查找使用阿拉丁产品的科研文献

Metabolomics Approach to Investigate Estrogen Receptor-Dependent and Independent Effects of o,p′-DDT in the Uterus and Brain of Immature Mice

Dezhen Wang,Wentao Zhu,Yao Wang,Jin Yan,Miaomiao Teng,Jiyan Miao,Zhiqiang Zhou

Previous studies have demonstrated the endocrine disruption of o,p′-DDT. In this study, we used a 1H NMR based metabolomics approach to investigate the estrogenic effects of o,p′-DDT (300 mg/kg) on the uterus and brain after 3 days of oral gavage administration, and ethynylestradiol (EE, 100 μg/kg) was used as a positive control. A supervised statistical analysis (PLS-DA) indicated that o,p′-DDT exerted both estrogenic receptor-(ER)-dependent and independent effects on the uterus but mainly ER-independent effects on the brain at metabolome levels, which was verified by coexposing with the antiestrogenic ICI 182,780. Four changed metabolites—glycine, choline, fumarate, and phenylalanine—were identified as ER-independent alterations in the uterus, while more metabolites, including γ-aminobutyrate, N-acetyl aspartate, and some amino acids, were disturbed based on the ER-independent mechanism in the brain. Together with biological end points, metabolomics is a promising approach to study potential estrogenic chemicals.

BiVO4 Film Coupling with CoAl2O4 Nanoparticles for Photoelectrochemical Water Splitting Utilizing Broad Solar Spectrum through p–n Heterojunction, Photothermal, and Cocatalytic Synergism

Yujie Huang,Binyao Liu,Yiwen Yang,Hao Xiao,Tao Han,Hanmei Jiang,Jiahe Li,Yong Zhou,Gaili Ke,Huichao He

Water oxidation is an endothermic and kinetics–sluggish reaction; the research of photoanodes with photothermal and cocatalytic properties is of great significance. Herein, BiVO4/CoAl2O4 film photoanodes were studied for solar water splitting through coupling spinel p-type CoAl2O4 nanoparticles on n-type BiVO4 films. Compared to the BiVO4 photoanode, better performance was observed on the BiVO4/CoAl2O4 photoanode during water oxidation. A photocurrent of 3.47 mA/cm2 was produced on the BiVO4/CoAl2O4 photoanode at 1.23 V vs RHE, which is two-fold to the BiVO4 photoanode (1.70 mA/cm2). Additionally, the BiVO4/CoAl2O4 photoanodes showed an acceptable stability for water oxidation. The BiVO4/CoAl2O4 photoanode being of higher water oxidation performance could be attributed to the presence of p–n heterojunction, cocatalytic, and photothermal effects. In specific, under the excitation of λ < 520 nm light, the holes produced in/on BiVO4 can be transferred to CoAl2O4 owing to the p–n heterojunctions of BiVO4/CoAl2O4. Meanwhile, the temperature on the BiVO4/CoAl2O4 photoanode rises quickly up to ∼53 °C under AM 1.5 G irradiation due to the photothermal property of CoAl2O4 through capturing the 520 < λ < 720 nm light. The temperature rising on the BiVO4/CoAl2O4 photoanode improves the cocatalytic activity of CoAl2O4 and modifies the wettability of BiVO4/CoAl2O4 for effective water oxidation.

Surface modification of Poly(p-phenylene terephthalamide) fibers by polydopamine-polyethyleneimine/graphene oxide multilayer films to enhance interfacial adhesion with rubber matrix

Xuan Yang,Qunzhang Tu,Xinmin Shen,Ming Pan,Chengming Jiang,Pengxiao Zhu,Yi Li,Pei Li,Caibing Hu

In order to improve the interfacial adhesion between the poly(p-phenylene terephthalamide) fibers and rubber matrix while enhance the fiber strength simultaneously, a mild surface modification method was presented to graft polydopamine-polyethyleneimine/graphene oxide (PDA-PEI/GO) multilayer films onto the fiber surface. In this way, PDA could be first non-covalently deposited onto the fiber surface via dopamine biomimetic modification, and then the positively charged PEI was absorbed on the PDA through Michael addition reaction. After that, the negatively GO was grafted on the surface by the layer-by-layer (LbL) assembly to construct the PDA-PEI/GO multilayer films. The results of mechanical properties tests and pull-out force tests showed that the highest single-filament tensile strength and the highest pull-out force of the modified fibers increased by 15.1% and 78.1%, respectively. The optimal time of PEI/GO multilayer for the enhancement of adhesive properties was 7 and the excessive amount of PEI/GO would lead to high aggregation to decrease the adhesive strength.

