MOLECULAR AND CELLULAR BIOCHEMISTRY
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2026
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IF 3.7
Shi Chenjun,Lu Conghua,Lin Caiyu,Lian Shaopan,Luo Huanyu,You Ziyin,Li Li
Defective alveolar re-epithelialization following acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) represents a critical barrier to clinical recovery. Intrinsic signals that could be harnessed to speed this repair remain poorly defined. Endogenous electric fields (EFs) arise immediately after epithelial injury and are recognized as mediators of cell migration and morphogenesis, but their impact on lung epithelial proliferation is unknown. Here we demonstrate that physiological-strength direct-current EFs (100–200 mV/mm) are potent pro-mitogenic signals for both human bronchial (BEAS-2B) and murine alveolar (MLE-12) epithelial cells. Within a custom live-cell electrotactic chamber, EFs exposure for 4 h doubled EdU incorporation, increased Ki-67 expression, and elevated real-time mitotic events without altering spindle orientation. RNA-seq analysis of BEAS-2B cells with EFs exposure identified 1,447 differentially expressed genes, with significant enrichment of the PI3K/AKT signaling pathway and immunoblotting further confirmed rapid phosphorylation of PI3K p85 (Tyr458)/p55 (Tyr199) and AKT (Ser473). Selective inhibition with Alpelisib or LY294002 abolished pathway activation and fully suppressed the pro-proliferative effect of EFs. Furthermore, EFs triggered AKT-dependent phosphorylation of glycogen synthase kinase-3β (GSK3β) at Ser9, while blockade with the GSK3β inhibitor Tideglusib or upstream PI3K inhibitors suppressed this event and attenuated EF-induced proliferation. Taken together, our findings delineate the PI3K/AKT/GSK3β signaling axis through which EFs enhance pulmonary epithelial proliferation. This work identifies physiological EFs as previously unrecognized regenerative cues in the lung and underscores bioelectric modulation as a promising therapeutic strategy to accelerate alveolar repair in ALI/ARDS.
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Scientific Reports
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2026
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IF 3.9
Zhang Fangxia,Luo Kunshun,Xuan Shaoyan,Chen Teng,Chen Zhiyong,Yang Jing,Zhou Ying,Feng Tingting,Zhu Yue,Wang Zuhua
Pancreatic cancer has a dismal prognosis due to the rapid progression and inefficiency of chemotherapy. To ameliorate this inefficiency of chemotherapy drug, we developed a long-circulating PEGylated nanoliposome (ORI@PD-Lipo) with 1,2-distearoylphosphoethanolamine- polyethyleneglycol-amine (DSPE-PEG 2000 -NH 2 ) to deliver oridonin, one of the active ingredients in Rabdosia rubescens ( R. rubescens ) in this study. For improving tumor-targeting delivery of oridonin, a pancreatic cancer targeting CKAAKN peptide was used to modify the nanoliposome (ORI@CPD-Lipo). Our results showed that ORI@CPD-Lipo had good stability and biosafety with average particle size of about 100 nm, which could selectively internalize into pancreatic cancer cells BxPC-3 during the short incubation time (1–4 h) in vitro under the mediation of CKAAKN peptide, compared with HPDE6-C7 cells. Furtherly, significantly higher uptake of ORI@CPD-Lipo nanoparticles by BxPC-3 tumors (positive-CKAAKN) than normal pancreatic tissue was observed in vivo during the whole experiment process (1–48 h), with increased ratio on experiment time. Our data also indicated the treatment of BxPC-3 cells with ORI@CPD-Lipo nanoparticles showed significantly enhanced antitumor effect and therapeutic efficacy than the treatment with the free ORI, non-targeting ORI@Lipo and CKAAKN-blocking ORI@CPD-Lipo. The enhanced antitumor activity to BxPC-3 cells should be attributed to the enhanced drug cellular uptake mediated by ORI@CPD-Lipo nanoparticles, chemical toxicity of the released ORI from the nanoparticles. Our study provided a valuable reference and strategy of CKAAKN-mediated targeting cancer chemotherapy based on ORI@CPD-Lipo against the pancreatic tumor.
