MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Guoni Huang,Jiezhen Pan,Junfang Zhu,Ye Zhang,Xiaohe Zhang,Shihua Luo
In this study, we introduce an ultrasensitive electrochemical RNA biosensor based on hyperbranched primer exchange reaction (HPER) cascade amplification and Au@Pt@UiO-66-NH 2 nanozymes. This strategy employs catalytic hairpin assembly (CHA) for precise target RNA recognition, which trigger the immobilization of HPER products onto the electrode surface, thereby providing binding sites for nanozymes. Then, the sDNA@Au@Pt@UiO-66-NH 2 signal probes (sDAPU probes) attach to the HPER scaffolds through base-pairing interactions, facilitating signal amplification. The nanozymes catalyze the decomposition of hydrogen peroxide into H 2 O and O 2 , producing a significantly amplified electrochemical signal. By combining CHA-HPER cascade amplification with the catalytic activity of sDAPU probes, the established biosensor achieves remarkable sensitivity, with a detection limit as low as 14.68 aM, and high specificity that enables the differentiation of non-target pathogen RNA. Furthermore, the biosensor also demonstrates excellent recovery rates in serum samples. Therefore, this electrochemical strategy shows great potential as a diagnostic tool for ultrasensitive Mycobacterium tuberculosis detection.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Zhao He,Jian Zhu,Xin Li,Guo-Jun Weng,Jian-Jun Li,Jun-Wu Zhao
Au@AuAg yolk-shell heterogeneous nanostructures (YSHNSs) with two major plasmonic absorption peaks of equal intensity are designed as multifunctional and multi-informational nanoprobes for detecting Cu 2+ and Hg 2+ , which are critical heavy metals threatening food safety and human health. By controlling the elemental distribution and morphological structure of Au@AuAg YSHNSs, two major absorption peaks can be accurately modulated. Since changing the thickness and composition ratio of Au@Ag alloy shell triggers a seesaw-like bidirectional conversion of two major absorption peaks, we establish the detection of Cu 2+ and Hg 2+ . The decrease and increase of intensity ratio of dual-peak show a good linear relationship with the concentration of Cu 2+ and Hg 2+ , with detection limits of 0.4 nM and 2 nM, respectively. This plasmonic nanoprobe based on Au@AuAg YSHNSs is successfully utilized for detecting Cu 2+ and Hg 2+ in various drinking water, providing a reliable solution for screening heavy metals with high specificity and sensitivity.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Mi Xiao,Zhuoyuan Song,Xiaofan Gao,Songyi Yang,Xinyu Hui,Xinyue Du,Wei Yao,Haotian Duan
In this paper, the role of magnetron sputtered Au nanoparticles in regulating morphology of CoNiSe 2 to improve the performance of electrode materials for the supercapacitors is studied for the first time. After nanoneedle-like Co(OH) 2 is grown on Ni foam using a hydrothermal method, followed by Au nanoparticle deposition via magnetron sputtering. The resulting material underwent solvothermal processing with ascorbic acid as a reducing agent to prepare CoNiSe 2 . Because of the Au deposition, the morphology is changed by regulating the relationship between the ion consumption rate during selenization and the ion transport rate on the surface. When the magnetron sputtering time is 10 s, uniform mace-like CoNiSe 2 (named as NCA10-S) is formed with the best performance. Its specific capacitance reaches up to 2068.3 F g −1 at 1 A g −1 , which is 122.93 % higher than that of the single CoNiSe 2 electrode. The asymmetric supercapacitor composed of NCA10-S achieves a specific capacitance of 263.1 F g −1 at 1 A g −1 . When the power density reaches 800.01 W kg −1 , it has an energy density of 93.56 Wh kg −1 . This work provides a method for controlling transition metal selenide surface morphology to improve energy storage performance in supercapacitor electrodes.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2024
·
IF 5.8
Yue Li,Junhao Zhou,Xiaoping He,Youzhou He,Jiajia Jing,Xingyan Liu,Siqi Li,Siping Wei
