CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Deng Xiao-Bo,Wei Hong-Xiu,Yang Lin,Luo Feng,Li Zhen,Tan Hong,Wang Yan-Chao,Li Jie-Hua
Enhancing the lubricating properties and antibacterial adhesion resistance of implantable medical materials is critical to prevent soft tissue injury during implantation and the formation of bacterial biofilms. Prior studies may have exhibited limitations in the preparation methodologies and long-term stability of coatings for implantable medical materials. In this study, we developed a multilayered hybrid hydrogel coating method based on the rate difference of polymerization initiation on the material surface. The acquired coating with persistent lubrication capability retained its functionality after 2×10 4 cycles of friction and 21 days of PBS immersion. A quaternary ammonium salt coating with antibacterial properties was introduced to further functionalize the coating. Animal experiments demonstrated that this coating exhibited remarkable effects on delaying encrustation and bacterial colonization. These studies indicate that this simple method of introducing lubricating and antibacterial coatings on catheters is likely to enhance the biocompatibility of medical devices and has broad application prospects in this field of medical devices.
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CHINESE JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 4
Ma Xiao-Jun,Hao Xiao-Qing,Wang Hong-Ji,Yao Han-Yu,Wang Zi-Qing,Lv Yin
The use of biomass feedstocks for the manufacture of high-performance polymers can help expand their range of applications and reduce their dependence on finite fossil resources. However, improving the heat resistance and hydrophilicity of bio-based polyesters remains a significant challenge. Herein, we introduce N,N′ - trans -1,4-cyclohexane-bis(pyrrolidone-4-methylcarboxylate) (CBPC), a novel bio-based tricyclic dibasic ester synthesized from renewable dimethyl itaconic acid and trans -1,4-cyclohexane diamine via an aza-Michael addition reaction. As a unique comonomer, CBPC features a rigid tricyclic backbone that significantly enhances chain packing and thermal stability, whereas its pyrrolidone side groups impart tunable polarity and improved hydrophilicity. Using CBPC, diphenyl carbonate, and 1,4-butylene glycol, a series of PBCC copolymers with 10 mol%–30 mol% CBPC was synthesized via ester-exchange and melt polycondensation methods. Incorporation of CBPC raised the melting temperature ( T m ) from 56.8 °C to 225.8 °C and the initial decomposition temperature ( T d5% ) from 258.0 °C to 306.7 °C, positioning PBCC among the most heat-resistant bio-based polyesters reported. Additionally, the pyrrolidone units enabled transformation from hydrophobic to hydrophilic. This study demonstrates that CBPC is an effective and innovative building block for the design of bio-based polymers with enhanced thermal and surface properties, offering a promising strategy for the development of high-performance sustainable materials.
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BMC BIOTECHNOLOGY
·
2025
·Vol. 25
·期 1
·1-18
·
IF 3.4
Zhou Hang,Xie Lu Yi,Hu Jiu Ping,Zhou Li Hong,Lu Ling Qing,Yang Yi,Zhang Rong Rong,He Yun Xue,Ren Ming Zheng
During the fermentation of small-leaved Kuding tea by Aspergillus cristatus , significant fluctuations in environmental osmotic pressure can affect the growth and metabolism of A. cristatus , thereby influencing the quality of the fermented tea. To investigate osmotic pressure effects on its metabolism, this study used NaCl (0%, 4%, 8% and 12%) in small-leaved Kuding tea medium to establish osmotic gradients, followed by morphological observation, in vitro antioxidant activity assays, and liquid chromatography‒mass spectrometry (LC‒MS) nontargeted metabolomics analysis. The results demonstrated that the NaCl concentration had significant effects on colony morphology and metabolites. The colony diameters and antioxidant activities were significantly greater at 4% and 8% NaCl than at 0% or 12% NaCl. Nontargeted metabolomics identified 556 differential metabolites, 93 of which common differential metabolites covered seven categories, such as amino acids, organic acids and flavonoids. Under 4% NaCl, key antioxidants (melatonin, erythritol, and luteolin) significantly accumulated, which correlated with the activation of the core metabolic pathways, including tryptophan metabolism and flavonoid biosynthesis. Hypertonic stress (12% NaCl) suppressed these core pathways, leading to the induction of repair metabolites (e.g., methyl jasmonate). Low salt (0% NaCl) also inhibited core pathways, leading to a reduction in broad-spectrum antioxidant capacity and an accumulation of specific metabolites (e.g., xanthoxylin). Aspergillus cristatus dynamically regulates metabolism to adapt to different salt concentrations, with 4%-8% NaCl optimal for achieving maximal growth–antioxidant defense equilibrium in small-leaved Kuding tea. These findings provide a foundation for optimizing fermented tea processes and high-antioxidant products.
