JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 10.6
Wang Yining,Zhou Qiaomei,Luo Wangping,Yang Xiaoyan,Zhang Jinguo,Lou Yijie,Mao Jin,Chen Jiayi,Wu Fan,Hou Jue,Tang Guping,Bai Hongzhen,Yu Risheng
Pancreatic ductal adenocarcinoma (PDAC), characterized by a dense extracellular matrix (ECM), presents significant therapeutic challenges due to its poor prognosis and high resistance to chemotherapy. Current chemodrugs and diagnostic agents largely fail to cross the barrier posed by the ECM, which severely limits the PDAC theranostics. This study introduces a novel theranostic strategy using thioether-hybridized hollow mesoporous organosilica nanoparticles (dsMNs) for the co-delivery of copper (Cu) and disulfiram (DSF), aiming to induce cuproptosis in PDAC cells. Our approach leverages the ECM-degrading enzyme collagenase, integrated with dsMNs, to enhance drug penetration by reducing matrix stiffness. Furthermore, the innovative use of a pancreatic cancer cell membrane coating on the nanoparticles enhances tumor targeting and stability (dsMCu-D@M-Co). The multifunctional platform not only facilitates deep drug penetration and triggers cuproptosis effectively but also utilizes the inherent properties of Cu to serve as a T1-weighted magnetic resonance imaging (MRI) contrast agent. In vitro and in vivo assessments demonstrate significant tumor size reduction in PDAC-bearing mice, highlighting the dual functionality of our platform in improving therapeutic efficacy and diagnostic precision. This integrated strategy represents a significant advancement in the management of PDAC, offering a promising new direction for overcoming one of the most lethal cancers.Graphical Abstract
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PubMed
高影响因子
RARE METALS
·
2024
·Vol. 43
·期 8
·3702-3712
·
IF 9.6
Mu Zi-Jie,Gao Yan-Jun,Dong Wen-Shuai,Li Zong-You,Song Qing-Yi,Huang Han-Jiao,Xing Li-Dong,Zhang Jian-Guo,Wang Wei,Yu Qi-Yao
The highly reversible insertion/extraction of large-radius K + into electrode materials remains a tough goal, especially for conversion-type materials. Herein, we design a current collector-integrated electrode (N–CoSe/CoSe 2 –C@Cu) as an advanced anode for potassium-ion battery (PIBs). The conductive CoSe/CoSe 2 heterojunction with rich Se vacancy defects, conductive sp 2 N-doped carbon layer, and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural stability. Consequently, the well-designed N–CoSe/CoSe 2 –C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity (325.1 mAh·g −1 at 0.1 A·g −1 after 200 cycles), an exceptional rate capability (223.5 mAh·g −1 at 2000 mA·g −1 ), and an extraordinary long-term cycle stability (a capacity fading of only 0.019% per cycle over 1200 cycles at 2000 mA·g −1 ). Impressively, ex situ scanning electron microscopy (SEM) characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N–CoSe/CoSe 2 –C@Cu heterostructure, which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process. Graphical abstract
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高影响因子
TRIBOLOGY INTERNATIONAL
·
2024
·
IF 6.1
Xingtao Cheng,Kaijun Wei,Hongjie Li,Na Teng,Shijun Xu,Quangang Chen,Xianmin Gong,Yi He,Siming Yan
At the present time, the subject of seawater scouring and corrosion phenomena is attracting considerable attention. Accordingly, the present study involved the synthesis of CuPP materials and the preparation of Ni-Cu/CuPP coatings for deployment in marine environments characterised by elevated stress and corrosion. The results show that CuPP can effectively enhance the wear resistance and long-term corrosion resistance of Ni-Cu coatings, which is attributed to ‘fine grain strengthening’ and ‘diffusion strengthening’. Furthermore, the formation of a friction transfer film and the transformation of the wear mechanism are the primary factors contributing to the exceptional wear resistance of the Ni-Cu/CuPP composite coatings.
