CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Yu Wang,Haojie Yu,Li Wang,Lei Zhang,Jinyi Liu,Dingning Chen,Jian Yang,Chenguang Ouyang,Jian Hu,Jingyi Feng,Chengjiang Li
Severely diabetic patients need insulin input to maintain the body's glycemic balance. However, traditional injection methods are often associated with poor adherence and an increased risk of hypoglycemia. Microneedle technology offers a promising solution by minimizing pain and trauma during insulin administration. Nonetheless, achieving prolonged glycemic control by microneedle with high insulin loading remains a significant challenge. Herein, we introduce an innovative microneedle patch that draws inspiration from the elegant light-induced blooming of water lily petals. The patch features a glucose-responsive hydrogel network crafted from two modified polysaccharide polymers, which enables the delivery of long-acting insulin without depending on glucose oxidase. By incorporating phenylboronic acid-modified sodium alginate, quaternary ammonium chitosan, and polyvinyl alcohol into a hydrogel matrix, we have created a microneedle system that harbors dynamic borate ester linkages and electrostatic attractions, resulting in heightened sensitivity to blood glucose levels. The electrostatic interaction acts as a relatively stable crosslinking point, balancing the dynamic reproducibility response based on the borate ester bond. This self-adaptive hydrogel can regulate insulin-controlled release by responding to changes in glucose concentration. Herein, we achieved massive insulin loading (20 IU) with long lasting glycaemic control (48 h) in a single treatment of diabetic SD rats.
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Foods
·
2025
·Vol. 14
·期 2
·181
·
IF 5.1
Hongyan Li,Ying Zong,Weijia Chen,Yan Zhao,Jianan Geng,Zhongmei He,Rui Du
Deer oil (DO) is a potentially beneficial functional oil; however, its sensitivity to environmental factors (e.g., oxygen and heat), difficulty in transport, and unfavorable taste hinder practical use. In this study, DO was encapsulated through the cohesive action of soy protein isolate (SPI) and chitosan (CS). The optimal preparation conditions yielded microcapsules with DO’s highest encapsulation efficiency (EE) (85.28 ± 1.308%) at an SPI/CS mixing ratio of 6:1 and a core-to-wall ratio of 1:2 at pH 6. Fluorescence and scanning electron microscopy were utilized to examine the microcapsules’ structure, showing intact surfaces and effective encapsulation of oil droplets through SPI/CS composite coalescence. Through Fourier transform infrared spectroscopy (FTIR), the electrostatic interplay between SPI and CS was verified during the merging process. At room temperature, the microcapsules resisted core oxidation by reducing gas permeation. In vitro simulated digestion results indicated the microcapsules achieved a slow and sustained release of DO in the intestinal tract. This study further expands the application scope of deer oil and promotes the development of deer oil preparations and functional foods.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xinxin Wang,Ruixue Meng,Shiyong Zhao,Zhenyu Jing,Yonghui Jin,Jie Zhang,Qiujiu Du,Xinxin Pi,Long Chen,Yanhui Li
To ensure the sustainable development of the nuclear industry, the effective capture of radioiodine from nuclear wastewater has attracted much attention. Herein, a novel MIL-88A(Al)/chitosan/graphene oxide (MCG) composite aerogel was prepared by using crosslinked chitosan and graphene oxide as the 3D network skeleton, and MIL-88A(Al) nanocrystalline particles were introduced into the skeleton by freeze-drying method. MIL-88A(Al) adsorption capacities for volatile and soluble iodine were 2.02 g g −1 and 850.00 mg g −1 , respectively. Owing to the synergistic effect of MIL-88A(Al), GO, CS, and the hierarchically porous structures of the MCG aerogel, the adsorption capacities for volatile and soluble iodine by the MCG aerogel were increased to 2.62 g g −1 and 1072.60 mg g −1 , respectively. Furthermore, the adsorption performance of the MCG aerogel for volatile and soluble iodine could be maintained at 83 % and 82 % after 5 cycles, suggesting excellent recoverability. Meanwhile, the adsorption mechanism studies showed the interactions between iodine and N H, Al O, and C O in MCG aerogel. Furthermore, the adsorption process is consistent with the Elovich kinetic and Sips isotherm models. MCG aerogels are potential candidates for enhanced radioiodine adsorption due to their high radioiodine capture performance and excellent recyclability.