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Ecological Processes
·
2025
·Vol. 14
·期 1
·1-17
·
IF 3.9
Zhang Hanyue,Du Yan,Pan Hongbing,Li Min,Hu Shiwen,Tang Yuanyuan,Wang Hanjie,Liu Xin,Hu Bin,Bao Weikai
Background Deforestation for terraced orchards, a common agricultural development pattern in mountainous ecosystems, drastically modifies soil physicochemical and biological properties. This conversion can affect soil microbial carbon use efficiency (CUE), which is a crucial indicator of soil carbon dynamics. However, the impact of this conversion on CUE remains unclear. Understanding how deforestation affects CUE will help predict soil carbon dynamics and guide the development of sustainable ecosystem strategies in fragile mountainous areas. Methods Herein, the response of CUE to environmental variations induced by deforestation for terraced orchards in an arid valley was explored. We quantified CUE using the 18 O-labeled water addition method. To identify the underlying driving factors, soil properties and microbial parameters were measured concurrently. Results Microbial CUE declined significantly after forest conversion to terraced orchards. Multiple factors, including soil micro-environmental conditions, stoichiometric traits, enzymatic properties, and microbial community attributes, were all closely associated with CUE. Furthermore, hierarchical partitioning analysis revealed soil stoichiometric traits as the primary drivers of CUE reduction, especially traits associated with the C:N and C:P ratios. During the conversion process, mechanical compaction and horizon inversion increased soil bulk density and clay content, thereby reducing soil aeration. These micro-environmental constraints were closely linked to intensified imbalances in the C:N and C:P ratios between microbes and soil. Along with the reduced soil C:N ratio, these stoichiometric shifts made it more difficult for microorganisms to obtain resources. Therefore, microbial C limitation intensified, soil microbes shifted from being primarily limited by P in forests to being co-limited by C and P in terraced orchards, which in turn stimulated greater microbial investment in resource-acquiring hydrolytic enzymes. Consequently, CUE declined because microbial growth decreased more significantly than microbial respiration. Conclusion In summary, deforestation for terraced orchards in the arid valley reduced CUE by constraining soil micro-environments and resource conditions. These findings advance our understanding of CUE variations following deforestation and have important implications for soil carbon cycling in vulnerable mountain ecosystems.
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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2025
·
IF 3
Zhang Wen,Zhang Ning,Gao Jianyang,Liu Fusheng,Zhang Yang,Xu Guang-Rui,Wang Lei
Recently, zinc-air batteries have been of great interest due to their high theoretical specific energy that plays an important role in renewable energy conversion, while the sluggish kinetics of their half-reactions of oxygen reduction and oxygen evolution (ORR/OER) limit their widespread applications. Herein, we report the synthesis of self-assembly Ni@PdNiO x seashell-like nanostructures (Ni@PdNiO x NSs) with low Pd content through a novel one-step wet chemical method for the first time. The optimized self-assembly Ni@PdNiO x NSs with a thickness of 2.06 nm are connected self-assembled to form a network structure, which exhibits a large surface area and unprecedented ORR/OER with a positive half-wave potential of 0.892 V vs. RHE and an overpotential of 230 mV at 10 mA/cm 2 in alkaline solution, outperforming most of the PdNi catalysts. When the self-assembly Ni@PdNiO x NSs are applied as electrodes for zinc-air batteries, they deliver a high power density of 88.9 mW/cm 2 and an impressive energy density of 714 mA·h·g −1 . This work opens up a new strategy for generating superior oxygen electrocatalysis and provides new insight into the correlation of low Pd content and Ni in the improvement of alkaline oxygen electrocatalysis.