Synthesis of LiFePO4 cathode materials from amorphous FePO4 precursor: Effects of Li/P molar ratio on crystal defect formation and electrochemical performance

Yongsheng Chen,Siman Yang,Jianbin Zheng,Mingwei Hu,Mingdeng Wei,Peixun Xiong

As an excellent cathode material, lithium iron phosphate (LiFePO 4 ) has been widely used in commercial lithium-ion batteries (LIBs). However, the impact of synthetic conditions on LiFePO 4 cathode derived from amorphous iron phosphate (FePO 4 ) remains underexplored. In the present study, the effects of Li/P molar ratio on the crystallinity and electrochemical properties of LiFePO 4 were investigated in detail using FePO 4 as a precursor. When the Li/P molar ratio in LiFePO 4 was approximately 1, the material exhibited an excellent long-term cycling stability with a high capacity retention of 97 % after 500 cycles. In addition, multiple characterizations demonstrate that the higher molar ratio of the Li/P resulted in the higher concentration of defects in LiFePO 4 crystals, which not only reduced the reversible capacity but also compromised the structural stability, leading to a poor cyclic stability and quick capacity degradation. Therefore, such a work could provide a scientific insight for rational design and synthesis of high-performance LiFePO 4 cathodes from amorphous FePO 4 precursor.

Fabricating a stable interface of tetracoordinated-phosphorus and framework Al within P-doping ZSM-5 zeolite for catalytic methanol-to-propylene reaction

Nengcui Zhang,Yimin Zhang,Feng Wu,Ziyan Liu,Xinyu Xu,Qiang Li,Yi Mei,Yun Zu

Phosphorus (P)-doping H-ZSM-5 zeolites, which is crucial for industrial applications, aim to adjust both acidity and framework stability while optimizing product distribution in heterogeneous catalysis. Nonetheless, current phosphating methods often suffer from inadequate phosphorus dispersion and unclear interfacial interactions with framework aluminum (Al). In this work, P-doping ZSM-5 zeolites were successfully one-step prepared by using tributylphosphine served as an organophosphorus precursor, assisting by density functional theory calculations. On account of this, a stable interface of tetracoordinated-phosphorus and framework Al was fabricated uniformly. Such an interfacial structure not only made more framework Al sit in the straight/sinusoidal channels, but also remodeled Brønsted acid sites and reinforced its acidity. Under comparable conditions, methanol-to-propylene (MTP) evaluations indicated that the high-silica PZ-75 zeolite catalyst displayed an appreciable catalytic lifetime (30 h) and a higher C 3 H 6 selectivity (52.4 %). Additionally, in-situ Fourier transform infrared spectroscopy further revealed that this exceptional MTP performance was attributable to the predominant olefinic pathway and lower hydrogen transfer ability. These results provide valuable information for cognizing phosphorus-zeolite chemistry and creating high-performance MTP catalytic materials.

Sintering-resistant and active-species-adjustable Ni catalysts supported on P-doped biochar via nanopore-confined activation for efficient levulinic acid hydrogenation

Xiaohao Liu,Dali Han,Jinming Xia,Dongxu Yan,Rui Diao,Fenglei Qi,Zhenyu Wang,Lei Yang,Xiang Wu,Peiyong Ma,Ying Zhang

Nanopore-confining strategy is an effective way to inhibit catalyst sintering and improve catalytic performance. However, the expensive material precursors and complex preparation process greatly limit the scale utilization of this particularly structured catalyst. Herein, nanopore-confined catalysts (Ni@PAC) with adjustable active species were successfully prepared by a very simple method exploiting the characteristics of phosphoric acid-activated biochar (PAC). The abundant phosphorous functional groups in PAC confined Ni well in pores and significantly inhibited sintering through the spatial-confined effect of nanopore. Moreover, the evolution and migration of P functional groups can be regulated by changing the reduction temperature, and the modulation of active species of Ni metal or nickel phosphide can be achieved. Using biomass-based levulinic acid hydrogenation as the probe reaction, it was found that the catalytic activity of 20Ni@PAC-600 was one order of magnitude higher than that of the non-phosphated 20Ni/ZAC-600 catalyst, and γ-valerolactone could be selectively prepared at near atmospheric pressure (1 bar). The formation of Ni2P and the spatial-confined effect of nanopore could be the main reasons for the high catalytic activity.

