Pharmaceutics
·
2025
·Vol. 17
·期 10
·1257
·
IF 5.5
Jialing Li,Ning Han,Mingyue Ruan,Hongmei Wei,Yunan Dong,Haitong Zhang,Zishuo Guo,Shouying Du,Pengyue Li
Background/Objectives:Triple-negative breast cancer (TNBC) exhibits pronounced biological heterogeneity, aggressive behavior, and a high risk of recurrence and metastasis. The conventional treatments for TNBC have notable limitations: surgical resection may leave residual tumor cells; chemotherapy (CT) frequently induces systemic toxicity and drug resistance; and radiotherapy damages surrounding organs and compromises the patients’ immune function.Methods: Herein, we designed a carrier-free nanodrug delivery system composed of self-assembled Curcumin nanoparticles (NPs) coated with a tannic acid (TA)/Fe(III) network (denoted as CUR@TA-Fe(III) NPs). We systematically evaluated the in vitro cytotoxicity and photothermal–ferroptosis synergistic therapeutic efficacy of CUR@TA-Fe(III) NPs in 4T1 breast cancer cells, as well as the in vivo antitumor activity using 4T1 tumor-bearing mouse models.Results:CUR@TA-Fe(III) NPs had high drug loading efficiency (LE) of 27.99%, good dispersion stability, and photothermal properties. Curcumin could inhibit the growth of 4T1 cancer cells, while TA-Fe(III) efficiently converted light energy into heat upon exposure to near-infrared (NIR) light, leading to direct thermal ablation of 4T1 cells. Additionally, TA-Fe(III) could supply Fe(II) via TA, increase intracellular Fe(II) content, and generate reactive oxygen species (ROS) through the Fenton reaction, in turn inducing lipid peroxidation (LPO), a decrease in mitochondrial membrane potential (MMP), and glutathione depletion, eventually triggering ferroptosis.Conclusions:This treatment strategy, which integrates CT, PTT, and ferroptosis, is expected to overcome the limitations of traditional single-treatment methods and provide a more effective method for the treatment of TNBC.
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PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2025
·
IF 4.8
Ruxing Zhao,Qingrun Meng,Guanchao Wang,Lin Xu,Weifeng Chu,Junjie Li
Intermolecular dehydration of 2-propanol (IPA) to di-isopropyl ether (DIPE) serves as an important process to produce the valuable chemical, however, developing advanced solid acid catalysts with high DIPE selectivity faces the great challenge of inhibiting the intramolecular dehydration reaction. In this context, we developed a highly selective intermolecular dehydration MFI nanosheet catalyst by synergistically modifying its diffusion and acid properties. We found that the DIPE selectivity over nanosheet ZSM-5 catalysts were obviously higher than that over the conventional ZSM-5 catalyst, benefited from the enhanced diffusion property over nanosheet catalysts that inhibited the further conversion of DIPE. However, the DIPE selectivity were still lower than 70 % over those catalysts attributed to their high acid strength that facilitated the intramolecular dehydration reaction. Thus, various heteroatoms (Fe, Ga, and B) substituted MFI zeolite nanosheet catalysts were prepared and employed in the dehydration reaction, Fe-MFI with a moderate acid strength exhibited the highest DIPE selectivity among those catalysts. Besides, the effects of acid amounts (Si/Fe ratio) and diffusion properties (thickness of b-axis) on the intermolecular dehydration selectivity and activities over nanosheet Fe-MFI catalysts were systematically investigated. An optimal Fe-MFI nanosheet catalyst with the b-axis thickness of ∼20 nm and Si/Fe ratio of ∼40 presented the stable high DIPE selectivity of ∼91 % in 360 h of time on stream, meanwhile the IPA conversions kept almost unchanged.
