LANGMUIR
·
2023
·
IF 3.9
Fang Chen,Li Yin,Teng He,Tao Chen,Hangbo Yue,Chufen Yang
To enhance the stability of the polymeric micelles and optimize their drug-controlled release ability, three disulfide-linked polyethylene glycol methyl ether methacrylate–disulfide–poly(ε-caprolactone-co-γ-amine−ε-caprolactone) (PPEGMA-SS-P(CL-co-ACL)) polymers were synthesized and characterized by 1H NMR, GPC, and FT-IR successfully, and their dual pH/reduction-responsive cross-linked polymeric micelles were prepared for paclitaxel (PTX) delivery by using 2,3-dimethylmaleic anhydride (DMMA) as the cross-linking agent. The PTX loading capacity (LC) and encapsulation efficiency (EE) values of the cross-linked micelles formed by PPEGMA8-SS-P(CL47-co-ACL15) achieved were 23.96% and 71.58%, slightly higher than those of un-cross-linked micelles. Both particle sizes of blank micelles and in vitro drug release of PTX-loaded micelles confirmed that compared with those un-cross-linked micelles, the cross-linked micelles were more stable at pH 7.4 + 0 mM DTT, with a PTX cumulative release of 13% at 120 h, while the PTX cumulative release of the cross-linked micelles at pH 5.0 + 10 mM DTT were close to that of un-cross-linked micelles after 60 h, indicating the successful reversible cross-linking and smooth drug release of the cross-linked micelles. The cytotoxicity assay showed that PPEGMA8-SS-P(CL47-co-ACL15) and its cross-linked micelles had low cell cytotoxicity, and both PTX-loaded micelles revealed a certain inhibitory effect on HepG2 cells. These results revealed that the dual pH/reduction-responsive cross-linked polymeric micelles prepared from PPEGMA8-SS-P(CL47-co-DCL15) were a promising candidate for PTX delivery.
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PubMed
高影响因子
RARE METALS
·
2023
·Vol. 42
·期 12
·4015-4028
·
IF 8.8
Ma Xiao-Fang,Xiao He,Jing Yan-Ying,Gao Yang,He Ying-Luo,Zhao Man,Jia Jian-Feng,Wu Hai-Shun
Ru-based electrocatalysts have demonstrated excellent electrocatalytic performance toward hydrogen evolution reaction (HER). However, designing Ru nanoparticles/nanoclusters (Ru NPs/NCs) with abundant accessible active sites is challenging. Herein, a selective facile hydrothermal in situ polymerization strategy is described to accurately control the anchoring point of Ru in hollow mesoporous carbon spheres (HMCs) (outer surface, HMCs@Ru; cavity, Ru@HMCs; and pore channels, Ru/S-HMCs). The HER mechanisms of the three catalysts over a wide pH range were revealed by analyzing the loading position, content, dispersion, particle size, and valence state of Ru. HMCs@Ru shows excellent area activity, with overpotentials of 64.3, 2.8, and 78.1 mV at 10 mA·cm −2 in 0.5 mol⋅L −1 H 2 SO 4 , 1 mol⋅L −1 KOH, and 0.5 mol⋅L −1 phosphate buffer saline (PBS) solutions, respectively. Ru/S-HMCs exhibit high mass activity, with values 43.3, 2.9, and 12.7 times those of Pt/C in alkaline, acidic, and neutral media, respectively, at − 50 mV (vs. reversible hydrogen electrode (RHE)). After 2000 cyclic voltammetry cycles, the performances of HMCs@Ru and Ru/S-HMCs hardly decrease, indicating good stability. The excellent electrocatalytic activity can be attributed to two main factors: (1) the confinement effect, which not only promotes high Ru dispersion but also prevents the leaching of active metal under harsh conditions, and (2) their excellent structural characteristics. The catalyst structure features a large hollow located in the center (~ 160 nm in diameter) and an ultrathin monolayer of mesopores (~ 6 nm) uniformly distributed on the hollow shells, ensuring fast mass diffusion and electron transfer kinetics, as well as complete accessibility of catalytic sites. Graphical abstract
