FUEL
·
2025
·
IF 7.5
Yangshuo Liu,Yaotian Yan,Feiyu Xu,Liang Qiao,Jiehe Sui,Wei Cai,Xiaohang Zheng
The activation of the lattice oxygen oxidation mechanism is vital for enhancing oxygen evolution reaction (OER) performance as it enables direct O–O bond formation, avoiding the *OOH formation. Compared with the conventional adsorbate evolution mechanism (AEM), the lattice oxygen-mediated mechanism (LOM) can break the theoretical limit of conventional adsorbate-based scaling relations and enhance the oxygen evolution reaction kinetics. Thus, there is an urgent need for an efficient strategy for designing OER electrocatalysts based on LOM. The O p band center is employed as descriptor in conjunction with machine learning to facilitate the activation of lattice oxygen. The descriptor can accelerate the catalyst design process as it circumvents the need for complex intermediate calculations. According to predictions, the Fe-Co 3 O 4 catalyst exhibits OER performance comparable to that of noble metal catalysts. The Fe-Co 3 O 4 catalyst achieves a low overpotential of 258 mV at 20 mA cm -2 in 0.5 M H 2 SO 4 , attributed to the shift in catalytic mechanism from AEM to LOM.The incorporation of Fe effectively induces an upshift in the O p band center and weakens the Co–O bond, thereby promoting direct O–O coupling for O 2 generation and consequently reducing the OER overpotential. Our study introduces a method to activate the lattice oxygen of metal oxide electrocatalysts, holding substantial promise for enhancing large-scale hydrogen production.
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2026
·
IF 9.2
Qingsong Liu,Yan Zhu,Wentao Li,Junci Wu,Yi Zhang,Shouchun Ma,Chuanli Qin
Modified graphitic carbon nitride (MCN) was synthesized via calcinating β-alanine introduced melamine supramolecular precursors and poly(3-methylthiophene-co-fluorene) (P(3MT-co-F)) with improved planarity was prepared by polymerization of 3-methylthiophene (3MT) and fluorene (F) monomers. P(3MT-co-F)/MCN heterojunction was constructed by electrostatic self-assembly and the optimal 3P(3MT 1 -co-F 1 )/MCN exhibits excellent H 2 production performance of 11108 μmol h −1 g −1 under visible light, 150 times higher than MCN. The enhancement is attributed to the following aspects: First, F monomer as a rigid unit can regulate the main-chain torsion of P(3MT-co-F), enhancing planarity and facilitating intramolecular charge transport within copolymer. Second, N⋯S interactions and π-π stacking interactions at heterojunction interface improve the charge transfer and separation. Third, the incorporation of P(3MT-co-F) with narrow band gap into MCN not only broadens visible light absorption range and enhances visible light response, but also forms a Z-scheme heterojunction with MCN, further enhancing the charge separation and retaining the electrons with strong reducibility.
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高影响因子
Pharmaceutics
·
2026
·Vol. 18
·期 8
·1031
·
IF 6.9
Yuchen Qu,Zhuan Yang,Wen Ma,Peng Xiao,Yani Gu,Jie Pan,Xinyun Zhang,Chen Zhao,Yunli Yu
Background: In patients with atrial fibrillation receiving long-term anticoagulation therapy with dabigatran etexilate (DABE), moxifloxacin (MFLX) is frequently coadministered to treat concurrent infections; however, the potential drug–drug interaction (DDI) between these agents remains unclear. Herein, we examined the underlying mechanism by which MFLX attenuates DABE pharmacokinetics in rats; subsequently, we elucidated the DDI in humans by establishing a physiologically based pharmacokinetic (PBPK) model based on these animal data.Methods: The 3- and 14-day effects of 40 mg/kg MFLX once daily and secondary bile acid (SBA)-containing dietary intervention on the pharmacokinetic profile of DABE and its active form, dabigatran (DAB), were examined in a rat model. Ileum tissues were harvested to measure the expression of P-glycoprotein (P-gp), pregnane X receptor (PXR), and peroxisome proliferator-activated receptor alpha (PPARα). In addition, we examined the effects of secondary bile acids (SBAs) on P-gp expression and quantified P-gp-mediated DABE efflux transport activity in Caco-2 cells. A PBPK model was used to predict the risk of DAB exposure under this DDI scenario and under combined high-risk conditions, including renal impairment and advanced age.Results:Treatment with MFLX for 3 and 14 days inhibited SBA-producing gut microbiota, thereby suppressing the conversion of primary bile acids to SBAs. Concurrently, a marked reduction in intestinal P-gp expression was observed, along with a significant