FUEL
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2023
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IF 7.4
Yu Chen,Lei Jiang,Bing Bao,Chunqiang Lu,Yunkun Zhao,Shiying Chang,Dongxia Yang,Depeng Zhao,Xianming Cheng,Hua Wang,Kongzhai Li
With the improvement of current global vehicle emission standards increase and widespread application of natural gas vehicles (CNG), existing three-way catalytic converters (TWCs) need to be modified to meet the new emission regulations. In recent years, the price of palladium has been rising, while platinum, which is also used in catalytic systems, is relatively cheap, and the industry has come up with the idea of replacing palladium with platinum. Palladium loaded with a mass fraction of 1% on Ce 0.4 Zr 0.5 La 0.05 Y 0.05 O 1.95 (CZLY) did show excellent catalytic activity, however, when palladium is replaced by platinum, the catalytic activity of the catalyst for methane combustion is significantly reduced. At 680 °C under oxygen-rich conditions (20%), methane conversion can typically reach 90%. The reduced 1% Pt/CZLY catalyst, on the other hand, was unstable in activity at high temperatures, although it was significantly higher at the starting temperature (T 50 = 378 °C). In this work, it was found that the addition of niobium to CZLY improved the activity of Pt-based catalysts. The 1% Pt/Ce 0.4 Zr 0.5 La 0.05 Nb 0.05 O 2 (1% Pt/CZLN) catalysts showed a decrease in T 90 (CO) of 26 °C and T 90 (CH 4 ) of approximately 250 °C. The activity of this catalyst is consistent with that of the reduction pre-treatment 1% Pt/CZLY catalyst. Results from thermal deactivation and sulphur poisoning experiments show that the 1% Pt/CZLN catalyst exhibits superior thermal stability and anti-sulphur toxicity. For example, methane conversion of the 1% Pt/CZLN catalyst maintained at 85% at 600 °C for 32 h with a 5% decrease in activity. To clearly explain the effect of niobium doping on the catalyst, BET, XRD, H 2 -TPR, XPS and TEM tests were performed on the catalysts confirming that the strong Pt-Nb interaction stabilizes the valence state of the platinum and loads the platinum on the carrier surface in the active metallic platinum state. The amount of niobium doping was positively correlated with the metallic Pt content in the catalyst. In conclusion, the addition of niobium to platinum-based catalysts increases the methane combustion activity of the catalyst and delays thermal deactivation and sulphur poisoning of the platinum-based catalyst, extending the service life of the platinum-based catalyst.
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高影响因子
INFLAMMATION
·
2023
·
IF 5.1
Feng Yong,Hu Jiapeng,Liu Fen,Shang Yunxiao
Asthma is a chronic inflammatory disease characterized by airway remodeling and lung inflammation. Collagen triple helix repeat containing 1 (CTHRC1), a glycoprotein, is involved in multiple pathological processes, including inflammation and fibrosis. However, the function of CTHRC1 in asthma remains unclear. In the present study, the mouse asthma model was successfully generated by sensitizing and challenging mice with ovalbumin (OVA). CTHRC1 expression at both RNA and protein levels was significantly upregulated in lung tissues of asthmatic mice. Asthmatic mice exhibited significant airway remodeling as evidenced by increased bronchial wall and smooth muscle cell layer thickness, goblet cell hyperplasia and collagen deposition, and epithelial-mesenchymal transition (EMT), but those characteristics were reversed by CTHRC1 silencing. The cell model with transforming growth factor-β1 (TGF-β1) induction in bronchial epithelial cells (BEAS-2B) was conducted to verify the effects of CTHRC1 on EMT, a classic mechanism that mediates airway remodeling. The results showed that TGF-β1 stimulation increased CTHRC1 expression, and CTHRC1 knockdown inhibited TGF-β1-induced EMT. OVA-treated mice