Nature Communications
·
2022
·Vol. 13
·期 1
·1-8
·
IF 17.694
Mu Shijia,Lu Honglei,Wu Qianbao,Li Lei,Zhao Ruijuan,Long Chang,Cui Chunhua
Cu δ+ sites on the surface of oxide-derived copper (OD-Cu) are of vital importance in electrochemical CO 2 reduction reaction (CO 2 RR). However, the underlying reason for the dynamically existing Cu δ+ species, although thermodynamically unstable under reductive CO 2 RR conditions, remains uncovered. Here, by using electron paramagnetic resonance, we identify the highly oxidative hydroxyl radicals (OH • ) formed at room temperature in HCO 3 - solutions. In combination with in situ Raman spectroscopy, secondary ion mass spectrometry, and isotope-labelling, we demonstrate a dynamic reduction/reoxidation behavior at the surface of OD-Cu and reveal that the fast oxygen exchange between HCO 3 - and H 2 O provides oxygen sources for the formation of OH • radicals. In addition, their continuous generations can cause spontaneous oxidation of Cu electrodes and produce surface CuO x species. Significantly, this work suggests that there is a “seesaw-effect” between the cathodic reduction and the OH • -induced reoxidation, determining the chemical state and content of Cu δ+ species in CO 2 RR. This insight is supposed to thrust an understanding of the crucial role of electrolytes in CO 2 RR.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2022
·Vol. 23
·期 6
·1-12
·
IF 4.026
Hu Mengru,Zhang Wenjing,Chen Weidong,Chen Yunna,Huang Qianqian,Bao Qianqian,Lin Tongyuan,Wang Lei,Zhang Shantang
Abstract. The combination of functionalized nanoparticles and chemotherapy drugs can effectively target tumor tissue, which can improve efficacy and reduce toxicity. In this article, pPeptide-PDA@HMONs-DOX nanoparticles (phosphopeptide-modified polydopamine encapsulates doxorubicin-loaded hollow mesoporous organosilica nanoparticles) were constructed that based on multiple modification hollow mesoporous organosilica nanoparticles (HMONs). The pPeptide-PDA@HMONs-DOX nanoparticles retain the biological functions of phosphorylated peptide while exhibiting biological safety that are suitable for effective drug delivery and stimulus responsive release. The degradation behaviors showed that pPeptide-PDA@HMONs-DOX has dual-responsive to drug release characteristics of pH and glutathione (GSH). In addition, the prepared pPeptide-PDA@HMONs-DOX nanoparticles have good biological safety, and their anti-tumor efficacy was significantly better than doxorubicin (DOX). This provided new research ideas for the construction of targeted nanodrug delivery systems based on mesoporous silicon. Graphical Abstract
Scheme 1 The preparation of pPeptide-PDA@HMONs-DOX and the process of drug release under multiple responses. (A) Schematic diagram of the synthesis process of pPeptide-PDA@HMONs-DOX. (B) The process in which nanoparticles enter the cell and decompose and release DOX in response to pH and GSH
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NPG Asia Materials
·
2022
·Vol. 14
·期 1
·1-9
·
IF 10.761
Wang Yuetong,Zhang Dagan,Zhang Hui,Shang Luoran,Zhao Yuanjin
Alkaline phosphatase (ALP) is an important marker for many diseases, yet an efficient and reliable detection method is still lacking. Here, we present a novel photonic alginate hydrogel particle as an ALP sensor based on the competitive combination of an intermediary agent, the pyrophosphate ion (PPi), with a hydrogel crosslinker, which can trigger a phase-transition response from the hydrogel. This response can be converted into dual optical readouts, a fluorescence signal and a structural color signal. Quantitative determination of ALP was established based on this dual-indicator system with high accuracy and reliability. These features suggest potential ideal applications of responsive photonic hydrogel particles to detect ALP and other macromolecules.