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Nature Communications
·
2024
·Vol. 15
·期 1
·1-15
·
IF 14.7
Zhu Wenjun,Wei Ting,Xu Yuchun,Jin Qiutong,Chao Yu,Lu Jiaqi,Xu Jun,Zhu Jiafei,Yan Xiaoying,Chen Muchao,Chen Qian,Liu Zhuang
Transdermal drug delivery has been regarded as an alternative to oral delivery and subcutaneous injection. However, needleless transdermal delivery of biomacromolecules remains a challenge. Herein, a transdermal delivery platform based on biocompatible fluorocarbon modified chitosan (FCS) is developed to achieve highly efficient non-invasive delivery of biomacromolecules including antibodies and antigens. The formed nanocomplexes exhibits effective transdermal penetration ability via both intercellular and transappendageal routes. Non-invasive transdermal delivery of immune checkpoint blockade antibodies induces stronger immune responses for melanoma in female mice and reduces systemic toxicity compared to intravenous injection. Moreover, transdermal delivery of a SARS-CoV-2 vaccine in female mice results in comparable humoral immunity as well as improved cellular immunity and immune memory compared to that achieved with subcutaneous vaccine injection. Additionally, FCS-based protein delivery systems demonstrate transdermal ability for rabbit and porcine skins. Thus, FCS-based transdermal delivery systems may provide a compelling opportunity to overcome the skin barrier for efficient transdermal delivery of bio-therapeutics.
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Drug Delivery and Translational Research
·
2024
·
IF 5.7
Zhang Wei,Zhang Qian,Yang Yuhan,Chen Yangyi,Wei Jinbin,Lu Fenglai,Li Dianpeng
A novel multi-functional micelle delivery system was developed for enhancing the oral absorption of paclitaxel (PTX). The delivery carriers were constructed by modifying chitosan-stearic acid (CS-SA) micelles with L-carnitine (LC) and co-encapsulating quercetin (Que), and the PTX-loaded micelles were prepared by film-sonication dispersing technique. The as-prepared micelles showed homogeneous spherical shapes with a small particle size of 148.3 ± 1.7 nm, high drug loading of 7.05% and low critical micelle concentration (CMC) of 16.89 µg/ml. Compared to the in-house PTX formulation similar to the commercial injection Taxol™, the target PTX-loaded micelles had obvious sustained-release effects and exhibited an oral relative bioavailability of 168.08%. The cellular uptake studies of Caco-2 cells confirmed the micellar modification of LC and the co-loading of Que played important roles in promoting the absorption of drug loaded in micelles. The CYP3A4 enzyme test demonstrated the micelles had an inhibitory effect on the metabolic enzyme due to the presence of Que. These findings confirmed the potential of the multi-functional chitosan polymeric micelles based on synergistic effect as an effective oral delivery system. Graphical abstract
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Journal of Environmental Chemical Engineering
·
2024
·
IF 7.4
Linshuang Liu,Haipeng Song,Shiqi Zhao,Huan Zhang,Peng Chen,Jingjing Wu,Feifei Jia,Shaoxian Song
