Nature Communications
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2026
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IF 18.1
Tang Yixiang,Wan Yuchi,Yan Wei,Zhang Jiujun,Lv Ruitao
Electrochemical nitrate upgrading presents a sustainable route for repairing unbalanced nitrogen cycle. However, the low energy efficiency caused by high overpotential impedes the industrialization progress. Herein, Ru clusters supported on metal hydroxide are constructed by a universal self-corrosion strategy, and the metal-support interaction is modulated to simultaneously optimize NO 3 − adsorption and water dissociation for achieving high energy efficiency at positive potentials. The Co(OH) 2 -supported Ru with moderate metal-support interaction exhibits a high energy efficiency of 49.5% and a high NH 3 Faradaic efficiency of ~100% at positive potentials. Furthermore, a long-term stability over 1200 h is achieved at an industrial-scale current density of 200 mA cm −2 . Moreover, the assembled rechargeable hybrid battery system shows a great potential in waste upcycling and energy conversion. This work underscores the significance of metal-support interaction for promoting nitrate electroreduction at positive potentials.
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Nature Communications
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2026
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IF 15.7
Huimin Wang,Gaoran Li,Jiamin Fu,Yongqiang Yang,Chi Zhang,Junhua Zhou,Xin Cheng,Jinxing Jiang,Qiyao Huang,Hwa-Yaw Tam,Xueliang Sun,Zijian Zheng
Rechargeable zinc metal batteries are promising for large-scale energy storage due to their low cost and high safety, but their development is seriously hindered by the dendritic growth and side reactions of zinc metal anodes. To address this challenge, we report here that rational design of low-surface-tension electrolytes can enable dense nucleation and fine-grained growth of zinc. This low-surface-tension strategy leads to high stability of the solid-electrolyte interface, dendrite-free morphology and suppressed side reactions. Therefore, zinc metal anodes achieve a high average Coulombic efficiency of 99.72% over a lifespan of 8400 hours at 1 mA cm −2 /1 mAh cm −2 . Even at harsh electrochemical conditions of 10 mA cm −2 /10 mAh cm −2 , the lifespans of zinc metal anodes exceed 2200 and 300 hours at 17% and 85% depth of discharge, respectively—over 20-fold and 150-fold improvements compared with those using conventional electrolytes (2 mol kg −1 zinc trifluoromethanesulfonate with 1.5 wt% zinc acetate dihydrate). A 1.27 Ah pouch cell is demonstrated to showcase the practicability of this strategy. This work uncovers the critical role of electrolyte’s surface tension for advanced zinc metal anodes, and offers a potentially cost-effective and sustainable pathway toward commercially viable rechargeable zinc metal batteries. Rechargeable zinc batteries are promising for grid energy storage but can suffer from short circuits and side reactions. Here, the authors design low-surface-tension electrolytes that enable dense, dendrite-free zinc deposition, achieving long-lasting batteries even under harsh operating conditions.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Yi Jintao,Fu Nani,Zhong Wenhui,Liu Xia,Zhou Anqi,Li Xun
Amoxicillin (AMO), a penicillin antibiotic, and ciprofloxacin (CIP), a quinolone antibiotic, are widely used to combat bacterial infections and are frequently co-administered to enhance therapeutic efficacy. However, improper use of AMO and CIP may lead to antibiotic residues in the environment, posing serious threats to human health. The visual detection of AMO and CIP remains significant challenges. Herein, the Eu-DPA@CQDs was used for the dual-mode detection of AMO and CIP, which was synthesized by CQDs doped in europium-DPA metal-organic framework. In the colorimetric mode, the catalase-mimicking Eu-DPA@CQDs oxidized TMB to blue oxTMB. Upon addition of AMO, the oxTMB was reduced, causing