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 12
·6941-6962
·
IF 6.123
Tan Wei,Ren Yuanlin,Guo Yingbin,Liu Yansong,Liu Xiaohui,Qu Hongqiang
A novel DOPO derived multi-claw reactive flame retardant (DMCFR) was designed to improve the flame retardancy of lyocell fabric. The chemical structure of DMCFR was identified by proton nuclear magnetic resonance ( 1 H-NMR) and Fourier transform infrared spectroscopy (FT-IR). The chemical structure and elemental composition of the modified lyocell fabric were investigated by FT-IR and X-ray photoelectron spectroscopy. The vertical burning test, limiting oxygen index (LOI) and cone calorimetry were applied to evaluate the flame retardancy of the original and treated samples. The results showed that the peak heat release rate and total heat release of the flame retardant lyocell (FR-lyocell) were significantly reduced by 90.6% and 65.5% compared to control sample. In addition, the LOI value of FR-lyocell fabric was up to 33% and remained 26% even after 20 laundering cycles (LCs). The thermal stability and char-forming capacity of the samples were measured by thermogravimetric analysis, and the residual char of the treated sample was as high as 9.15% and 42.5% under air and nitrogen atmosphere respectively, which were much higher than that of the original sample. Furthermore, the flame retardant mechanism was evidenced via scanning electron microscopy (SEM), Raman spectroscopy, thermogravimetric combined with Fourier transform infrared spectroscopy (TG-IR) and pyrolysis–gas chromatography-mass spectrometry (PyGC-MS), which supported the condensed and gas phase flame retardant mechanism. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
IRANIAN POLYMER JOURNAL
·
2022
·Vol. 31
·期 10
·1225-1235
·
IF 2.485
Mehmood Sahid,Uddin Md Alim,Yu Haojie,Wang Li,Amin Bilal Ul,Haq Fazal,Fahad Shah,Haroon Muhammad
Polymeric materials are used as ideal carriers for drug delivery applications due to their excellent physicochemical properties, however, the controlled preparation and drug release behavior of cross-linked polymeric microspheres are still open to discussion. Hexacyclotriphosphazene (HCCP), as one of the prominent members of polyphosphazene, can be easily treated with many monomers to produce micro/nanospheres. In this research work, cross-linked poly(cyclotriphosphazene- co -resveratrol) (PCTPRS) microspheres were prepared by the precipitation reaction of HCCP and resveratrol (RSV). The apparent peak at 961 cm −1 in FTIR spectra of the microspheres revealed that the polymerization between RSV and HCCP was successful. The TGA results showed that the increase in thermal properties was owing to the highly cross-linked structure of the microspheres. The XRD patterns showed the amorphous nature of the microspheres compared to the monomers. The obtained SEM micrographs dictated that the HCCP:RSV mole ratio had a significant impact on the size of the microspheres. The PCTPRS microspheres were used as carriers for the drug loading and release study of the anti-cancer model drug camptothecin (CPT). The drug loading efficiency of the PCTPRS microspheres was found to be 89.9 mg/g. Whereas the release study revealed that 53.0% of CPT was released at pH 4.0 and 37.5% at pH 7.4 from the drug-loaded microspheres after 11 days. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2022
·Vol. 33
·期 23
·18922-18937
·
IF 2.779
Lu Jinghua,Wang Jiaheng,Gong Jiaxu,Hu Cunhai
The design of structure and morphology is the key to improve the performance of supercapacitors. This work reports a facile method for the synthesis of MXene-NiCo 2 O 4 @NiCo-MOF/CC(M-NiCo 2 O 4 @NiCo-MOF/CC) materials by hydrothermal method and electrodeposition. Density functional theory (DFT) calculations illustrating the change in density of states (DOS) at the heterojunction demonstrate that the composite can improve electronic performance. M-NiCo 2 O 4 @NiCo-MOF/CC electrode can reach a high specific capacity of 1150.0 C g −1 (2091.0 F g −1 ) at 1 A g −1 , with a retention of 90.3% after 6000 cycles, reflecting excellent electrochemical performance. In addition, the assembled M-NiCo 2 O 4 @NiCo-MOF/CC//AC device exhibits excellent performance, and can reach a high energy density of 56.7 Wh kg −1 at 750 W kg g −1 , reflecting the broad application prospects.