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JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 15
·6270-6284
·
IF 3.5
Wu Hongmei,Liu Baoshan,Zhang Yao,Li Feng,Liu Jing,Zhao Liping,Zhang Peng,Gao Lian
Cobalt-based transition metal phosphides (TMPs) exhibit huge potential as efficient OER electrocatalysts for commercial applications. Zeolitic imidazolate framework-67 (ZIF-67) has been served as an appealing precursor for the synthesis of cobalt-based TMPs owing to its distinctive structural advantages. However, the poor conductivity and structural variability of ZIF-67 affect the materials’ OER electrocatalytic performance. To enhance the structural stability and OER performance of ZIF-67 derived TMPs, in this work, a polyhedral TMP nanocomposite with porous hollow structure, featuring Fe-CoP on the outer shell and CoP nanoparticles within the cavity, was synthesized using ZIF-67 as template. The ZIF-67 served as both Co precursor and structure template, and the [Fe(CN) 6 ] 3− served as precursor of Fe dopant and structure stabilizer. The resulting TMP composite electrode (Fe-CoP) effectively retains the framework of ZIF-67, exhibiting prominently improved OER activity (η 10 = 297 mV) and exceptional stability (over 260 h). The Fe–C≡N–Co bonds positively influence the preservation of the sample’s morphology after phosphorization. Additionally, a ligand-substitution strategy is proposed for the formation of the designed structure. This strategy, regulating the morphology of 3D structured MOFs, offers a new understanding on stabilizing the geometric structure of MOFs and their derivatives as structure templates. Graphical abstract
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高影响因子
JOURNAL OF ENVIRONMENTAL MANAGEMENT
·
2024
·
IF 8
Xin Li,Aiyu Niu,Shanshan Yang,Fei Liu
Determining the contaminants reduction rate by dissolved ferrous iron (Fe(II) aq ) bound to iron oxides is curial for evaluating the abiotic attenuation of contaminants in aquifers. However, few studies have assessed the contaminants reduction rate controlled by thermodynamic parameters in heterogeneous systems with different iron oxides. In this study, a linear free energy relationship (LFER) was established between the nitrobenzene reduction rate and the thermodynamic driving force (reduction potential (E H ) and pH) in Fe(II) aq -goethite-hematite co-existing systems. Results showed that the reduction rate of nitrobenzene correlated with the E H of the heterogeneous system. The standard reduction potential (E H 0 mix ) of the mixed iron oxides could be obtained by a proportionate linear combination of the single iron oxide system E H 0 . Based on this, the E H of the heterogeneous systems could be calculated theoretically by combining E H 0 mix and the Nernst equation. Furthermore, a parallel LFER with the slope of 1 was established to associate the nitrobenzene reduction rate with E H and pH. The intercept term was related to the adsorption capacity of different iron oxides towards Fe(II) aq . The Fe(II) aq saturation adsorption capacity of hematite was 1.5 times higher than that of goethite. After normalizing the nitrobenzene reduction rate to the Fe(II) aq saturation adsorption capacity, the maximum difference in intercept terms was reduced from 37% to 15%. These findings would provide an important and feasible methodological support for the quantitative evaluation of abiotic attenuation of contaminants in groundwater.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Yuchen Xing,Xiuli Shen,Qijian Niu,Hongwei Duan,Chengshun Tang,Bo Tao,Siyu Chen,Qianyi Shangguan,Bo Feng,Haizhang Yu,Zhong Tang,Guanya Ji
Nanoplastics, characterized by their small size, high diffusion, and stability, have emerged as the new class of pollutants posing a global threat. For achieving both chemical and thermal stability of adsorbents, this study synthesized FeMg-LDO@BC, a novel adsorbent prepared through the in-situ growth and calcination of FeMg-layered double hydroxide (FeMg-LDH) on pre-treated biochar. FeMg-LDO@BC demonstrated an excellent adsorption rates and removal efficiencies for polystyrene nanoplastics (PSNPs) as determined by pseudo-first-order kinetic model and Sips isotherm model, reaching a 99.8 % adsorption efficiency and the maximum capacity of 97.93 mg/g. The removal mechanism was primarily attributed to π-π EDA interactions, surface complexation, and hydrogen bonding. Furthermore, the composite exhibited excellent chemical and thermal stability, demonstrating robust environmental adaptability and regenerative performance. After five cycles of adsorption-thermal degradation, FeMg-LDO@BC maintained 80 % of its initial adsorption capacity. The thermal regeneration products were primarily composed of styrene, with the presence of alkenes and aromatic hydrocarbons, confirming the simultaneously degradation of nanoplastics and the regeneration of the biochar adsorbent.
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高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Junjie Su,Qi Yang,Zhihu Zhang,Ziyue Zhang
Nowadays, Ni/Fe bimetallic nanocomposites have shown great potential for removing Cr(VI). However, the action of Ni 0 in Cr(VI) removal is still controversial, which was studied in this work. In this study, Ni/Fe@Fe 3 O 4 -g-C 3 N 4 (NFFOCN) nanocomposites were applied to remove Cr(VI) from aqueous solutions and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and other methods. Batch experiments were conducted to evaluate the Cr(VI) removal performance. Experimental results demonstrated that under optimal operating conditions (pH 5.5, 10 mg/L Cr(VI), 0.3 g/L NFFOCN, 30°C), a Cr(VI) removal efficiency of 90.78% was achieved within 50 min. Theoretical maximum adsorption capacity was calculated to be 36.101 mg/g. Combining experimental and characterization results, it could be concluded that Cr(VI) removal was attributed to the synergistic effect of the NFFOCN components. Ni 0 not only participated directly in the reduction of Cr(VI) as an electron donor, but also converted the corrosion product H 2 of nano-zero-valent iron (nZVI) into highly reducible atomic hydrogen (·H) to remove Cr(VI). Additionally, Ni 0 could form a primary battery with nZVI, facilitating the electron transfer between nZVI and Cr(VI). NZVI and its derivatives, Fe 2+ ions and green rust, were responsible for Cr(VI) reduction. Furthermore, the presence of Fe 3 O 4 and carbon nitride (g-C 3 N 4 ) improved the stability and reactivity of the nanocomposites.
