ACTA PHARMACOLOGICA SINICA
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2026
·
IF 10.4
Jiang Feng,Fu Huang-xi,Wang Lan,Pan Ze-zheng,Jiang Yan-qi,Liu Ning,Chen Xue-qin,Gao Zi-zheng,Wu Wen-tong,Yan Hao,Yang Xiao-chun,Yang Bo,He Qiao-jun,Luo Pei-hua,Xu Zhi-fei
Ceritinib, an anaplastic lymphoma kinase (ALK) inhibitor, is associated with cardiovascular adverse events, yet the mechanisms remain incompletely understood. Here, we show that ceritinib impairs left ventricular systolic function in mice and induces cardiomyocyte apoptosis, and identify AKT (Ser473) suppression as a key initiating event. Loss of AKT activity is paralleled by reduced phosphorylation of mTOR (Ser2448) and ULK1 (Ser757), consistent with enhanced autophagy initiation. Concurrently, loss of inhibitory GSK3β (Ser9) phosphorylation correlates with impaired lysosomal function, reflected by disrupted cathepsin D maturation and reduced lysosomal acidification. This mismatch between enhanced autophagy initiation and impaired lysosomal clearance impairs autophagic flux despite preserved autophagosome-lysosome fusion, and causes mitochondrial damage, evidenced by reduced TOMM20 and HSP60 expression and membrane potential loss. Transcriptomic and functional analyses identify AKT2 as a particularly vulnerable isoform in this network. Metformin co-treatment preserves cardiac function and attenuates apoptosis. Mechanistically, metformin increases AMPK (Thr172) phosphorylation and reduces TFEB (Ser122) phosphorylation, restores CTSD maturation, and decreases LC3-II accumulation. These protective effects occur without reversing the suppressed AKT (Ser473) or GSK3β (Ser9) phosphorylation. Together, these findings establish that AKT suppression drives ceritinib cardiotoxicity through autophagic flux impairment and mitochondrial injury, and position AMPK-driven, TFEB-associated lysosomal restoration as a mechanism-based cardioprotective strategy independent of AKT recovery.
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高影响因子
JOURNAL OF POLYMER RESEARCH
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2026
·Vol. 33
·期 8
·354
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IF 3.5
Zhang Feng,Yao Ying,Zhao Keli,Guo Ming
The synergistic removal of wastewater containing heavy metals and organic pollutants remains a major challenge. Although multifunctional materials can enable one-step treatment, their high cost limits practical application, making sequential treatment with single-functional materials a feasible strategy. In this study, two lignin-based hydrogels were developed for stepwise removal of heavy metals and tetracycline (TC). Iron-manganese-modified lignin hydrogel (IM-LH) was prepared by copolymerizing acrylamide with lignin, in situ loading iron and manganese ions, and subsequent sulfuration, enabling efficient adsorption of Cd(II) and As(III). The immobilized enzyme composite hydrogel (HRP@HPAAM-LA) is made by chemically attaching horseradish peroxidase (HRP) to the pores and surfaces of a lignin-based semi-interpenetrating network carrier (HPAAM-LA), which is built through free radical copolymerization, using an EDC/NHS-mediated amidation reaction. This material can both adsorb and concentrate TC while letting HRP carry out oxidative degradation. The hydrogels were characterized by SEM, FTIR, XRD, XPS, and TGA, and their continuous removal performance and mechanisms were investigated. Both hydrogels exhibited uniform porous networks and abundant active sites. IM-LH showed maximum adsorption capacities of 86.20 mg·g − 1 for Cd(II) and 60.01 mg·g − 1 for As(III), retaining removal rates of 65.46% and 51.44% after 15 cycles. HRP@HPAAM-LA achieved an HRP immobilization rate of 78.13% and a TC removal rate of 92.22%, retaining 61.82% after 13 cycles. This study successfully prepared two lignin-based hydrogels, achieving the synergistic removal of heavy metals and organic pollutants. It provides a new method for the hierarchical and synergistic treatment of complex environmental wastewater, while also promoting the high-value utilization of biomass resources in environmental remediation.
