SOLAR ENERGY MATERIALS AND SOLAR CELLS
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2025
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IF 6.3
Yi Zhang,Huilong Chen,Junfeng Qu,Rui Wang,Shuhong Xu,Jiayu Zhang,Gavin Conibeer
The hot carrier multi-junction solar cell (HCMJSC) is an advanced concept solar cell with a theoretical efficiency greater than 65 %, which consists of a thin top junction with a wide bandgap and a thick bottom junction with a narrow bandgap to absorb high and low energy photons, respectively. Wide bandgap perovskites are expected to be a suitable candidate for top absorption layers due to their ease of band engineering. However, the carrier thermalization mechanisms of quaternary A-site perovskites have not been well studied until now. Conventionally, the incorporation of larger A-site cations induces lattice expansion and enhances thermal fluctuations, thereby accelerating carrier cooling. In this work, the incorporation of guanidinium (GA) did not immediately shorten the cooling process but instead exhibited a non-monotonic trend, initially slowing then accelerating the thermalization process. The thermalization coefficients ( Q th ) of the quaternary A-site perovskites with different GA doping ratio were obtained from the power dependent-steady state photoluminescence spectra. Moderate addition of GA can prolong the thermalization process of the hot carriers and reduce Q th , which will improve power conversion efficiency, with the optimal effect achieved at 3 % GA incorporation in the A-site. This work lays the foundation for a theoretical framework that incorporates perovskite materials which may be suitable as the top absorption layer of HCMJSC.
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Journal of Environmental Sciences
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2025
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IF 6.3
Xiaotian Huang,Zuhong Lin,Denglong Lu,Haipu Li
Perfluorooctanoic acid (PFOA) is a persistent toxic chemical that enters the human body through the food chain and causes harm. In this study, human thyroid follicular epithelial cells (Nthy-ori3-1 cells) were used as a model. PFOA was shown to reduce cell viability through a cell activity assay. Notably, at a concentration of 100 μmol/L, PFOA enhanced the activity of antioxidant enzymes ((Total superoxide dismutase (T-SOD), catalase (CAT), glutathione (GSH), total Antioxidant Capacity (T-AOC)), while the level of intracellular reactive oxygen species (ROS) remained elevated. PFOA triggered oxidative stress by inducing abnormal ROS levels, which subsequently exacerbated the inflammatory response and affected cellular activity. Therefore, pretreatment with 10μmol/L EVP4593 (QNZ, an NF-κB inhibitor) increased the percentage of normal cells from 74.06 % to 83.74 % at 1 μmol/L PFOA. Molecular docking and molecular dynamics indicated that QNZ competitively inhibited the interaction between PFOA and nuclear factor kappa-B (NF-κB) proteins. Correspondingly, Western blotting and qPCR analyses confirmed that QNZ suppressed the expression of apoptosis-related proteins ((Tumor protein p53 (P53), tumor necrosis factor-alpha (TNF-α), Bcl2-associated X (BAX), B-cell lymphoma-2 (BCL-2), cysteine aspartate protease-3 (Caspase-3), NF-κB) and their related genes. Additionally, PFOA prompted cells to release T4 and T3. This study not only elucidates the toxic effects of PFOA on cells, but also reveals the defense mechanism by which QNZ effectively alleviates cell toxicity.
