ACS Nano
·
2024
·
IF 15.8
Kuo Wang,Yajie Luo,Hongtu Zhan,Xiao-Xia Liu,Xiaoqi Sun
Zn metal anodes experience dendritic growth and hydrogen evolution reactions (HER) in aqueous batteries. Herein, we propose an interface regulation strategy with a trace (1.4 × 10–4 mol kg–1) all-in-one epicatechin (EC) electrolyte additive to solve the above issues and reveal the roles of individual functional groups. By the disassembly of EC into simple molecules combined with entire molecule investigations, we show that phenol and ether sites preferentially anchor on the Zn surface, while the hydroxyl group pointing outward enters Zn2+ solvation shells at the interface. It modifies the following desolvation path, which not only enables uniform deposition with the thermodynamically favored plate morphology but also inhibits HER. With these synergistic effects of trace EC additive, the lifespan of symmetric cells extends to 8.5 times that of the baseline ZnSO4 electrolyte. The capacity retention of Zn//MnO2 full batteries with N/P = 3 also increases from 59.1 to 85.6% after 500 cycles.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Yucheng Wu,Yanli Yu,Wei Shen,Yimin Jiang,Rongxing He,Ming Li
Developing simple and energy-saving pathways to prepare high-efficient and robust non-noble metal based electrocatalysts remains a huge challenge to hydrogen production from seawater electrolysis. Here we demonstrate a facile hydrothermal-calcination-etching approach that simultaneously achieves the required surface N doping and Fe vacancies generation to activate the Ni-O-Fe active motifs in N -v Fe -NiFe 2 O 4 /NF. The unique localized environments (Ni- N -Fe structures and unsaturated O- and N -coordination) due to dual-defect strategy can effectively regulate the electronic structure of the Ni-O-Fe motif to make the motif more reactive. As a result, the N -v Fe -NiFe 2 O 4 /NF catalyst exhibits overpotentials of 210, 213 and 222 mV to deliver 100 mA cm −2 in 1.0 M KOH, simulated seawater and alkaline seawater environments, respectively. Theoretical calculations prove that the Ni-O-Fe structure is the active motif and that the presence of special localized environments can optimize the adsorption of key intermediates on the activated active motifs.
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SCIENCE OF THE TOTAL ENVIRONMENT
·
2024
·
IF 8.2
Hanwen Zhang,Jiabin Jin,Xini Wang,Wei Han,Lei Qin,Lin Chen,Xiaoyan Mao,Zhenjiang Liu,Xingwei Xiang
The presence of pesticide residues in aquatic environments poses a significant threat to both aquatic ecosystems and human health. The presence of these residues can result in significant harm to aquatic ecosystems and can negatively impact the health of aquatic organisms. Consequently, this issue requires urgent attention and effective measures to mitigate its impact. However, developing sensitive and rapid detection methods remains a challenge. In this study, an all-in-one test strip, which integrated bioenzymes, nanoenzymes, and a chromogen, was developed in combination with an enzyme labeling instrument for a highly sensitive and convenient sensing of malathion residues. The oxidase activity of heme chloride (Hemin) in the strip can catalyze the oxidation of H 2 O 2 and 3,3′,5,5′-tetramethylbenzidine (TMB) to produce a blue-colored oxide. Simultaneously, the alkaline phosphatase (ALP) present in the strip can break down l -ascorbic acid-2-phosphate to produce ascorbic acid (AA). This AA then acts to reduce the oxidized form of TMB, turning it into a colorless substance and leading to the disappearance of its fluorescent signal. In the presence of a pesticide, the activity of ALP is inhibited and formation of AA is blocked, thereby preventing the reduction of oxidized TMB and producing a colored signal. According