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
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IF 4.6
Qian Yue-Yuan,Sun Xiang-Bin,Liu Ya-Lei,Li Zhi-Bo
As plastic pollution has become increasingly severe, the development of recyclable and rapidly degradable polyesters has significant practical value and significance. In this study, seven-membered cyclic 1,3-propylene glycol oxalate (POx) was successfully synthesized through a two-step polycondensation-depolymerization method using dimethyl oxalate (a low-cost and readily accessible bulk chemical) and bio-based 1,3-propylene glycol as the starting materials. Using Sn(Oct) 2 as the catalyst, high-molecular-weight poly(1,3-propylene oxalate) (PPOx) was efficiently prepared via ring-opening polymerization (ROP) of POx. This ROP demonstrated excellent reactivity, attaining a monomer conversion up to 95% within 10 min, and PPOx had a maximum intrinsic viscosity ( η ) of 1.06 dL/g. Furthermore, the prepared PPOx could be catalytically depolymerized to enable efficient recovery of the POx monomer, with a yield of 60% and a purity of 98%. The degradation performance tests indicated that PPOx exhibited rapid degradation, reaching a degradation rate of up to 99% within 50 days. Owing to the innovative selection of raw materials and the design of a closed-loop process, this study provides a new economical and sustainable strategy for reducing dependence on petroleum resources, offering valuable insights into the development of recyclable and rapidly degradable polyesters.
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Nature Nanotechnology
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2026
·
IF 37.5
Jin Ruo-Xi,Lei Xincheng,Su Xiao-Chuan,Zhang Xing,Zhao Yao,Qi Xiaodong,Lu Zhuo-Ya,Zhang Xu-Sheng,Zhang Yu-Ying,Zhang Jin,Yuan Qingxi,Zhang Jing,Zheng Lirong,Guo Yu-Jie,Xin Sen,Su Dong,Wen Rui,Wan Li-Jun,Guo Yu-Guo
The Fe( III )|Fe( IV ) redox couple in iron-containing Na layered oxides enables high-capacity, cost-effective positive electrodes. However, although a high iron content (when the Fe concentration exceeds 33 at.% on transition metal layers) leads to rapid capacity decay during battery cycling, the underlying mechanism of this detrimental behaviour remains unclear. Here we report that the electrochemomechanical failure mechanism in Fe-rich Na layered oxides is related to the stability of the Fe octahedral coordination environment at the nanoscale. Fe-ion migration and dissolution govern the formation of intragranular microcracking in the positive electrode active material particles, accompanied by dislocations and an uneven distribution of mechanical stress. Driven by the non-uniform strain field, microcracks proliferate and planar gliding occurs, resulting in a stepped surface. By nanoscale doping with Al( III ) (1 at.%), Y( III ) (1 at.%) and Co( III ) (3 at.%), we inhibit the Fe-ion migration and dissolution, thereby reducing cracks and planar gliding. Using the multi-element nanoscale-doped iron-rich sodium layered oxide at the positive electrode and a hard-carbon-based negative electrode, we assembled and tested 2.7-Ah Na-ion pouch cells showing an initial specific energy of 121 Wh kg −1 (based on the total mass of the cell) at 26 mA g −1 , and a discharge capacity retention of 83.4% after 2,000 cycles at 130 mA g −1 at 25 °C.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2026
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IF 4.1
Hu Zhi,Xiao Jinna,Hu Lianqi,Xie Haijiao,Liao Zhengzheng,Li Zhentao
The increasing misuse of psychiatric drugs has led to their emergence as environmental contaminants in water and food matrices, raising public health concerns. In this study, a hydroxyl-rich covalent organic framework (Py-DHBD-COF) was solvothermally synthesized and coated onto a stainless steel fiber for use in direct-immersion solid-phase microextraction (DI-SPME). The fabricated fiber was employed to extract psychiatric drugs from environmental water and pretreated milk extracts, followed by analysis using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The hydroxyl-rich structure of the Py-DHBD-COF coating can provide hydrogen-bonding, hydrophobic interactions, and π-π interactions with the target analytes, resulting in high extraction efficiency. Key parameters affecting extraction performance, including extraction time, volume, pH, and desorption conditions, were systematically optimized. Under optimal conditions, the method exhibited good linearity ( R 2 = 0.9992–0.9996) for quetiapine, olanzapine, and clozapine over a concentration range of 1–500 ng/mL, with low limits of detection (0.010–0.024 ng/mL). The reproducibility was satisfactory, showing relative standard deviations below 5.38%, and recoveries ranged from 85.1 to 114.6% in both sample matrices. These results demonstrate that the proposed SPME-HPLC-MS/MS method is a sensitive, reliable, and environmentally friendly approach for monitoring trace levels of psychiatric drugs in complex water and milk samples. Graphical abstract