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Journal of Materials Chemistry A
·
2024
·
IF 10.7
Zhichao Ma,Chenyi Wang,Tianfang Yang,Gangya Wei,Jinrui Huang,Mengran Liu,Kun Zhang,Zunjie Zhang,Yang Liu,Shuyan Gao
Electrocatalytic nitrate (NO3−) reduction to ammonia (NH3) (NRA) is of great significance for solving the problem of urgent NO3− pollution in the environment and opening up a new route to synthesize NH3. However, NRA is limited by its multi-electron/proton transfer process and the NRA process relies heavily on atomic H* produced by H2O splitting, undergirding the necessity for effective NRA catalysts. Herein, three-dimensional (3D) porous phosphorus (P)-doped Cu–Ni alloy materials are constructed through a one-step electrodeposition synthesis. 3D porous materials modulate hydrophilicity and enrich active sites. The Cu d-band center can be tuned through Ni alloying to modify the adsorption energies of intermediates such as *NO3−, *NO2−, and *NH2. The hydrogenation evolution capacity of P promotes the hydrogenation process in the atomic H* path and effectively accelerates the NRA reaction rate. Density functional theory (DFT) calculations demonstrate that the charge transfer between the negatively charged Pδ− and the positively charged Niδ+ and Cuδ+ assists in generating more atomic H* for coupling with reaction intermediates, showing an enhanced catalytic activity at low overpotential. The optimal sample exhibits an exceptional NRA performance with an ammonia yield rate of 848.1 μmol h−1 cm−2 and a faradaic efficiency of 96.1%. This work provides a strategy for creating effective NRA catalysts through enhancing the atomic H* reduction strategy.
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MICROCHIMICA ACTA
·
2024
·Vol. 192
·期 1
·1-12
·
IF 5.3
Hou Linqian,Wei Jinya,Xiang Chen,Yang Dezhi,Yang Yaling
A novel copper and iron doped containing chitosan and heparin sodium carbon dots (CS-Cu,Fe/HS) nanozyme was formulated through a single-step microwave digestion method. CS-Cu,Fe/HS exhibits excellent peroxidase (POD)-like activity and positive charge characteristics, and it can oxidize the negatively charged 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) in the presence of H 2 O 2 to produce a green compound (ox-ABTS). Furthermore, CS-Cu,Fe/HS enhances electron transfer and provides additional active sites through the valence state transformations of Fe 2+ /Fe 3+ and Cu 2+ /Cu + . Interestingly, the POD-like activity of CS-Cu,Fe/HS is inhibited with the introduction of ampicillin (AMP), which may be because the Cu and Fe ions in CS-Cu,Fe/HS form complexes with AMP, leading to changes in the structure or surface properties of the nanozyme, thereby reducing the number of active sites on the nanozyme. Drawing from this, a straightforward and reliable colorimetric sensor was constructed for AMP detection, featuring a linear range of 0.033 to 110 μg/mL and a detection limit as low as 11.6 ng/mL. The proposed detection method for AMP performed well in real samples, with recoveries ranging from 94.8% to 110.2%. Graphical abstract
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高影响因子
APPLIED SURFACE SCIENCE
·
2017
·
IF 3.387
Dan Lv,Yu Liu,Jiasheng Zhou,Kunlun Yang,Zimo Lou,Shams Ali Baig,Xinhua Xu
In this study, a novel bamboo activated carbon (BAC) with ethylene diamine tetraacetic acid (EDTA) functionality was prepared by direct grafting in the presence of tetraethyl orthosilicate (TEOS) as a crosslinking agent. The BAC@SiO 2 -EDTA was characterized by SEM, TEM, TGA, FTIR, XPS and its adsorption property for removal of Pb(II) and Cu(II) under various experimental conditions was also investigated. The characterization results reflected that EDTA was successfully assembled on the surface of the BAC and average pore size increased from 4.10 to 4.83 nm as BAC grafted with EDTA. Adsorption data fitted very well in Langmuir isotherm model and pseudo-second-order kinetic model. As compared with the raw BAC, the maximum adsorption capacities of BAC@SiO 2 -EDTA for the Pb(II) and Cu(II) increased from 45.45 to 123.45 mg g −1 and from 6.85 to 42.19 mg g −1 , since the existence of EDTA on modified BAC promoted the formation of chemical complex. The removal of heavy metal ions mainly depended on the complexation with EDTA and the electrostatic attractions with negatively charged surface of BAC@SiO 2 -EDTA. The adsorption of Pb(II)/Cu(II) on the BAC@SiO 2 -EDTA was pH dependent and pH 5–6 was considered an optimum. However, lower temperature favored the adsorption and the maximum adsorption was recorded at 20 °C. In addition, BAC@SiO 2 -EDTA had an excellent reusability with about 40% decline in the adsorption capacity for Pb(II) after fifth reuse. Insignificant influences of co-existing cations and natural organic matter (NOM) were found on the adsorption of Pb(II) and Cu(II). All the results demonstrate that BAC@SiO 2 -EDTA is a potential adsorbent for metal ions in wastewater.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2017