to this principle, the integrated test strip detected the target pesticide with high performance as per the optical density value determined via an enzyme marker. The detection limit of the test strip was 0.209 ng/mL with good sensitivity. The method was used for detecting malathion in actual river water samples, and the recoveries were in the range of 93.53 %–96.87 %. The newly devised technique effectively identified malathion in samples of natural water. This research has introduced a novel approach for the precise and convenient surveillance of pesticide remnants. Additionally, these discoveries could inspire the advancement of proficient multi-enzyme detection systems.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Yukun Liu,Xinshuang Lin,Bing Li,Hanwen He,Hangyuan Xing,Yuqing Zhang,Yang Song,Sen Zhang,Chao Deng
The delicate design and fabrication of transition metal-based heterostructures with abundant active sites are a crucial issue for achieving superior electrocatalytic properties. In this work, we introduce a novel bio-assisted strategy for assembling cobalt-based heterostructures on nitrogen and phosphorus codoped carbon nanobelts, which serve as highly efficient bifunctional oxygen catalysts. The fungus of Rhizopus is utilized to encapsulate the Co-CoTe within the in-situ formed nitrogen and phosphorus codoped carbon nanotubes (NPCNT), resulting in hairy nanobelts with a porous structure and excellent flexibility. Both experimental and theoretical analyses results reveal the superior geometric configuration, electronic structure, and the low energy barrier of the bio-Co-CoTe@NPCNT nanobelts. Benefitting from these advantages, the bio-Co-CoTe@NPCNT nanobelts demonstrate rapid kinetics, impressive catalytic performance, and high durability in both oxygen evolution and reduction (OER/ORR) reactions. The aqueous zinc-air batteries (ZAB) employing the prepared bio-Co-CoTe@NPCNT nanobelt cathode exhibit the stable cycling properties and good reliability. Furthermore, the solid-state ZAB demonstrates high reliability, pliability, and durability under various deformations.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Fangfang Ye,Xiaoying Jin,Zuliang Chen
Innovative iron-based nanoparticles (NPs) made from biomass provide sustainable solutions for environmental cleanup, integrating better environmental management with resource recycling. This study introduces biomass-derived carbon-coated iron sulfide (FeS@CMP) as an efficient Fenton catalyst for phenol oxidation, addressing challenges associated with FeS NPs in advanced oxidation processes (AOPs), for example deactivation and aggregation. Firstly, advanced characterization reveals its porous structure, high surface area, and abundant active sites, compared to carbonized biomass precursor (CMP), while FeS@CMP demonstrates superior physical and chemical stability. Secondly, FeS@CMP achieves remarkable efficiency in activating hydrogen peroxide (H 2 O 2 ) for phenol removal (94.08%), which is much greater than that of CMP (40.70%). Further, mechanistic analysis identifies a synergistic electron transfer process involving multiple ROS, including •OH, SO 4 -•, and 1 O 2 , driving effective phenol degradation. Thirdly, using Density Functional Theory (DFT) calculations and Liquid Chromatography-Mass Spectrometry (LC-MS), a specific degradation pathway for phenol is proposed. Finally, toxicity assessments reveal a marked decline in toxicity of degradation products and excellent reusability over multiple cycles. FeS@CMP also effectively degrades contaminants in real wastewater. This study converts waste into high-performance biomass-based catalysts, advancing sustainable development and offering an eco-friendly method for phenol removal, enhancing low-impact AOP technologies.