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Nano-Micro Letters
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2026
·Vol. 18
·期 1
·439
·
IF 38.5
Li Kaiyuan,Li Linhong,Song Guichen,Qin Yue,Chen Hanxi,Zhao Zujian,Yang Boren,Zhou Yiwei,Wang Yandong,Yang Rongjie,Li Maohua,Chen Fei,Cai Tao,Lin Cheng-Te,Nishimura Kazuhito,Jiang Nan,Yu Jinhong
With the trend toward high-power radio-frequency (RF) electronic devices, flexible thermally conductive composite films are regarded as a key engineering interfacial material to address the critical problem of signal transmission and heat dissipation. However, achieving simultaneous optimization of high thermal conductivity and low loss in the same material remains a significant challenge, particularly in films with high filler loading. Here, a bottom-up regulatory strategy is proposed to address this challenge. Through the synergistic optimization of interface modification design and spatial orientation arrangement of hexagonal boron nitride (BN), the fabricated composite film achieves an exceptional in-plane thermal conductivity of 78.50 W m⁻ 1 K⁻ 1 , significantly surpassing that of the film with BN. This remarkable enhancement is primarily attributed to the altered surface properties of the aminated BN (BN-NH 2 ). The introduction of amine groups enhances the compatibility with the polymer matrix through electrostatic interactions to facilitate more efficient interfacial thermal transport. Furthermore, the highly oriented spatial arrangement of BN in the film not only preserves the electromagnetic wave transparency (99.94%), but also enhances its breakdown strength. This study underscores the critical role of molecular-level filler modification combined with micro-nanostructural engineering in synergistically strengthening the filler-matrix interface and boosting film thermal transport.
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JOURNAL OF NANOPARTICLE RESEARCH
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2026
·Vol. 28
·期 8
·219
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IF 3.5
Hu Xingao,Wang Yuxiang,Wang Song,Tan Liqiang
The growing application of engineered nanoparticles has heightened concerns regarding their environmental release; gaining a robust understanding of their transport mechanisms, environmental fate, and behavioral dynamics in natural aquatic systems is therefore of particular importance. This study systematically investigated the aggregation and disaggregation behavior of ZnO nanoparticles in the presence of humic acid (HA) and/or Ca 2+ ions across a range of pH values. Additionally, controlled shear conditions were applied to assess the influence of hydrodynamic shear forces on ZnO nanoparticle stability. The addition of HA to the suspensions resulted in a significant decrease in zeta potential and an increase in the hydrodynamic diameter of ZnO nanoparticles, implying the occurrence of charge neutralization between nanoparticles. High shear forces were sufficient to overcome interparticle attractive forces, thereby disaggregating large particle clusters into smaller entities; in contrast, low shear forces promoted nanoparticle aggregation by enhancing collision frequency and efficiency. Higher strength factors (SF) values observed in reaction systems with elevated Ca 2+ ion concentrations indicated that aggregates formed under such conditions exhibited more compact structures and greater resistance to shear-induced fragmentation. Fluorescence spectra analysis indicated that the compact structure of ZnO nanoparticles formed under high Ca 2+ ion concentrations was most likely due to the strong chemical binding with HA and bridging mechanisms involving divalent cations formed during the aggregation process. The findings of this study provide a mechanistic basis for predicting the environmental fate and transport behavior of ZnO nanoparticles in natural aquatic environments.