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npj Computational Materials
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2026
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IF 11.9
Huang Lin,Zhang Xinyu,Li Shuxing,Xie Rongjun
The data-driven discovery of luminescent materials is hindered by a critical paradox: while decades of research have generated extensive data, the unstructured textual format of such data in literature precludes its systematic reuse. While text mining enables conversion to structured datasets, general natural language processing (NLP) tools fail at domain-specific challenges, such as fragmented host-dopant syntax and incomplete representations of property relationships. To address these limitations, we developed a novel NLP pipeline specifically tailored to the phosphor domain, integrating three key algorithms: chemically-aware parsing, frequency-driven subject recovery, and context-aware disambiguation algorithms. Using this approach, we successfully extracted 6,400 material-emission relationships from 16,659 scientific papers, with F1 scores of 0.956 for phosphor formula extraction and 0.851 for relation extraction. Additionally, a machine learning model trained on the extracted dataset predicted Eu 2+ emission wavelengths, with a coefficient of determination (R 2 ) of 0.91. Guided by predictions, we synthesized novel phosphors (e.g., CaGd 2 S 4 : Eu 2+ ), the experimental emission spectra of these materials deviated by around 10 nm from predictions, verifying the robustness of the “data extraction-model prediction-experimental validation” workflow. This study bridges computational discovery and experimental validation, offering an open framework and tools to accelerate luminescent materials innovation.
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APOPTOSIS
·
2026
·Vol. 31
·期 2
·52
·
IF 8.1
Mao Dong,Sun Jufeng,Zhang Xiaowei,Wang Zhaoping,Zhang Yun
Colorectal cancer (CRC) is a malignant tumor originating from the epithelial cells of the colon and rectum. Interleukin enhancer binding factor 2 (ILF2), an emerging RNA-binding protein, has been implicated in the regulation of multiple cancer-related processes. However, its specific role in the pathogenesis and progression of CRC remains largely unexplored. In this study, we systematically investigated the functional role of ILF2 in CRC through multi-level experiments. ILF2 expression was first assessed in clinical CRC tissues via quantitative real-time PCR and western blot. Functional implications were further examined through gain-of-function and loss-of-function approaches. Cellular assays included CCK-8 proliferation, colony formation, Transwell migration/invasion, macrophage coculture, and flow cytometry for apoptosis, complemented by immunofluorescence staining. In vivo relevance was confirmed using xenograft models for tumor growth and metastasis. Mechanistically, Co-IP revealed a robust interaction between ILF2 and ILF3, while RIP, RNA pull-down and dual-luciferase reporter assays demonstrated direct binding of ILF3 to KLF16 mRNA, suggesting a novel regulatory axis in CRC progression. Our results demonstrated that both ILF2 mRNA and protein were significantly upregulated in colorectal cancer (CRC) tissues compared to matched peritumoral tissues. Functional assays revealed that ILF2 overexpression enhanced, whereas ILF2 knockdown suppressed, the proliferation, migration, and invasion capabilities of CRC cells in vitro. Additionally, ILF2 overexpression induced M0 macrophages to polarize toward an M2-like phenotype. Consistent with these findings, in vivo experiments indicated that ILF2 facilitated tumor growth and promoted liver metastasis in CRC. Our work suggests that ILF2 formed a complex with ILF3 to enhance the stability of KLF16 mRNA, thereby contributing to CRC progression through the regulation of KLF16. Graphical abstract A proposed working model of the ILF2/ILF3/KLF16/β-catenin axis in colorectal cancer progression. Hypothetical model illustrating that ILF2 binding to ILF3 stabilizes KLF16 mRNA, which in turn activates β-catenin signaling. This pathway ultimately promotes CRC cell proliferation, invasion, liver metastasis, and M2-type macrophage polarization.