color fading. Subsequent introduction of CIP restored nanozyme activity, regenerating the blue signal and enabling dual-analyte antibiotic detection. In the fluorescence mode, the Eu-DPA@CQDs probe exhibited dual emission at 440 nm and 613 nm. Upon AMO addition, the fluorescence at both wavelengths was quenched, accompanied by a color change from red to purple. In the presence of CIP, the emission at 440 nm increased and redshifted to 490 nm, while the signal at 613 nm was quenched, resulting in a multicolor transition from red to cyan. The Eu-DPA@CQDs sensor enabled rapid and dual-mode detection of AMO and CIP. The colorimetric method exhibited wide linear ranges of 0.005–25 μM for AMO and 0.007–4.25 μM for CIP, with detection limits of 1.67 nM and 3.75 nM, respectively. A visible color transition from dark blue to colorless was observed with increasing AMO concentration, while the addition of CIP reversed the signal back to dark blue. Similarly, the fluorescence detection achieved wide linear ranges from 0.005 to 30 μM for AMO and 0.005 to 15 μM for CIP, with detection limits as low as 4.74 nM and 3.11 nM, respectively, also within only 1 min. As the concentration of AMO increased, the color shifted from red to purple. In contrast, increasing CIP concentration induced a color transition from red to cyan. These color transitions were both clearly visible to the naked eye. The sensor demonstrated excellent selectivity and anti-interference capability, providing a reliable platform for accurate, sensitive, and quantitative determination of both antibiotics in real samples. Graphical abstract
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PLANT AND SOIL
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2026
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IF 4.8
Zheng Tiantian,Chi Qing,Wang Yue,Li Ting,Liu Wenzhe,Zhao Luyao,Yang Shuo,Cui Dongjie,Xu Ruqiang,Jiao Zhen,Zhang Hanfeng
Aims The escalating soil salt stress poses a severe threat to food security, while existing mitigation strategies suffer from multiple limitations. As a low-toxicity nanomaterial, carbon dots (CDs) exhibit significant potential in enhancing plant stress resistance. This study focuses on the mechanism by which CDs alleviate salt stress in wheat through regulating wheat genes and soil microorganisms. Methods Wheat plants grown in soil were subjected to salt stress and CDs treatment. Subsequently, plant samples, rhizosphere soil samples, and bulk soil samples were collected. The activities of plant antioxidant enzymes, malondialdehyde (MDA) content, and ion contents were determined. Additionally, transcriptome analysis and soil microbial community analysis were conducted. Results Under 150 mM NaCl stress, the application of CDs at a concentration of 15 mg/L significantly enhanced the growth performance and physiological stress tolerance of wheat. This enhancement was manifested by an increase in plant height (11.3%) and biomass (47.7%), as well as a substantial elevation in the activities of key antioxidant enzymes, including superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT). Meanwhile, CDs remarkably inhibited the accumulation of malondialdehyde (MDA) and effectively maintained Na⁺/K⁺ homeostasis. At the molecular level, transcriptome analysis revealed that CDs triggered extensive gene reprogramming, with 374 and 872 differentially expressed genes (DEGs) identified in the shoots and roots, respectively. These DEGs were mainly enriched in pathways such as plant hormone signal transduction, glutathione metabolism, and metal ion binding. Furthermore, the application of CDs reshaped the structure of the soil microbial community, indicating that CDs enhance plant adaptability to salt stress through a multi-faceted mechanism. Conclusions Carbon dots effectively maintain Na⁺/K⁺ homeostasis and thereby alleviate salt stress in wheat by synergistically activating the plant's antioxidant defense/growth regulation system and reshaping the rhizosphere microbiome.