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 11
·1-15
·
IF 2.4
Yang Dawei,Hu Yanan,Qi Zhiwei,Li Qiaoling,Yu Chengcheng
The world is currently facing the dual challenges of energy scarcity and environmental degradation. As a highly promising carrier of clean and renewable energy, hydrogen has attracted significant attention, with high-efficiency water electrolysis recognized as a key pathway for the large-scale production of green hydrogen. Among various electrocatalysts, transition metal Co-V-based materials demonstrate remarkable potential. In this study, we successfully synthesized a highly stable amorphous Co-V-B catalyst on a nickel foam (NF) substrate by constructing a Co-V bimetallic system followed by boron doping to enhance its performance. Electrochemical evaluations indicated that the catalyst delivers superior Hydrogen evolution reaction (HER) performance, requiring only 47 mV overpotential to attain a current density of − 10 mA cm −2 , along with a low charge transfer resistance of 1.14 Ω. Additionally, the catalyst demonstrated remarkable durability, sustaining stable HER activity during 16 h of continuous chronopotentiometric (CP) operation. This study systematically explores the preparation of Co-V/NF catalysts and highlights the significant impact of boron incorporation on improving catalytic performance, providing meaningful guidance for developing advanced electrocatalysts for water splitting applications. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-16
·
IF 15.7
Wu Sheng,Wang Shunyu,Shao Zhigang,Wang Yinzhen,Xiong Puxian
Near-infrared mechanoluminescent (NIR ML) materials attract considerable attention for their force-to-light conversion capabilities. However, current materials generally have disadvantages such as high threshold and poor self-recovery ability, which limit their practical applications. Herein, we present a self-powered NIR ML material MgF 2 :Cr 3+ , which does not require pre-charging process. Leveraging the structural similarity between MgF 2 and MgO, we design a MgO/MgF 2 :Cr 3+ heterojunction piezo-photonic system that exhibits high intensity, low activation threshold, and excellent self-powered ML performance. By tuning the molar ratio of MgO to MgF 2 , the optimized ML intensity enhances by ≈18 times. Kelvin probe force microscopy surface potential measurement reveals a significant built-in electric field at MgF 2 :Cr 3+ heterojunction interface. Based on the first-principle calculation results, the excellent ML performance originates from the offset of the valence band and the conduction band in the MgO/MgF 2 :Cr 3+ heterostructure and the narrowing of the band gap, which significantly improve the electron (4.09 × 10 2 cm 2 V -1 s -1 ) and hole (4.62 × 10 2 cm 2 V -1 s -1 ) mobility, thereby boosting charge transfer and recombination processes. This study provides a strategy for designing high-performance self-powered NIR ML materials based on interfacial effects, offering insights into their expanded applications in the potential bio stress related biological field.
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BMC GASTROENTEROLOGY
·
2025
·Vol. 25
·期 1
·1-14
·
IF 2.6
Yuan Zuohui,Yang Xiaoping,Wang Xiaochun,Shi Xinlong,Chen Jia,Huang Lijun,Yang Jie,Shi Yuping,Zhang Liping,Mai Ping
Section
Background
This study aimed to investigate the effects of melatonin on diarrhea and visceral hypersensitivity in rats with diarrhea-predominant irritable bowel syndrome (IBS-D) and to explore its potential mechanisms through modulation of the TLR4/MyD88/NF-κB pathway.
