Food Bioscience
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2024
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IF 4.8
Qianzhu Lin,Han Jiang,Xiaojing Li,David Julian McClements,Shangyuan Sang,Jinpeng Wang,Aiquan Jiao,Zhengyu Jin,Chao Qiu
β-Carotene is a hydrophobic molecule that can be isolated from plants that acts as a natural pigmen and nutraceutical. However, the limited water-solubility, oxidative-stability, and bioavailability limit its utilization in functional food, supplement, and pharmaceutical products. Pickering emulsions stabilized by chitosan-phytic acid-cyclodextrin (CS-PA-CD) nanoparticles were prepared to improve the delivery, stability, and bioavailability of β-carotene. The impact of nanoparticle concentration (0.1%, 0.5%, 1.0%, 1.5%, 2.0% w/v) and oil phase fraction (30%, 40%, 50%, 60%, 70% v/v) on the stability of β-carotene-loaded Pickering emulsions was investigated. The Pickering emulsions that were most stable to phase separation were formed at intermediate oil concentrations (50%-60% v/v). The encapsulated β-carotene exhibited improved resistance to heating (70 °C) and UV light exposure. Moreover, the bioaccessibility of β-carotene was also improved using a simulated gastrointestinal model. Overall, our findings highlight the potential of CS-PA-CD nanoparticles for forming and stabilizing Pickering emulsion-based delivery carrier for hydrophobic bioactive substances.
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MICROCHEMICAL JOURNAL
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2024
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IF 4.9
Yuanhao Yan,Si Wu,Tao Feng,Zili Yin,Shijing Wu,Daheng Wang,Wei Fang,Qingmiao Wang,Yu Wang,Ning Hu,Li Wang
In this study, a novel functional hydrogel film was synthesized using natural polymer chitosan and quercetin as raw materials. Fourier transform infrared (FT-IR) spectra and X-ray photoelectron spectroscopy (XPS) analysis indicate that phenylboronic acid modified carbon nanodots (PBA-CDs) were successfully prepared via a simple microwave-assisted hydrothermal method. The experimental results demonstrate that a dual electrochemical and fluorescence detection of glucose can be realized based on the boronate ester bonding between chitosan/quercetin (Chit 0 /Quer) films and PBA-CDs. The addition of PBA-CDs hinders the electron transfer between the phenolic hydroxyl groups of quercetin and the redox mediators, and inhibits the intramolecular rotation of quercetin, which leads to a decreased electrical signal and enhanced fluorescence intensity. After the addition of glucose, the peak redox current of the Chit 0 /Quer hydrogel film is restored due to the competitive binding of glucose to the boronate ester, resulting in a dual-input logic circuit for the qualitative detection of glucose. In addition, the fluorescence intensity of the hydrogel decreases with increasing glucose concentration, and the concentration of glucose can be quantitatively detected by detecting the change in fluorescence intensity. Besides, the sensor has better stability and selectivity for biomarkers. Finally, we demonstrate that the electrochemical and fluorescence sensing strategies can be used for the detection of glucose in real beverage samples. In conclusion, based on the redox activity of quercetin and the competitive binding of boronate ester bonds, we explored a new strategy for enzyme-free electrochemical and fluorescence sensing for the detection of glucose, which is expected to be applied in biomedicine, food industry and other fields.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Ming Ma,Yi Guo,Ruotong Ji,Luwei Wang,Yan Zhang,Xinchen Du,Sujuan Zeng
This study presents a thrombin-loaded cationized chitosan (TCCS) sponge with highly effective hemostatic and antibacterial activity. The TCCS sponge, prepared using a multistep method, features a porous structure, favorable mechanical properties, excellent water absorption ability, and shape recovery triggered by water or blood. The TCCS sponge exhibited strong antibacterial activity against Methicillin-resistant Staphylococcus aureus and Escherichia coli . Additionally, it demonstrated enhanced procoagulant and hemostatic efficacy in rat tail amputation and rat liver perforation wound models compared to commercial hemostats. Furthermore, the sponge exhibited favorable biocompatibility and biosafety. These findings suggest that the TCCS sponge has substantial potential for practical applications in managing severe hemorrhages and bacterial infections.