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PubMed
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CELLULAR SIGNALLING
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2025
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IF 3.7
YaoNan Han,XingTong Wang,DeShui Yu
Spinal cord injury (SCI) is a serious central nervous system disease. Ferroptosis is one of the major causes of spinal cord neurological loss, and targeting ferroptosis is a promising therapeutic strategy. Roflumilast has shown promising applications in the treatment of neurological diseases due to its potent anti-inflammatory and anti-oxidative stress effects. This study aimed to investigate whether roflumilast could inhibit neuronal ferroptosis to improve motor function after SCI in rats. In vitro experiments, we found that roflumilast significantly increased cell survival in an in vitro ferroptosis model, improved mitochondrial function, reduced intracellular iron, reactive oxygen species (ROS), and lipid peroxides accumulation as well as the expression of the pro-ferroptosis proteins, long-chain acyl-coenzyme A synthase 4 (ACSL4), and prostaglandin-endoperoxide synthase 2 (PTGS2), and increased the expression of ferroptosis-inhibitory protein glutathione peroxidase 4 (GPX4), and ferritin heavy chain 1 (FTH1) expression. Mechanistically, these protective effects were achieved by activating AMP-dependent protein kinase (AMPK)/nuclear factor E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling and were attenuated when AMPK signaling was blocked. In vivo experiments, roflumilast attenuated spinal cord tissue damage, increased the number of motor neuron survivors, and improved motor function after SCI in rats. Overall, activation of AMPK/Nrf2/HO-1 signaling by roflumilast attenuated neuronal ferroptosis and improved motor function after SCI in rats.
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CHEMICAL ENGINEERING JOURNAL
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2026
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IF 13.2
Liuzi Du,Xiaodong Zhai,Jianchun Wu,Xiaowei Huang,Xiaobo Zou,Zhihua Li
To address the challenge of short shelf life and microbial contamination in food preservation, this study aims to develop an intelligent pH-responsive antibacterial fiber film with controlled release capability. The modification of alkaline lignin improved the structural stability and specific surface area of HKUST-1 (from 547 to 1483 m 2 /g), while the composite film exhibited excellent mechanical properties (tensile strength: 3.74 MPa, elongation: 96.25%) and hydrophobicity (water contact angle: 120.55°). The film exhibited strong pH-dependent controlled release, with 81% of antibacterial agents released at pH 6.0 within 120 h. In vitro antibacterial tests demonstrated broad-spectrum activity against Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ), and Pseudomonas aeruginosa ( P. aeruginosa ). When applied to beef preservation, the film significantly reduced total volatile basic nitrogen (15.35 mg/100 g), total viable count (6.23 log CFU/g), and pH (6.02) after 9 days of storage, extending the shelf life by 4 days compared to the control. This work provides a feasible strategy for developing intelligent pH-controlled-release antibacterial packaging materials.
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BIOCATALYSIS AND BIOTRANSFORMATION
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2021
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IF 2.181
Hongqian Dai,Yuan Lu,Hanbing Shi,Lan Tang,Xingyuan Sun,Zhimin Ou
Fe3O4 magnetic nanoparticles were prepared by chemical co-precipitation and modified with 3-aminopropyltriethoxysilane (APTES) and CS2 to form Fe3O4-APTES-CS2 magnetic carriers. Magnetically immobilized enzymes are attractive owing to their potential applications in many biological fields. When an alternating magnetic field is applied, the magnetic nanoparticles experience a force in the direction of the field, and the magnetic moments of the magnetic nanoparticles are apt to align in the direction of the field. Thus, magnetic nanoparticles behave like microscopic stirrers. The optimal reaction conditions of the acylation reaction using Fe3O4-APTES-CS2-lipase were 200 mmol/L 1-methyl-3-amphetamine, 100 mg immobilized lipase, 200 μL ethyl acetate, 12.6 × g rotating speed, 40 °C, and 5 days in the shaker. The conversion and enantiomeric excess of R-2a reached a maximum of 36.8% and 98.5%, respectively. 1-Methyl-3-phenylpropylamine was resolved using Fe3O4-APTES-CS2-lipase in an alternating magnetic field. The optimal magnetic field frequency and magnetic field intensity were determined to be 500 Hz and 12 Gs, respectively. The conversion and enantiomeric excess of R-2a reached a maximum of 40.3% and 98.5%, respectively. The results revealed that conversion under a magnetic field was significantly higher than that without a magnetic field. Highly optically active (R)-N-acetyl-1-methyl-3-amphetamine can be obtained via an efficient resolution of racemic 1-methyl-3-phenylpropylamine with immobilized lipase magnetic nanoparticles as a catalyst and ethyl acetate as an acyl donor in organic solvents in an alternating magnetic field.