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2023
·
IF 6.1
Yi Ding,Jun Yuan,Feixu Mo,Shuai Wu,Yue Ma,Rongyu Li,Ming Li
Smart metal–organic framework nanocarriers that respond to microenvironmental stimuli related to plant diseases can achieve the on-demand release of active ingredients to control diseases. The plant essential oil citral (CT) has significant biological activity against most pathogens but its poor stability limits its application in the field. To improve the applicability of plant essential oils, we aimed to construct a pH responsive essential oil delivery system (CT@ZIF-8) based on the zeolitic imidazolate framework-8 in this study. The high specific surface area of ZIF-8 enables CT@ZIF-8 remarkable loading capacity, and the metal–organic framework effectively delays the volatilization of CT. The results showed that CT@ZIF-8 was approximately 177 nm in size, had a stable nanostructure, and displayed a high pesticide loading efficiency (15.22%). The photodegradation rate of CT loaded in ZIF-8 under UV irradiation (48 h) was only 17.99%, much lower than that of CT alone (51.18%). The CT@ZIF-8 had a pH-responsive controlled release property, releasing CT from CT@ZIF-8 in a pH-dependent manner. The bioactivity results showed that CT@ZIF-8 had a lower EC50 than CT against three fungi (Magnaporthe oryzae, Botryosphaeria dothidea, and Fusarium oxysporum), enhancing the antifungal activity of CT. After 3 d of reagent treatment, only CT@ZIF-8 maintained good control against rice blast (75.76%) and soft rot (63.69%) infection. We have constructed a smart delivery system for essential oils, which provides a new pathway for the efficient application of plant-derived essential oils in the green control of plant diseases.
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PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Fangfang Zhang,Peng Cui,Dongni Liu,Zhuo Han,Jie Zhu,Yan Huang,Yanhong Chao,Yuanbin She,Wenshuai Zhu,Zhichang Liu
Fluid catalytic cracking (FCC) diesel provides most polycyclic aromatic hydrocarbons (PAHs) in diesel. The removal of PAHs by adsorption and separation method is an efficient way to obtained purified diesel. As a kind of green economy adsorbent, porous carbon materials (PCMs) have been widely used in the adsorption of gases, aromatics and organic pollutions. Here, by direct carbonization, the PCMs are prepared from the novel Ph-POSS based porous organic polymers (POPs) which possessed high BET surface areas (∼1000 m 2 /g). The PCMs possess abundant microporosity and O atoms in the skeleton. The PCMs exhibit high PAHs adsorption capacity because of the hierarchical micropore size, high degree of graphitization and abundant O atoms. The strategy of construction PCMs with hierarchical micropore and heteroatoms provides an effective method to remove PAHs in the FCC diesel.