Section
Methods
Adult male Sprague-Dawley (SD) rats were used to establish an IBS-D model through a combination of chronic and acute stress. The rats were randomly divided into four groups: healthy control (HC), IBS-D, IBS-D + melatonin 5 mg/kg (M-L), and IBS-D + melatonin 10 mg/kg (M-H), with six rats in each group. Visceral sensitivity was assessed using the abdominal withdrawal reflex (AWR). The expression levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in colon tissue were measured using enzyme-linked immunosorbent assay (ELISA). Western blotting and immunohistochemistry were employed to detect the expression of TLR4, MyD88, and NF-κB proteins in colon tissue. Additionally, 16 S rRNA sequencing was used to analyze the composition of the intestinal microbiota.
Section
Results
Compared to the HC group, the IBS-D group exhibited colonic inflammatory injury, increased AWR scores, elevated levels of TNF-α, IL-6, TLR4, MyD88, and NF-κB in the colon, and altered intestinal microbiota composition. Melatonin treatment reduced colonic inflammatory injury, decreased AWR scores, and lowered the levels of TNF-α, IL-6, TLR4, MyD88, and NF-κB in a dose-dependent manner. The intestinal microbiota composition in melatonin-treated groups showed a trend towards that of the HC group.
Section
Conclusion
Melatonin improved diarrhea and visceral hypersensitivity in IBS-D rats, potentially through the modulation of the TLR4/MyD88/NF-κB pathway and partial restoration of the intestinal microbiota.
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Human Cell
·
2025
·Vol. 38
·期 6
·1-17
·
IF 3.1
Li Qingsheng,Liu Yuxi,Zhang Lin,Zheng Yi,Feng Xiaofan,Wang Yanjie
The occurrence of tumor metastasis is associated with the phenotype of tumor-associated macrophages (TAMs). Within the tumor microenvironment, TAMs undergo metabolic reprogramming. Aerobic glycolysis contributes to TAM polarization into an M2-like phenotype. Cedrol is a component extracted from herbal medicines. Anti-cancer activities of cedrol have been reported, however, its effect on the metabolic reprogramming and pro-metastatic ability of TAMs remains unclear. Here, we found that cedrol reduced THP-1-derived macrophage polarization into M2-like phenotypes. Cedrol impaired the promoting effects of TAMs on the migration and invasion of lung cancer cells. Tumor metastasis in C57BL/6 mice was reduced following cedrol treatment, accompanied by decreases in M2-like TAMs in the lung tissues. Cedrol treatment decreased glucose consumption and lactate production and downregulated glycolysis-associated gene expression. A glycolytic inhibitor (2-DG) was utilized to confirm that suppression of glycolysis in TAMs limited the metastasis of lung cancer cells. MYC was identified as a downregulated gene in cedrol-treated TAMs based on the mRNA sequencing analysis. MYC overexpression could reverse the effects of cedrol on TAMs. Cedrol treatment reduced MYC expression at least partly via the PI3K-Akt pathway. These findings suggest that cedrol exerts anti-tumor effects by inhibiting TAM polarization into an M2-like phenotype by modulating MYC-mediated aerobic glycolysis, indicating cedrol as a potential drug for lung cancer treatment.
