Frontiers in Pharmacology
·
2023
·
IF 5.6
Niu Ting,Wei Zhiying,Fu Jiao,Chen Shu,Wang Ru,Wang Yuya,Zheng Ruihe
Introduction: Venlafaxine is one of the most commonly used anti-depressant and antineoplastic drug. Previous studies have predicted venlafaxine as an anti-cancer compound, but the therapeutic effects of venlafaxine in melanoma have not yet been demonstrated. Nur77 is an orphan nuclear receptor that highly expressed in melanoma cells and can interact with Bcl-2 to convert Bcl-2 from an antiapoptotic to a pro-apoptotic protein.Method: We examined the effects of venlafaxine in MV3 cells in vitro and MV3 xenograft tumor in nude mice. Western-blot, PCR, TUNEL assay and immunofluorescence were used to reveal the growth of melanoma cells.Results: Here, our data revealed that venlafaxine could reduce the growth, and induce apoptosis of melanoma cells through a Nur77-dependent way. Our results also showed that treatment with venlafaxine (20 mg/kg, i.p.) potently inhibited the growth of melanoma cells in nude mice. Mechanistically, venlafaxine activated JNK1/2 signaling, induced Nur77 expressions and mitochondrial localization, thereby promoting apoptosis of melanoma cells. Knockdown of Nur77 and JNK1/2, or inhibition of JNK1/2 signaling with its inhibitor SP600125 attenuated the anti-cancer effects of venlafaxine.Conclusion: In summary, our results suggested venlafaxine as a potential therapy for melanoma.
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JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2019
·Vol. 166
·期 2
·H1
·
IF 3.12
Bin Hu,Chun-yang Li,Jun-wei Chu,Zeng-chen Liu,Xin-lei Zhang,Lin Jin
Three new 2, 5-di(2-thienyl)-1H-pyrrole(DTP) derivatives, 10-[4-(2,5-Di- thiophen-2-yl-pyrrol-1-yl)-phenyl]-10H-pheno-thiazine (TPPT), 10-[4-(2,5-Di- thiophen-2-yl-pyrrol-1-yl)-phenyl]-10H-phenox azine (TPPO) and 10- [4-(2,5 -Di-thiophen-2-yl-pyrrol-1-yl)-phenyl]-10H-acridin-9-one (TPAO), were synthesized and characterized. TPPT and TPPO showed similar absorption and emission feature owing to similar chemical structure, TPAO displayed bathochromic-shift for both absorption and emission feature due to the existence of ketone group. All the monomers could be electropolymerized to form their polymer film on the electrode surface via oxidative coupling reactions of DTP units. PTPPT film showed yellow-green, green and purple red color upon different applied potentials. PTPPO and PTPAO films exhibited green and yellow at the neutral state, respectively, and turned into the similar violet color for the oxidized state. Moreover, the copolymer P(TPPT/EDOT) and P(TPAO/EDOT) not only showed obvious color change(red, yellow, green and blue), but also possessed better electrochemical stability.
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Molecular Medicine Reports
·
2019
·Vol. 19
·期 3
·1781-1790
·
IF 1.851
Yan Luo,Daogong Zhang,Yueling Chen,Zhongsheng Cao,Zhaomin Fan
The brain‑derived neurotrophic factor (BDNF) and c‑Jun NH 2‑terminal kinase (JNK) signaling pathways are therapeutic targets to prevent degeneration in the central nervous system. Dexamethasone (DXMS), a glucocorticoid, protects against vestibular brain injury, however, the molecular mechanisms have yet to be fully elucidated. To investigate whether the BDNF and JNK signaling pathways are involved in the protective effects of DXMS in rats with vestibular dysfunction, a rat model of severe vestibular deficits was established by middle ear injection of arsanilic acid (AA; 100 mg/ml; 0.05 ml). After 3 days, rat symptoms and behavior scores with vestibular disorders were detected. In brain tissues, histopathological alterations, cell apoptosis, expression levels and patterns of BDNF signaling pathway‑associated BDNF, tyrosine receptor kinase B (TrKB) and K+/Cl‑ cotransporter isoform 2 (KCC2), and the expression of apoptosis‑related cleaved‑caspase 3 and the JNK signaling pathway were detected. It was identified that DXMS relieved AA‑induced vestibular dysfunction, leading to improvement in rat behavior scores to normal levels, minimizing brain damage at the histopatholojnnkngical level, reducing cell apoptosis, enhancing the expression of BDNF, TrKB and KCC2, and downregulating cleaved‑caspase 3 and phosphorylated‑JNK1/2 in brain tissues. Together, these findings indicated the protective effect of DXMS on AA‑induced rat vestibular dysfunction, and that activating BDNF and inhibiting JNK singling pathways were the underlying mechanisms. In addition, with additional treatment of mifepristone (RU486), a specific glucocorticoid agonist, all the events elicited by DXMS mentioned above in the AA‑treated rat rats were reversed. In conclusion, DXMS was identified as a therapeutic agent targeting the BDNF and JNK singling pathways for AA‑induced rat vestibular dysfunction.