also showed increased inflammatory cell infiltration and the production of OVA-specific immunoglobulin E (IgE), interleukin (IL)-4, IL-5, and IL-13, which were decreased by CTHRC1 downregulation. The effects of CTHRC1 on OVA-induced airway inflammation were further determined by treating BEAS-2B cells with IL-13, in which CTHRC1 knockdown reduced the IL-13-induced secretion of pro-inflammatory factors, including IL-4 and IL-5. In conclusion, these results indicate that CTHRC1 silencing attenuates asthmatic airway remodeling and inflammation in vivo and in vitro, suggesting that CTHRC1 may be a potential target for asthma treatment. Graphical Abstract
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PubMed
高影响因子
CANCER LETTERS
·
2023
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IF 9.7
Xiaosong Wei,Beibei Wang,Zixin Wu,Xiaoming Yang,Yufeng Guo,Yang Yang,Zhiwei Fang,Chengzhi Yi,Liuhui Zhang,Xin Fan,Lirong Zhang,Dongkui Song
One of the most abundant protein-protein interaction domains in the human proteome is the WD40 repeat (WDR) domain. A Gene Expression Omnibus dataset revealed 37 differentially expressed WDR domain genes in bladder cancer (BC). WD repeat domain 54 ( WDR54 ), an upregulated WDR domain gene, was selected for further investigation. Sixty pairs of frozen BC tumor and non-malignant bladder tissues and 83 paraffin-embedded BC tissue specimens were obtained. Loss-/gain-of-function experiments were carried out using BC and xenograft tumor models. WDR54 was overexpressed in BC cells, and its high expression was linked to tumor stage and lymph node metastases in patients. WDR54 contributed to the tumorigenesis and metastasis of BC and impaired its chemosensitivity. WDR54 prevented the degradation and ubiquitination of the mediator of ErbB2-driven cell motility 1 (MEMO1). WDR54 also promoted the interaction between MEMO1 and insulin receptor substrate 1 (IRS1) and activated the IRS1/AKT/β-catenin pathway in BC cells. Particularly, WDR54 depended on MEMO1 to exert its biological functions. Our study demonstrated the relevance of WDR54 in BC and provides insight into the molecular mechanism underlying BC.
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PubMed
高影响因子
Aggregate
·
2023
·Vol. 4
·期 4
·e318
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IF 18.8
Chang'an Wang,Guoqing An,Jing Lin,Xiaowei Zhang,Zhiyuan Liu,Yibin Luo,Siqi Liu,Zhixiang Cheng,Tingting Guo,Hongyi Gao,Ge Wang,Xingtian Shu
Simultaneous achievement of constructing mesopores and eliminating anatase is a long-term pursuit for enhancing the catalytic performance of TS-1. Here, we developed an aromatic compounds-mediated synthesis method to prepare anatase-free and hierarchical TS-1 for olefin epoxidation. A series of hierarchical TS-1 zeolites were prepared by introducing aromatic compounds containing different functional groups via the crystallization process. The formation of intercrystalline mesopores and insertion of titanium into framework were facilitated at different extent. The synergistic coordination of carboxyl and hydroxyl in aromatic compounds with Ti(OH) 4 realizes the uniform distribution of titanium species and eliminates the generation of anatase. Noteworthily, eight machine learning models were trained to reveal the mechanism of additive functional groups and preparation conditions on anatase formation and microstructure optimization. The prediction accuracy of most models can reach more than 80%. Benefiting from the larger mesopore volumes (0.37 cm 3 ·g −1 ) and higher content of framework Ti species, TS-DHBDC-48h samples exhibit a higher catalytic performance than other zeolites, giving 1-hexene conversion of 49.3% and 1,2-epoxyhenane selectivity of 99.9%. The paper provides a facile aromatic compounds-mediated synthesis strategy and promotes the application of machine learning toward the design and optimization of new zeolites.