·Vol. 134
·期 46
·45431
·
IF 1.86
Ya Liu,Peng Qian,Yang Yu,Li Xiao,Yongliang Wang,Shufeng Ye,Yunfa Chen
Heavy metal ions such as Cu 2+ and Pb 2+ impose a significant risk to the environment and human health due to their high toxicity and non-degradable characteristics. Herein, Al(OH) 3 -polyacrylamide chemically modified with dithiocarbamates (Al-PAM-DTCs) was synthesized using formaldehyde, diethylenetriamine, carbon disulfide, and sodium hydroxide for rapid and efficient removal of Cu 2+ and Pb 2+ . The synthesized adsorbent was characterized by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis, scanning electron microscopy–energy dispersive X-ray spectroscopy analysis, and transmission electron microscope measurements. Al-PAM-DTCs showed rapid removal of Cu 2+ (<30 min) and Pb 2+ (<15 min) with high adsorption capacities of 416.959 mg/g and 892.505 mg/g for Cu 2+ and Pb 2+ respectively. Al-PAM-DTCs also had high capacities in removing suspended solids and metal ions simultaneously in turbid bauxite suspensions. FTIR, thermodynamic study, and elemental mapping were used to determine the adsorption mechanism. The rapid, convenient, and effective adsorption of Cu 2+ and Pb 2+ indicated that Al-PAM-DTCs has great potential for practical applications in purification of other heavy metal ions from aquatic systems. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 45431.
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NEW JOURNAL OF CHEMISTRY
·
2017
·Vol. 41
·期 13
·5436-5444
·
IF 3.269
Hao Li,Sirong Yu
A superhydrophobic Cu–Zn coating was fabricated on a steel surface by facile one-step electrodeposition, without being chemically modified by a low surface energy material. It was noted that three-level hierarchical structures, just like the surface morphology of a lotus leaf, were formed on the Cu–Zn coating surface via scanning electron microscopy (SEM) images. The water contact angle of the prepared Cu–Zn coating surface was 153.40°, and the sliding angle was less than 10°. From the aspect of chemical composition, it was characterized to confirm that the oxidation of Cu and Zn, and oxygen adsorption were the reasons for the superhydrophobicity. In terms of the surface morphology, based on the classical Wenzel and Cassie models, an idealized three-dimensional (3D) model was fabricated to demonstrate the rationality of the superhydrophobicity without chemical modification. Moreover, this three-level hierarchical Cu–Zn coating had stable superhydrophobicity, excellent self-cleaning properties, and stability.
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MOLECULES
·
2024
·Vol. 29
·期 16
·3832
·
IF 4.2
Song-Yu Luo,Chun-Mei Zeng,Ping Xu,Ye Ning,Meng-Lin Dong,Wen-Hua Zhang,Guangliang Yu
In this work, we report the synthesis of a new thiosemicarbazone-based drug of N′-(di(pyridin-2-yl)methylene)-4-(thiazol-2-yl)piperazine-1-carbothiohydrazide (HL) featuring a thiazole spectator for efficient coordination with Cu(II) to give [CuCl(L)]2(1) and [Cu(NO3)(L)]2(2). Both1and2exhibit dimeric structures ascribed to the presence of di-2-pyridylketone moieties that demonstrate dual functions of chelation and intermolecular bridging. HL,1, and2are highly toxic against hepatocellular carcinoma cell lines Hep-G2, PLC/PRF/5, and HuH-7 with half maximal inhibitory concentration (IC50) values as low as 3.26 nmol/mL (HL), 2.18 nmol/mL (1), and 2.54 × 10−5nmol/mL (2) for PLC/PRF/5. While the free ligand HLmay elicit its anticancer effect via the sequestration of bio-relevant metal ions (i.e., Fe3+and Cu2+),1and2are also capable of generating cytotoxic reactive oxygen species (ROS) to inhibit cancer cell proliferation. Our preliminary pharmacokinetic studies revealed that oral administration (per os, PO) of HLhas a significantly longer half-lifet1/2of 21.61 ± 9.4 h, nearly doubled as compared with that of the intravenous (i.v.) administration of 11.88 ± 1.66 h, certifying HLas an effective chemotherapeutic drug via PO administration.