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高影响因子
Journal of Cleaner Production
·
2026
·
IF 10.7
Zhonghao Yu,Luyang Wang,Junsheng Tan,Fuyuan Guo,Qingqing Yang,Haonan Shi,Fengxia An,Huan Chen,Fang Jiang
TiG waste was upcycled into pH-gated CaO 2 HBs for eutrophic remediation. • Hydrogel gating restrains CaO 2 hydrolysis under non-alkaline pH. • Bloom-like alkaline pH activates controlled CaO 2 hydrolysis. • CaO 2 HBs integrate oxygenation, bacterial inactivation, and phosphate removal. • PEG-400 was the main cost hotspot; spent beads showed P-reuse potential. Cleaner remediation of eutrophic waters requires technologies that simultaneously improve chemical-use efficiency and create value from industrial by-products. Here, titanium gypsum (TiG), a calcium-rich industrial by-product, was upcycled into CaO 2 nanoparticles (CaO 2 NPs) and encapsulated in a sodium alginate/carboxymethyl chitosan/gelatin matrix to fabricate CaO 2 hydrogel beads (CaO 2 HBs) enabling pH-responsive swelling-controlled release. The biopolymer network served as a structural gate: protonation-driven contraction under acidic or near-neutral conditions restricted water access to CaO 2 , whereas alkaline deprotonation induced swelling and promoted CaO 2 hydrolysis. This pH-responsive swelling-controlled response increased H 2 O 2 accumulation under alkaline conditions while moderating alkaline shock, thereby reducing premature CaO 2 consumption under non-target conditions. CaO 2 HBs enhanced oxygenation, model bacterial inactivation, and Ca 2+ -mediated phosphate mineralization, reducing phosphate from 20 to below 2.0 mg PO 4 3− L −1 in a high-phosphate model solution under alkaline conditions. In simulated complex waters, the beads retained better multifunctional performance than bare CaO 2 NPs. A 1 L high-load simulated black-odorous wastewater test increased DO to 4.15 mg L −1 and achieved 94.36% relative bacterial inactivation, while partially reducing phosphate in a chemically complex matrix. Preliminary cost analysis identified PEG-400 as the principal cost hotspot in the nano-CaO 2 route, while a proof-of-concept plant-growth assay provided preliminary evidence that P-loaded spent beads could potentially be reused as a soil phosphorus source. Overall, this study establishes a recovery-conversion-remediation-reuse pathway that couples titanium gypsum valorization with regulated CaO 2 utilization, integrated water treatment, and phosphorus-reuse potential. Download: Download high-res image (260KB) Download: Download full-size image
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高影响因子
Food Bioscience
·
2023
·
IF 5.2
Qiuyi Li,Pingxiong Cai,Huining Xiao,Yuanfeng Pan
The development and utilization of abundant biomass resources is a promising solution to the problems of fossil resource scarcity and the difficulty in the biodegradation of waste faced by traditional food packaging films. Novel biomass-based films are not only biodegradable but can also be endowed with a variety of functional characteristics, including smart pH indicating film that can show color changes according to pH changes during food storage to achieve real-time visual detection of the degree of food spoilage, which is intuitive, sensitive, and convenient compared to traditional food packaging films. In this work, an environmentally friendly smart pH indicating film was prepared by incorporating natural polymer chitosan (CS) with anthocyanin-rich purple yam extract (PYE). The effect of different additions (1.5, 3, 4.5, 6 wt%) of PYE on the mechanical properties, water vapor barrier properties, antioxidant, antibacterial and pH sensitivity properties of chitosan films were investigated. The results showed that the films supplemented with 4.5% and 6% PYE demonstrated higher antioxidant capacity and antibacterial properties , while showing a more pronounced color change in different pH buffers. The results of FT-IR, scanning electron microscopy and X-ray diffraction analysis indicated the presence of hydrogen bonding between CS and PYE molecules. The application of films for in-situ monitoring the freshness of food (e.g., shrimp) was also studied, and films with PYE additions between 3% and 6% all showed visible color changes. Consequently, CS-PYE films are of great potential as smart and active packaging materials for keeping and monitoring the freshness of foods.
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高影响因子
Journal of Saudi Chemical Society
·
2023
·
IF 5.6
Shenna Chen,Yunping Hao,Sha Liu,Yanxu Liu,Ziyan Zhang,Mei Fang,Lina Geng
Carbon dots doped with boron and nitrogen atoms (B, N-CDs) were designed and prepared by hydrothermal strategy using citric acid, urea and borax as raw materials. The structure and optical properties of B, N-CDs were characterized by various characterization technologies. The results showed that the B, N-CDs exhibited good mono-dispersion, excellent fluorescence stability, and high fluorescence intensity (quantum yield up to 32 %). A dual-functional Fe 3+ and pH detection platform based on B, N-CDs was constructed. The Fe 3+ sensing method based on B, N-CDs fluorescence quenching showed an excellent linear relationship between 0.044–70 μM (R 2 = 0.994), with a detection limit as low as 0.044 μM. Then, this detection method was successfully applied to the high-accuracy detection of Fe 3+ in water samples and iron supplement tablets. The study of the quenching mechanism showed that the fluorescence of B, N-CDs was quenched by Fe 3+ in two ways: static quenching and dynamic quenching. Moreover, B, N-CDs can also be used as a pH fluorescence sensor in the ranges of pH 2.0–4.8 and 5.2–7.6. The developed sensing system based on B, N-CDs has high selectivity and sensitivity for the detection of Fe 3+ , and a wide detection range for pH.