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Frontiers of Chemical Science and Engineering
·
2017
·Vol. 12
·期 1
·32-42
·
IF 1.712
Jiang Yuxia,Wang Donge,Pan Zhendong,Ma Huaijun,Li Min,Li Jiahe,Zheng Anda,Lv Guang,Tian Zhijian
Flower-like intercalated MoS 2 nanomaterials have been successfully synthesized via a microemulsionmediated hydrothermal (MMH) method, and characterized by X-ray diffraction, Raman spectroscopy, element analysis, scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy in detail. Their catalytic performance for anthracene hydrogenation was evaluated using a slurry-bed batch reactor with an initial hydrogen pressure of 80 bar at 350 °C for 4 h. The intercalated MoS 2 nanoflowers synthesized from Na 2 MoO 4 (MoS 2 -S) and H 2 MoO 4 (MoS 2 -A) as molybdenum precursors have diameters of about 150 and 50 nm, respectively. MoS 2 nanosheets on MoS 2 -S and MoS 2 -A possess stacking layer numbers of 5–10 and 2–5, and slab lengths of about 15 and 10 nm, respectively. The interlayer distances of MoS 2 -S and MoS 2 -A are both enlarged from 0.62 nm to about 0.95 nm due to the intercalation of NH4 + and surfactant molecules. The MoS 2 nanoflowers have high catalytic activities for anthracene hydrogenation. The selectivity for octahydroanthracene, a deeply hydrogenated product, over MoS 2 -A is 89.8%, which is 31.0 times higher than that over commercial bulk MoS 2 . Fully hydrogenated product (perhydroanthracene) was also detected over MoS 2 nanoflowers with a selectivity of 3.7%. The enhanced hydrogenation activities of MoS 2 nanoflowers can be ascribed to the high exposure of catalytic active sites, resulting from the smaller particle size, fewer stacking layer, shorter slab length and enlarged interlayer distance of MoS 2 nanoflowers compared with commercial bulk MoS 2 . In addition, a possible growth mechanism of MoS 2 nanoflowers synthesized via the MMH method was proposed.
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Nano-Micro Letters
·
2023
·Vol. 15
·期 1
·1-13
·
IF 26.6
Liu Liming,Ma Yajie,Wang Yousheng,Ma Qiaoyan,Wang Zixuan,Yang Zigan,Wan Meixiu,Mahmoudi Tahmineh,Hahn Yoon-Bong,Mai Yaohua
A graded inverted solar cell configuration is developed by hole-transport management aiming to suppress interface defects-induced non-radiative recombination for efficient hole transport.
NiO x -based inverted PSCs present a power-conversion-efficiency over 23% with a high fill factor of 0.84 and open-circuit voltage of 1.162 volts, one of the best performances reported so far for 1.56-electron volt bandgap formamidinium-based triple-halide perovskites.
Devices show high operational stability over 1,200 h during T 90 lifetime measurement under 1-sun illumination in ambient-air conditions.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-16
·
IF 10.6
Xiao Rui,Liu Jia,Shi Lin,Zhang Ting,Liu Jie,Qiu Shuyi,Ruiz Matthieu,Dupuis Jocelyn,Zhu Liping,Wang Lin,Wang Zheng,Hu Qinghua
Background Despite recent advances the prognosis of pulmonary hypertension remains poor and warrants novel therapeutic options. Extensive studies, including ours, have revealed that hypoxia-induced pulmonary hypertension is associated with high oxidative stress. Cerium oxide nanozyme or nanoparticles (CeNPs) have displayed catalytic activity mimicking both catalase and superoxide dismutase functions and have been widely used as an anti-oxidative stress approach. However, whether CeNPs can attenuate hypoxia-induced pulmonary vascular oxidative stress and pulmonary hypertension is unknown. Results In this study, we designed a new ceria nanozyme or nanoparticle (AuCeNPs) exhibiting enhanced enzyme activity. The AuCeNPs significantly blunted the increase of reactive oxygen species and intracellular calcium concentration while limiting proliferation of pulmonary artery smooth muscle cells and pulmonary vasoconstriction in a model of hypoxia-induced pulmonary hypertension. In addition, the inhalation of nebulized AuCeNPs, but not CeNPs, not only prevented but also blunted hypoxia-induced pulmonary hypertension in rats. The benefits of AuCeNPs were associated with limited increase of intracellular calcium concentration as well as enhancement of extracellular calcium-sensing receptor (CaSR) activity and expression in rat pulmonary artery smooth muscle cells. Nebulised AuCeNPs showed a favorable safety profile, systemic arterial pressure, liver and kidney function, plasma Ca 2+ level, and blood biochemical parameters were not affected. Conclusion We conclude that AuCeNPs is an improved reactive oxygen species scavenger that effectively prevents and treats hypoxia-induced pulmonary hypertension. Graphical Abstract
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