Based on the strong activation activity and affinity of Co and MoS 2 for peroxymonosulfate (PMS), respectively, in this study, a CoS 2 /MoS 2 @chitosan (CoS 2 /MoS 2 @CS) gel with favorable photo responsive behavior was synthetically synthesized for more potent degradation of tetracycline (TC). It was found that CoS 2 /MoS 2 @CS had excellent catalytic active for the degradation of TC under visible light irradiation. The presence of CoS 2 /MoS 2 interfacial structure improve the electron transfer ability of the MoS 2 interface, and the degradation rate of TC was increased from 0.0106 min −1 to 0.0463 min −1 , with a high degradation rate of 97.4 %. CoS 2 /MoS 2 can effectively degrade TC within 5 cycles, demonstrating superior cycling stability. In addition, the system degraded different organic pollutants (tetracycline (TC), tetracycline hydrochloride (TCH), crystal violet (CV), and methylene blue (MB)) with a degradation rate higher than 96 %, which supports the ability of the CoS 2 /MoS 2 @CS-PMS system to degrade various chemical contaminants. Quenching analysis indicates that SO 4 •− is the primary reactive chemical free radical for the degradation of TC in the CoS 2 /MoS 2 @CS-PMS system. It provides an approach of combining the synergistic action of Co (II) and photogenerated carriers for more efficient activation of PMS that some inspirations of heterojunction catalysts for AOP applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yongliang Ouyang,Xiaoju Su,Xiaoyi Zheng,Liang Zhang,Zheng Chen,Qiling Yan,Qinyuan Qian,Jiulong Zhao,Ping Li,Shige Wang
Hydrogels have been widely used as wound dressings to accelerate wound healing . However, due to the impaired skin barrier at the wound site, external bacteria can easily invade the wound and cause infection. In this study, we designed a dopamine-modified sodium alginate/carboxymethyl chitosan/polyvinylpyrrolidone (CPD) hydrogel, which was able to promote wound healing while preventing wound infection. Due to the high content of catechol groups, the CPD hydrogel exhibited good tissue adhesion ability and a significant scavenging ability for DPPH• and PTIO• radicals. Under near-infrared laser irradiation, the temperature of CPD hydrogel increased significantly, which significantly killed the Staphylococcus aureus and Escherichia coli . The cell migration test confirmed that CPD hydrogel could promote the cell migration ratio. In the in vivo wound healing test for infected full-thickness skin defect, CPD hydrogel significantly inhibited bacterial proliferation and enhanced wound healing rate. Therefore, the multifunctional hydrogel is expected to be applied to wound healing.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Wenbiao Nie,Wenzhen Zhong,Lin Qian,Huiyun Zhong,Yusen Hou,Haiting Xu,Shanshan Qi,Linxin Dai,Xiaoqin Han,Xinyue Yang,Runchun Xu,Yao He,Dasheng Lin,Fei Gao
The food-derived ingredients Rhein (RH) and chlorogenic acid (CGA) have DEMONSTRATED a potential synergistic effect in the treatment of ulcerative colitis (UC) through their anti-inflammatory and antioxidant properties. However, the oral co-delivery of RH and CGA faces challenges such as differences in hydrophilicity and hydrophobicity, gastrointestinal instability, and inadequate colonic targeting. To address these issues, shell-core nanoparticles were developed for the co-encapsulation of RH and CGA (CP@CGA-FA/TA@RH NPs). These nanoparticles utilize cyclodextrin-based polymers and folate-amantadine polymers to form a supramolecular core that targets macrophages for anti-inflammatory action with RH, while chitosan cross-link to CGA in the outer shell provides microenvironment-sensitive antioxidant release. The results indicate that CP@CGA-FA/TA@RH NPs could effectively inhibit the classical TLR4/MyD88/NF-κB-mediated anti-inflammatory pathway and activate the Nrf2/HO-1-mediated antioxidant pathway, offering a novel approach to UC treatment. Q-value analysis confirms the substantial co-medication effect between RH and CGA. This study is the first to develop a nano-system combining two food-derived ingredients for the integrated treatment of UC.