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ACS Applied Nano Materials
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2021
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IF 5.097
Pengtao Tang,Haibo Shu,Mingjun Yang,Mingsong Zhang,Chuangwei Sheng,Pei Liang,Dan Cao,Xiaoshuang Chen
Monolayer transition metal dichalcogenide (TMD) alloys with tunable band gaps exhibit huge potential in nanoelectronics, optoelectronics, and photonics. The scalable production of uniform atomically thin TMD alloys is a key step for the realization of their device applications but remains a large challenge so far. Here, we report oxygen-assisted chemical vapor deposition (CVD) of uniform atomically thin MoS2(1–x)Se2x semiconductor alloys via a vertical Mo-precursor supply strategy. The growth scheme leads to the formation of highly crystalline MoS2(1–x)Se2x monolayer films within a short growth time of 8 min, which benefits from a stable and homogeneous Mo-precursor feeding environment and the synergic effect of NaBr and oxygen carrier on the growth. The high-resolution spectral characterizations and density functional theory calculations demonstrate that the chemical composition of the as-grown MoS2(1–x)Se2x monolayers can be continuously tuned from x = 0 to 1, leading to the corresponding band gap being gradually changed from 1.81 to 1.55 eV. This work provides an efficient strategy to obtain large-area uniform MoS2(1–x)Se2x monolayer alloys with tunable compositions and optical properties, which is essential for driving their applications in various functional optoelectronic devices, especially for high-performance flexible photodetectors.
研究领域:
材料科学
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纳米电子学
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光电子学
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光子学
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半导体合金
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薄膜生长
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TURKISH JOURNAL OF CHEMISTRY
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2024
·Vol. 48
·期 4
·597-619
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IF 1.3
YUAN HANG,CAO GUI-PING,LV HUI
The reaction solvent and catalyst play an essential role in the Prins reaction for the synthesis of 3-methyl-3-buten-1-ol (MBO) from formaldehyde and isobutene. The reactivity of the solid base catalyzed Prins condensation reaction by formaldehyde and isobutene in supercritical CO2 was investigated using CsH2PO4 modified HZSM-5. We finds that the alkaline sites of the alkali-loaded catalyst can extract the α-H on isobutene to generate olefin carbon negative ions, while the supercritical CO2 with weak Lewis acidity can activate formaldehyde to carbon positive ions, which can combine more easily with the carbon negative isobutene to react, thus improving the reactivity of the reaction system.
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JOURNAL OF HAZARDOUS MATERIALS
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2026
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IF 10.6
Huiliang Tang,Dawei Wang,Guozhi Deng,Qinian Wang,Chao Wu
Phthalate esters (PAEs) are ubiquitous synthetic plasticizer pollutants posing severe ecological and human health risks. This study compared microbial community structures and dibutyl phthalate (DBP) degradation kinetics of two consortia: 7-day enriched MC1 (50 mg/L DBP) and 6-cycle acclimated MC7 (50–1000 mg/L DBP), demonstrating directional DBP stress selection generated a low-diversity, highly specialized degradative community with a 25.4 mg/L/h maximum degradation rate ( V max ), 1.68-fold higher than MC1. Four dominant DBP-degrading strains were isolated from MC7; Pseudarthrobacter scleromae HL-1 showed the highest efficiency with 17.1 mg/L/h V max and complete 500 mg/L DBP removal within 72 h, broad substrate spectrum, and strong adaptability after optimization. Whole-genome sequencing and GC-MS/MS elucidated a dual-parallel DBP mineralization pathway, first reported in Pseudarthrobacter , integrating ester hydrolysis and side-chain β-oxidation. ECOSAR and Chlorella vulgaris bioassays confirmed progressive toxicity attenuation, with > 99% relative toxicity reduction after 72 h and no toxic intermediate accumulation. Natural lake water trials with trace background PAEs showed HL-1 successfully colonized aquatic environments, reshaped indigenous communities into synergistic degradative consortia, and achieved 99.2% DBP removal in 84 h. This work provides comprehensive insights into PAE biodegradation mechanisms from community to single strain and highlights HL-1 as a promising candidate for remediating PAE-polluted aquatic ecosystems.