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npj Flexible Electronics
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2026
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IF 15.5
Lin Feifei,Ni Hao,Zhao Weiwei,Liu Leilei,Zhang Yijie,Huang Zijing,Wang Wenjin,Wang Qixiang,Wang Tushun,Bai Yan,Ding Ning,Liu Shujuan,Huang Wei,Zhao Qiang
Flexible millimeter-wave (mmWave) antennas hold great promise for conformal integration across diverse devices and high-speed, large-channel capacity in 5G/6G wireless communications. Spoof surface plasmon polaritons (SSPPs) structure with periodic grooves is well-suitable for designing miniaturized, flexible and ultra-wideband planar mmWave antennas. However, achieving high-precision fabrication of SSPP configurations with optimal micrometer-scale filling factors using flexible conductive materials remains highly challenging. Herein, we report the high-precision all-Ti 3 C 2 -printed flexible ultra-wideband mmWave endfire antennas based on SSPPs for wireless communication. The SSPPs antenna exhibits a wide operating bandwidth of 25–49 GHz, which stems from the reactance properties of the ordered multilayer structure of Ti 3 C 2 . The S- parameter and gain can be well maintained even after cyclic bending, owing to the robust adhesion between the polydopamine-modified substrate and the Ti 3 C 2 film. This work pioneers the demo instance of flexible Ti 3 C 2 antenna for high-speed (446.06 Mbps), large-capacity, and low-latency mmWave wireless communication.
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Nature Communications
·
2026
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IF 15.7
Chen Yue,Chen Qinyi,Ma Yuanyuan,Zhang Cheng,Xu Jie,Li Kejing,Sun Yajie,Su Xinge,Wei Mingguang,Bao Rui,Ding Tong,Tang Longguang,Yu Wenying,Ju Shenghong,Fan Wenpei
Radiotherapy (RT) is a clinical mainstay of cancer treatment that triggers tumor-specific immune responses. However, the effectiveness is usually hampered due to the hypoxic tumor microenvironment (TME) and the ambivalent impact of RT on the immune landscape of tumors. Herein, we develop an injectable hydrogel encapsulating interleukin-12 (IL-12)/anti-CTLA-4 (aCTLA-4) co-engineered red blood cells (RBC), which is in situ self-assembled within the TME to increase oxygen supply and instigate sequential aCTLA-4/IL-12 release, thus achieving Ba/O 2 self-compensated radiosensitization and activating multistage immune responses. Once in the acidic TME, the in situ injected BaO 2 undergoes hydrolysis to generate H 2 O 2 and Ba 2+ , followed by the rapid reaction of Ba 2+ with sodium alginate to afford a biocompatible hydrogel. Meanwhile, catalase presented on RBC converts H 2 O 2 into O 2 , thereby alleviating hypoxia-induced radioresistance and inducing O 2 -mediated pore formation on RBC membrane for rapid release of aCTLA-4 to relieve tumor immunosuppression. Subsequently, IL-12 anchored on RBC is dilatorily released and interacts with T/NK cells within the TME to induce IFN-γ-dependent antitumor immunity. Taken together, the in situ self-assembled cell reservoir hydrogel offers a futuristic avenue to realize multistage radioimmunotherapy for effective tumor regression by programmable immunoregulation with significant clinical value.
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Science China-Materials
·
2026
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IF 7.4
Zhang Shuoning,Liu Jiale,Zhang Jianying,Sun Chang,Ren Yunxiao,Zhang Lanying,Hu Wei,Yang Huai
Nematic liquid crystal elastomers (NLCEs) have excellent mechanical properties and varied deformation modes. Cholesteric liquid crystal elastomers (CLCEs) as a photonic crystal (PC) have excellent optical performance and intelligent response characteristics. Combining the two elastomers with their respective advantages into a monolithic material is a worthwhile challenge and promising. Here, we designed and synthesized a new diselenide bonded molecule (named DSeAc), whose lower bond energy between two selenium atoms endows it with an excellent bond exchange ability. Therefore, two matrixes of LCEs containing DSeAc molecules can achieve seamless bonding under a milder conditions by the bond exchange of the dynamic diselenide bond. Combining a CLCE film and an NLCE actuator into a monolithic film enables the integration of two functional components, whose functional characteristics can be tailored as required. This function block combination strategy is a promising pathway for developing smart materials with complex functions, which show great potential in information storage, anti-counterfeiting and biomimetics.