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高影响因子
Nanoscale
·
2024
·Vol. 16
·期 22
·10727-10736
·
IF 5.8
Peijiao Chen,Zhijun Li,Pengze Wang,Yuxin Yao,Tianwei Dou,Yang Qu,Liqiang Jing
The photocatalytic water-mediated CO2 reduction reaction, which holds great promise for the conversion of CO2 into valuable chemicals, is often hindered by inefficient separation of photogenerated charges and a lack of suitable catalytic sites. Herein, we have developed a glycerol coordination assembly approach to precisely control the distribution of atomically dispersed Cu species by occupying Ti-defects and adjusting the ratio between Cu species and Ti-defects in a hierarchical TiO2. The optimal sample demonstrates a ∼4-fold improvement in CO2-to-CO conversion compared to normal TiO2 nanoparticles. The high activity could be attributed to the Ti defects, which enhance the photogenerated charge separation and simultaneously facilitate the adsorption of water molecules, thereby promoting the water oxidation reaction. Moreover, by means of in situ EPR and FTIR spectra, we have demonstrated that Cu species can effectively capture photogenerated electrons and facilitate the adsorption of CO2, so as to catalyze the reduction of CO2. This work provides a strategy for the construction of atomic-level synergistic catalytic sites and the utilization of in situ techniques to reveal the underlying mechanism.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2024
·
IF 8.1
Ruihong Guo,Yujuan Zhang,Xiutang Zhang,Hong Yang,Tuoping Hu
The development of efficient bifunctional catalysts is the key technology to replace oxygen evolution reaction (OER) with hydrazine oxidation reaction (HzOR) with lower theoretical potential to achieve high efficiency and energy-saving hydrogen production . In this work, the Co 0·52 Cu 0·48 /Cu@S–C (−1.3 V) composite with flower-like array was prepared by two-step electrodeposition coupled pyrolysis method. The electrochemical measurements showed that the driving voltages of the optimal composite for HzOR and hydrogen evolution reaction (HER) are respectively −118 mV and 47 mV at a current density (j) of 10 mA cm −2 . The excellent performance of Co 0·52 Cu 0·48 /Cu@S–C (−1.3 V) composite is attributed to the fact that the flower-like structure exposes more active areas and facilitates the diffusion of electrolyte, the strong electron interaction between Co 0·52 Cu 0·48 /Cu and S –C substrate, which can be verified by X-ray photoelectron spectroscopy (XPS), enhances the electrical conductivity , the Co 0·52 Cu 0·48 /Cu heterogeneous interface reduces the water dissociation barrier and facilitates the dehydrogenation kinetics of N 2 H 4 determined by density functional theory (DFT) calculations. Due to the excellent performance of Co 0·52 Cu 0·48 /Cu@S–C (−1.3 V), the overall hydrazine splitting (OHzS) electrolytic cell was constructed with Co 0·52 Cu 0·48 /Cu@S–C (−1.3 V) as electrodes. The results showed the voltages required by the cell are 36, 210 and 282 mV at the current density values of 10, 100 and 200 mA cm −2 respectively, showing that Co 0·52 Cu 0·48 /Cu@S–C (−1.3 V) can be used for energy-saving hydrogen production by hydrazine assisted water electrolysis.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiawei Zhao,Rui Liu,Tiantian Tang,Zihao Liu,Xiaozhi Liu,Kai Yu,Ye Zhang,Hao Wang
Drug-resistant bacterial infections and biofilm formation have long posed significant challenges to public health, particularly in the context of chronic wound healing. In this study, the CuHspMOF were derived from copper and hesperitin (Hsp). The photocurable Epsilon-poly-l-lysine (EPLMA) and blueberry anthocyanin (BA) were synthesized through free radical polymerization. The multifunctional EB@CuHsp hydrogel exhibits excellent photothermal effect. One of the key features of the EB@CuHsp hydrogel is its ability to monitor the healing environment through color changes in response to variations in pH. This property allows for real-time assessment of the wound’s pH levels, reflecting the body fluid’s pH range during the healing process (pH 5–9). The hydrogel components work synergistically to facilitate wound healing. The EPLMA, with its positively charged, could captures bacteria and enable copper ions to eradicate bacteria at lower concentrations. This dual action leads to the creation of an optimal healing environment conducive to wound healing. During the inflammatory phase, BA and Hsp could collaborate to combat inflammation, which transited from the inflammatory stage to the proliferative phase soon. Continuous release of BA and Cu 2+ , coupled with thermotherapy, significantly enhances epithelial and blood vessel regeneration, thereby expediting the healing of chronic wounds. Overall, this multifunctional composite hydrogel holds great promise for promoting the regeneration of infected wound tissue, making it a potential candidate for chronic wound dressings.
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