BMC Chemistry
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2024
·Vol. 18
·期 1
·1-15
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IF 4.3
Huang Xiaomin,Wang Ting,Wang Ludan,Sun Yantao,Zhang Ziru,Zhang Yajun
In the investigation of active ingredients from natural products, current technologies relying on drug–target affinity recognition analysis face significant challenges. This is primarily due to their limited specificity and inability to provide downstream pharmacodynamic information, such as agonistic or antagonistic activity. In this study, a two-point method was developed by immobilizing M3 acetylcholine receptor (M3R) through the combination of the conformation-specific peptide BJ-PRO-13a and the HaloTag trap system. We systematically assessed the specificity of the immobilized M3R using known M3R antagonists (pirenzepine and atropine) and agonists (cevimeline and pilocarpine). By frontal analysis and nonlinear chromatography, the performance of immobilized M3R was evaluated in terms of binding kinetics and thermodynamics of four drugs to the immobilized M3R. Additionally, we successfully identified two M3R antagonists within an extract from Daturae Flos (DF), specifically hyoscyamine and scopolamine. Our findings demonstrate that this immobilization method effectively captures receptor-ligand binding interactions and can discern receptor agonists from antagonists. This innovation enhances the efficiency of receptor chromatography to determine binding-affinity in the development of new drugs, offering promise for the screening and characterization of active compounds, particularly within complex natural products.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-10
·
IF 5.3
Zou Ziwei,Chen Yi,Sun Rengang,Shi Boya,Jiang Li,Huang Feixiang
A surface plasmon resonance imaging (SPRi) biosensor is presented which facilitates rapid and sensitive detection of the ovarian cancer biomarker carbohydrate antigens 125 (CA125). The CA125 protein was specifically captured and directly recognized by polyadenylic (polyA)-modified DNA aptamer on the surface of a Au chip. The biosensor demonstrated a linear range of direct detection of CA125 based on SPRi from 20 nM to 0.5 nM, with a detection limit of 0.47 nM. Furthermore, Fe 3 O 4 nanoparticles were synthesized in situ on the carboxyl-functionalized two-dimensional (2D) material Ti 3 C 2 to obtain MXC/Fe 3 O 4 nanocomposites. The large surface area of Ti 3 C 2 provides ample binding sites for the in situ generation of Fe 3 O 4 and this facilitates subsequent immobilization of DNA aptamers. The amino-modified DNA aptamer interacted with carboxylate sites activated on the surface of Ti 3 C 2 , and the aptamer was immobilized on the MXC/Fe 3 O 4 nanocomposite surface. Due to the magnetic properties of Fe 3 O 4 nanoparticles within the composite material, CA125 protein in serum can be effectively captured and separated under an external magnetic field. The captured protein forms a sandwich amplification structure with the DNA adapter on the surface of the Au chip, thereby enhancing the detection signal of CA125. The biosensor demonstrates a linear detection range from 0.5 pM to 1000 pM, with a detection limit as low as 81 fM. The unique separation capability of the composite nanomaterials enables the biosensor to detect CA125 protein as low as 1 pM in complex liquid matrices such as serum, achieving exceptional selectivity, accuracy, and sensitivity in detecting the ovarian cancer marker. This capability significantly supports the early diagnosis of ovarian cancer. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 19
·8287-8297
·
IF 3.5
Liu Yang,Jiang Lu,Jiang Ruonan,Liu Huanhuan
Researchers are showing a great deal of interest in hydrogels due to the presence of high-water content, self-healing variants. Despite this, research into the development of smart hydrogels that have the combination of toughness, self-healing, and responsiveness to external stimuli is still lacking. Here, tough, and intelligent nanocomposite (NC) hydrogels have been developed by utilizing modified nano-crosslinker by means of gold-selenium (Au-Se) coordination interaction. The NC hydrogels demonstrate remarkable elasticity and strength, even when exposed to notches. With the optimal formulation, the nanocomposite hydrogel can achieve a maximum elongation of 1970%, a maximum fracture stress of 2.48 MPa, and a toughness of up to 9.95 MJ/m 3 , thanks to the dynamic gold crosslinks with improved branching. The presence of this structural attributes facilitates efficient energy dissipation within the hydrogel system. Combining Au-Se interaction as a healing element and the remarkable optothermal effect of nanoparticles, NC hydrogels can be quickly self-healed in near-infrared light exposure of 2 min, achieving a self-healing efficiency of 91%. Additionally, the hydrogels demonstrate repair potential when exposed to microwave irradiation, acid solution, and ultrasound stimulus. Moreover, a multi-responsive hydrogel composed of photothermal gold nanostructures can serve as a light-controlled drug carrier, which has smart drug release ability under external light stimulation. The advantageous properties of hydrogel make it a great option for biomedical and engineering fields.