enhancement of the oral bioavailability of DABE. These effects were reversed by SBA-containing diets. In vitro experiments using Caco-2 cells revealed that physiologically relevant concentrations of SBA significantly upregulated P-gp expression and function, whereas MFLX incubation alone showed no direct modulatory effect on these transporters or regulators. PBPK simulation results showed that in vivo exposure of DAB would increase by 41.7%, 104%, 251%, and 115% when coadministered with MFLX alone, with coexisting mild renal impairment, moderate renal impairment, and aging, respectively.Conclusions: MFLX increases DAB exposure by reducing SBA-regulated intestinal P-gp function. PBPK simulations suggest a low risk of DDI from MFLX coadministration alone; however, caution is warranted in patients with aging or renal impairment.
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2026
·
IF 7.6
Yueyuan Liu,Feifei Wang,Xiaozhe Chen,Fuhui Cui,Yang Lu,Rongke Gao,Liandong Yu
The widespread application of Internet of Things (IoT) technology promotes the miniaturization and intelligent development of electronic devices, posing significant challenges to the effective microenergy harvesting and optimization of self-powered devices. Here, we present NaNbO3/P(VDF-TrFE)-based piezoelectric nanogenerators (NP-PENGs) based on femtosecond laser surface modification for bioenergy harvesting and human motion monitoring. In this study, NaNbO3 nanoparticles are synthesized by liquid-phase pulsed laser ablation, and the phase structure of P(VDF-TrFE)-based composite materials is processed by femtosecond laser surface modification. The aim is to establish a synergistic system of nanoparticle induction and laser precise control to enhance the content of the β-phase in three dimensions from nucleation initiation, orientation control, and structural stability. Importantly, the output potential of flexible P(VDF-TrFE) and 5 wt % NaNbO3/P(VDF-TrFE)-based PENGs after femtosecond laser processing can reach 26.1 V (36% improvement) and 40 V (52% improvement), respectively. Furthermore, the flexible PENG exhibits great stability under cyclic mechanical stress for 3000 s and successfully powers 20 LEDs. By attaching the NP-PENG to various parts of the human body, it can not only precisely sense human motion status but also real-time monitor the output voltage changes. This study provides an efficient and straightforward method for achieving precise control of high β-phase content and high-performance PENGs, and it demonstrates its enormous potential in the field of intelligent wearable devices.
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高影响因子
TISSUE & CELL
·
2026
·
IF 3.1
Jun Ma,Hongying Zhang,Linlong Wu,Huiyun Shen,Aifei Chen,Aiping Wu,Ying Hu
AS-IV ameliorates oxaliplatin-induced damage to DRG neurons. • AS-IV exerts neuroprotective effects by inhibiting the p53/p-Drp1 signaling pathway in OIPN. • AS-IV corrects mitochondrial dysfunction and energy metabolism disorders in OIPN. • AS-IV improves mechanical hyperalgesia and thermal hypersensitivity in OIPN rats. • AS-IV antagonizes OIPN through the p53/p-Drp1/mitochondrial axis. Objective This study targeted to explore the effect of Astragaloside IV (AS-IV) on oxaliplatin (OHP)-induced peripheral neuropathy (OIPN). Methods OHP-induced rat dorsal root ganglion (DRG) neurons were treated with AS-IV and/or p53 inhibitors or agonists. Cell viability, apoptosis, mitochondrial membrane potential, ROS, oxidative stress-related indicators, and mitochondrial complex activity were examined. The interaction between p53 and Drp1 was explored and validated. In vivo , an OIPN rat model was established via intraperitoneal injections of OHP and treated with AS-IV. Behavioral assessments were conducted, and histological examinations were performed on DRG tissues from OIPN rats. Results AS-IV significantly enhanced DRG neuronal viability following OHP induction, inhibited apoptosis, improved mitochondrial function, alleviated oxidative stress, and simultaneously suppressed OHP-induced p53 upregulation and its interaction with Drp1. p53 inhibitors mimicked these protective effects, while agonists blocked these effects. In vivo experiments demonstrated that AS-IV significantly alleviated cold, heat, and mechanical pain sensitivity in OIPN rats, reduced DRG histopathological damage and neuronal apoptosis, improved oxidative stress, and inhibited activation of the p53/p-Drp1 signaling pathway. Conclusion AS-IV protects DRG neurons from OHP-induced injury and alleviates OIPN-related symptoms by inhibiting the p53/p-Drp1 axis.
