·
IF 23.4
Suo Hao,Wang Nan,Zhang Yu,Zhang Xin,Xiang Jinmeng,Wang Xiaojia,Xing Guansheng,Guo Dongxu,Chang Jiwen,Wang Yu,Li Panlai,Wang Zhijun,Zhang Yuhai,Chen Bing,Li Shuzhou,Guo Chongfeng,Wang Feng
Low-dimensional lead-free metal halide perovskites are highly attractive for cutting-edge optoelectronic applications. Herein, we report a class of scandium-based double perovskite crystals comprising antimony dopants that can generate multiexcitonic emissions in the ultraviolet, blue, and yellow spectral regions. Owing to the zero-dimensional nature of the crystal lattice that minimizes energy crosstalk, different excitonic states in the crystals can be selectively excited by ultraviolet light, X-ray irradiation, and mechanical action, enabling dynamic control of steady/transient-state spectral features by modulating the excitation modes. Remarkably, the transparent crystal exhibits highly efficient white photoluminescence (quantum yield >97%), X-ray excited blue emission with long afterglow (duration >9 h), and high-brightness self-reproducible violet-blue mechanoluminescence. These findings reveal the exceptional capability of low-dimensional perovskite crystals for integrating various excitonic luminescence, offering exciting opportunities for multi-level data encryption and all-in-one authentication technologies.
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Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 5
·1-11
·
IF 23.2
Wen Xiaohong,Zhao Zengcai,Chen Yuchang,Shan Xinzhi,Zhao Xuefeng,Gao Xiumin,Zhuang Songlin
Multifunctional integrated flexible electronic skin (e-skin) is the essential medium for information exchange between humans and machines. Especially, the proximity/pressure/strain sensing has become a technological goal for various emerging wearable electronic devices, such as biomonitoring devices, smart electronics, augmented reality, and prosthetics. Herein, a stretchable hybrid electronic network-based e-skin is presented, fabricated by embedding 3D hollow MXene spheres/Ag NWs hybrid nanocomposite into PDMS, which can effectively avoid the electrode falling off due to stress concentration. This e-skin works in noncontact mode (proximity-negative capacitance) and contact mode (pressure-positive capacitance and strain-resistance) for multiplex detection of random external force stimuli without mutual interference. The macroscopic physical structure of stretchable electrodes and the microscopic hybrid three-dimensional conductive network jointly contribute to the good sensing performance of the device. This work provides an effective and universal strategy for the application of wearable intelligent electronic products that demand noncontact interaction and multimodal tactile perception.
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