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Nano Research
·
2024
·
IF 9.5
Guo Xu,Song Liru,Wang Wenyu,Li Fengfeng,Ha Minh Ngoc,Tang Jun,Ling Qiang,Cui Ping,Ke Qingping
Heterogeneously catalyzed liquid oxidation of olefins with O 2 provides an alternative way for synthesizing high-value added chemicals. Herein, we report a straightforward urea-redox and sol-gel process for synthesizing LaCo x Cu 1− x O 3 for aerobic photo-oxidation of cyclohexene. Our research highlights a marked increase in the proportions of Co 2+ and Cu + species in a low chemical state, as well as enhanced visible light absorption through this method. Mechanistic investigations suggest that the catalytic process, particularly with LaCo 0.7 Cu 0.3 O 3 , involves a radical pathway mediated by reactive oxygen species. The presence of Cu + /Co 2+ species and surface oxygen vacancies is proposed to boost O 2 adsorption and activation on the catalyst, facilitating the formation of 2-cyclohexene-1-hydroperoxides. Furthermore, Cu 2+ /Co 3+ species are thought to aid in generating cyclohexene-derived radical species. The efficient aerobic oxidation of cyclohexene on LaCo 0.7 Cu 0.3 O 3 catalyst relies on the formation of reactive oxygen species and carbon radicals, facilitated by its strong visible light illumination. It achieves a cyclohexene conversion of 89.4% and selectivity to cyclohex-2-ene-1-one of 72.2%, along with stable recyclability after six reuses. The creation of nano-structured LaCo x Cu 1− x O 3 through the urea-redox and sol-gel process offers a promising avenue for the development of highly efficient catalysts for the aerobic photo-oxidation of cyclohexene to cyclohex-2-ene-1-one in the future.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-11
·
IF 14.7
Liu Jiale,Zhang Shuoning,Wang Zichen,Xia Xinzhao,Zhang Jianying,Yu Yinuo,Xiao Yixian,Ren Yunxiao,Chen Jiajun,Yang Bo,Xie Wenting,Hu Wei,Yang Huai
Optical properties of cholesteric liquid crystal elastomers (CLCEs) can be tuned by an external field, however, it will spontaneously restore to the original state after the field is removed. Here, we introduce diselenide dynamic covalent bonds (DCBs) into CLCEs, whose optical properties can be reversibly and precisely tuned under the combined action of force and light. The tuned optical properties will be written into and remembered by the CLCEs, thus a programming effect is achieved. The prepared dynamical diselenide bonded CLCE films have the typical reversibly mechanochromism property, and high-resolution colourful patterning can be programmed by adjusting exposure time and intensity of masked visible-light under different tensile or compressive strain states. The DCB-CLCEs combine the novel anisotropy of CLCEs and the dynamic chain exchangeable ability of DCBs, which endows the materials with reprogrammable optical properties. We demonstrate a simple strategy of writing naked-eye high-resolution colourful patterning into a film with mechanochromism property by thermal or visible-light, it shows great potential in display devices, anticounterfeiting labels, sensors, optical films and smart materials.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
Fan Yamei,Li Rongtan,Wang Beibei,Feng Xiaohui,Du Xiangze,Liu Chengxiang,Wang Fei,Liu Conghui,Dong Cui,Ning Yanxiao,Mu Rentao,Fu Qiang
Sintering of active metal species often happens during catalytic reactions, which requires redispersion in a reactive atmosphere at elevated temperatures to recover the activity. Herein, we report a simple method to redisperse sintered Cu catalysts via O 2 -H 2 O treatment at room temperature. In-situ spectroscopic characterizations reveal that H 2 O induces the formation of hydroxylated Cu species in humid O 2 , pushing surface diffusion of Cu atoms at room temperature. Further, surface OH groups formed on most hydroxylable support surfaces such as γ-Al 2 O 3 , SiO 2 , and CeO 2 in the humid atmosphere help to pull the mobile Cu species and enhance Cu redispersion. Both pushing and pulling effects of gaseous H 2 O promote the structural transformation of Cu aggregates into highly dispersed Cu species at room temperature, which exhibit enhanced activity in reverse water gas shift and preferential oxidation of carbon monoxide reactions. These findings highlight the important role of H 2 O in the dynamic structure evolution of supported metal nanocatalysts and lay the foundation for the regeneration of sintered catalysts under mild conditions.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-12
·
IF 14.7
Li Xiaopei,Zhang Yongjie,Shi Zhenqiang,Wang Dongdong,Yang Hang,Zhang Yahui,Qin Haijuan,Lu Wenqi,Chen Junjun,Li Yan,Qing Guangyan