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PubMed
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Mingfang Sun,Jun Wang,Jun Kang,Yaxin Zhao,Huafeng Tian,Yujuan Jin,Rakesh Kumar,Junfeng Wang
This study utilizes electrospinning to develop bio-based fibrous films composed of zein and polylactic acid (PLA), with chitosan added in varying concentrations. The resulting films exhibit remarkable filtration efficiency, capturing over 95 % of airborne pollutants, while maintaining a low pressure drop of less than 4 mbar. A key innovation in this work is the integration of chitosan. Chitosan, a naturally derived polysaccharide, significantly increases the conductivity and viscosity of the spinning solution, enhancing interactions among PLA, chitosan, and protein molecules. This leads to a robust network structure with improved hydrophobicity and a bimodal structure, both essential for maintaining high filtration efficiency without reducing breathability. The addition of chitosan effectively addresses the common issue of high pressure drop in PLA/zein composite films, improving the product's efficiency and practicality for air filtration applications. Furthermore, the inherent mechanical strength and ductility of chitosan contribute to the fibrous films' overall durability and functionality. These properties make chitosan-modified zein/PLA fibers highly suitable for air pollution control, especially in personal protective equipment. This research underscores the potential of chitosan-enhanced bio-based materials as sustainable and effective solutions for advanced air filtration technologies.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Chengyu Ji,Nan Shi,Yingjie Li,Daihuo Liu,Qingcong Wei,Guanglei Ma,Xiaofang Shi,Zhiguo Hu
Hydrogels are currently under extensive research as flexible quasi-solid electrolytes for zinc-ion batteries. However, the non-degradability and non-recyclability of hydrogel electrolytes pose significant issues, leading to resource wastage and plastic pollution. Moreover, the increasing needs of hydrogel electrolyte with various shapes to meet individual requirements of next-generation flexible battery raise significant challenges. In this study, we introduce the Hofmeister effect and multiple non-covalent interactions to fabricate an eco-friendly and recyclable multifunctional hydrogel electrolyte using biomass natural polymers. This is achieved by simply soaking primary hydrogel networks of carboxymethyl chitosan (CMCS) and gelatin in zinc sulfate (ZnSO4) aqueous solutions, abbreviated as GCZ-x. The GCZ-x hydrogels exhibit both stiffness and toughness due to the formation of crystalline domains and ionic crosslinks. The dynamic physical interactions and temperature and pH responsiveness of the GCZ-x hydrogels enable them excellent processability and recyclability. The zinc-ion battery with GCZ-x hydrogel as electrolyte exhibits high specific capacity and superior cyclic performance (2200 h at 0.1 A g −1 ) without the formation of zinc dendrites. The GCZ-x electrolyte is sustainable with high recycling rate (above 80 %). It is envisaged that the GCZ-x hydrogel electrolyte will initiate new prosperity of green zinc-ion batteries in energy-efficient and environmentally sustainable ways.