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Science China-Information Sciences
·
2026
·Vol. 69
·期 2
·122404
·
IF 7.6
Meng Xiangyu,Tang Hongyao,Lü Xiaozhou,Zhang Jiayao,Shi Yaoguang,He Yumeng,Bao Weimin
Flexible pressure sensors are widely used in wearable electronic devices, human motion detection, and electronic skin. Conductive composites are the core component of flexible pressure sensors. However, they suffer from mechanical damage during long-term cycling, which degrades sensor performance. This study proposed a biomimetic cell in-situ self-healing polycaprolactone/carbon nanotube composite (BCISPC). The core-shell structure of BCISPC endows the composite with a low percolation threshold (0.012 vol%), high electrical conductivity (13.3 S/m), and fast electrothermal self-healing capability (18 s). The efficient in-situ self-healing ability of the composite preserves its surface microstructure during self-healing. In addition, a self-healing hierarchical microstructured flexible pressure sensor was prepared using BCISPC. The sensor has a high sensitivity (159.4 kPa −1 ), wide linear measurement range (0–500 kPa), fast response time (34 ms), and good cycling durability (1000 cycles). Given its high performance, this sensor has various applications in wearable electronics, medical monitoring, and human-machine interfaces.
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Chemical and Biological Technologies in Agriculture
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2026
·Vol. 13
·期 1
·1
·
IF 5.2
Meng Lifen,Ding Pengpeng,Ou Meiya,Zhang Yu
Background CQDs are an ideal platform material that integrates excellent optical properties, superior biosafety, flexible, and adjustable chemical properties. They serve as a bridge connecting nanotechnology with fields such as life sciences, environmental energy, and more. Methods In this study, Hc -DES-CQDs based on natural deep eutectic solvents and Houttuynia cordata were successfully prepared. Results The prepared Hc -DES-CQDs exhibits strong blue fluorescence and excellent photostability. The detection of trace Cr 6+ under acidic and alkaline conditions can be realized by Hc -DES-CQDs, and also successfully applied to practical environmental water samples. Spectral analysis reveals that Hc -DES-CQDs exhibits emission behavior related to excitation, with a quantum yield of approximately 17.3%. The Hc -DES-CQDs demonstrated excellent antibacterial and free radical scavenging effects (such as DPPH, ·OH). Conclusions Therefore, the Hc -DES-CQDs has potential applications in the analysis and combating of cellular oxidative stress. Graphical abstract
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CELL RESEARCH
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2026
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IF 25.9
Liao Kun,Cao Fen,Wei Chen,Qian Zheng-Yu,Hu Hong-Rong,Pan Wen-Feng,Feng Zi-Qing,Lian Sen-mao,Xiao Zi-Xuan,Sheng Hui,Mo Hai-Yu,Zhao Yi-Xuan,Wu Qi-Nian,Zeng Zhao-Lei,Li Bo,Xu Rui-Hua,Ju Huai-Qiang
Methionine metabolism generates the substrate S-adenosylmethionine (SAM), which regulates epigenetic modifications crucial for various cellular processes, particularly tumorigenesis. However, whether methionine metabolism involves epigenetic mechanisms independent of SAM and what roles such mechanisms play in tumorigenesis remain unclear. We show here that the adenosylhomocysteinase (AHCY)–adenosine complex increases mRNA m 6 A levels in a non-global manner, promoting fatty acid synthesis and tumorigenesis. Adenosine increases mRNA m 6 A levels by binding to the methionine metabolism enzyme AHCY to form a complex, rather than depending on adenosine receptors. The AHCY–adenosine complex facilitates AHCY dimerization, with adenosine being crucial for dimer stability. AHCY dimers hinder the binding of fat mass and obesity-associated protein (FTO) at the Q86 site to RNA containing the VWDRACH motif, increasing m 6 A levels and upregulating lipogenesis genes, especially ACACA and SCD1, thus leading to reprogramming of lipid metabolism. Conversely, AHCY mutants that have lost dimerization or FTO-binding ability but retain hydrolase activity suppress lipogenesis and tumor growth without significantly affecting methionine catabolism mediated by AHCY. Loss of AHCY in mice and disruption of AHCY dimerization in tumor cells and patient-derived xenograft models restricted tumor growth. Our findings demonstrate a key SAM-independent link between methionine metabolism and mRNA m 6 A modification that affects demethylase substrate specificity. This novel link between the methionine cycle and lipid metabolism suggests new strategies for anticancer therapy.
