Acta Biomaterialia
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2022
·
IF 10.633
Jingjing Zhou,Zhaopeng Wang,Changyan Yang,Hanru Zhang,Muhammad Subaan Fareed,Yuhang He,Jie Su,Panpan Wang,Zhiqiang Shen,Wenjin Yan,Kairong Wang
Bacterial infection and local growth factor deficiency are two of the major causes of the nonunion of diabetic wounds. Antimicrobial peptides (AMPs) are believed to be alternatives to antibiotics against drug-resistant bacterial infections. 8-Bromoadenosine-3’, 5’-cyclic monophosphate (8Br-cAMP) can promote cells to secrete growth factors and accelerate cell proliferation . In the present study, we constructed a hydrogel with antimicrobial peptide Jelleine-1 (J-1) and 8Br-cAMP without any other gelators or chemical crosslinking agents. The hydrogel was proved to promote the secretion of transforming growth factor-β (TGF-β) and vascular endothelial growth factor-A (VEGFA) in vitro and in vivo . Notably, it exhibited potent potential for wound healing in methicillin-resistant Staphylococcus aureus ( MRSA ) infected diabetic wounds. This would be attributed to the retention of AMPs and 8Br-cAMP on the wound site by the hydrogel system. In addition, the hydrogel also showed good biodegradability , proper stability, and good biocompatibility. This study would shed light on the development of carrier-free and multifunctional hydrogel for wound healing. Statement of significance Bacterial infection and local growth factor deficiency are two of the major causes for the nonunion of refractory wounds. In the present study, an injectable carrier-free hydrogel was constructed of a natural antimicrobial peptide J-1 and 8Br-cAMP by eco-friendly physical crosslinking without any other gelators or chemical crosslinking agents. The hydrogel exhibited excellent antimicrobial activity and was proved to promote the secretion of TGF-β and VEGFA in vitro and in vivo . Correspondingly, the hydrogel showed exceptionally wound healing effects in the wound model of MRSA infected diabetic rats. This study would provide an alternative strategy or a potential hydrogel dressing for the treatment of chronic or refractory wounds.
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BIOMEDICINE & PHARMACOTHERAPY
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2022
·
IF 7.419
Xi Luo,Yi Zheng,Yong-rui Bao,Shuai Wang,Tian-jiao Li,Jia-peng Leng,Xian-sheng Meng
Colitis-associated cancer (CAC) is the colorectal cancer (CRC) subtype that is difficult to treat, and shows high mortality. The consumption of flavonoid-rich fructus aurantii extracts (FAE) has been associated with multiple beneficial effects including anti-inflammatory and anti-cancer properties, but the potential effects on the colitis-associated carcinogenesis have not been thoroughly investigated. Recent clinical data show that, as yet, few agents clearly inhibited CRC development in long-standing inflammatory bowel diseases. Here, we identified that FAE showed significant efficiency to inhibit HT-29 cell proliferation. The potential of FAE in vivo was further evaluated in an AOM/DSS-induced CAC mouse model. Intriguingly, FAE diminished the number of polyps in mice. Furthermore, FAE inhibited CAC by regulating the gene expression of Notch/ NF-κB/IL-1 signaling pathways. Collectively, these results were indicative of FAE has great potential in CAC prevention and treatment.