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高影响因子
COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Tian Fang,Jiujun Zhu,Qixiong Zhang,Xiaopeng Li,Yafei Hou,Renlu Han,Jing Cuan,Weiping Li
Polymer dielectric capacitors are pivotal for advanced electronics, while their limited energy density ( U d ) impedes further miniaturization. Constrcution of nanocomposites to utilizing their both merits seems to improve their U d , however, conventional single-filler systems typically enhance either dielectric constant ( ε r ) or breakdown strength ( E b ), at the expense of the other. Herein,A dual-filler approach is developed to achieve concurrent enhancement of ε r and E b , thereby overcoming the trade-off limitation inherent in single-filler systems. In this study, a series of nanocomposites are designed by incorporating carbon quantum dots (C QDs) into a P(VDF-HFP) matrix with Ni(OH) 2 nanosheets (Ni(OH) 2 NSs). C QDs enhance ε r through the micro-capacitor effect and suppress electron migration via the Coulomb blockade effect. Concurrently, Ni(OH) 2 NSs act as scattering centers and barriers, extending the breakdown path to improve E b . Simulation results confirm synergistic suppression of electrical tree growth. The best nanocomposite obtains a U d of 21.9 J/cm 3 at 570.3 MV/m with charge-discharge efficiency ( η ) of 72.3%. This U d shows a 188% improvement over the single-filler counterpart. Meanwhile, excellent cyclic stability over 10 4 cycles and rapid discharge (τ 0.9 = 117 ns) are also demonstrated. This dual-filler system provides a rational route to concurrently improve ε r and E b for next-generation dielectric capacitors.
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Shixuan Yu,Shiying Fan,Shaomin Liu,Xinyong Li
The direct photocatalytic oxidation of inert methane (CH 4 ) to high-value-added oxygenates remains a significant challenge. This study precisely controls generated reactive oxygen species (ROS) types by modulating interfacial electronic interactions in Zn-Pt δ− -PS photocatalysts, promoting CH 4 conversion into formaldehyde (HCHO). Under ambient conditions, a HCHO production rate reached 3308 μmol·g −1 with a high selectivity of 77%. In situ spectroscopy and theoretical studies demonstrated that the elevated Pt d-band center in Pt-*OOH (* represents the adsorption state) lowered the occupancy of antibonding orbitals, thereby enhancing the interaction between Pt and *OOH, markedly polarizing the O O bond, facilitating its cleavage, and enabling the preferential in situ generation of •OH rather than •OOH. Furthermore, adequate •OH radical accelerated activation of the C H bond in CH 4 and induced the cleavage of its O H bond in methanol (CH 3 OH), promoting HCHO formation. This strategy may guide the rational design of the catalyst's electronic structure to enhance CH 4 photocatalytic oxidation. Download: Download high-res image (175KB) Download: Download full-size image
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Yanhong Zhang,Liulu Liu,Nanke Ma,Lixia Xie,Yuan Jin,Guangli Li
PNHC@Pt/TiO₂ core–shell heterojunction for trace Cu²⁺ monitoring. • N/P doping & O defects boost Cu²⁺ coordination and enrichment. • Low LOD 0.006 µM, wide linear range 0.001–20 µM. • Excellent selectivity against multiple coexisting heavy metal ions. • Reliable recoveries (87.1–103.3%) in tap water, soil, serum. Copper ion (Cu 2+ ) is a prevalent heavy metal contaminant in industrial wastewater and natural water bodies. Although it plays a vital role as a trace element in human physiology, overconsumption can result in severe systemic disorders. In this work, a novel electrochemical sensing platform based on P, N co-doped hollow carbon (PNHC) decorated with Pt/TiO 2 nanoparticles (PNHC@Pt/TiO 2 ) was developed for the ultrasensitive detection of Cu 2+ . The composite was systematically characterized by SEM, TEM, XRD, FTIR, Raman