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高影响因子
Frontiers in Bioengineering and Biotechnology
·
2023
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IF 5.7
Xiong Liping,Bao Han,Li Size,Gu Deao,Li Yuyang,Yin Qianwen,Li Wen,Miao Leiying,Liu Chao
Oxidative stress is closely linked to the etiology of temporomandibular joint osteoarthritis. (TMJ-OA) and is an important therapeutic target. Cerium oxide nanoparticles (CNPs) have been broadly studied owing to their powerful antioxidant properties and potential preventive and therapeutic effects against chronic diseases. The current study was designed to explore the protective effects of CNPs on the progression of TMJ-OA and their potential mechanisms. We detected the ability of CNPs to eliminate reactive oxygen species (ROS) in chondrocytes. Moreover, their protective effects on chondrocytes were detected in the level of gene and protein. Furthermore, TUNEL assay, histology and safranin O-fast green staining were used to detect the beneficial effects of CNPs on cartilage explants. The mechanism of CNPs, protecting condylar cartilage by reducing inflammation, was further explored by knocking down the Nuclear factor-erythroid 2-related factor (Nrf2) gene. CNPs could reduce the ROS levels in chondrocytes and cartilage explants and reverse the IL-1β-induced imbalance of cartilage matrix metabolism and apoptosis. The protective effects of CNPs on cartilage were lost after key antioxidant factors including Nrf2 and heme-oxygenase 1(HO-1) were significantly reduced. In conclusion, this study demonstrated for the first time that activating the Nrf2/HO-1 signaling pathway by CNPs might have therapeutic potential for TMJ-OA.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2023
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IF 4.2
Hongyu Qu,Xiangcheng Li,Xiao Han,Xinqiang Feng,Junjie Li,Zhendong Wang,Weimin Yang
The upgrading and utilization of 5-hydroxymethylfurfural (HMF) as a platform chemical for the manufacture of biofuels and biopolymers have drawn a lot of attention, especially for the selective hydrogenation of HMF to the biobased polymeric monomer tetrahydrofuran-2,5-dimethanol (THFDM). However, the catalytic hydrogenation of HMF with sustainability remains challenging. Herein, we report the synthesis of the Ni@U-Silicalite-1 catalyst, which shows a satisfying selectivity to THFDM (95.6%) under mild reaction conditions (1.5 MPa H2 and 130 °C). Characterization results show that the U-Silicalite-1 zeolite has a short b-axis, a flat reaction surface, and enlarged mesopores, which facilitate the accessibility to active sites of HMF. Meanwhile, the high distribution and small size of Ni nanoparticles contribute to the excellent catalytic efficiency and recyclability. Moreover, the strong interaction between Ni species and U-Silicalite-1 zeolite prevents the aggregation and leaching of Ni nanoparticles and endows the Ni@U-Silicalite-1 catalyst with good stability.
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JOURNAL OF CONTROLLED RELEASE
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2023
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IF 10.8
Xin Yang,Wanqiong Li,Shuzhen Li,Shaomeng Chen,Zheng Hu,Zhuoying He,Xueqin Zhu,Xiaoshuang Niu,Xiuman Zhou,Huihao Li,Youmei Xiao,Juan Liu,Xinghua Sui,Guanyu Chen,Yanfeng Gao
Peptide immune checkpoint inhibitors in cancer immunotherapy have attracted great attention recently, but oral delivery of these peptides remains a huge challenge due to the harsh gastrointestinal environment, large molecular size, high hydrophilic, and poor transmembrane permeability. Here, for the first time, a fish oil-based microemulsion was developed for oral delivery of programmed death-1/programmed cell death-ligand 1 (PD-1/PD-L1) blocking model peptide, OPBP-1. The delivery system was characterized, in vitro and in vivo studies were conducted to evaluate its overall implication. As a result, this nutraceutical microemulsion was easily formed without the need of co-surfactants, and it appeared light yellow, transparent, good flowability with a particle size of 152 ± 0.73 nm, with a sustained drug release manner of 56.45 ± 0.36% over 24 h and a great stability within the harsh intestinal environment. It enhanced intestinal drug uptake and transportation over human intestinal epithelial Caco-2 cells, and drastically elevated the oral peptide bioavailability of 4.1-fold higher than that of OPBP-1 solution. Meanwhile, the mechanism of these dietary droplets permeated over the intestinal enterocytic membrane was found via clathrin and caveolae-mediated endocytic pathways. From the in vivo studies, the microemulsion facilitated the infiltration of CD8 + T lymphocytes in tumors, with increased interferon-γ (IFN-γ) secretion. Thus, it manifested a promising immune anti-tumor effect and significantly inhibited the growth of murine colonic carcinoma (CT26). Furthermore, it was found that the fish oil could induce ferroptosis in tumor cells and exhibited synergistic effect with OPBP-1 for cancer immunotherapy. In conclusion, this fish oil-based formulation demonstrated great potential for oral delivery of peptides with its natural property in reactive oxygen species (ROS)-related ferroptosis of tumor cells, which provides a great platform for functional green oral delivery system in cancer immunotherapy.