P/N/Si-containing hyperbranched polyamide-amine salt with adaptive interfaces: a solution to break the performance paradox in flame-retardant polypropylene

Wei-Chen Zhou,Shuang He,Ze-Yong Zhao,Cong Deng,Yu-Zhong Wang

The intrinsic flammability of polypropylene (PP)—a pivotal thermoplastic in automotive engineering—poses a significant safety challenge amid the accelerating shift toward new energy transportation. However, achieving high flame retardancy without compromising mechanical performance remains a critical challenge due to the poor compatibility between non-polar PP and polar flame retardants—a dilemma known as the “performance paradox.” In this study, we report the design of a novel flame retardant, BAPPAM, featuring adaptive interfaces, constructed through the ionic complexation of hyperbranched semi-aromatic polyamide-amine (BA-PAMAM) with phytic acid, followed by sol–gel-based silane encapsulation to yield a phosphorus–nitrogen–silicon hybrid architecture. Benefiting from the synergistic effects among P, N, and Si elements, BAPPAM endows PP composites with outstanding flame retardancy—achieving a limiting oxygen index of 28.5 %, UL-94V-0 rating, and effective suppression of heat release (86 % reduction in peak heat release rate and 69 % decrement in total heat release) and smoke emission (72 % decline in peak smoke production rate and 67 % slippage in total smoke production) at a 20 wt% loading. Remarkably, the adaptive interfaces formed by BAPPAM accommodate mechanical deformation under stress, affording a high elongation at break (up to 453.4 %) comparable to pure PP, along with enhancements of 41.2 % in Young’s modulus (1440 MPa) and 11.2 % in impact strength (3.9 kJ/m 2 ). This work pioneers a novel interfacial engineering strategy that reconciles fire safety with mechanical robustness, offering a solution for the next generation of high-performance, flame-retardant polyolefin composites.

Acute hypobaric hypoxia attenuates the anti-fatigue effects of pitolisant by downregulating the expression of organic cation transporter 1 and P-glycoprotein

Gang Zhao,Yajuan Li,Mengyuan Liu,Wei Chang,Hui Shen,Junhui Xue,Fengzhou Liu

Objective: This study investigates the effects of acute hypobaric hypoxia (HH) on the anti-fatigue properties of pitolisant and explores the underlying mechanisms. The aim is to provide a theoretical basis for expanding its clinical indications and optimizing its use in individuals exposed to HH conditions.Methods: The anti-fatigue effects of pitolisant were evaluated using the water maze, novel object recognition, and rotating rod tests. Drug concentrations and dopamine levels were analyzed using High-Performance Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (HPLC-MS/MS). Additionally, gene and protein expression levels of P-glycoprotein (P-gp) and organic cation transporter 1 (OCT1) were assessed to explore the mechanisms by which HH affects pitolisant’s pharmacodynamics.Results: A 40 mg/kg dose of pitolisant significantly improved learning, memory, cognitive, and motor functions in sleep-deprived mice under HH conditions (P < 0.05). Pharmacokinetic analysis revealed a reduction in pitolisant concentration in the brain under HH conditions. Furthermore, OCT1 protein expression decreased after 1 h and 1 day of HH exposure (P < 0.05), while P-gp expression decreased after 1 h (P < 0.05).Conclusion: HH possibly reduced pitolisant’s brain concentration and efficacy by altering the expression of OCT1 and P-gp transporters. A 40 mg/kg dose was necessary for an effective anti-fatigue response. Pitolisant shows potential for supporting circadian rhythm regulation in shift workers and individuals suffering from jet lag. When used under HH conditions, adjusting the dose and frequency may be necessary due to altered pharmacokinetics.