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ELECTROCHIMICA ACTA
·
2019
·
IF 5.383
Bin Hu,Chunyang Li,Zengchen Liu,Xinlei Zhang,Wen Luo,Lin Jin
Two novel asymmetric structure monomers , 3,6-Bis-(2,3-dihydro-thieno[3,4- b][1,4]dioxin-5-yl)-9-[4-(2,5-di-thiophen-2-yl-pyrrol-1-yl)-phenyl]-9H-carbazole (BDTC) and 2,7-Bis-(2,3-dihydro-thieno[3,4-b][1,4]dioxin-5-yl)-9-[4-(2,5-di-thio phen-2-yl-pyrrol-1-yl)-phenyl]-9H-carbazole (BDDC), were designed and synthesized. Both the monomers could be electropolymerized to form the related polymer films. The electrochemical and electrochromic properties of polymer films were different from that of their homopolymers , which could be attributed to the similar copolymerization effect of asymmetric structure. Different linked positions also led to different features, PBDDC film showed more colors (orange, yellow green, green and blue) than that of PBDTC film (yellow, green and purple blue). However, after the introduction of 2, 2′-Bi(3,4-ethoxylene dioxy thiophene)(BIEDOT), the resulting copolymers exhibited similar electrochromic features(red, brown yellow, green and blue) due to the leading effect of EDOT units. Moreover, all the polymer films displayed fast switching time, reasonable optical contrast and good coloration efficiency, which made them have potential application in electrochromic devices.
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Nanoscale
·
2018
·Vol. 10
·期 47
·22173-22179
·
IF 7.233
Kai Li,Jingwen Ma,Xinglong Guan,Hongwei He,Min Wang,Guoliang Zhang,Fengbao Zhang,Xiaobin Fan,Wenchao Peng,Yang Li
Electrolyzing water as a sustainable energy source is a promising and appealing method to resolve the environmental crisis. Developing efficient and stable bifunctional electrocatalysts for the hydrogen evolution reaction (HER) and the oxygen evolution reaction (OER) is crucial and challenging in the overall water splitting process. Herein, we report the synthesis of Ni(PO3)2–MoO3 nanorods anchored on nickel foam (Ni(PO3)2–MoO3/NF) within a two-step strategy and their application as a bifunctional water splitting electrocatalyst. The results show that the optimal Ni(PO3)2–MoO3/NF electrodes exhibit superior catalytic activity with robust durability and ultralow overpotentials of 86 mV for HER and 234 mV for OER to achieve 10 mA cm−2 (η10) in alkaline solution. The favorable performance of the obtained catalyst is attributed mainly to the synergetic effect between Ni(PO3)2 and MoO3, as well as the self-supporting porous conductive substrate. As a result, the integrated Ni(PO3)2–MoO3/NF electrodes deliver η10 at a small potential of 1.47 V for overall water splitting, highlighting a promising application as a bifunctional electrocatalyst.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2018
·
IF 3.141
Rui Zhang,Wusan Jiang,Zhiwu Liang,Xiao Luo,Qi Yang
The CO2 reaction rate in aqueous 2-methylpiperazine (2MPZ) solution was investigated in terms of the pseudo-first-order rate constant (k0) by using a stopped-flow apparatus with amine concentration ranges of 0.05–0.125 mol/L and the measuring temperature ranges of 293.15–313.15 K. The results show that the CO2 reaction rate in the 2MPZ solution increased as the temperature and the amine concentration increases. The results also demonstrate that the 2MPZ has a faster reaction rate in terms of k0 than 3-dimethylaminopropylamine, 3-diethylaminopropylamine, and monoethanolamine (MEA) but slower than that of PZ at the same amine concentration. The equilibrium solubility as an important absorption parameter for CO2 capture also were measured at 298.15, 313.15, and 333.15 K with CO2 partial pressures of 5–100 kPa, respectively, in 2 M 2MPZ solution. The results show that the CO2 equilibrium solubility of 2MPZ increased as the CO2 partial pressure increased but decreased as the temperature increased. The heat of CO2 absorption in 2 M 2MPZ solution was estimated by using the Gibbs–Helmholtz equation, and the value (−70.9 kJ/mol) is similar to that of PZ but lower than that of MEA. Besides the conclusions stated above, the results of the 13C NMR quantitative investigation suggest that 2MPZ can produce less carbamate and more bicarbonate than PZ at the same CO2 loading.