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Nature Photonics
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2026
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IF 32.9
Cao Wei,Tian Sen,Zhong Chao,Qiu Li,Zeng Pan,Chen Zhiming,Zhang Xiancheng,Liu Haitao,Liu Kaitao,Li Jian,Sun Tao,Ning Pingfan,Zhang Delin,Wang Wenhong,Jiang Yong,Cao An,Li Liang,Liu Dilong,Nie Zhihong,Yang Fan,Li Fushan,Li Yue
High pixel resolution is critical for next-generation quantum-dot light-emitting diode (QLED) display technologies. Although advances in quantum-dot patterning have improved resolution, the reduction in pixel size often degrades emission efficiency and pattern uniformity. Here we develop a nanoimprint strategy using nanohole-array moulds to fabricate nano-QLEDs via capillary action-induced self-assembly of quantum dots. We realize pixels as small as sub-100 nm with ultrahigh pixel resolution up to 169,333 pixels per inch over an electroluminescent area of 4 mm 2 . Benefiting from the closely packed light-emitting quantum-dot monolayers, our nano-QLEDs show minimal performance degradation upon reducing the pixel size. Notably, the smallest red, green and blue nano-QLEDs maintain average external quantum efficiencies of 17.0%, 10.5% and 5.7%, respectively. We also demonstrate fabrication on flexible substrates as well as an active-matrix display by imprinting micro-QLEDs on a thin-film-transistor backplane, showing images and videos with a resolution of 100 pixels × 180 pixels. This work provides a powerful method for fabricating ultrahigh-resolution nano-QLED arrays with high external quantum efficiency for next-generation displays.
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Nature Communications
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2026
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IF 18.1
Shao Xinyu,Lv Shiyu,Qin Xiang,Cheng Fangchao,Hu Dongying,Wu Yiqiang,Xu Xiaofei,Zhao Shuangliang
The development of cellulose triacetate (CTA)-based reverse osmosis membranes offers a sustainable approach to alleviating the global freshwater crisis, yet overcoming the inherent permeability–selectivity trade-off remains a significant challenge. Herein, we propose a homologous matching strategy to address the trade-off by incorporating carbon dots (M-CDs) derived from m-phenylenediamine (MPD) into the interfacial polymerization process between CTA and polyamide (PA). Systematic characterization and molecular dynamics simulations reveal that M-CDs, which are structurally analogous to the MPD monomer, promote monomer diffusion, regulate cross-linking density, and refine the microstructure of the PA layer. At an optimal M-CDs concentration, the resulting membrane achieves simultaneous enhancements in both salt rejection (99.1% vs. 96.5%) and water flux (18.3 vs. 15.2 L·m -2 ·h -1 ), thus surpassing conventional CTA membranes. The incorporation of M-CDs results in a thinner, denser, and more hydrophilic barrier layer with reduced pore size and narrowed distribution, as confirmed by post-annealing structural analysis. Moreover, hydrogen bonding between M-CDs and MPD improves chlorine resistance, maintaining high performance even after exposure to 2000 ppm NaClO solution. Molecular dynamics further illustrate that M-CDs promote water cluster transport while hindering ion penetration, thereby effectively mitigating the trade-off. The innovative use of homologous carbon dots to optimize the CTA–PA interface through structural matching, offering inspiring avenues for developing advanced bio-derived desalination technologies.
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JOURNAL OF NANOBIOTECHNOLOGY
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2026
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IF 12.6
Hao Zhang,Xiaoyu Song,Leilei Zhao,Chenlong Wang,Shen Chen,Yinghui Wang,Li Zhang,Fangyi Xu,Hongjie Zhang,Qilong Wang,Chao Luo
Photodynamic therapy (PDT) holds significant potential for tumor treatment, yet its immunotherapeutic efficacy is severely constrained by the immunosuppressive tumor microenvironment (TME) marked by lactate accumulation, hypoxia, and glutathione (GSH) overexpression. To overcome these limitations, we engineered an injectable hydrogel system (FPH@A/C) that synergistically integrates oxygen-independent PDT, ferroptosis activation, and lactate metabolic reprogramming to remodel immunosuppressive TME and potentiate antitumor immunity. The hydrogel comprises singlet oxygen-preloaded iron-based nanoparticles (FPH), lithium carbonate (LC), and sodium alginate (ALG), rapidly crosslinking into a stable matrix when encountering physiological Ca²⁺ concentration for localized therapeutic delivery. Within TME, GSH-triggered FPH degradation releases Fe²⁺ and pre-stored singlet oxygen, enabling chemodynamic therapy (CDT) and photo-independent PDT to induce tumor ferroptosis. Simultaneously, LC reprograms lactate-a metabolic byproduct-into an energy substrate for CD8⁺ T cells, counteracting lactate-driven immunosuppression. Notably, combining FPH@A/C with immune checkpoint blockade (ICB) therapy demonstrates synergistic effects, robustly enhancing dendritic cell maturation and cytotoxic T lymphocyte infiltration. This multifunctional platform establishes a novel paradigm for colorectal cancer immunotherapy by concurrently addressing metabolic constraints and immune evasion mechanisms.