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WEED SCIENCE
·
2024
·
IF 2.1
Yu Liu,Kerong Shi,Haitao Gao,Shaojing Yin,Liyao Dong,Zhike Feng
Barnyardgrass [Echinochloa crus-galli (L.) P. Beauv.] is increasingly infesting imidazolinone-tolerant (IMI-T) rice fields in China, imazamox resistance of E. crus-galli has become the major concern for weed management in IMI-T rice fields. In this study, the susceptible population JLGY-3 (S) and the suspected resistant population JHXY-2 (R) collected from IMI-T rice fields were used as research subjects. When treated with imazamox, JHXY-2 (R) population showed a high level of herbicide resistance with a resistance index (RI) of 31.2. JHXY-2 (R) was cross-resistant to all five acetolactate synthase (ALS) inhibitors from different chemical families, but sensitive to herbicides inhibiting acetyl-CoA carboxylase (ACCase). In order to understand the reason why JHXY-2 (R) was resistant to imazamox, we performed experiments to characterize potential TSR and NTSR mechanisms. A trp-574-leu amino acid mutation in ALS and low imazamox ALS sensitivity were the main mechanism underlying imazamox resistance in this JHXY-2 (R) population. There was no significant difference in ALS gene expression and ALS protein abundance between R and S populations. High-performance liquid chromatography-tandem mass spectrometry analysis showed enhanced metabolism of imazamox in JHXY-2 (R), which was in contrast to the results of pretreatment with a metabolic enzyme inhibitor. Treatments with the P450/GST inhibitors did not alter the resistance level of JHXY-2 (R) against imazamox. To further clarify the NTSR mechanism of JHXY-2 (R), transcriptome sequencing showed that there was almost no significant difference in the expression of P450 and GST metabolic enzyme genes between R and S populations, and only GST-U1 showed a significant induction in R population. In conclusion, amino acid mutation and higher enzyme activity of ALS are the main causes of imazamox resistance in JHXY-2 (R). However, given the differences in imazamox residues in the leaves of the E. crus-galli, there may still be undetectable NTSR that are causing imazamox resistance in the R population.
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PHYTOTHERAPY RESEARCH
·
2025
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IF 6.3
Xia Xiao,Yanhu Huang,Wei Liu,Yuan Liu,Haijie Zhang,Chuang Meng,Zhiqiang Wang
The rising prevalence of multidrug-resistant (MDR) Gram-positive bacteria threatens the effectiveness of current antibiotic therapies. However, the development of new antibiotics has stagnated in recent years, highlighted the critical need for the discovery of innovative antimicrobial agents. This study aims to evaluate the antibacterial activity of naphthoquinones derived from Arnebia euchroma (Royle) Johnst (ADNs) and elucidate their underlying mechanisms. The antibacterial efficacy of ADNs was assessed using the microbroth dilution method. The antibacterial mechanism of acetylshikonin (ASK) was further explored through scanning electron microscopy, RNA-Seq and transcriptomic analysis, fluorescent probes, high-performance liquid chromatography, qRT-PCR and molecular docking. The results demonstrated that all the ADNs exhibit potent antibacterial activity against MDR Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus , and linezolid-resistant Enterococcus . Notably, ASK showed minimum inhibitory concentration of 1–2 μg/mL against MRSA. Mechanistic investigations revealed that ASK operates through a multifaceted antibacterial mechanism. First, ASK disrupts bacterial membrane integrity and dissipates proton motive force by targeting membrane phospholipids. Further analysis demonstrated a significant reduction in oxygen consumption and ATP production, indicative of respiratory chain inhibition. Additionally, ASK interferes with bacterial cell wall synthesis, as evidenced by reduction of peptidoglycan precursors and downregulated expression of genes involved in peptidoglycan synthesis. In conclusion, ASK represents a promising antimicrobial agent with potential efficacy against infections caused by MDR Gram-positive bacteria and offers valuable insights for the development of novel therapeutic strategies.