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 9
·1-11
·
IF 6.408
Yang Yu-Ping,Chen Ji-Kai,Guo Ping,Lu Yan-Rui,Liu Cai-Fang,Wang Bang-Jin,Zhang Jun-Hui,Xie Sheng-Ming,Yuan Li-Ming
A spherical chiral porous organic polymer (POPs) COP-1 is synthesized by the Friedel–Crafts alkylation reaction of Boc-3-(4-biphenyl)-L-alanine (BBLA) and 4,4′-bis(chloromethyl)-1,1′-biphenyl (BCMBP), which was used as a novel chiral stationary phase (CSPs) for mixed-mode high-performance liquid chromatography (HPLC) enantioseparation. The racemic compounds were resolved in normal-phase liquid chromatography (NPLC) using n-hexane/isopropanol as mobile phase and reversed-phase liquid chromatography (RPLC) using methanol/water as mobile phase. The COP-1-packed column exhibited excellent separation performance toward various racemic compounds including alcohols, amines, ketones, esters, epoxy compounds, organic acids, and amino acids in NPLC and RPLC modes. The effects of analyte mass and column temperature on the separation efficiency of racemic compounds were investigated. In addition, the chiral resolution ability of the COP-1-packed column not only can be complementary in RPLC/NPLC modes but also exhibit a good chiral recognition complementarity with Chiralpak AD-H column and chiral porous organic cage (POC) NC1-R column. The relative standard deviations (RSD) ( n = 5) of the retention time, resolution value, and peak area by repeated separation of 1-(4-chiorophenyl)ethanol are all below 3.0%. The COP-1 column shows high column efficiency (e.g., 17,320 plates m −1 for 1-(4-chlorophenyl)ethanol on COP-1 column in NPLC), high enantioselectivity, and good reproducibility toward various racemates. This work demonstrates that chiral POPs microspheres are promising chiral materials for HPLC enantioseparation. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Hiu Lam So,Wei Chu
This study demonstrated a simultaneous photocatalysis and adsorption of 1-naphthol by peroxymonosulfate (PMS), FeOOH and UV-C in a novel column reactor, which is composed of a submerged UV-C lamp, mixed quartz bead-FeOOH media bed and a continuous supply of oxidant. Around 80 % of 1-naphthol was removed at its optimal condition. The reaction mechanism was found to be pH dependent. At lower pH, photocatalysis and adsorption are favored as the catalyst surface is protonated (≡FeOH 2 + ) to promote PMS activation and 1-naphthol adsorption, and the dissolution of Fe 3+ enhanced homogeneous activation of PMS. At pH level higher than 8, the reaction becomes retarded due to the deprotonation of catalyst surface and dissociation of 1-naphthol into its conjugate base. Superoxide radical (O 2 •- ), singlet oxygen ( 1 O 2 ) and sulfate radical (SO 4 •- ) were confirmed to contribute to 1-naphthol oxidation . The reactor design was optimized at 20 min retention time. Due to the regeneration of Fe III /Fe II sites on FeOOH, the performance of reused catalyst is maintained at 90 % after 5 cycles of reuse. A quadratic regression with R 2 = 0.929 was used to model the concentration gradient of 1-naphthol along the column at different time intervals.
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ChemistrySelect
·
2022
·Vol. 7
·期 36
·e202203100
·
IF 2.307
Yanhong Wang,Duming Gong,Hongcheng Lu
Graphical Two new three-dimensional coordination polymers based on same semi-flexible ligand 1,4-bis(imidazole-1-ylmethyl)benzene (bix) have been successfully synthesized under hydrothermal condition. Both of them have similar local coordination environments but different magnetic properties due to their different topological structures and spin number S . Two new coordination polymers Ni(bix) 3 ⋅ 2(NO 3 ) ⋅ (H 2 O) 1 and Co(bix) 2 ⋅ 2(NO 3 ) 2 (bix=1,4-bis(imidazole-1-ylmethyl)benzene) have successfully been synthesized via hydrothermal reactions. These two compounds have similar local coordination environments but different topological networks due to the flexibility of the bix ligand. Additionally, magnetic studies reveal that 1 and 2 also exhibit different magnetic behaviors. Although magnetic exchange pathways are same as M II -bix-M II (M=Ni 1 , Co 2 ), 1 shows purely paramagnetic state almost down to 2 K with weak antiferromagnetic interaction; while stronger antiferromagnetic interaction in 2 is suggested. Meanwhile, an anomaly around 38 K in zero-field-cooled mode is observed but suppressed in field-cooled mode, which may be suggesting the spin canting for 2 . The field dependent magnetizations show magnetization of 2.17 μ B and 2.44 μ B at 7 T for 1 and 2 , respectively. Also, the magnetic interaction J / k B of −3.3 K is estimated for 2 .