spectroscopy, and XPS, confirming the formation of a core-shell structure with a uniform spherical morphology (104.20 ± 0.21 nm), along with N/P heteroatoms that provide specific coordination affinity toward Cu 2+ . Compared to bare and single-component electrodes, the PNHC@Pt/TiO 2 -modified GCE delivered an enlarged electroactive surface area (0.1289 cm 2 ) and lower charge-transfer resistance; under the optimized parameters (pH 5.0, accumulation potential −0.8 V, accumulation time 180 s, and modifier volume 5 µL), this sensor presented a Cu 2+ linear detection range of 0.001–20 µM, a low limit of detection (LOD) of 0.006 µM (S/N = 3), and a high sensitivity of 6.102 µA µM −1 . The sensor also exhibited excellent selectivity against common interfering ions (K + , Na⁺, Ni 2+ , Co 2+ , Zn 2+ , Cd 2+ ), good reproducibility, and long-term stability (83.7% current retention after 8 days). Practical applicability was validated by successful determination of Cu 2+ in tap water, soil, and serum samples with recoveries ranging from 87.1% to 103.3%, demonstrating the reliable performance of the proposed sensor for environmental and biological monitoring.
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高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Chunyan Fan,Zehao Zang,Yao Tang,Yahui Cheng,Lanlan Li,Xiaofei Yu,Xiaojing Yang,Zunming Lu,Xinghua Zhang,Hui Liu
Bifunctional N,P-codoped Ag catalyst achieves outstanding seawater electrolysis performance. • Enhanced HER via optimized H adsorption and H–H coupling enabled by N,P codoping. • In situ generated PO 4 3− activates lattice oxygen, lowers OER barrier, suppresses Cl − adsorption. Herein, we present a bifunctional N,P-co-doped Ag (N,P–Ag) catalyst synthesized via one-step electrodeposition for efficient alkaline seawater splitting. The catalyst achieves low overpotentials of 260 mV@50 mA cm −2 for oxygen evolution reaction (OER) and 49 mV@10 mA cm −2 for hydrogen evolution reaction (HER), along with excellent reaction kinetics and long-term stability (sustained operation for 200 h at 100 mA cm −2 ). DFT calculations disclose that N, P co-doping enhances HER activity by disrupting Ag's electronic configuration to create new hybrid orbitals and delocalized electronic states, which in turn optimize H* adsorption and accelerate H–H bond formation. In-situ Raman spectroscopy captures the surface restructuring process during OER that leads to the formation of the active phase PO 4 3- -AgO. The lattice oxygen-mediated mechanism (LOM) enables lattice oxygen to participate directly in the OER process, helping to optimize the energy levels of intermediate reactions and weaken Cl − adsorption, thereby effectively suppressing chloride ion corrosion. This work demonstrates a combined approach of non-metallic doping for electronic tuning and in-situ anion modification for lattice oxygen activation, providing a viable route to achieve efficient and corrosion-resistant seawater electrolysis. By modulating electron conduction via N/P doping, localized charge enrichment zones are created around Ag atoms as HER-active sites, while in situ-generated PO 4 3− activates lattice oxygen, lowering the reaction barrier and inhibiting chloride corrosion. Download: Download high-res image (357KB) Download: Download full-size image
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Materials
·
2026
·Vol. 19
·期 14
·3069
·
IF 3.7
Bo Ma,Guoqiang Huang,Wenwen Hu,Wenxue An,Gailan Ma,Maohui Li,Youjun Lu