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JOURNAL OF ETHNOPHARMACOLOGY
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2025
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IF 5.4
Xiaolin Xie,Haikang Fu,Zhixuan Ai,Ziwei Huang,Wenwen Tan,Qingfeng Xie,Yuhong Liu,Yucui Li,Jiannan Chen,Xiaobo Yang,Ziren Su,Zhengquan Lai,Jianhui Xie
Ethnopharmacological relevance Coptidis Rhizome (CR), a cornerstone medicinal herb, is routinely used to treat metabolic diseases for centuries in China. However, the potential mechanism has not been completely elucidated. Preceding investigation has reported that berberine in CR can bind to hemoglobin (Hb) and utilize erythrocyte-Hb self-assembly drug delivery system to significantly upregulate HO-1 expression. Aim of the study This study was designed in a pioneering endeavor to explore the therapeutic potential and underlying mechanism of CR in dexamethasone- and fructose-induced glycolipid metabolism disorders (GLD) rat models. Material and methods The major elements of CR were identified by high performance liquid chromatograph (HPLC). Dexamethasone- and fructose-induced rat GLD model was constructed. Glucolipid metabolism, oxidative status, and insulin sensitivity were investigated. Histopathological, transcriptomic, in silico simulations, immunofluorescence, immunohistochemistry, and Western blotting analyses were performed to gain further mechanism insight. Results HPLC analysis revealed that berberine, palmatine, coptisine, epiberberine, and jatrorrhizine were detected in CR, with berberine as the most abundant. Administration of CR favorably regulated the organ indexes, and significantly improved glucose metabolism by decreasing the FBG and GSP levels along with improved OGTT. CR promoted insulin sensitivity by suppressing the increased levels of FINS, HOMA-IR and ISI, and concomitantly improving ITT. Furthermore, CR normalized lipid metabolism by decreasing the elevated TG, TC and LDL-C levels. Additionally, CR effectively ameliorated histopathological deterioration in pancreatic and hepatic tissues and reduced serum ALT and AST activities. CR also ameliorated oxidative stress by remarkably lowering hepatic ROS fluorescence intensity and serum MDA content, whereas enhancing SOD and CAT enzymatic activity, and T-AOC level. Hepatic transcriptomics analysis revealed the oxidative stress-related gene HMOX1 encoding HO-1 and AMPK pathway critically involved in the therapeutic effect of CR. Furthermore, CR was found to significantly up-regulate the protein expression levels of HO-1, NQO1 and p-AMPK. On the other hand, in silico simulations indicated that strong van der Waals forces interaction between these alkaloids and HO-1. Notably, CR exhibited potent HO-1 agonistic activity comparable to the HO-1 inducer hemin, as manifested by enhanced HMOX1 mRNA level, HO-1 expression level, cytoplasmic HO-1 fluorescence intensity, carbon monoxide production, and reduced heme level, which were the markers of erythrocyte metabolism. Administration of CR or hemin significantly improved fasting glycemia, blood fat, insulin sensitivity, and antioxidant capacity. Nevertheless, these effects were observably reversed by the HO-1 inhibitor zinc protoporphyrin (ZnPP). Conclusion CR effectively ameliorated insulin resistance, hyperglycemia, and dyslipidemia, and its mechanism of action may be at least partially, mediated through HO-1 activation via erythrocyte metabolic regulation. This study provided further evidences for the historical use of CR in the therapy of metabolic diseases. These results highlighted the potential of CR as a novel HO-1 agonist for the development of innovative treatments for GLD.