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TETRAHEDRON
·
2021
·
IF 2.457
Qin He,Fangdi Dong,Longjiang Xing,Huahong He,Xiaoping Chen,Huaqian Wang,Shaomin Ji,Yanping Huo
A series of perylene derivatives bearing electron-donating group (amino) and electron-withdrawing group (nitro, maleimide) at the 1- and 3-position have been synthesized. Interestingly, 3-monosubstituted perylenes shown different photophysical properties compared with 1-monosubstituted perylenes. 3-nitroperylene ( 3-NO ) attained 80.62% photoluminescence quantum yield ( Φ PL ) in toluene which is higher than 3-aminoperylene ( 3-NH , Φ PL = 71.70%) and 1-aminoperylene (1-NH, Φ PL = 48.04%), but for 1-nitroperylene ( 1-NO ), no fluorescence in any solvent were observed. The calculated ground-state geometries of 3-monosubstituted perylenes actually correspond to nearly planar structures, but the molecules substituted at the 1-position all have a twisted structure. Among them, 3-NO had a great π-conjugated system, resulting in the allowed ππ∗ fluorescence. In contrast, the twisting structure of 1-NO enhanced nonradiative decay pathways, coupled with the electron-withdrawing effect of the nitro group, which can explain the non-luminescence of 1-NO . Furthermore, the moleculars with maleimide group were used as “off-on” fluorescent probes and successfully used for imaging biothiols in living H1299 lung cancer cells. The fluorescence of probe 2 (substitutes at 3-position of perylene) afforded a 188-fold intensity increase after reaction with thiol which is much higher than (65-fold) probe 1 (substitutes at 1-position) because of the better π-conjugated structure. We envision that the investigation on the effects of substitute at 1-and 3-positions of perylene may be helpful for a rational design and application of highly fluorescent molecule base on perylene.
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CHEMICAL ENGINEERING JOURNAL
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2021
·
IF 13.273
Hao Zhang,Fan Yu,Yong Wang,Lixiong Yin,Jiayin Li,Jianfeng Huang,Xingang Kong,Qi Feng
CdS has suitable band gap and high photoelectric conversion efficiency, which has attracted widespread attention. However, its severe photocorrosion and low photocatalytic activity limits its application. Generally, constructing heterojunction structure can effectively improve the separation efficiency of CdS photogenerated carriers, and its photocatalytic activity and stability can be further improved. Here, we prepared CdS hexagonal pyramid single crystal with co-exposed {0001} and {10 1 ¯ 1} crystal planes by the urothermal method. Type II heterojunction can be formed between {0001} and {10 1 ¯ 1} crystal planes, which can effectively improve the photocatalytic hydrogen production activity of CdS hexagonal pyramid. The photocatalytic hydrogen production activity of CdS hexagonal pyramid is 10.64 mmol·h -1 ·g -1 with an apparent quantum efficiency of 15.6% at 420 nm, which is 5.8 times and 13.2 times as high as CdS nanorod and CdS nanoparticles, respectively. Even after the 100 h cycle test, the CdS hexagonal pyramid shows still high photocatalytic activity. This work showed that the photocatalytic activity can be effectively improved by adjusting the crystal faces, which can further generaliza to other photocatalysts.