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Surface Science and Technology
·
2026
·Vol. 4
·期 1
·40
·
IF 7
Chen Liyang,Yang Yumeng,Jiang Xinyi,Zhang Ping,Zhang Yang,Ye Hanxue,Zhu Benfeng,Liu Jiao,Jiang Li,Wei Guoying
Electrophoretic paints, by virtue of their low cost, straightforward processing and excellent resistance to weathering and pollution, have found extensive application across a wide range of industries. However, their applications are limited by poor thermal stability. To address these issues, this study investigated the preparation and properties of electrophoretic paint/CeO 2 composite coatings fabricated through a one-step electrophoretic deposition method, focusing on the impact of cerium acetate concentration and different cerium compounds (cerium acetate versus CeO 2 nanoparticles) on coating performance. Results revealed that, relative to neat electrophoretic coatings, the addition of cerium compounds markedly improved thermal stability, corrosion resistance and autonomous self-healing capability. The optimal concentration of cerium acetate was determined to be between 0.001 and 0.01 M, within which the coatings exhibited uniform and dense surfaces. Higher concentrations led to particle agglomeration and surface defects. The addition of cerium acetate increased the char yield from 36.13% to 55.54% at 800 °C and reduced the corrosion current density by a factor of ten. Additionally, the coatings demonstrated self-healing capabilities, with cracks healing following thermal treatment at 200 °C. Flame retardancy was also improved, demonstrated by a reduction in the peak heat release rate from 340.9 W/g to 240.6 W/g. In summary, cerium acetate was found to be more effective than CeO 2 nanoparticles in enhancing coating performance. These enhancements make electrophoretic paint/CeO 2 composite coatings highly suitable for high-temperature applications.
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Science China-Materials
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2026
·
IF 7.7
Xu Hui,Liu Chunbao,Zhang Hao,Yang Konghua,Luo Yuchao,Ren Lei,Ma Suqian,Liang Yunhong
Ionic-polymer metal composites (IPMCs) actuators are smart materials that have garnered increasing attention in the field of soft robotics due to their large bending deformation and rapid response to low operating voltages. However, conventional fabrication methods, such as solution-casting, have inherent limitations, including long fabrication times, simple geometries, and a single deformation mode. This study develops a polylactic acid (PLA)-reinforced perfluorosulfonic acid resin (PFSR) composite filament for fabricating IPMC actuators with programmable deformation via fused filament fabrication (FFF) 3D printing. Incorporating PLA into soft PFSR filaments improves printability and allows the printed parts to be reshaped into desired geometries that are difficult to print directly. The 3D-printed actuator exhibits superior actuation performance, with a bending angle of 169° (5.72% bending strain) under a DC voltage of 3 V and a swing speed of 56° s −1 at 3 V, 1.0 Hz sinusoidal voltage. Interestingly, its shape morphing can also be pre-programmed to switch between bending and helical deformation by controlling printing parameters. These deformations can be predicted by the proposed finite element numerical method. As proof-of-concept demonstrations, various intriguing applications, including a U-shaped structure, a spiral structure, a bionic flower, and a microarchitecture for robotic metamaterials, are fabricated, revealing the potential of the 3D printing method in the realms of stimuli-responsive materials, robotic applications, biomimetic devices, and beyond.