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Polymer Chemistry
·
2024
·Vol. 15
·期 47
·4875-4887
·
IF 4.1
Yangyang Xu,Wenlong Tang,Hui Deng,Jianjun Zhang,Zhongquan Zhu,Changjiang Yu,Haiguang Zhu,Ke Sun,Jiazhu Li,Jacques Lalevée
Polymerization reactions induced by light are gaining increasing importance in the field of polymer synthesis; however, effective photopolymerization under visible light emitting diodes (LEDs), as opposed to UV light, remains limited and warrants further research and development. In this work, a family of bisbenzothieno[b]-fused boron dipyrromethene (BODIPY) derivatives, which have not been previously tested for photopolymerization, were designed. They contain seven fused aromatic rings with broad absorption properties and were introduced with amine and iodonium salt to form three-component photoinitiating systems (PISs) for the first time. Remarkably, under visible light irradiation, e.g. LED@405 nm and LED@660 nm, these PISs were able to initiate the free radical polymerization of acrylate monomers and cationic polymerization of epoxy monomers at room temperature, displaying different photopolymerization kinetics. This excellent initiation ability at both ends of the visible spectrum (i.e. the highest and lowest photon energy) indicated a remarkable panchromatic initiation ability. The exceptional photochemical reactivity of these BODIPY dyes and the underlying photoinitiation mechanisms of the PISs were thoroughly investigated through steady-state photolysis, fluorescence quenching experiments, and theoretical calculations. Finally, three-dimensional patterns with excellent spatial resolution were successfully printed using the BODIPY dye with the highest photoinitiation efficiency via direct laser writing, highlighting its significant potential for 3D printing applications.
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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
·
2024
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IF 6
Zheren Tong,Xiaolu Jie,Ziwei Chen,Mingtao Deng,Xin Li,Zhiwen Zhang,Faxiang Pu,Zhangfu Xie,Zijin Xu,Ping Wang
Crocetin (CCT), a natural bioactive compound extracted and purified from the traditional Chinese medicinal herb saffron, has been shown to play a role in neurodegenerative diseases , particularly depression. However, due to challenges with solubility, targeting, and bioavailability, formulation development and clinical use of CCT are severely limited. In this study, we used the emulsification-reverse volatilization method to prepare CCT-loaded nanoliposomes (CN). We further developed a borneol (Bor) and lactoferrin (Lf) dual-modified CCT-loaded nanoliposome (BLCN) for brain-targeted delivery of CCT. The results of transmission electron microscope (TEM) and particle size analysis indicated that the size of BLCN (∼140 nm) was suitable for transcellular transport across olfactory axons (∼200 nm), potentially paving a direct path to the brain. Studies on lipid solubility, micropolarity, and hydrophobicity showed that BLCN had a relatively high Lf grafting rate (81.11 ± 1.33 %) and CCT entrapment efficiency (83.60 ± 1.04 %) compared to other liposomes , likely due to Bor improving the lipid solubility of Lf, and the combination promoting the orderly arrangement of liposome membrane molecules. Microplate reader and fluorescence microscopy analysis showed that BLCN efficiently promoted the endocytosis of fluorescent coumarin 6 into HT22 cells with a maximal fluorescence intensity of (13.48 ± 0.80 %), which was significantly higher than that of CCT (5.73 ± 1.17 %) and CN (12.13 ± 1.01 %). BLCN also exhibited sustained function, remaining effective for more than 12 h after reaching a peak at 1 h in cells, while CN showed a significant decrease after 4 h. The uptake mechanisms of BLCN in HT22 cells mainly involve energy-dependent, caveolae-mediated, and microtubule-mediated endocytosis, as well as micropinocytosis. Furthermore, BLCN displayed a significant neuroprotective effect on HT22 cells in glutamate-, corticosterone-, and H 2 O 2 -induced models. Tissue fluorescence image analysis of mice showed that BLCN exhibited substantial retention of fluorescent DiR in the brain after nasal administration for 12 h. These findings suggest that CCT has the potential for cellular uptake, neuroprotection , and targeted delivery to the brain following intranasal administration when encapsulated in Bor and Lf dual-modified nanoliposomes.