Under the global dual-carbon goal, photocatalysis technology is being employed as a green technology for NO removal and hydrogen production . However, the application of photocatalysts is often limited by the weak response to visible light and the low separation efficiency of photogenerated carriers. In this paper, we designed a simple and efficient photocatalyst Au@NM-125/PdTCPP for NO removal and hydrogen evolution . By adding PdTCPP molecule with excellent light absorption ability combine with MIL-125-NH 2 (Ti), the introduction of PdTCPP expands the absorption range of visible light. On the other hand, the introduction of Au NPs with surface plasmon resonance effect promotes electron transport between PdTCPP and MIL-125-NH 2 (Ti), thus greatly improving the photocatalytic performance. Compared with the NO removal efficiency of the original NM-125 (22.06 %), the NO removal rate of NM-125/PdTCPP was 63.72 %, while the NO removal rate of Au@NM-125/PdTCPP was the highest, reaching 73.23 %. What’s more, Au@NM-125/PdTCPP also demonstrated excellent hydrogen evolution performance (12.659 mmol/g, in 4 h), with a hydrogen evolution effect 2.14 times that of NM-125/PdTCPP (5.911 mmol/g, in 4 h) and 6.85 times that of the initial material NM-125 (1.848 mmol/g, in 4 h). Based on the results of UV-Vis spectroscopy, Mott-Schottky and XPS spectrum, we proposed a possible photocatalytic mechanism, the suitable band gap value of MIL-125-NH 2 (Ti) and PdTCPP makes them form a Z-scheme heterojunction , where electrons flow from PdTCPP to MIL-125-NH 2 (Ti), and Au NPs acts as an electron bridge to promote more electron transfer, thus improving the photocatalytic performance. It is a practicable strategy to achieve excellent photocatalytic performance by combining metalloporphyrin molecules as semiconductors directly with MOFs to form heterojunctions and adding Au NPs as electronic bridges, which is also valuable for environmental remediation and energy production.
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RSC Advances
·
2026
·
IF 6.1
Chenxi Xie,Dong Zhang,Yijiang Wu,Yuan He,Yiman Ge,Bin Deng
In this study, a highly sensitive surface-enhanced Raman scattering (SERS) microarray chip was developed for the detection of reduced glutathione (GSH) in the serum of colorectal cancer (CRC) patients. Gold-palladium nanorods (Au@Pd NRs) with peroxidase-like activity were synthesized and assembled into holes on the polydimethylsiloxane (PDMS)-indium tin oxide (ITO) glass substrate via electrophoretic deposition (EPD). The Au@Pd NRs catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to oxidized TMB (oxTMB) in the presence of hydrogen peroxide (H 2 O 2 ), producing a characteristic SERS peak at 1605 cm −1 . Prior to detection, a thiolated GSH aptamer was immobilized on the microarray chip to specifically capture GSH, effectively avoiding interference from other reducing substances in the complex serum matrix. The captured GSH then reduces oxTMB back to TMB, causing signal attenuation proportional to GSH concentration. The limit of detection (LOD) reached 93 pmol L −1 , with a relative standard deviation (RSD) of 6.36% for reproducibility. Clinical serum analysis of 30 healthy individuals and 30 CRC patients demonstrated results consistent with the gold standard testing method of high-performance liquid chromatography (HPLC) (relative error < 8%), confirming the potential of this approach for the effective detection of GSH and early CRC diagnosis. In this study, a highly sensitive surface-enhanced Raman scattering (SERS) microarray chip was developed for the detection of reduced glutathione (GSH) in the serum of colorectal cancer (CRC) patients.
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Nanoscale
·
2023
·Vol. 15
·期 15
·7032-7043
·
IF 6.7
Bowei Pan,Shuang Shan,Junpeng Wang,Quan Tang,Longfei Guo,Tao Jin,Qiao Wang,Zhen Li,Muhammad Usman,Fuyi Chen
The study provides a proof of concept for the first time that unique palladium–gold (PdAu) and palladium–silver (PdAg) nanodendrites are bifunctional catalytic active sites for formate oxidation reactions (FORs) and formate dehydrogenation reactions (FDRs). The unique nanodendritic structure was developed via a simple galvanic displacement reaction for the direct growth of PdAu and PdAg nanodendrites on a nickel foam (PdAu/NiNF and PdAg/NiNF). These PdAu/NiNF and PdAg/NiNF electrodes exhibited 2.32 and 1.59 times higher specific activity than that of the commercial Pd/C electrode and promising stability toward FORs. Moreover, the PdAu/NiNF and PdAg/NiNF nanodendrites were also highly active and selective catalysts for hydrogen generation from a formate solution with turnover frequency (TOF) values of 311 h−1 and 287 h−1 respectively. Impressively, a passive air-breathing formate fuel cell with PdAu/NiNF used as an anode can yield an open-circuit voltage of 1.12 V and a peak power density of 21.7 mW cm−2, which outperforms most others reported in the literature. PdAu and PdAg nanodendritic catalysts supported on a nickel foam demonstrate an open structure and uniform catalyst distribution and offer a promising nanoalloy for air-breathing formate fuel cells and on-site chemical hydrogen production systems.