Influence of P(VDF-TrFE) Membranes with Different Surface Potentials on the Activity and Angiogenic Function of Human Umbilical Vein Endothelial Cells

Yan Xu,Mingwei Cheng,Peijun Zhu,Shuo Yang,Chunhua Lai,Shulan Xu

During bone tissue regeneration, neovascularization is critical, and the formation of a blood supply network is crucial for bone growth stimulation and remodeling. Previous studies suggest that bioelectric signals facilitate the process of angiogenesis. Owing to their biomimetic electroactivity, piezoelectric membranes have garnered substantial interest in the field of guided bone regeneration. Nevertheless, the knowledge of their influence due to varying surface potentials on the progression of angiogenesis remains ambiguous. Therefore, we proposed the preparation of an electroactive material, P(VDF-TrFE), and investigated its effects on the activity and angiogenic functions of human umbilical vein endothelial cells (HUVECs). The HUVECs were directly cultured on P(VDF-TrFE) membranes with different surface potentials. Subsequently, cell viability, proliferation, migration, tube formation, and expressions of related factors were assessed through appropriate assays. Our results revealed that the negative surface potential groups exerted differential effects on the modulation of angiogenesis in vitro. The P(VDF-TrFE) membranes with negative surface potential exhibited the greatest effect on cellular behaviors, including proliferation, migration, tube formation, and promotion of angiogenesis by releasing key factors such as VEGF-A and CD31. Overall, these results indicated that the surface potential of piezoelectric P(VDF-TrFE) membranes could exert differential effects on angiogenesis in vitro. We present a novel approach for designing bioactive materials for guided bone regeneration.

Strong interlayer coupling in p-Te/n-CdSe van der Waals heterojunction for self-powered photodetectors with fast speed and high responsivity

Yanjie Hu,Xiaohui Song,Dongliang Jia,Wanhan Su,Xiaojing Lv,Lin Li,Xueping Li,Yong Yan,Yurong Jiang,Congxin Xia,Congxin Xia

Preparation of graphene/poly(p-phenylenebenzobisoxazole) composite fibers based on simultaneous zwitterion coating and chemical reduction of graphene oxide at room temperature

Jianqiang Guo,Guohu Guan,Wen Zhou,Chuncheng Li,Yaonan Xiao,Wenxiang Zhu,Liuchun Zheng

Zwitterion-coated reduced graphene oxide (rGO) was used in fabricating graphene/PBO composite fibers via in situ polymerization. The zwitterionic 1 : 1 adducts were formed by two monomers of PBO and they could be crystallized using rGO sheets as templates. Covalent bonds could be formed between GO and 4,6-diaminoresorcinol dihydrochloride (DAR·2HCl, a monomer for PBO) with GO being reduced simultaneously at room temperature. The structure of rGO sheets was well characterized and a mechanism including nucleophilic addition and E1 dehydration was proposed. Zwitterions could precipitate out from water rapidly and yet dissolve in PPA easily. Thereby, rGO sheets could be homogeneously dispersed in the PBO matrix as zwitterions dissolve and polymerize. By adjusting the feeding of zwitterion-coated rGO sheets, various composites with 0.1–3.0 wt% GO sheets incorporated were obtained. With very low rGO sheet content, both the mechanical properties and thermal stability of rGO/PBO fibers increased remarkably.

A Covalent Heterostructure of Metal Phosphide Quantum Dots Anchored in N, P Co-doped Carbon Nanocapsules for Fast and Durable Lithium Storage

Xiangdong Ma,Chuang Ji,Xiaoyuan Yu,Yike Liu,Xunhui Xiong

Transition-metal phosphides (TMPs) anodes for lithium ion batteries (LIBs) usually show poor rate capability and rapid capacity degradation owing to their low electronic conductivities, huge volumetric changes, as well as inferior reversibility of the discharge product Li3P. Herein, a covalent heterostructure with TMPs quantum dots anchored in N, P co-doped carbon nanocapsules (NPC) has been prepared in which the P element in TMPs is simultaneously doped into the carbon matrix. As a proof of concept, Co2P quantum dots covalently anchored in NPC (Co2P QDs/NPC) is prepared and evaluated as an anode for LIBs. The Co2P QDs/NPC electrode not only demonstrates a high capacity and an extraordinary rate performance but also delivers an impressive cyclability with a high capacity retention of 102.5% after 1600 cycles, one of the best reported values for TMPs-based electrode materials for LIBs. The covalent heterostructure can facilitate the electron/ion transfer and maintain the structural stability during the intensive cycles. Moreover, density functional theory calculations demonstrate that the interfacial covalent coupling can enhance the electrochemical reversibility of the discharge product Li3P in the charge processes via lowering the conversion reaction energies. This work presents an effective interfacial engineering strategy for developing high-performance TMPs anodes for advanced LIBs.