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Nature Synthesis
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2026
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IF 20
Zhou Donglai,Yang Ruyu,Jia Zijin,Cai Yuhai,Zhao Luyuan,Guo Lulu,Ye Guilin,Wang Song,Chen Linjiang,Liu Daobin,Smith Pieter E. S.,Huang Yan,Zhu Qing,Jiang Jun
The vast compositional space of high-entropy materials offers exceptional opportunities for the development of powerful catalysts. However, the inverse design of these materials remains unfeasible due to the lack of robust theoretical frameworks and high-throughput experimental tools. This study demonstrates a practical inverse design approach that integrates spectroscopic descriptors, generative machine learning, and a robotic experimental platform to synthesize and optimize catalysts for the oxygen evolution reaction. The automated system substantially accelerated catalyst design and experimental validation, reducing the time required for synthesis, characterization and performance testing from approximately 20 h to only 78 min per sample. Following a rapid screen for efficient senary high-entropy catalysts, the spectroscopic generative model further optimized the top-performing candidate, lowering its overpotential at 10 mA cm −2 by an additional 32.0 mV. Our findings demonstrate the potential of an inverse design approach that incorporates spectroscopic descriptors into generative machine learning to accelerate catalyst discovery. Moreover, this approach is expected to drive the intelligent design of high-performance complex materials.
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Nature Communications
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2026
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IF 15.7
Tang Zhiling,Wang Yingli,Qin Tian,Wei Yuechang,Xiong Jing,Wang Xiong,Li Xuanzhen,Liu Min,Liu Yunpeng,Liu Xi,Zhao Zhen
Photocatalytic conversion of carbon dioxide to value-added chemicals, particularly multi-carbon products, offers a promising route toward carbon-neutral cycles. However, achieving high activity and selectivity remains extremely challenging due to the instability of key reaction intermediates and limited C–C coupling efficiency. Herein, we report a low-coordination manganese single-atom catalyst embedded in zinc sulfide (Mn 1 –ZnS v ) that enables efficient and selective CO 2 -to-C 2+ conversion. In-situ spectroscopic analyses and density functional theory calculations reveal that sulfur vacancies are created at the Mn single-atom coordination sites and induce the formation of coordination-unsaturated Mn-S 2 configuration. The asymmetric coordination environment of Mn modulates local charge distribution, strengthens *CO adsorption, and promotes *CO and *CHO coupling to form the *COCHO intermediate for efficient C–C coupling. As a result, the Mn 1 –ZnS v catalyst achieved 99.1% selectivity for ethylene with a formation rate of 76.6 μmol g -1 h -1 . This study highlights the critical role of atomic-level coordination engineering in advancing photocatalytic CO 2 -to-C 2+ conversion.