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CHEMICAL RESEARCH IN TOXICOLOGY
·
2021
·
IF 3.739
Tingjie Zhan,Shixuan Cui,Xujun Liu,Chunlong Zhang,Yu-ming M. Huang,Shulin Zhuang
Benzophenone-1 (BP-1), one of the commonly used ultraviolet filters, has caused increasing public concern due to frequently detected residues in environmental and recreational waters. Its susceptibility to residual chlorine and the potential to subsequently trigger endocrine disruption remain unknown. We herein investigated the chlorination of BP-1 in swimming pool water and evaluated the endocrine disruption toward the human androgen receptor (AR). The structures of monochlorinated (P1) and dichlorinated (P2) products were separated and characterized by mass spectrometry and 1H–1H NMR correlation spectroscopy. P1 and P2 exhibited significantly higher antiandrogenic activity in yeast two-hybrid assays (EC50, 6.13 μM and 9.30 μM) than did BP-1 (12.89 μM). Our 350 ns Gaussian accelerated molecular dynamics simulations showed the protein dynamics in a long-time scale equilibrium, and further energy calculations revealed that although increased hydrophobic interactions are primarily responsible for enhanced binding affinities between chlorinated products and the AR ligand binding domain, the second chloride in P2 still hinders the complex motion because of the solvation penalty. The mixture of BP-1–P1–P2 elicited additive antiandrogenic activity, well fitted by the concentration addition model. P1 and P2 at 1 μM consequently downregulated the mRNA expression of AR-regulated genes, NKX3.1 and KLK3, by 1.7–9.1-fold in androgen-activated LNCaP cells. Because chlorination of BP-1 occurs naturally by residual chlorine in aquatic environments, our results regarding enhanced antiandrogenic activity and disturbed AR signaling provided evidence linking the use of personal care products with potential health risks.
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EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2021
·Vol. 2021
·期 23
·2201-2210
·
IF 2.524
Shiwei Wang,Bo Yan,Juan Chai,Tianhao Li,Hongbo Yu,Tong Li,Peng Cao,Fan Yang,Xuemin Yuan,Hongfeng Yin
Graphical A prominently size-dependent intrinsic catalytic activity or structure-sensitive catalysis in N 2 O decomposition appeared over Rh encapsulated within silicalite-1 (Rh@S-1). The size of metal species plays a pivotal role in governing catalytic performance of supported metal catalysts. In this work, a series of Rh encapsulated within silicalite-1 catalysts with different sizes were prepared by one-pot hydrothermal method and employed to catalyze the decomposition of N 2 O. Detailed structure determinations by HAADF-STEM, XPS and CO-DRIFTS demonstrate that subtle modulation of the encapsulated Rh species were achieved easily from single-atom to nanoclusters and nanoparticles by controlling the loading and reduction conditions of Rh. The turnover frequency (TOF) of N 2 O decomposition showed a typical volcano-type dependence on Rh size. Kinetic studies revealed that this structure-sensitive catalysis was related to the difference in N 2 O and O 2 adsorption/desorption for various Rh species. Furthermore, a Rh@S-1 catalyst with a proper Rh size (ca. 1.6 nm) was identified as the best-performing catalyst with a maximum TOF (ca. 95 h −1 ), showing much superior activity than other reported Rh-based catalysts.
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ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Libin Pang,Pengfei Tian,Xu Cui,Xiuping Wu,Xiaoli Zhao,Hui Wang,Deping Wang,Haobo Pan
The hypoxia-inducible factor 1-alpha (HIF-1a) pathway plays a key role in regulating angiogenesis during wound healing. However, the diabetic condition hampers the stabilization of HIF-1a and thus inhibits the subsequent angiogenesis, and meanwhile, the function and phenotype transition of macrophage are impaired in the diabetic condition, which leads to prolonged and chronic inflammation. Both angiogenesis inhibition and inflammatory dysfunction make diabetic wound healing a major clinical challenge. Here, borosilicate (BS), a new group of bioceramics with a coupled network of interconnected [BO3] and [SiO4] which can incorporate therapeutic ions such as Cu2+, is synthesized and combined with silk fibroin (SF), a biocompatible natural amino acid polymer whose composition and structure are similar to a natural extracellular matrix (ECM), to obtain a compound system which can transform into a SF-MA-BS hydrogel under UV radiation via methacryloyloxy (MA) groups modified on both BS and SF. When in use, the compound system can thoroughly spread to the whole wound surface and be in situ photo-cross-linked to form an integral SF-MA-BS hydrogel that firmly adheres to the wound, protects the wound from external contamination, and further spontaneously promotes wound regeneration by releasing therapeutic ions. The wound repair of Streptozotocin-induced diabetic rats shows that diabetic wound healing is obviously accelerated by SF-MA-BS, interestingly the HIF-1a pathway is restored via interaction between HIF-1a and Cu2+, and angiogenesis is therefore enhanced. Meanwhile, inflammation is well regulated by SF-MA-BS, and long-term detrimental inflammation is avoided. These findings indicate that the SF-MA-BS hydrogel regenerates diabetic wounds, and further clinical trials are anticipated.