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DALTON TRANSACTIONS
·
2019
·Vol. 48
·期 16
·5315-5326
·
IF 4.052
Shaolei Zhao,Keyu Tao,Yun Gong
Co-Incorporated NiV2O6/Ni(HCO3)2 arrays with different morphologies can grow on nickel foam (NF) via a mild one-step hydrothermal method. Among them, S-0.5-20 and S-0.25-20 were obtained at a 1 : 1 : 20 molar ratio of Co/V/urea with 0.5 and 0.25 mmol Co(NO3)2, respectively. They demonstrate high areal capacities of 0.99 mA h cm−2 (7.94 F cm−2) and 0.56 mA h cm−2 (4.48 F cm−2) at 1 mA cm−2, respectively, which are superior to that of Co-incorporated Ni(HCO3)2/NF synthesized in the absence of Na3VO4. S-0.25-20 possesses good rate capability with 82.1% retention when the current density is increased 20-fold, and it shows superior long-term durability with 106.2% retention of the initial capacity after 10 000 charging/discharging cycles at 100 mA cm−2. These results are associated with the porous and orderly hierarchical Co-incorporated NiV2O6/Ni(HCO3)2 nanoflake arrays directly grown on the Ni foam. Moreover, due to the synergetic effect of the individual components, electrons can be transferred from V centers to Ni active sites, thus improving the stability of the vanadate. The generation of more active species, such as Co3+, during cycling could account for the increased capacity. A S-0.25-10//activated carbon (AC) asymmetrical supercapacitor shows a high energy density of 0.533 mW h cm−2 at a power density of 0.232 mW cm−2 (0.415 mW h cm−2 at 4.983 mW cm−2). Furthermore, the formation mechanism of the Co-incorporated NiV2O6/Ni(HCO3)2 nanoflake arrays is proposed.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2018
·Vol. 30
·期 2
·1626-1636
·
IF 2.324
Li Yuexuan,Duan Yugang
Silicon coupling reagent is regarded as a common additive on surface treatment of polymer due to its high bonding strength and low cost. In this paper, a series of γ-(2, 3-epoxypropoxy) propyltrimethoxysilane (KH560)-based reduced graphene oxide (RGO)@Fe 3 O 4 (KH560/RGO@Fe 3 O 4 ) composites with different ratio of Fe 3 O 4 nanoparticles (NPs) are synthesized by a facile hydrothermal method. It is confirmed that the silicon reagent KH560, as a hopeful candidate for increasing the RGO lattice defects, is favorable to improve the electromagnetic wave absorption. Meanwhile, the microwave attenuation mechanism of KH560/RGO@Fe 3 O 4 composite suggests that the dielectric loss mainly causes by multiple Debye dipolar relaxation and its magnetic loss comes from the eddy-current effect of Fe 3 O 4 NPs over the high frequency range. In consequence, the KH560/RGO@Fe 3 O 4 composite endows the excellent absorption performance, the reflection loss (RL) value is optimized to − 25 dB at 14.1 GHz with a thickness of 3 mm and the maximum frequency bandwidth for RL < − 10 dB is 4.1 GHz with a thickness of 4 mm.