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Nature Communications
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2026
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IF 15.7
Chen Keyi,Lei Meng,Wang Tengfei,Li Guyue,Li Chilin
Rechargeable magnesium batteries have emerged as a competitive next-generation energy storage technology owing to their abundant resources and inherent safety. The development of Mg batteries, especially regarding specific energy, has been compromised by the lack of high-performance positive electrodes. Here, we design an anion-receptor-mediated all-phenyl-complex electrolyte that enables the electrochemical cooperation between fluoride and magnesium, and develop a Mg | |FeO 0.7 F 1.3 battery prototype. The anion receptor of tris(pentafluorophenyl)borane alters the chemical compositions of electrolyte and regulates its solvation structures via dipole-ion and dipole-dipole interactions with chloride-based ionic species and solvent molecules. The tailored electrolyte mitigates the chloride-originated anodic instability and upgrades the desolvation kinetics of cationic carriers. The dual-cation co-driven conversion-type Mg | |FeO 0.7 F 1.3 batteries exhibit the high reversible capacities in a wide temperature range, delivering 354 mAh g⁻¹ at 25 °C and 177 mAh g⁻¹ at –20 °C. Moreover, the high reversibility over 500 cycles with a low capacity decay rate of 0.054% per cycle can be realized when confined to intercalation chemistry. This work provides an anion receptor-based electrolyte design strategy that expands positive material horizons for magnesium batteries to high-energy fluorides.
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Stem Cell Reviews and Reports
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2026
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IF 4.2
Yue Wei,Yang Yue,Miao Yan,Li Jinqi,Li Shanshan,Yang Yi,Zhang Yingwen,Qian Baohua,Li Yanxin,Gu Haihui
Objective The global shortage of platelets presents a significant challenge in healthcare. Although human induced pluripotent stem cells (hiPSCs) offer a renewable source for ex vivo platelet production, the current approach remains constrained by heterogeneity, low yield, and high costs. This study introduces an optimized differentiation scheme (ODS) to improve ex vivo platelet differentiation from hiPSCs. Methods A systematically optimized culture protocol was developed, incorporating: (1) a higher initial dose of embryoid body (EB) cells, (2) refining culture medium, (3) substitution of cytokines with small molecules, and (4) enhancement of megakaryocyte (MK) polyploidization via small-molecule supplementation. Feasibility and effectiveness were evaluated using microscopy, cell counting, flow cytometry, Wright-Giemsa staining, immunofluorescence (IF), and transmission electron microscopy (TEM). Results Increasing the initial EB cell count significantly promoted megakaryocyte production and accelerated the process. A serum-free medium supplemented with human platelet lysate (HPL) was favorable for megakaryocyte generation. Small molecules 740Y-P and butyzamide effectively substituted SCF and TPO for differentiation, while the combination of blebbistatin and 616452 enhanced megakaryocyte maturation. Mature megakaryocytes continuously generated functional platelets that, upon thrombin activation, facilitated fibrin clot formation and contraction in vitro. This method shortened differentiation to 19 days, enhanced output to 1.42 CD41⁺ megakaryocytes and 14.9 platelets per iPSC, and reduced costs by 58.3%. Conclusion We have established a cost-effective strategy for platelet production via hiPSC differentiation, with potential applications in cell therapy and gene editing. Graphical
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Nature Communications
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2026
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IF 15.7
Xu Qingyang,Luo Kangwei,Wang Yipu,Wu Jiajie,Lu Hongwei,Chen Manyu,Xiong Zuping,Sun Jing Zhi,Zhang Jianyu,Huang Feihe,Tang Ben Zhong,Zhang Haoke
Multi-axis atropisomers are ubiquitous in nature, and their intricate stereoconformations not only deepen stereochemical understanding but also elucidate fundamental principles of molecular atropisomeric dynamics. Nevertheless, insights into multi-axis atropisomerism remain limited. This work presents a systematic investigation of three classes of LaPlente-type biaxial atropisomers based on naphthalene rotors and phenyl linkers. Thermodynamically and kinetically controlled interconversion of molecular conformations is achieved in 22-NB, 11-NB, and 11-NB-8DMe. Concurrently, a direct correlation between molecular dynamics and electronic through-space conjugation (TSC) is elucidated. Furthermore, absolute separation of syn and anti conformers is accomplished in 11-NB-2DMe, whose distinct TSC-induced fluorescence enables direct visualization of dynamic conformer populations and kinetics during temporally sequential crystallization. This work provides fundamental mechanistic insights into multi-axis atropisomer stereochemistry and establishes a fluorescence-based approach as an in-situ platform for real-time analysis of molecular dynamics across life and materials sciences.
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