Boroxines are significant structures in the production of covalent organic frameworks, anion receptors, self-healing materials, and others. However, their utilization in aqueous media is a formidable task due to hydrolytic instability. Here we report a water-stable boroxine structure discovered from 2-hydroxyphenylboronic acid. We find that, under ambient environments, 2-hydroxyphenylboronic acid undergoes spontaneous dehydration to form a dimer with dynamic covalent bonds and aggregation-induced enhanced emission activity. Intriguingly, upon exposure to water, the dimer rapidly transforms into a boroxine structure with excellent pH stability and water-compatible dynamic covalent bonds. Building upon these discoveries, we report the strong binding capacity of boroxines toward fluoride ions in aqueous media, and develop a boroxine-based hydrogel with high acid–base stability and reversible gel–sol transition. This discovery of the water-stable boroxine structure breaks the constraint of boroxines not being applicable in aqueous environments, opening a new era of researches in boroxine chemistry.
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European Journal of Wood and Wood Products
·
2024
·
IF 2.4
Liu Caimei,Xizhi Wu,Li Xianjun,Liu Xiubo
Bamboo is comprised of parenchyma and vascular bundles, which contain vessels, sieve tubes, and fiber cells exhibiting numerous cavities or loose structures. Bamboo bundles undergo a series of mechanical rolling and disintegration processes to transform them into longitudinally continuous and transversely separated bamboo bundles and there is still a significant amount of vascular bundles and parenchyma that remain undissociated. Partial vessels, sieve tubes, and a majority of the parenchyma cell cavities are still discernible in the bamboo scrimber through the process of hot pressing, which significantly diminishes properties of bamboo scrimber, such as the strength, rigidity, and the water resistance. Therefore, this paper presented a new type of bamboo scrimber made from refined bamboo bundles, which is called high-density bamboo scrimber. That is, based on conventional bamboo bundles, a small amount of NaOH was employed to selectively eliminate a portion of the hemicellulose and soften bamboo bundles. Subsequently, a mechanical hammering technique was employed to disintegrate the bamboo bundles into single vascular bundles and surrounding parenchyma. This process increased the resin infiltration pathways and a multi-scale bonding interface structure was formed, and the densification and physical properties of the bamboo scrimber were improved. In high-density bamboo scrimber, the fiber cells maintained their original structural morphology, while the vessel cells and parenchyma cells were completely compacted, resulting in indistinguishable cell contours, and there was no discernible demarcation between the vascular bundles and parenchyma. Compared to ordinary bamboo scrimber, the bending strength, bending modulus, and maximum displacement of high-density bamboo scrimber exhibited a significant increase of 40.1%, 37.3%, and 18.2% respectively. The water resistance, surface roughness after sanding, and mildew resistance of this particular bamboo scrimber were better than those of ordinary bamboo scrimber. High-density bamboo scrimber exhibited a broader spectrum of applications within architectural structures.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 7
·1-10
·
IF 2.8
Gong Guoliang,Liu Chun,Zhu Jiawei,Huang Guojun,Zhang Tianyong
Compounds with crystallization and vitrification capabilities can achieve more uniform grains with higher crystalline density after glass crystallization, improving the fluorescence properties of glass ceramics (GCs). In this work, a series of Tb 3+ -doped SrLa 2 Ga 4 Si 2 O 14 glasses and glass ceramics were prepared through traditional melt quenching and thermal treatment. The glass exhibits good transmittance and a sharp exothermic peak at 961 ºC. The photoluminescence and radioluminescence properties were studied in detail, and the Tb 3+ aggregation in glass and GC was discussed. Compared with the glasses, the opaque GCs show inferior fluorescence properties but better X-ray irradiated fluorescence, about 10% of the integrated emission intensity of the commercial BGO scintillation crystal. More precise processing in glass–ceramics towards homogeneous crystallization and good transmittance need to be addressed, and a promising scintillator with improved scintillating performance can be expected.