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BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Limin Yang,Heng Guo,Ting Hou,Jingang Zhang,Feng Li
Breast cancer (BC) is the most common cancer in the world and circulating tumor cells (CTCs) are reliable biomarkers for early breast cancer diagnosis in a non-invasive manner. However, effective isolation and sensitive detection of BC-CTCs by portable devices in human blood samples are extremely challenging. Herein, we proposed a highly sensitive and portable photothermal cytosensor for direct capture and quantification of BC-CTCs. To achieve efficient isolation of BC-CTCs, aptamer functionalized Fe 3 O 4 @PDA nanoprobe was facilely prepared through Ca 2+ -mediated DNA adsorption. To further detect the captured BC-CTCs with high sensitivity, multifunctional two-dimensional Ti 3 C 2 @ [email protected] nanozyme was synthesized, which not only possessed superior photothermal effect but also exhibited high peroxidase-like activity for catalyzing 3,3′,5,5′-tetramethylbenzidine (TMB) to produce TMB oxide (oxTMB) with a strong photothermal characteristic, combining with Ti 3 C 2 @ [email protected] to synergistically amplify the temperature signal. Moreover, numerous Ti 3 C 2 @ [email protected] nanocomposites would be selectively attained on the BC-CTCs surface through multi-aptamer recognition and binding strategy, which further enhanced the specificity and facilitated signal amplification . Therefore, direct separation and highly sensitive detection of BC-CTCs was successfully achieved in human blood samples. More significantly, the controlled release of the captured BC-CTCs without affecting cell viability could be straightforwardly realized by a simple strand displacement reaction. Thus, with the distinct features of portability, high sensitivity, and easy operation, the current method holds great promise for early diagnosis of breast cancer.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Hong Liu,Ren Zhu,Nannan Shi,Long Zhang,Shun Li,Jianming Zhang
Charge carrier transfer efficiency as a crucial factor determines the performance of heterogeneous photocatalysis. Here, we demonstrate a simple nanohybrid structure of BaTiO3-Au (BTO-Au) for the efficient selective oxidization of benzyl alcohol to benzaldehyde upon piezotronic effect boosted plasmonic photocharge carrier transfer. With the aid of ultrasonic mechanical vibration, the reaction rate of the photocatalytic organic conversion would be considerably accelerated, which is about 4.2 and 6.2 times higher than those driven by sole visible light irradiation and sole ultrasonication, respectively. Photoelectrochemical tests under ultrasonic stimuli reveal the BTO-Au catalytic system is independent of the light intensity, showing a consistent photocurrent density, over a wide range of incident light brightness. The largely enhanced photocatalytic activity can be ascribed to the synergetic effect of surface plasmonic resonance (SPR)–piezotronic coupling by which a built-in electric field induced by the piezotronic effect significantly favors the oriented mobilization of energetic charge carriers generated by the SPR effect at the heterojunction. Notably, a decrease of the Schottky barrier height of ∼0.3 eV at the BTO-Au interface is verified experimentally, due to the band bending of BTO induced by the piezotronic effect, which can greatly augment the hot electron transfer efficiency. This work highlights the coupling of the piezotronic effect with SPR within the BTO-Au nanostructure as a versatile and promising route for efficient charge transfer in photocatalytic organic conversion.
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ANALYTICAL LETTERS
·
2023
·
IF 2
Xiaoyu Zhang,Peiran Meng,Wei Wang,Xiwen Li,Zuan Yang,Shaokai Du,Yue Sun
Simultaneous determination of erythromycin (Ery) and hemoglobin (Hb) is of great significance for clinical diagnosis of many diseases. ZnO nanorods modified with Au nanoparticles were fabricated as an interface on the flexible carbon cloth (CC) and utilized to simultaneously determine Ery and Hb by a simple electrochemical method. The results demonstrated that Au/ZnO/CC displayed excellent analytical performance for Ery with a low detection limit of 3.38 × 10−7 mg/L and a linear range from 1 × 10−6 to 1 × 10−1 mg/L. At the same time, the sensor also showed a sensitive response to Hb with a low detection limit of 2.07 × 10−7 mg/L and a linear range from 1 × 10−6 to 1 × 10−1 mg/L. This work provides a viable approach for designing a flexible electrode and sensitive simultaneous determination of Ery and Hb.