✓ 已验证
产品关联
DOI
高影响因子
CANCER GENE THERAPY
·
2022
·Vol. 29
·期 12
·1939-1950
·
IF 5.854
Yang Fan,Li Lin,Mu Zhenzhen,Liu Pengyue,Wang Ying,Zhang Yue,Han Xiuping
The nuclear import receptor karyopherin β1 (KPNB1), a member of the Karyopherin protein family, is reported to be overexpressed in various cancers and promote carcinogenesis. By analyzing the correlation between the expression of KPNB1 and the overall survival rate of melanoma patients, we found that melanoma patients with higher expression of KPNB1 had worse survival. Furthermore, the database analyzed that the KPNB1 mRNA level was higher in melanoma samples than that in skin nevus tissues. We thus proposed that KPNB1 played a role in promoting melanoma development, and conducted gain-of- and loss-of-function experiments to test our hypothesis. We found that KPNB1 knockdown significantly retarded the growth and metastasis of melanoma cells in vitro and in vivo, and increased their sensitivity towards the anti-tumor drug cisplatin. KPNB1 overexpression had opposite effects. Notably, in melanoma cells, KPNB1 overexpression significantly decreased Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) protein level, which was also overexpressed in melanoma samples and enhanced malignant behaviors of melanoma cells. We further demonstrated that KPNB1 overexpression induced deubiquitination of G3BP1, and prevented its degradation. However, KPNB1 overexpression hardly affected the nuclear translocation of G3BP1. Additionally, alterations induced by KPNB1 overexpression were partly reversed by G3BP1 inhibition. Therefore, the results suggest that KPNB1 may promote melanoma progression by stabilizing the G3BP1 protein. KPNB1-G3BP1 axis represents a potential therapeutic targetable node for melanoma.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2022
·Vol. 29
·期 15
·8133-8150
·
IF 6.123
Sun Liangyun,Han Juan,Tang Chaofan,Wu Jiacong,Fang Sihan,Li Yuanyuan,Mao Yanli,Wang Lei,Wang Yun
As an effective substitute for ionic liquids (ILs), deep eutectic solvents (DESs) are known as a new generation of green solvents. In addition, DESs are considered to be the best solvents to replace traditional organic solvents and ILs due to their advantages of economy, simple preparation and biodegradability, which can be used to further break through the technical bottleneck in the field of biomass pretreatment. This study synthesized a series of choline chloride-based (ChCl-based) DESs and used them to pretreat microcrystalline cellulose (MCC) without dissolution, in order to achieve the purpose of improving the saccharification effect. DES-9 (ChCl/hydroquinone), DES-12 (ChCl/acetamide) and DES-16 (ChCl/acetic acid) were better pretreatment solvents. The optimum conditions for the pretreatment of MCC by DES-9 and DES-12 were both at 110 °C for 4 h, and the optimum condition of DES-16 was at 90 °C for 4 h. Compared with untreated MCC (26.66%), the saccharification yield of pretreated MCC with DES-16 increased by 20.5%. Finally, the structure and morphology changes of MCC before and after pretreatment were investigated in detail through the degree of polymerization (DP), SEM and enzyme adsorption. The results showed that DESs pretreatment made the surface of MCC become rough, which enhanced the accessibility of cellulose and enzymes, improving the saccharification effect. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Nano-Micro Letters
·
2022
·Vol. 14
·期 1
·1-13
·
IF 23.655
Zhao Jun,Wang Di,Zhang Fan,Pan Jinshan,Claesson Per,Larsson Roland,Shi Yijun
The as-designed triboelectric nanogenerator (TENG) generates an excellent electric output, which is an order of magnitude higher than that of TENGs made from commercial dielectric materials.