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高影响因子
Innovative Food Science & Emerging Technologies
·
2023
·
IF 6.6
Yueru Wang,Xinhua Liu,Shunjing Luo,Chengpeng Zhong,Jiangping Ye,Chengmei Liu
The composition and aggregation of rice dreg protein (RDP) have a major impact on its properties. The aim of the present study was to investigate the effects of pH shifting combined high-pressure homogenization (HPH) treatment on functional properties of RDP. The improvement of RDP functional properties with pH shifting at alkaline (pH 12) condition followed by HPH treatment (20, 40, 60, 80, 100 MPa) prior to neutralization at pH 7 was much better than that of HPH and/or pH shifting. The method carried out at under pH 12 followed by HPH 100 MPa was found to be the most efficient treatment for increasing the solubility of RDP from 0.86% to 63.50%, the emulsification from 3.13% to 7.10%, and the foaming capacity from 19.33% to 179.67%. It was revealed that pH shifting combined HPH treatment depolymerized the aggregates, reduced the particle size, spread the structure, decreased the surface hydrophobicity of RDP, and avoided any bitterness production. These results have important implications for the modification of proteins with improved functional profiles.
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高影响因子
MOLECULES
·
2023
·Vol. 28
·期 20
·7029
·
IF 4.6
Yanjie Li,Rui Fan,Pengfei Gao,Chang-Hua Hu
Lipid droplets (LDs) targeting probes are important for investigating the biological functions of LDs. The interplay between LDs and some other organelles can help to further understand the biological functions of these organelles. However, it is still a challenge to design functional probes that can specifically target LDs and are responsive to some other organelles. Herein, a multifunctional aggregation-induced emission luminogen (AIEgen), namely the TPA-CN, was prepared by the simple aldimine condensation reaction for lipid droplet-specific imaging and tracing. TPA-CN can be sensitively responsive to the acid environment of lysosomes due to the pH-response detachable connector in TPA-CN. With the assistance of this characteristic, it can be concluded from the fluorescence imaging and co-localization analysis results that the internalization of TPA-CN and the targeting of LDs does not involve the lysosome and the lysosomal escape process. At last, the TPA-CN was successfully used for the high-sensitivity imaging of dynamic information of LDs.
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PubMed
高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Qiaoyan Wang,Changyu Zhou,Qiang Xia,Daodong Pan,Lihui Du,Jun He,Yangying Sun,Fang Geng,Jinxuan Cao
In order to investigate the effect of pH treatments on the coacervation mechanism of fibrinogen hydrolysates and carrageenan complex, the cold-set hydrogels of carrageenan and fibrinogen hydrolysates derived from the hydrolysis of chymotrypsin, alcalase and flavourzyme were prepared under different pH; mechanical strength, rheological properties, gelling structure, morphological observation, and chemical action force were investigated, and the antioxidant capacity of the hydrogels was further evaluated in meat preservation model. The results indicated that the hydrogels of carrageenan and fibrinogen hydrolysates derived from the hydrolysis of alcalase (AHs) showed the largest gel strength and the best viscoelasticity at pH 7.0 compared with other pH and hydrolase treatments. FTIR spectrum revealed that AHs showed more β-sheet and β-turn at pH 7.0 among all treatments. The interaction forces of these hydrogels showed various under different pH and hydrolase treatments, and the network of AHs hydrogels at pH 7.0 was mainly stabilized by electrostatic interaction and hydrophobic interaction. SEM and AFM demonstrated that the more regular three-dimensional network with smaller pore sizes was formed in AHs at pH 7.0 compared with pH 5.0 and pH 9.0. The AHs showed the largest scavenging ability for DPPH radicals (72.4%) at pH 7.0 in vitro , and the coated meat samples with AHs significantly increased the preservation times of fresh pork and dry-cured ham during the storage by inhibiting the increase of TBARS, TVB-N, and metmyoglobin. The finding of this work is expected to broaden the application of fibrinogen hydrolysate hydrogels into the field of food industry.