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高影响因子
ADVANCED MATERIALS
·
2024
·
IF 27.4
Huiwen Zhang,Hsiao-Chien Chen,Solmaz Feizpoor,Linfeng Li,Xia Zhang,Xuefei Xu,Zechao Zhuang,Zhishan Li,Wenyu Hu,Rony Snyders,Dingsheng Wang,Chundong Wang
The interaction between oxygen species and metal sites of various orbitals exhibits intimate correlation with the oxygen reduction reaction (ORR) kinetics. Herein, a new approach for boosting the inherent ORR activity of atomically dispersed Fe−N−C matrix is represented by implanting Fe atomic clusters nearby. The as-prepared catalyst delivers excellent ORR activity with half-wave potentials of 0.78 and 0.90 V in acidic and alkaline solutions, respectively. The decent ORR activity can also be validated from the high-performance rechargeable Zn–air battery. The experiments and density functional theory calculations reveal that the electron spin-state of monodispersed Fe active sites is transferred from the low spin (LS, t 2g 6 e g 0 ) to the medium spin (MS, t 2g 5 e g 1 ) due to the involvement of Fe atomic clusters, leading to the spin electron filling in σ∗ orbit, by which it favors OH − desorption and in turn boosts the reaction kinetics of the rate-determining step. This work paves a solid way for rational design of high-performance Fe-based single atom catalysts through spin manipulation.
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高影响因子
Chem
·
2022
·
IF 25.832
Xiaoqian Wei,Shaojia Song,Weiwei Cai,Xin Luo,Lei Jiao,Qie Fang,Xiaosi Wang,Nannan Wu,Zhen Luo,Hengjia Wang,Zhihong Zhu,Jing Li,Lirong Zheng,Wenling Gu,Weiyu Song,Shaojun Guo,Chengzhou Zhu
The development of Fe single-atom catalysts is greatly impeded by their lower oxygen reduction reaction (ORR) performance in acid electrolytes when compared with Pt/C catalyst. Herein, we report an unprecedented ORR catalyst consisting of Pd nanoclusters (Pd NC ) and Fe single atoms (Fe–N–C/Pd NC ). Experimental investigations and theoretical calculations indicate that the enhanced ORR activity results from the Pd NC -induced spin-state transition of Fe(II) from low spin to intermediate spin, activating O–O bond through the side-on overlapping and achieving the pathway transition from associative to dissociative process. The over-binding of OH∗ can be facilely released to suppress the site-blocking effect and accelerate the removal of OH∗. In acid conditions, Fe–N–C/Pd NC exhibits excellent ORR performance with impressive half-wave potential (0.87 V), insignificant decay after 30,000 cycles, and a high maximum power density of 920 mW/cm 2 in fuel cell, superior to Pt/C catalyst. This work provides an efficient pathway to design non-Pt catalysts through the spin-regulation strategy.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2025
·
IF 21.1
Shengjia Ma,Bingtao Dong,Yuxin Zheng,Shuai Tang,Tao Zhang,Yaping Zhao
This work elucidated the dual-substrate activation mechanism of a Fenton-like system, enabled by the upcycling of plastics into a highly efficient catalyst. A synergistic pyrolysis strategy was employed to upcycle polyethylene microplastics into nitrogen-doped carbon while simultaneously constructing Fe clusters and WS 2 co-catalyst (WS 2 /Fe-N-C). In the H 2 O 2 activation system, WS 2 /Fe-N-C achieved a remarkable rate constant of 0.949 min −1 toward bisphenol A, which was 52 times higher than that of Fe-N-C, outperforming previously reported representative co-catalyst systems and Fe-based carbon catalysts. Correlation analysis, electrochemical tests and theoretical calculations demonstrated that Fe sites primarily activated H 2 O 2 to generate •OH, while WS 2 adsorbed bisphenol A and facilitated a non-radical electron transfer pathway, enabling dual-substrate synergistic catalysis for highly efficient pollutant removal. This work provides a feasible strategy for plastic upcycling and offers innovative insights into the synergy between metal centers and cocatalysts, paving the way for the rational design of high-performance catalysts.