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CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Yanjun Huang,Hailing Wu,Taikang Shao,Xia Zhao,Hong Peng,Yuefa Gong,Huihai Wan
A novel composite adsorbent of Ca-DTCS/ALG bead was prepared by immobilization of DTPA-modified chitosan micro-gels (DTCS) into the alginate matrix. The copper sorption properties of Ca-DTCS/ALG beads were tested and compared with the other two adsorbents of DTCS powder and plain alginate (ALG) beads. In addition, the mechanisms of copper sorption on the adsorbents were investigated by FTIR and XPS analysis. Similar to DTCS powder, Ca-DTCS/ALG beads exhibited high copper removal efficiency in strongly acidic solutions, whereas calcium, sodium and aluminum salts had little effect on its copper adsorption capacities. The maximum adsorption capacities of Ca-DTCS/ALG and DTCS were 107.5 and 106.0 mg g −1 at pH 3.0, respectively, which were close to the values predicted by the Sips model. However, the maximum adsorption capacity of ALG beads predicted by the Sips model was much higher than its experimental one (101.1 mg g −1 ). The copper adsorption equilibrium by DTCS powder was achieved within 1 min, nevertheless, ALG and Ca-DTCS/ALG gel beads reached the adsorption equilibrium within 500 min and 1440 min, respectively. Moreover, Ca-DTCS/ALG gel beads showed good reusability, but DTCS powder was not easily reused due to its notable swelling property. Furthermore, the efficiency of copper recovery by Ca-DTCS/ALG beads in the simulated electroplating wastewater at the copper concentration of 1–5 mg L −1 was much higher than that of DTCS and ALG beads. These results reveal that immobilization of DTCS into the alginate matrix greatly improves the adsorption and separation performance of the adsorbent.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Beibei Wang,Xiaodeng Yang,Congde Qiao,Yan Li,Tianduo Li,Chunlin Xu
The effects of N -(2-hydroxyl)-propyl-3-trimethylammonium chitosan chloride (HTCC) on the physicochemical properties of sodium carboxymethyl cellulose (CMC)-based films were investigated. The prepared HTCC/CMC film-forming solutions (FFSs) with varying mass ratios exhibited shear-thinning behavior and typical pseudo-plasticity. The highest apparent viscosity and lowest crossover frequency was obtained for the HTCC/CMC FFS with a mass ratio of 10%, due to the formation of the strongest intermolecular interactions, which also led to the best mechanical properties. Furthermore, the effects of temperature and degree of substitution of HTCC on the composite film properties were also investigated. Structural property assessment by FTIR, SEM, and DSC showed a clear interaction between HTCC and CMC, leading to the formation of a new composite material with enhanced physicochemical properties. The data demonstrate the importance of HTCC in CMC-based films for food and drug packaging.
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Nuclear Engineering and Technology
·
2017
·
IF 1.144
Shuting Zhuang,Yanan Yin,Jianlong Wang
Chitosan was modified by gamma radiation–induced grafting with maleic acid and then used for the removal of cobalt ions from aqueous solutions. Chitosan-g-maleic acid was characterized by Fourier Transform infrared spectroscopy (FT-IR). The effect of the dose (1–5 kGy) and monomer concentration (0.3–1.3%, m/v) on the grafting ratio was examined. The adsorption kinetics and isotherms were also investigated. The results showed that the optimal dose for grafting was 2 kGy. When monomer concentration was within the range of 0.3–1.3% (m/v), the grafting ratio increased almost linearly. For the adsorption of cobalt ions by chitosan-g-maleic acid beads, the pseudo second-order kinetic model (R 2 = 0.99) and Temkin isotherm model (R 2 = 0.96) were able to fit the experimental data reasonably well. The equilibrium adsorption capacity of cobalt ions increased from 2.00 mg/g to 2.78 mg/g after chitosan modification.
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INTERNATIONAL JOURNAL OF FOOD PROPERTIES
·
2018
·
IF 1.845
Yongli Jiang,Chenjun Zhuang,Yu Zhong,Yanyun Zhao,Yun Deng,Haiyan Gao,Hangjun Chen,Honglei Mu
The composite bilayer film based on polyvinyl alcohol, sodium alginate, and chitosan were developed in this study, and the effects of the related coating on internal-quality changes of salted duck eggs (SDEs) during storage were determined. The results showed that the overall properties of the bilayer film were better than those of monolayer films, including storage stability. Coatings could significantly (p < 0.05) reduce quality deterioration of SDEs such as water loss, oil exudation, and gritty. The bilayer coating was more effective in inhibiting the increase of egg yolk pH and total bacterial counts than monolayer coatings. After storage for 60 days, water content of bilayer coated SEDs was 19.7% higher than that of the control SDEs, oil exudation was 38% higher, and gritty texture was 27.9% higher. Moreover, bilayer coating could prolong the shelf life of SDEs to more than 60 days at 25°C and 50% relative humidity according to the results of total bacterial count experiment, while the shelf life of control SDEs was less than 45 days. This study indicated the potential application of bilayer composite coating for preservation of SDEs.
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