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Polymers
·
2019
·Vol. 11
·期 7
·1152
·
IF 3.164
Huiqin Zhang,Pan Liu,Zheng Chi,Xuegang Chen
Hydrophilic copolymers containing 2,2′:6′,2″-terpyridine moieties and acrylic acid (AA) units poly (acrylic acid-co-4-(2,2′:6′,2″-terpyridin-4′-yl)styrene) (P(AA-co-TPY)) were synthesized and characterized. Coordinated with different transition metal ions, the dilute aqueous solution of the copolymers exhibited red-shifted UV-vis absorption peaks of π-π* transition from 317 to 340 nm. Further, interacting with iron ions, the copolymer showed new absorption peaks at a longer wavelength region (570 nm) and the absorption intensity enhanced with increase of the ion concentration. When enough ions were added to coordinate with the 2,2′:6′,2″-terpyridine moieties, novel metallo-supramolecular hydrogels were obtained due to the formation of metal coordination bonds between polymer back bones and transition metal ions (Ni2+, Zn2+, Cd2+, Fe2+and Cu2+), which acted as self-assembly crosslinking structures. The mechanical strength and morphology of the resulting metallo-supramolecular hydrogels have been investigated.Keywords:terpyridine;hydrophilic polymer;metallo-supramolecular;hydrogels
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Nanoscale
·
2019
·Vol. 11
·期 30
·14400-14409
·
IF 6.97
Lei Xia,Xiaoyi Guo,Teli Liu,Xiaoxia Xu,Jinquan Jiang,Feng Wang,Zhen Cheng,Hua Zhu,Zhi Yang
Somatostatin receptor subtype 2 (SSTR2) is highly expressed in pulmonary neuroendocrine tumors, which account for approximately 25% of all lung cancers including small-cell lung cancer (SCLC). It is possible to establish SCLC-specific imaging agents for multimodal imaging to obtain tumor integrity information. Herein, we constructed novel multifunctional organic melanin nanoparticles (MNPs) as a carrier and surface-loaded somatostatin analog octreotide to produce a human small-cell lung cancer-targeted nanoprobe OCT-PEG-MNPs. MNPs have an excellent photoacoustic imaging (PAI) function and can be directly chelated with the magnetic resonance contrast agent Mn2+, and N-bromo succinimide (NBS) can be used as an oxidant to label the nanoparticles with the long half-life radionuclide 124I by an electrophilic substitution reaction. Therefore, (124I, Mn) OCT-PEG-MNPs can not only be used for PAI but also be used for positron emission tomography (PET) and magnetic resonance imaging (MRI). The NCI-H69 SCLC tumor xenograft model with high SSTR2 expression was constructed to evaluate the multimodal imaging ability of (124I, Mn) OCT-PEG-MNPs. This nanoprobe showed good imaging abilities in PAI, MRI and PET. The PA images showed that the photoacoustic signal in the NCI-H69 tumor site gradually increased with time, and the NCI-H69 xenograft showed a clear increase in the T1-weighted signal intensity after injection of Mn-OCT-PEG-MNPs at 24 h compared to that in the prescan. MicroPET and biodistribution studies showed that the uptake of NCI-H69 tumors (8.03 ± 0.37% ID g−1) was significantly higher than that in the control A549 model (3.35 ± 0.54% ID g−1) after injection of (124I, Mn) OCT-PEG-MNPs at 24 h. The (124I, Mn) OCT-PEG-MNPs were successfully applied to multimodal imaging in a small-cell lung cancer model with high SSTR2 expression. This nanoprobe may be considered for clinical trials since it combines the numerous advantages of organic nanoparticles.
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POLYMER BULLETIN
·
2019
·Vol. 77
·期 2
·989-1001
·
IF 1.858
Qiu Bining,Tian Hua,Yin Xueqiong,Zhou You,Zhu Li
In this study, 2-phenyl ethanol (2-PEA) was microencapsulated with natural and semisynthetic carbohydrate polymers as the wall material. The wall material components methylcellulose (MC), alginate sodium (ALG), and carboxymethyl chitosan were optimized according to the results of microscopy images, zeta potential, and 2-PEA content. The combination of MC/ALG/MC was selected as the best wall components. Cobalt chloride (CoCl 2 ) was used as the core material to prepare microcapsules whose color was measured with a colorimeter to intuitively express the water absorption of the microcapsules. The absorbed water mass and b* were related to one variable quadratic equation. The rapid release properties and the natural long-term release properties of 2-PEA microcapsules were measured.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2019
·
IF 4.175
Huichang Li,Senlin Wang,Junhui Ye,Weijun Liang,Yanxiu Zhang,Jian Gu
A unique 3D hierarchical mesoporous Al-doped α-Ni(OH) 2 /reduced graphene oxide (NH/rGO) composite for supercapacitor has been successfully synthesized via homogeneous precipitation method. In this process, urea as the alkali source and mild reducing agent, to make graphene oxide (GO) convert into rGO. Thus, The NH uniformly grew on the rGO nanosheets . The as-prepared mesoporous NH/rGO composite exhibited high capacitance performance with a specific capacitance of 2558 F g −1 at the current density of 1 A g −1 , and presented good rate capability with still held 75.3% capacity at 30 A g −1 . Moreover, we used the NH/rGO as the positive electrode and the rGO aerogel as the negative electrode to assemble an asymmetric supercapacitor (ASC) device. This ACS device showed excellent specific energy of 166.97 Wh kg −1 at the power density of 0.38 kW kg −1 , and it still retains the specific energy of 100.91 Wh kg −1 under the higher specific power of 7.76 kW kg −1 . And it also displayed high rate performance and cycling durability with keeps 72% of the initial capacity after 3000 cycles (at 3 A g −1 ).
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危险品化学品经营许可证（带存储）