The degradation of organic pollutants through photocatalysis is currently a major research focus. Core–shell heterostructures of metal semiconductors have been widely recognized as an effective strategy for enhancing photocatalytic performance, particularly when alloy nanoparticles are incorporated due to their unique electronic and catalytic properties. However, conventional synthetic approaches typically rely on high-temperature and high-pressure conditions, which often induce undesirable particle overgrowth and aggregation. Herein, AuPt bimetallic alloy nanoparticles were successfully fabricated via two successive in situ redox processes under room-temperature and ambient-pressure conditions, which were in situ integrated with Cu2O to form multilevel core–shell composite particles. Structurally, an octahedral Cu2O crystal serves as the inner core (denoted as Cu2O(O)), sequentially coated with a Cu2O nanoparticle (denoted as Cu2O(P)) interlayer and a AuPt alloy nanoparticle shell. Functionally, the enhanced photocatalytic activity of Cu2O(O)@Cu2O(P)@AuPt was proven to be attributed to a dual function of AuPt, which includes an adsorption-induced polarized interface and an efficient charge-transfer mediator with the ohmic contact. This work demonstrates a mild and versatile synthetic strategy for constructing semiconductor–alloy heterostructures, offering valuable insights into the rational design of highly efficient and stable photocatalysts.
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PubMed
高影响因子
GREEN CHEMISTRY
·
2026
·
IF 9.2
zonghao xu,Zongyu Guan,Yan Song,Xiran Zhao,Yaodong Yuan,Zhipeng Yan,Junhang Tian,Xueyi Sun,Biwei Xiao,Weidong Zhuang
Direct recycling of spent LiFePO₄ (LFP) cathodes is a sustainable and energy-efficient strategy for recovering valuable materials while preserving the intrinsic olivine structure. Herein, we report a LiI-assisted regeneration approach that achieves electronic structure reconstruction and reinforced Fe–O d–p orbital hybridization, enabling simultaneous repair of structural defects and enhancement of Li⁺ transport kinetics. The reductive I⁻ ions promote Fe³⁺→Fe²⁺ conversion and effectively eliminate Fe–Li antisite defects, while Li⁺ replenishment restores the stoichiometry of degraded LFP. Density functional theory (DFT) calculations reveal that LiI triggers a downward shift of the Fe 3d band center and an upward shift of the O 2p band center, narrowing their energy separation and strengthening Fe–O covalency. These electronic modifications reduce Li⁺ migration barriers and reconstruct continuous Li⁺ transport channels, as further validated by ab initio molecular dynamics simulations. In-situ XRD measurements confirm reduced unit-cell volume fluctuations and enhanced FeO₆–PO₄ framework stability, demonstrating improved structural reversibility during cycling. Benefiting from this coupled structural–electronic reconstruction, regenerated LFP delivers 146.9 mAh g⁻¹ at 1 C and retains 97.4% capacity after 500 cycles, outperforming the spent material. This work proposes a green and low-energy direct regeneration route for cathode materials and provides important theoretical guidance for their efficient repair and regeneration.
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RSC Advances
·
2016
·Vol. 6
·期 65
·59946-59955
·
IF 3.289
Liangliang Dong,Yue Wang,Mingqing Chen,Dongjian Shi,Xiaojie Li,Chunfang Zhang,Hui Wang
We report a high performance and CO2-philic, comb copolymer consisting of poly(ethylene glycol) methyl ether methacrylate (PEGMA), polymethyl methacrylate (PMMA) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) for use in composite membranes for CO2/N2 separation. Since the copolymers contain ethylene oxide (EO) groups and amino groups, the separation performance was expected to be enhanced by the synergistic effect of (1) the increased solubility of CO2 by dipole–dipole interactions between CO2 and EO units and (2) the enhanced CO2 transport by reversible reactions between CO2 and amino groups. The best separation performance was obtained from the PEDM5 composite membrane with 25 mol% of PEGMA, at which the CO2 permeability was 308 barrer and CO2/N2 selectivity was 38, which displays a potentially promising alternative for CO2 separation from N2.
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