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高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2021
·
IF 19.503
Weiju Hao,Dongxue Yao,Qiuyu Xu,Ruirui Wang,Chenglong Zhang,Yanhui Guo,Ruimin Sun,Mingxian Huang,Ziliang Chen
The aggregation of transition metal nanoparticles severely degrades their catalytic activity towards water splitting. Although this issue can be alleviated by the popular carbon-hybridization and metal foam-confinement strategies, the complicated fabrication procedure and the support corrosion parasitic in these strategies inevitably result in high usage cost and unsatisfactory cycle durability. Herein, we in-situ space-confined boron-inserted Fe-Ni solid solution nanosheets onto the activated hydrophilic sponge (B-FeNi@HS) via substitution of Fe by Ni and insertion of B within the Fe lattice interstitials in the presence of NH 4 + -modified dimethylamino borane solution. When served as the bifunctional electrocatalysts, B-FeNi@HS only needs overpotentials of 54 and 171 mV to afford 10 mA cm –2 for HER and OER in 1.0 M KOH, respectively. In addition, the alkaline overall-water splitting system constructed by using B-FeNi@HS as two-electrodes only delivers an ultralow cell voltage of 1.456 V to drive 10 mA cm –2 , and shows negligible activity decay even at 500 mA cm –2 for 3 days. Such outstanding performance can be traced to the synergism of corrosion-resistant support, hierarchical morphology with favorable surface area and dual solid-solution crystal structure, ensuring robust mechanical stability, rapid charge/mass transfer kinetics as well as the energetically favorable formation of intermediates during catalysis. The proposed strategy is versatile and can be extended to synthesize other efficient B-inserted Fe-based electrocatalysts.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 34
·期 33
·2316654
·
IF 18.5
Feng Xu,Ming Chen,Yaoxuan Cui,Libin Qian,Jin Wang,Zhao Han,Yanli Lu,Di Wang
The electronic nose aims to emulate the olfactory capabilities of osmatic animals, utilizing olfactory sensing array with different sensing characteristics to perceive odors. However, the separate precursors and preparation methods of sensing materials pose challenges in the fabrication of an olfactory sensing array. In this work, the customization of the surface crystal phase of Sr─Fe─O materials (SFO) is demonstrated through the control of annealing temperature, enabling the simple fabrication of an olfactory sensing array using a single precursor. Significantly, the SFO materials exhibit diverse proportions of surface crystal phases, showcasing varied selective characteristics toward volatile organic compounds (VOCs). The materials also demonstrate remarkable responsiveness, linearity, and response/recovery times. Furthermore, this study unraveles the intricate gas-sensor mechanism through first principle calculations, revealing that Fe spin-down d band center of Sr 3 Fe 2 O 7 , located near the Fermi level, significantly enhances the binding strength of intermediates, leading to a higher response specifically to certain VOCs. Integrating these materials into a unified device, the sensor array quantitatively and discriminatively detected different VOCs. The results indicate that SFO materials hold tremendous potential as a promising and easily manufacturable olfactory material system.
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Fang Wu,Yuhong Jiao,Jinlong Ge,Yujun Zhu,chao feng,Zhong Wu,Chang-Peng Lv
Exploring highly active, low-cost electrocatalysts for oxygen evolution reaction (OER) is of great significance but still a major challenge. Here, we synthesized Ni(OH)2@Ni(Fe)OOH with a sea urchin structure on nickel foam via a simple hydrothermal and subsequent soaking process. Experimental results indicate that incorporation of Fe into Ni(OH)2 is favorable for modulate the electronic structure, faster electron transfer and improved intrinsic activity, thereby leading to excellent OER activity. The optimized Ni(OH)2@Ni(Fe)OOH exhibits superior OER activity with overpotentials of 245 and 310 mV at 10 and 100 mA cm-2, respectively, and a small Tafel slope of 40.7 mV dec-1, and along with high stability over 100 h, which is more active than benchmark RuO2 and sever control samples without introduction of Fe. More importantly, the overall water splitting system by using Ni(OH)2@Ni(Fe)OOH-100 as anode and Pt/C as the cathode only requires a cell voltage of 1.54 V to afford 10 mA cm-2. This work not only demonstrate the key factor of Fe doping, but also offers a new path for the development of NiFe-based OER catalysts.
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