The as-designed TENG-based sensor can detect worn debris in oils at least down to 0.01 wt% and water contamination down to 100 ppm, which are much better than other online monitoring methods (particle > 0.1 wt%; water > 1000 ppm).
A high-selective monitoring system is successfully developed for distinguishing water contamination from the multi-mixed contaminants in lubricating oils.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 414
·期 23
·6871-6880
·
IF 4.478
Qi Qiaofang,Shang Cuiling,Wang Huayu,Ge Chunpo,ZhijunYang,Ni Tianjun,Chang Kaiwen
In this work, we introduced the acrylate recognition group into dicyanoisophorone derivative DCI-C–OH to construct the NIR fluorescent probe DCI-C-Cys with a large Stokes shift (240 nm). DCI-C-Cys could specifically respond to Cys, resulting in a 22-fold increase in fluorescence intensity at 702 nm. Meanwhile, the probe has the advantages of good water solubility, high sensitivity (93 nM), and excellent biocompatibility. Moreover, DCI-C-Cys successfully monitored endogenous and exogenous Cys in HepG2 cells and zebrafish. Most importantly, we found that balsam pear polysaccharide could lead to the increase of intracellular Cys levels, which might be conducive to the further study of the antioxidant mechanism of balsam pear polysaccharide. Graphical abstract
✓ 已验证
DOI
PubMed
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2022
·Vol. 395
·期 10
·1283-1295
·
IF 3.195
Xiong Ziwei,Cui Yushun,Wu Jiahui,Shi Lingyu,Quan Wen,Yang Shilin,Feng Yulin
Pteris cretica L. var. nervosa is one of the most well-known Chinese medicines. Although it is widely used to treat jaundice hepatitis, the main ingredient for its treatment was not thoroughly explored until recently. Essentially, the purpose of this study is to find the monomer compound in Pteris cretica L. var. nervosa , which is most likely to be effective in treating liver injury. Through the model of LPS/D-gal-induced liver injury in mice, the best therapeutic site of the total extract was explored, the chemical components of the parts with the best therapeutic effect were separated, a total of 10 flavonoids were isolated, and the RAW264.7 cells induced by LPS were used as the experimental model to explore the preliminary anti-inflammatory activity of NO production in vitro. Finally, the anti-inflammatory activity and the highest content in this plant Luteolin-7-O-rutinoside (LUT) were selected, as the object of study in vivo. It was found that LUT could not only reduce alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, but also significantly reduce the release of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β), and inhibit PI3K/AKT/AMPK/NF-κB pathway. In addition, LUT can increase levels of SOD and GSH to reduce oxidative stress. It has an obvious therapeutic effect on acute liver injury induced by LPS/D-gal in mice. Therefore, infer LUT is a functional substance in Pteris cretica L. var. nervosa. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CATALYSIS LETTERS
·
2022
·Vol. 153
·期 4
·1109-1119
·
IF 2.936
Ren Yanrong,Pu Hongzheng,Zeng Hanlu,Deng Chaofang,Yin Fengling,Wu Ya,Yang Dingfeng,Li Yuanyuan
Modulating the band edge position of a photocatalyst is important in photocatalysis. In this study, a more positive valence band position was realized by doping Sb in Li 2 SnO 3 . The downshifted valence band position was mainly attributed to the relatively low Sb energy level resulting from its higher electronegativity. Such band structure modification resulted in a stronger photo-oxidative capability for photogenerated holes (h + ), leading to an enhanced photodegradation rate toward tetracycline (TC) solution. For Li 2 Sn 0.9 Sb 0.1 O 3 , the efficiency reached 74% within 30 min, which was approximately 2.5 times that of Li 2 SnO 3 . Radical trapping experiments showed that h + played the dominant role in the photodegradation process. Finally, the photodegradation pathway was analyzed using liquid chromatography–mass spectrometry (LC–MS). These results might provide important insight for designing photocatalysts with high efficiency through band structure modification. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）