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CATALYSIS COMMUNICATIONS
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2012
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IF 2.986
Jinjin Zang,Shaoyi Jia,Yong Liu,Songhai Wu,Yinbao Zhang
In this paper, polyvinyl alcohol (PVA) was modified with 3-aminopropyl triethoxysilane (APTES) and formed chemically crosslinked beads with chitosan. FTIR and SEM were used to characterize the support and immobilized catalase. Compared with control group, the activity of modified group increased about 1400 U/g support . The optimal temperature and optimal pH of immobilized catalase were 45 °C and pH 7.0. The thermal stability of catalase also enhanced after immobilization. Moreover, the immobilized catalase retained more than 90% of its original activity after using it for 9 times.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Zherui Zhao,Wanting Shi,Yufei Wu,Linxiu Kong,Jun Gao,Yong Kong
A stimuli-responsive drug delivery system is developed for controlled delivery of curcumin (Cur) and chemo-photothermal therapy of breast cancer (BC). Cur is first loaded into mesoporous polydopamine nanoparticles (mPDA NPs) by π-π stacking, and then the Cur loaded mPDA NPs (mPDA NPs@Cur) are encapsulated in the hydrogels prepared through the crosslinking of oxidized konjac glucomannan (oxKGM) and carboxymethyl chitosan (CMCS). Owing to the pH-sensitivity of the hydrogels and the outstanding photothermal conversion capability of mPDA NPs, the release of Cur from the hydrogels can be greatly accelerated in acidic media upon near infrared (NIR) irradiation. Cytotoxicity assay indicates that the hydrogels have significant cytotoxicity against murine breast tumor cell 4 T1 while the drug-free hydrogels (oxKGM/CMCS/mPDA NPs) show good biocompatibility. In addition, the hyperthermia generated upon NIR irradiation can lead to the apoptosis of cancer cells, achieving chemo-photothermal combination therapy of BC. Release kinetics study reveals that the release of Cur from the hydrogels follows zero-order model.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Weiwei Zhang,Yuxi Li,Yixing Wei,Yuqin Jiang,Zhiguo Hu,Qingcong Wei
Diabetic wound healing faces several complex challenges, such as hypoxia, oxidative stress, and bacterial infections, which severely inhibit the wound-healing process. Herein, a quaternary ammonium salt-crosslinked carboxymethyl chitosan hydrogel (TPC) with excellent antioxidant and antibacterial properties was developed to immunoregulate the diabetic wound microenvironment. The TPC hydrogel was prepared by first mixing carboxymethyl chitosan (CMCS) and protocatechualdehyde (PA), followed by the addition of a quaternary ammonium cross-linker (TSPBA) and a superoxide dismutase (SOD)–catalase (CAT) cascade system. The immobilized SOD and CAT retained their activity, continuously converting endogenous ·O 2 − and H 2 O 2 to O 2 and H 2 O. PA also provided the TPC hydrogel excellent oxygen and nitrogen radical scavenging capacity. The quaternary ammonium groups in TSPBA significantly enhanced the inherent antibacterial ability of CMCS-based hydrogels. In diabetic wound-healing experiments, this porous and adhesive TPC hydrogel effectively closed wounds and regenerated skin tissue, resulting in shorter wound edges, thicker granulation, and higher collagen deposition levels compared with other groups. The TPC hydrogel also promoted macrophage polarization toward the M2 phenotype, accelerating wound healing by upregulating IL-10 expression, downregulating IL-6 expression, and enhancing angiogenesis. These results demonstrate the great potential of TPC hydrogel as a promising therapeutic dressing for treating diabetic wounds.
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POLYMER DEGRADATION AND STABILITY
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2011
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IF 2.594
Qin Chen,Wenjun Xiao,Lilong Zhou,Tinghua Wu,Ying Wu
Hydrolysis of chitosan in ionic liquids was carried out under microwave irradiation (MW) using sulfonic acid-functionalized ionic liquids (SFILs) as catalysts. The effect of microwave power, irradiation time, dosage of SFILs and DMSO was investigated by orthogonal tests. Under the optimal reaction conditions, the yield of total reducing sugars (TRS) reached over 90% within 2 min. The viscosity-average molecular weight of degraded chitosan was determined by viscosity method. The structures of the original and degraded chitosan were characterized by Fourier-transform infrared (FTIR) spectra, X-ray powder diffraction (XRD) analysis and carbon-13 nuclear magnetic resonance spectroscopy ( 13 C NMR). The influence of microwave power and irradiation time on the TRS and M v was further studied. This method can dramatically reduce reaction time.