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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
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2023
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IF 2.3
Qin Qin,Cao Weiqi,Zhaxi DaWa,Chen Xianyong,Andreeva Daria V.,Chen Kefan,Yang Shuai,Tian Hao,Shaker Majid,Jin Zhan,Novoselov Kostya S.
Phase change materials (PCMs) offer efficient solutions for energy sustainability. Here, we used 1-decanol, expanded graphite (EG) with high thermal conductivity, and silica aerogel (SA), which is often used for thermal insulation protection, to prepare composite PCMs (EG-PCM and SA-PCM) with stable shape through the vacuum absorption method. The leakage rate test after heat treatment determined the optimum contents of EG and SA in the composite PCMs to be 9 and 14 wt.%, respectively. Even after 220 heating/cooling cycles, the fabricated composite PCMs still maintain good thermal stability. The thermal conductivity enhancement of EG-PCM and SA-PCM to 16.09 times and 1.21 times of the neat PCM, respectively. Moreover, we tested the prepared two composite PCMs by yogurt preservation experiments in a cold chain transport portable box, which proved that they could effectively maintain the temperature and acidity of yogurt for several hours without any cooling system. Based on these results, EG-PCM and SA-PCM have broad application prospects in cold chain transport of temperature-sensitive products such as food, medicine, and vaccine.
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高影响因子
ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Can Cheng,Heng Li,Jingwen Liu,Liang Wu,Zhengdong Fang,Geliang Xu
Tissue engineering approaches such as the electrospinning technique can fabricate nanofibrous scaffolds which are widely used for small-diameter vascular grafting. However, foreign body reaction (FBR) and lack of endothelial coverage are still the main cause of graft failure after the implantation of nanofibrous scaffolds. Macrophage-targeting therapeutic strategies have the potential to address these issues. Here, we fabricate a monocyte chemotactic protein-1 (MCP-1)-loaded coaxial fibrous film with poly(l-lactide-co-ε-caprolactone) (PLCL/MCP-1). The PLCL/MCP-1 fibrous film can polarize macrophages toward anti-inflammatory M2 macrophages through the sustained release of MCP-1. Meanwhile, these specific functional polarization macrophages can mitigate FBR and promote angiogenesis during the remodeling of implanted fibrous films. These studies indicate that MCP-1-loaded PLCL fibers have a higher potential to modulate macrophage polarity, which provides a new strategy for small-diameter vascular graft designing.