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Advanced Fiber Materials
·
2026
·
IF 21.3
Zhong Yuanyuan,Ma Lijun,He Pengfei,Huang Liangkang,Lu Yuyan,Li Jianwei
Aerogels have emerged as ideal materials for extreme environments due to their excellent thermal insulation. However, conventional aerogels often suffer from poor mechanical properties, limited thermal stability, and inadequate breathability. Herein, a fluorinated polyimide (FPI) nanofibrous aerogel with ultralight weight, and high mechanical strength is constructed by moisture-assistant electrospinning for self-powered sensing. Due to the rapid phase transition of the charged jet through interaction between the fluorinated polyamic acid solution (FPAA) and water molecules, enabling the interweaving and cross-linking of nanofibers into a fluffy aerogel structure. Furthermore, the resulting FPI nanofibrous aerogels exhibit exceptional thermal insulation property with low thermal conductivity (0.045 W·m −1 ·K −1 ), super-hydrophobicity with water contact angle of 151° and superior moisture permeability of 10150 g/(m 2 ·24 h). Moreover, the FPI nanofibrous aerogels show excellent piezoelectric properties (up to 34 V), rendering them ideal candidates for next-generation wearable electronics, particularly in high-precision physiological signal monitoring applications. In addition, the speech recognition system was able to recognize everyday sentences with precise detection of pauses and intonations. This work presents a novel strategy for designing FPI-based nanofibrous aerogels, paving the way for their practical applications in thermal insulation and self-powered sensing under extreme environmental conditions. Graphical abstract
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Nature Communications
·
2026
·
IF 15.7
Zhang Xiaofei,Liu Zhengzheng,Wang Lin,Liu Junchuan,Li Qian,Wang Jihao,Liang Chaohui,Kong Lingmei,Duan Rui,Wang Sheng,Leng Yuxin,Sun Handong,Du Juan,Yang Xuyong
Blue light-emitting diodes based on reduced-dimensional pure bromide perovskites have attracted increasing attention due to their superiority in achieving stable and efficient blue emissions. Yet, the employment of abundant insulating long-chain organic spacer cations severely limits the charge carriers transport capability and electroluminescence performance. Here, we utilize short-chain iminodi(methylphosphonic acid) ligand with two-terminated phosphonic groups that can strongly interact with the lead bromide octahedra via synergetic covalent bonds, facilitating the interlayer charge transfer and simultaneously reduces the defect density in perovskite films, thereby improving the light emission efficiency. Iminodi(methylphosphonic acid) ligand also enhances the dielectric confinement, leading to higher exciton binding energy and accelerated radiative recombination in perovskite emitters. The resulting blue light-emitting diode achieves a maximum external quantum efficiency of 25.4% and an operational lifetime exceeding 800 min, which represents a significant advancement among state-of-the-art blue light-emitting diodes based on pure bromide perovskites.
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危险品化学品经营许可证（带存储）