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ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 18
·2010603
·
IF 18.808
Chao Liu,Shuang Liu,Yifan Wang,Yanmeng Chu,Kai Yang,Xiadong Wang,Chenxu Gao,Qifei Wang,Jiankang Du,Sheng Li,Yue Hu,Yaoguang Rong,Lianbo Guo,Anyi Mei,Hongwei Han
Additives are widely adopted for efficient perovskite solar cells (PSCs), and proper additive design contributes a lot to PSCs’ various breakthroughs. Herein, a novel additive of N ,1-fluoroformamidinium iodide (F-FAI), whose cation replaces one amino group in guanidinium (GA + ) with electron-withdrawing fluorine group, is synthesized and applied as the additive for PSCs. The electron-withdrawing effect of fluorine promotes the molecular polarity of N ,1-fluoroformamidine (F-FA), enhancing the interaction of N ,1-fluoroformamidinium (F-FA + ) with MAPbI 3 . Compared with the nonpolar GA + , F-FA + improves the crystallinity, passivates the defect, and downshifts the Fermi level of MAPbI 3 more significantly. The charge transfer and built-in field in printable triple mesoscopic PSCs are therefore enhanced. Moreover, charge transport in MAPbI 3 is also promoted by F-FAI. With these benefits, a power conversion efficiency of 17.01% for printable triple mesoscopic PSCs with improved open-circuit voltage and fill factor is obtained with the addition of F-FAI, superior to the efficiency of 15.24% for those devices with guanidinium iodide additives.
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Frontiers in Cell and Developmental Biology
·
2020
·
IF 5.186
Hong Lin,Chen Jundixia,Wu Fang,Wu Fengjiao,Shen Xin,Zheng Peisen,Shao Rongrong,Lu Kongqin,Liu Zhiguo,Chen Daoxing,Liang Guang,Cai Yuepiao,Zou Peng,Xia Yiqun
Colon cancer is one of the leading causes of cancer-related death in the world. The development of new drugs and therapeutic strategies for patients with colon cancer are urgently needed. Isodeoxyelephantopin (ESI), a sesquiterpene lactone isolated from the medicinal plant Elephantopus scaber L., has been reported to exert antitumor effects on several cancer cells. However, the molecular mechanisms underlying the action of ESI is still elusive. In the present study, we found that ESI potently suppressed cell proliferation in human colon cancer cells. Furthermore, our results showed that ESI treatment markedly increased cellular reactive oxygen species (ROS) levels by inhibiting thioredoxin reductase 1 (TrxR1) activity, which leads to activation of the JNK signaling pathway and eventually cell death in HCT116 and RKO cells. Importantly, we found that ESI markedly enhanced cisplatin-induced cytotoxicity in HCT116 and RKO cells. Combination of ESI and cisplatin significantly increased the production of ROS, resulting in activation of the JNK signaling pathway in HCT116 and RKO cells. In vivo, we found that ESI combined with cisplatin significantly suppressed tumor growth in HCT116 xenograft models. Together, our study provide a preclinical proof-of-concept for ESI as a potential strategy for colon cancer treatment.
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