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RENAL FAILURE
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2023
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IF 3
Chenlei Lv,Tianyang Cheng,Bingbing Zhang,Ke Sun,Keda Lu
Objectives: Diabetic nephropathy (DN) is the most common microvascular complication of diabetes mellitus. This study investigated the mechanism of triptolide (TP) in podocyte injury in DN.Methods: DN mouse models were established by feeding with a high-fat diet and injecting with streptozocin and MPC5 podocyte injury models were induced by high-glucose (HG), followed by TP treatment. Fasting blood glucose and renal function indicators, such as 24 h urine albumin (UAlb), serum creatinine (SCr), blood urea nitrogen (BUN), and kidney/body weight ratio of mice were examined. H&E and TUNEL staining were performed for evaluating pathological changes and apoptosis in renal tissue. The podocyte markers, reactive oxygen species (ROS), oxidative stress (OS), serum inflammatory cytokines, nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway-related proteins, and pyroptosis were detected by Western blotting and corresponding kits. MPC5 cell viability and pyroptosis were evaluated by MTT and Hoechst 33342/PI double-fluorescence staining. Nrf2 inhibitor ML385 was used to verify the regulation of TP on Nrf2.Results: TP improved renal function and histopathological injury of DN mice, alleviated podocytes injury, reduced OS and ROS by activating the Nrf2/heme oxygenase-1 (HO-1) pathway, and weakened pyroptosis by inhibiting the nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) inflammasome pathway. In vitro experiments further verified the inhibition of TP on OS and pyroptosis by mediating the Nrf2/HO-1 and NLRP3 inflammasome pathways. Inhibition of Nrf2 reversed the protective effect of TP on MPC5 cells.Conclusions: Overall, TP alleviated podocyte injury in DN by inhibiting OS and pyroptosis via Nrf2/ROS/NLRP3 axis.
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CERAMICS INTERNATIONAL
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2023
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IF 5.2
Chao Ma
Composite thin films consisting of (1-x)Mn 1.56 Co 0.96 Ni 0.48 O 4 /xLaMnO 3 (MCN/LM, 0.1≤x ≤ 0.9) were synthesized by chemical solution deposition, and their microstructure, cation distribution, optical, and electrical properties were investigated. The crystal structure of the composites is comprised of a mixed phase of spinel and perovskite , with gradual particle refinement as the LM content increases. At the same time, the resistance of the composite thin films decreases, primarily due to film densification and an increase in the highly conductive component. The thermal constant of the thin films increases from 3058.8 to 4236.1 K as the composite content varies. At x = 0.5, the composite exhibits the highest activation energy , which is determined by the discontinuity of grain boundaries and the energy bands influenced by the concentrations of Mn 3+ and Mn 4+ . In addition, the resonance coupling between the strong polar LM and MCN can significantly enhance the infrared light absorption at an appropriate ratio.
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Neural Regeneration Research
·
2023
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IF 6.1
Jingwen Jiang,Hong Pan,Fanxia Shen,Yuyan Tan,Shengdi Chen
Alzheimer’s disease is a progressive neurological disorder characterized by cognitive decline and chronic inflammation within the brain. The ketogenic diet, a widely recognized therapeutic intervention for refractory epilepsy, has recently been proposed as a potential treatment for a variety of neurological diseases, including Alzheimer’s disease. However, the efficacy of ketogenic diet in treating Alzheimer’s disease and the underlying mechanism remains unclear. The current investigation aimed to explore the effect of ketogenic diet on cognitive function and the underlying biological mechanisms in a mouse model of Alzheimer’s disease. Male amyloid precursor protein/presenilin 1 (APP/PS1) mice were randomly assigned to either a ketogenic diet or control diet group, and received their respective diets for a duration of 3 months. The findings show that ketogenic diet administration enhanced cognitive function, attenuated amyloid plaque formation and proinflammatory cytokine levels in APP/PS1 mice, and augmented the nuclear factor-erythroid 2-p45 derived factor 2/heme oxygenase-1 signaling pathway while suppressing the nuclear factor-kappa B pathway. Collectively, these data suggest that ketogenic diet may have a therapeutic potential in treating Alzheimer’s disease by ameliorating the neurotoxicity associated with Aβ-induced inflammation. This study highlights the urgent need for further research into the use of ketogenic diet as a potential therapy for Alzheimer’s disease.
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