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PubMed
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
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2023
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IF 2.6
Jiajun Wei,Lingxiao Yi,Wang Yuxin,Erkang Li,Zhen Yujie,Fangyu Zhang,Xinlei Niu,Jinshan Wang,Deming Zhao,Yingmin Yu
Liquid–liquid equilibrium (LLE) measurements were conducted at a temperature of 298.2 K and a pressure of 101.3 kPa for the ternary system consisting of 1,3-propanediol, 2-propyl-1-heptanol, and various extractants (n-hexane, vinyl acetate, ethyl benzene, and water). By calculating the distribution constant (D) and selectivity (S) in each system, the ability of four extractants to separate the mixture of 1,3-propanediol and 2-propyl-1-heptanol was compared. Furthermore, the LLE data underwent regression using thermodynamic models NRTL and UNIQUAC. The degree of deviation between the experimental data and regression data was assessed using the root mean square deviation (RMSD) and the average absolute deviation (AAD). The RMSD values for the NRTL and UNIQUAC models were below 0.74 and 0.76%, respectively, with corresponding AAD values below 0.39 and 0.60%. These results indicate a robust concurrence between the experimental data and the outcomes of the regression analysis. Finally, the GUI-MATLAB tool was employed to validate the coherence of the experimental data with the regression parameters. σ-Profiles are used to discuss the interactions of substances in this work. The results showed that the D and S of all four systems were greater than 1, indicating that all four extractants were effective in separating 1,3-propanediol and 2-propyl-1-heptanol. The order of their extraction capacity was water ≥ hexane ≥ ethyl benzene ≥ vinyl acetate.
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Molecular Catalysis
·
2023
·
IF 4.6
Junya Cao,Xiaoxuan Wang,Liguo Wang,Yan Cao,Xiang Hui,Peng He,Huiquan Li
The carbonylation of 1,6-hexanediamine (HDA) is an important method for the production of dimethyl hexane-1,6-dicarbamate (HDC), which is of great significance for the non-phosgene synthesis of hexamethylene-diisocyanate. This research focuses on the synthesis of HDC through the methoxycarbonylation of HDA using methyl carbamate as a carbonyl source. The study investigates the utilization of CeO 2 catalyst prepared via H 2 O 2 assisted precipitation. Various characterization techniques, including N 2 physical adsorption and desorption, SEM, TEM, XRD, NH 3 TPD, CO 2 TPD, and XPS are employed to analyze the texture and structure of CeO 2 catalysts prepared through different methods. In situ FTIR experiments are conducted to monitor the potential process of the carbonylation reaction. The results of the in situ FTIR spectroscopy clearly indicate the formation of polyurea as an intermediate compound, which subsequently converts into HDC. The findings demonstrate that CeO 2 prepared using the hydrogen peroxide precipitation method exhibits a larger specific surface area, stronger acid-base properties, and a higher content of surface-adsorbed oxygen. These characteristics are favorable for the carbonylation reaction. Under optimized conditions, the HDC yield reaches 96.0% with complete conversion of HDA. The catalyst's activity essentially maintained throughout ten cycles. Additionally, a substrate versatility study reveals that CeO 2 exhibits excellent catalytic properties for synthesizing a range of aliphatic and alicyclic dicarbamates.
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ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Li Xu,Xidong Wang,Luhan Wang,Shuyang Bao,Yu Wang,Xiaojuan Liang,Weidong Xiang
Inorganic fluorescent glass films have been widely considered in the field of high power laser lighting because of their excellent comprehensive properties as fluorescent conversion materials. Herein, we adjust the optimum sintering temperature to prepare a series of La3Si6N11:Ce3+ phosphor-in-glass films (LSN PiFs) with excellent optical properties on a single sapphire structure. The prepared LSN PiF has ultrahigh internal quantum efficiency (IQE) (98%) and excellent thermal stability. The thermal conductivity at room temperature can reach 9.8 Wm–1 K–1. When the temperature is 100 °C, the fluorescence intensity can still be maintained. The LSN:Ce phosphor particles did not react with the glass matrix and retained the original luminescence properties. Moreover, by further adjusting the concentration and thickness of LSN PiF, the luminous flux and luminous efficiency of LSN PiF under optimal conditions can reach 1071.73 and 207.58 lmW–1 under the excitation of 460 nm, which is the optimal result reported so far. In addition, the color rendering index (CRI) and low color temperature (CCT) are 64.05 and 5612.6 K, respectively, and the color coordinates are all close to the white light region. All the results show that LSN PiF has great application prospects in the high quality and high brightness laser lighting field.
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危险品化学品经营许可证（带存储）