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Journal of Physical Chemistry C
·
2011
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IF 4.524
Deping Huang,Xiangtao Bai,Liqiang Zheng
Three-dimensional dendritic gold nanostructures were prepared via an ultrafast one-step homogeneous solution method. Cationic surfactants, decane-1,10-bis(methylpyrrolidinium bromide) ([mpy-C10-mpy]Br2), were used as the capping agent and l-ascorbic acid (AA) was used as the reducing agent. The as-prepared gold dendrites present a [111] plane and grow along the ⟨211⟩ direction. The AA plays an important role in the formation of the dendritic nanostructures. The methylpyrrolidinium quaternary ammonium headgroups and bolaform nanostructures of the surfactants are the key factors for the formation of dendritic structures. Further investigation revealed that the reaction time and concentration of HAuCl4 weakly affect the formation of the dendrites. Moreover, the obtained gold dendrites exhibit excellent activity toward the catalytic reduction of p-nitraniline and higher enhancement of surface-enhanced Raman scattering when using Rhodamine 6G as the model molecules.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2009
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IF 2.562
Zhao-Feng Li,Bin Li,Zhi-Guo Liu,Miao Wang,Zheng-Biao Gu,Guo-Cheng Du,Jing Wu,Jian Chen
Overexpression of recombinant genes in Escherichia coli and targeting recombinant proteins to the culture medium are highly desirable for the production of industrial enzymes. However, a major barrier is inadequate secretion of recombinant protein across the two membranes of E. coli cells. In the present study, we have attempted to circumvent this secretion problem of the recombinant α-cyclodextrin glycosyltransferase (α-CGTase) from Paenibacillus macerans strain JFB05-01. It was found that glycine, as a medium supplement, could enhance the extracellular secretion of recombinant α-CGTase in E. coli. In the culture with glycine at the optimal concentration of 150 mM, the α-CGTase activity in the culture medium reached 23.5 U/mL at 40 h of culture, which was 11-fold higher than that of the culture in regular TB medium. A 2.3-fold increase in the maximum extracellular productivity of recombinant α-CGTase was also observed. However, further analysis indicated that glycine supplementation exerted impaired cell growth as demonstrated by reduced cell number and viability, increased cell lysis, and damaged cell morphology, which prevented further improvement in overall enzyme productivity. Significantly, Ca2+ could remedy cell growth inhibition induced by glycine, thereby leading to further increase in the glycine-enhanced extracellular secretion of recombinant α-CGTase. In the culture with 150 mM glycine and 20 mM Ca2+, both extracellular activity and maximum productivity of recombinant enzyme were 1.5-fold higher than those in the culture with glycine alone. To the best of our knowledge, this is the first article about the synergistic promoting effects of glycine and Ca2+ on the extracellular secretion of a recombinant protein in E. coli.
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Materials Today Communications
·
2025
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IF 4.5
Yi'an Chen,Mengxue Zhou,Jingyue Wang,Yunji Fei,Xiaoling Yan,Xin Hao,Ansha Zhao
Atherosclerotic plaques can be eliminated using approaches such as endarterectomy. However, intimal damage resulting from surgery is frequently challenging to address. Traditional surgical techniques often incorporate foreign substances such as modified stents or drugs to counter the consequences of intimal defects. Such treatment makes it difficult to repair vascular defects in endothelial segments. It is prone to cause problems such as hyperplasia and abnormal blood supply due to vascular endothelial defects. In this study, hyaluronic acid (HA), a natural extracellular mechanism component that is not prone to actively induce coagulation, was employed as a biomimetic material for intimal repair. Through chemical grafting modification, the gel was endowed with rapid photocuring performance within 3 s, and the scientific attributes of the gel-series materials were enhanced. The additional incorporation of Cu 2+ into the gel-prepared HMN-Cu 2+ hydrogel augmented the anticoagulant effect of the material while enhancing blood cell compatibility. The results of material science experiments indicate that HMN gel can adhere stably to various biological interfaces in a fluid environment mimicking blood flow, and its swelling and degradation properties are appropriate. Cell experiments and blood evaluation demonstrated that the gel exhibited favorable erythrocyte compatibility and anticoagulant and endothelial spreading capabilities during intimal repair. The gel has the potential to substitute the intima barrier, improve the intima repair environment, and facilitate subsequent intima repair. It can effectively resolve the problem of intima layer irreparability during novel low-damage vascular surgeries such as intima stripping and plaque rotation.
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