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Analytical Methods
·
2022
·Vol. 14
·期 27
·2703-2713
·
IF 3.532
Min Wang,Mingzhe Jiang,Xiaochen Liao,Xiao Wang,Wenjing Lai,Pengli Li,Jiajia Li,Chenglin Hong,Yu Qi
The effective amplification of the signal is the prerequisite for the ultrasensitive detection of electrochemical immunosensors. To quantitatively detect alpha-fetoprotein (AFP), we prepared a sandwich-type electrochemical immunosensor. Using a gold nanoparticles (Au NPs) modified glassy carbon electrode (GCE) as the sensing platform and Cu/Cu2O-rGO@Au as the signal label, differential pulse voltammetry (DPV) was used to achieve sensitive detection of AFP. We found that the nanomaterials can undergo electro-oxidation and electro-reduction reactions between Cu(I) and Cu(II) in a buffer solution of pH = 6.0. It is worth mentioning that the incorporation of metals into metal oxide substrates is a new strategy to combine the catalytic activity of metal oxides with the electrical conductivity of metals. Reduced graphene oxide (rGO), which is rich in oxygen-containing groups, can load more Cu/Cu2O and Au NPs and increase the conductivity. The modification of Au NPs makes them have better biocompatibility and conductivity. Under the best detection conditions, the prepared immunosensor realizes the specific and ultrasensitive detection of AFP. The detection range is 0.01–50 ng mL−1 and the limit of detection (LOD) was as low as 0.589 pg mL−1 (S/N = 3); meanwhile it also has good practical application ability. Therefore, this immunosensor provides an important means for the early screening and detection of AFP.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 16
·7695-7703
·
IF 3.925
Qi Wu,Changfeng Zhao,Qinzhong Wang,Jing Liu
This study proposes the efficient separation of Au(III)/Pd(II)/Pt(IV)/Rh(III) through the 2-mercaptobenzothiazole-functionalised ionic liquid ([C6mim][2MBT]) using a cloud point extraction system. Direct cloud point extraction of Au(III) (about 99.9%) was realised without involving any functionalised ionic liquids. A significant enhancement of the Pd(II) extraction performance was found by adding rationally constructed [C6mim][2MBT]. Consequently, a fairly high extraction percentage of about 99.4% was obtained. However, further advancement of the proposed cloud point extraction showed that it could not be applied for the preconcentration of Pt(IV) and Rh(III) without adding stannous chloride, which plays a critical role in the segregation and could be adjusted by changing the hydrochloric acid concentration. Under the optimised conditions, the Rh(III) extraction process shows a high yield percentage (ca. 83.0%), where the majority of Pt(IV) was enriched in the aqueous phase. In addition, the underlying possible extraction mechanism was investigated using UV-vis, FT-IR and TEM measurements, which indicated that TX-114 acted as a solvent for the extracted metals. The developed procedure reveals efficient direct Au(III)/Pd(II)/Pt(IV)/Rh(III) separation using [C6mim][2MBT] via cloud point extraction.
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Qinchao Shao,Xiubin Zhang,Pei Liang,Qiang Chen,Xiaohua Qi,Mingqiang Zou
Fabrication of a magnetic substrate based on metal–organic frameworks (MOFs) with high sensitivity and stability for surface-enhanced Raman scattering (SERS) analysis were reported in this paper. MIL-101(Cr) nanoparticle prepared via a traditional hydrothermal reaction, which was combined with Fe 3 O 4 to synthesize the Fe 3 O 4 /MIL-101(Cr) composites. Then, the concentration of chloroauric acid and the time of reduction reaction were adjusted to acquire the optimal Au/Fe 3 O 4 /MIL-101(Cr) (AF-MIL) SERS substrate. The detection ability of the substrate can down to 10 -8 mol/L for Rhodamine 6G (R6G) as probe molecule, and the relative standard deviation (RSD) is only about 4.48 %, which indicates that it possesses wonderful SERS performance and uniformity. Finally, the as-synthesized substrate has been adopted to test the trace level sulfapyridine, with its desirable detection ability can down to 10 -6 mol/L. Such desirable SERS substrate with facile and effective operation holds great promise in the fast sensitive detection of the antibiotic residue and some other pollutants in environment.
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