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Science China-Materials
·
2026
·Vol. 69
·期 2
·1104-1112
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IF 7.7
Sun Guifang,Jin Yuefan,Sun Zhouquan,Lu Haifeng,Li Linpeng
Sutures, as necessary medical devices for postoperative treatment, are no longer merely supportive but are required to have advanced functions to promote repair. Here, we report an absorbable self-powered electrical stimulation suture. The suture is composed entirely of absorbable materials (magnesium, polylactic acid, and polycaprolactone) and can be used in vivo for incision closure and repair. The suture has the capacity to generate spontaneous electrical stimulation in response to body movement, allowing for accelerated tissue reconstruction. An in vivo muscle incision repair model demonstrated that the wound healing rate under treatment with this suture was 1.6 times faster than that of commercial sutures, proving its postoperative therapeutic capability.
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RESEARCH ON CHEMICAL INTERMEDIATES
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2026
·
IF 3.3
Chen Ziang,Liu Yanbing,Zhou Ting,Shi Yu,Tao Yuanyuan,Jiang Wei,Gu Binxian,Hu Qingsong
Developing green and efficient photocatalysts is crucial in addressing the energy crisis and environmental remediation. In this study, we synthesized novel S, N co-doped graphene quantum dots (S, N-GQDs) anchored PbBiO 2 I nanospheres employing a reactive ionic liquid-assisted facile one-step solvothermal approach. We prepared a variety of S, N-GQDs/PbBiO 2 I nanocomposite with different loading amounts of S, N-GQDs and investigated their photocatalytic performance. Among these, S, N-GQDs/PbBiO 2 I-2 exhibits the highest degradation efficiency for antibiotic removal. The incorporation of S, N-GQDs significantly broadens the visible-light absorption range and accelerates the migration of photoinduced carriers, thereby enhancing photocatalytic activities. Various characterization techniques and experimental analyses were employed to explore the charge carrier transfer pathway in this system. Notably, the developed photocatalyst demonstrates two exceptional advantages: a broad-spectral response capability and environmentally-friendly properties, which are of significant relevance for practical applications. This study provides insights for the rational design of high-performance, wide-spectral-light-driven, and environmentally-friendly photocatalysts in the field of environmental remediation.
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Bulletin of Engineering Geology and the Environment
·
2026
·Vol. 85
·期 6
·377
·
IF 4.9
Ling Sixiang,Zhang Xuening,Camaiti Mara,Cao Yijian
The weathering issues in Nankan Grottoes has significantly impaired the appreciation of its historic and artistic values. Yet, there is a lack of appropriate protective materials. This work aimed to evaluate the effectiveness, compatibility and durability of four protective products (MTES, OT-40, Acrylic, and nano-SiO 2 ) for three sandstones (yellow, cyan, and gray) presented in Nankan Grottoes. The hydrophobic effect, mechanical property, microscopic observation, chromatic alteration, and weathering resistance of the treated samples were systematically evaluated. MTES and OT-40 were the most effective in hydrophobic effect. Nano-SiO 2 contributed least to hardness improvement due to its lowest application amounts. Overall chromatic changes in the treated samples were below the detection limit of the naked human eye (ΔE * <3), except for the yellow sandstone treated with OT-40 and cyan sandstone treated with MTES. Microscopic observations revealed that the four agents provided better protection for grey sandstone, due to the smallest grain size and porosity of the gray sandstone. The four agents improved the salt weathering resistance of the three sandstones, except for the yellow sandstone treated with nano-SiO 2 , whose salt weathering resistance was reduced. Therefore, hydrophobic nano-SiO 2 may severely damage porous sandstone during salt weathering, due to the huge interfacial stress produced at the interaction between the hydrophobic superficial layer and the hydrophilic rock substrate. The anti-UV ageing stability relied mainly on the porosity and grain size of the substrates. Our research has advanced the fundamental understanding of the performance of novel protective materials, also paved the way for the conservation of sandstone heritages.
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