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IONICS
·
2024
·
IF 2.4
Li Ao,Liang Ying,Zhang Zhen,Fang Bin
It has been widely recognized that the structure, composition, and morphology of materials determine their properties. Sulfur-doped nickel cobalt hydroxide (S-Ni 1− x Co x (OH) 2 ) nanostructures were synthesized directly on the surface of stainless steel wire mesh via a one-step facile electrodeposition route. Comparative experiments have shown that the presence of thiourea can inhibit the reduction of nickel and cobalt ions, while promoting the formation of hydroxides and further sulfurization, thereby obtaining sulfur-doped nickel cobalt hydroxide nanostructures. The doping of sulfur has been found to improve the specific capacities of the monometallic hydroxides (Ni(OH) 2 and Co(OH) 2 ), while the synergistic effect between Ni and Co has a more pronounced impact on energy storage performance. In addition, the molar ratio of nickel to cobalt can affect the morphology of material. S-Ni 0.5 Co 0.5 (OH) 2 with a favorable morphology of nanosheet array, and porous structure exhibits the highest specific capacity, optimal rate performance, and improved cycling stability among the studied electrodes. In 1 M KOH electrolyte, the specific capacities of S-Ni 0.5 Co 0.5 (OH) 2 electrode at current densities of 1 and 10 A g −1 are 488 and 275 C g −1 , respectively, and the capacity retention is 56.6% after 10,000 cycles at the current density of 10 A g −1 .
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BULLETIN OF MATERIALS SCIENCE
·
2024
·Vol. 47
·期 3
·1-13
·
IF 1.9
Ji Xiaoli,Ma Qianqian,Liu Jian,Yuan Haoze,Ma Xukai
Titanium dioxide/multi-walled carbon nanotubes (TiO 2 /MWCNTs) are nanocomposites (NCs) prepared via click reaction of TiO 2 nanoparticles (TiO 2 NPs) with azide groups (TiO 2 –N 3 ) on the surface and MWCNTs with alkynyl groups (MWCNTs–ALK) on the surface. The phase structure, graphitization degree, structure, elemental composition, the microstructure of TiO 2 /MWCNTs NCs were characterized by XRD, Raman, IR, XPS and SEM, and their electromagnetic (EM) parameters were determined by the vector network analyser. For TiO 2 /MWCNTs NCs with click reaction, the minimum reflection loss (RL min ) is up to −47.87 dB at 12.02 GHz, the matching thickness is 2.0 mm, and the bandwidth is lower than −10 dB in the range of 7.7–12.48 GHz. Compared with the physically mixed TiO 2 /MWCNTs composites, TiO 2 /MWCNTs NCs prepared by click reaction show more excellent EM absorption properties, which is mainly due to the binding of covalent bonds between the two kinds of materials that lead to the enhancement of interfacial effects, the improvement of impedance matching and the increase of electron migration.
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MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 5
·1-12
·
IF 5.3
Wei Zhanxiang,Qin Cong,Yang Xuhui,Zhu Linghao,Zhao Xiaoyan,Cao Jianliang,Wang Yan
Abstract The detection of hazardous CO gas is an important research content in the domain of the Internet of Things (IoT). Herein, we introduced a facile metal-organic frameworks (MOFs)-templated strategy to synthesize Cd-doped Co 3 O 4 nanosheets (Cd-Co 3 O 4 NSs) aimed at boosting the CO-sensing performance. The synthesized Cd-Co 3 O 4 NSs feature a multihole nanomeshes structure and a large specific surface area (106.579 m 2 ·g -1 ), which endows the sensing materials with favorable gas diffusion and interaction ability. Furthermore, compared with unadulterated Co 3 O 4 , the 2 mol % Cd-doped Co 3 O 4 (2% Cd-Co 3 O 4 ) sensor exhibits enhanced sensitivity (244%) to 100 ppm CO at 200 °C and a comparatively low experimental limit of detection (0.5 ppm/experimental value). The 2% Cd-Co 3 O 4 NSs show good selectivity, reproducibility, and long-term stability. The improved CO sensitivity signal is probably owing to the stable nanomeshes construction, high surface area, and rich oxygen vacancies caused by cadmium doping. This study presents a facile avenue to promote the sensing performance of p-type metal oxide semiconductors by enhancing the surface activity of Co 3 O 4 combined with morphology control and component regulation. Graphical Abstract
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