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Regenerative Biomaterials
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2024
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IF 5.6
Zhang Wanting,Shi Kejia,Yang Jianfeng,Li Wenjing,Yu Yang,Mi Yu,Yao Tianyu,Ma Pei,Fan Daidi
Cartilage defects are frequently caused by trauma, illness and degradation of the cartilage. If these defects are not sufficiently treated, the joints will degrade irreversibly, possibly resulting in disability. Articular cartilage lacks blood vessels and nerves and is unable to regenerate itself, so the repair of cartilage defects is extremely challenging in clinical treatment. Tissue engineering technology is an emerging technology in cartilage repair and cartilage regeneration. 3D-printed hydrogels show great potential in cartilage tissue engineering for the fabrication of 3D cell culture scaffolds to mimic extracellular matrix. In this study, we construct a 3D-printed hydrogel loaded with nanoparticles by electrostatic interaction and photo cross-linking for the regeneration of cartilage, which has adaptable and drug-continuous release behavior. A photopolymerizable bioink was prepared using recombinant collagen, chitosan, nanoclay Laponite-XLG and nanoparticles loaded with Kartogenin (KGN). This bioink was added with KGN, a small molecule drug that promotes cartilage differentiation, and as a result, the 3D-printed CF/CM/3%LAP/KGN scaffolds obtained by extrusion printing is expected to be used for cartilage repair. It was shown that the 3D-printed scaffolds had good cytocompatibility for human bone marrow mesenchymal stem cells (hBMSCs) and exhibited excellent antimicrobial properties, the continuous release of KGN in the scaffold induced the hBMSCs differentiation into chondrocytes, which significantly enhanced the expression of collagen II and glycosaminoglycan. In vivo studies have shown that implantation of KGN-loaded scaffolds into cartilage-injured tissues promoted cartilage tissue regeneration. This study demonstrated that 3D-printed CF/CM/3%LAP/KGN scaffolds can be used for cartilage repair, which is expected to lead to new healing opportunities for cartilage injury-based diseases.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Xiaobi Fang,Xiaojing Chen,Wei Dong,Fan Ye
In the management of diabetic oral ulcers, current treatments frequently fall short due to complications from bacterial contamination, oxidative damage, and impaired angiogenesis. These shortcomings highlight the pressing need for more efficacious interventions that not only circumvent these issues but also expedite healing processes. To bridge this gap, we have introduced a novel hydrogel patch, POQ2 [a poly(tannic acid) particle-incorporated oxidized β-glucan/quaternized chitosan hydrogel]. POQ2 demonstrated significant improvements in healing outcomes by enhancing bacterial clearance (up to 99.7 % against Escherichia coli and 99.2 % against Staphylococcus aureus ), reducing oxidative stress through efficient ROS scavenging (70.2 % reduction in DPPH radicals), and promoting angiogenesis. In vivo experiments on diabetic rat models showed accelerated wound closure and reduced IL-6 inflammatory markers, with nearly complete ulcer healing within seven days. The introduction of POQ2 into clinical protocols represents a substantial advancement in the management of diabetic oral ulcers, promising not only improved patient outcomes but also a shift in the standard of care in this challenging clinical area. This innovation not only fills a significant gap in diabetic wound care but also sets a new benchmark for the development of future treatments, potentially influencing broader therapeutic strategies for managing complex diabetic wounds.
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DRUG DELIVERY
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2012
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IF 1.456
Ning Li,Chun-Yang Zhuang,Mi Wang,Cheng-Guang Sui,Wei-San Pan
In this study, low molecular weight chitosan coated liposomes (LCHL) were designed and prepared for ocular drug delivery, the coating mechanism was studied, and in vitro and in vivo characterization was conducted. The effects of molecular weight and concentration of low molecular weight chitosan on the liposomal coating were studied. The numeric relations between coating variables and coating efficiency were established using a mathematical model. Morphology of LCHL was examined by transmission electron microscopy (TEM). Cytotoxicity and cell internalization of FITC-BSA labeled LCHL in a rabbit conjunctival epithelium (RCE) cell line were studied. Cyclosporin A (CsA) was encapsulated as a model drug, and in vitro drug release and in vivo drug absorption were investigated. LCHL demonstrated low toxicity to RCE cells. In vitro drug release measurement showed that LCHL had a delayed release profile compared with non-coated liposomes. In vivo study in rabbits showed that the concentrations of CsA in cornea, conjunctiva, and sclera were remarkably increased by LCHL. In conclusion, LCHL might be a potential ocular drug carrier with characteristics such as prolonged drug retention, enhanced drug permeation, and biocompatibility.
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