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高影响因子
ACS Applied Bio Materials
·
2023
·
IF 4.7
Shweta Pawar,Hamootal Duadi,Moran Friedman Gohas,Yoram Cohen,Dror Fixler
When exposed to specific light wavelengths, carbon dots (CDs), which tend to be fluorescent, can emit colorful light. It provides them with a lot of adaptability for different applications including bioimaging, optoelectronics, and even environmental sensing. Poly(ethylenimine) (PEI) coated carbon dots (PEI-CDs) with a long emission wavelength were synthesized via the hydrothermal method. The resultant CDs show strong fluorescence with quantum yield up to 20.2%. The PEI-CDs exist with distinct pH-sensitive features with pH values in the range of 2–14. The optical characteristics of CDs are pH-responsive due to the presence of different amine groups on PEI, which is a functional polycationic polymer. One of the most widely employed nanoparticles for improving the fluorescence plasmonic characteristics of a nanocomposite is gold. Gold nanoparticles were coupled with PEI-CDs in this assay by using the EDC-NHS coupling to increase the photoluminescence property of the PEI-CDs by using the metal-enhanced fluorescence approach. In the presence of gold nanoparticles, the fluorescence is enhanced 5–6 times. The likely mechanism in our investigation was primarily derived from enhancement of the intrinsic radiative decay rate rather than the local electric field impact. Moreover, PEI-CDs can be used as a bioimaging agent, as these molecules are nontoxic to the cells, and the positively charged PEI-CDs have the potential for nuclear targeting, allowing for electrostatic contact with DNA in the nucleus. This finding will expand the application that the PEI-CDs can be used in the future for targeted imaging applications.
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PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
·
2023
·
IF 13.1
Chunlin Li,Jinyuan Chen,Guoying Deng,Peilin Wang,Hao Zhang,Kai Zhu,Qitao Hu,Shiqing Feng,Qiugen Wang,Haodong Lin
Diabetic wounds management remains a significant global challenge due to impaired wounds healing, bleeding, and infection. Oxidative stress (OS), resulting from dysregulated mitochondrial reactive oxygen species (mtROS), plays a crucial role in the diabetic wounds pathogenesis. Furthermore, diabetic infected wounds can induce excessive ROS production and an acidic microenvironment due to the accumulation of bacterial metabolic products. Thus, a pH-sensitive intelligent dressing could serve as an ideal carrier for precise regulation of mtROS and promote faster diabetic wounds healing. In this study, we fabricated a pH-sensitive and mitochondria-modulating intelligent multilayered dressing system. We synthesized mesoporous silica-coated selenium particles (SS) for mtROS regulation and infection resistance. These SS were then loaded into a polyvinyl alcohol (PVA)/(N-[(2-hydroxy-3-trimethylamine) propyl] chitosan chloride, HTCC) hydrogel for pH-sensitive controlled release, blood coagulation, and antibacterial treatment. Finally, the resulting system was cross-linked with carboxymethyl cotton gauze (CG) to enhance hemostatic ability and reduce adhesiveness. Experimental results from cellular and animal models of diabetic wounds demonstrated that HTCC/PVA/SS-CG dressing promotes faster hemostasis, protects against microbial infection, and accelerates diabetic wounds healing through its mitochondria-modulating action, which offers a comprehensive treatment strategy for diabetic wounds and shows promising prospects for clinical transformation.
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高影响因子
危险品化学品经营许可证（带存储）