POLYMER BULLETIN
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2019
·Vol. 77
·期 2
·989-1001
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IF 1.858
Qiu Bining,Tian Hua,Yin Xueqiong,Zhou You,Zhu Li
In this study, 2-phenyl ethanol (2-PEA) was microencapsulated with natural and semisynthetic carbohydrate polymers as the wall material. The wall material components methylcellulose (MC), alginate sodium (ALG), and carboxymethyl chitosan were optimized according to the results of microscopy images, zeta potential, and 2-PEA content. The combination of MC/ALG/MC was selected as the best wall components. Cobalt chloride (CoCl 2 ) was used as the core material to prepare microcapsules whose color was measured with a colorimeter to intuitively express the water absorption of the microcapsules. The absorbed water mass and b* were related to one variable quadratic equation. The rapid release properties and the natural long-term release properties of 2-PEA microcapsules were measured.
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JOURNAL OF CHEMICAL THERMODYNAMICS
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2019
·
IF 2.29
Lemeng Wang,Xiangfeng Tian,Dong Fu,Xiaoqian Du,Junhong Ye
Experimental data of CO 2 absorption capacity for high concentrated 1-dimethylamino-2-propanol (DMA2P)–monoethanolamine (MEA) aqueous blends are presented under atmospheric pressure in a temperature range of 303.2–323.2 K, at different mass fractions of DMA2P (30 wt%–50 wt%) and MEA (5 wt%–15 wt%). The mass fraction and temperature dependences of the absorption capacity are illustrated. The addition of small amount of MEA into DMA2P aqueous solution leads to an obvious increase in the absorption rate of CO 2 . However, the absorption rate increases not so significantly when w MEA is of high value. Moreover, the temperature affects the absorption rate not so significantly as compared to solution concentration. The CO 2 absorption heat of DMA2P-MEA based on the Gibbs-Helmholtz equation was found to be −55.0 kJ/mol. Besides, the viscosities of both CO 2 -unloaded and CO 2 -loaded aqueous solutions were measured and modeled in a temperature range of 303.2–323.2 K, and in atmospheric pressure. The effects of temperature, composition and CO 2 loading on viscosities were demonstrated. The Weiland equation gave a good prediction with an average relative deviation of 2.42%. Moreover, the activation energy ( E a) was estimated based on the viscosity.
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EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Peng Zhang,Lei Kan,Xinyue Zhang,Rui Li,Chuanqi Qiu,Ning Ma,Hao Wei
Multiple hydrogen bonds have been widely used to form a supramolecular network and endow materials with enhanced mechanical strength, good elasticity, and/or self-healing properties. In this study, 2-ureido-4[1H]-pyrimidone (UPy) compounds were synthesized and chemically grafted onto the side chain of epoxy resins. The UPy-modified epoxy resin demonstrated substantial improvements in toughness and elasticity compared with unmodified epoxy resin as proven by a tensile test and distortion test. The breaking elongation of the UPy-modified epoxy resin was 5 times higher than that of unmodified epoxy resin under a tensile test. In addition, the fracture mechanism of the modified epoxy resin matched with the ductile fracture rather than the brittle fracture of unmodified epoxy resins. The introduction of quadruple hydrogen bonds by chemical modification may provide a simple and effective way to design and prepare highly flexible thermosetting resin materials.
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JOURNAL OF ALLOYS AND COMPOUNDS
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2019
·
IF 4.175
Huichang Li,Senlin Wang,Junhui Ye,Weijun Liang,Yanxiu Zhang,Jian Gu
A unique 3D hierarchical mesoporous Al-doped α-Ni(OH) 2 /reduced graphene oxide (NH/rGO) composite for supercapacitor has been successfully synthesized via homogeneous precipitation method. In this process, urea as the alkali source and mild reducing agent, to make graphene oxide (GO) convert into rGO. Thus, The NH uniformly grew on the rGO nanosheets . The as-prepared mesoporous NH/rGO composite exhibited high capacitance performance with a specific capacitance of 2558 F g −1 at the current density of 1 A g −1 , and presented good rate capability with still held 75.3% capacity at 30 A g −1 . Moreover, we used the NH/rGO as the positive electrode and the rGO aerogel as the negative electrode to assemble an asymmetric supercapacitor (ASC) device. This ACS device showed excellent specific energy of 166.97 Wh kg −1 at the power density of 0.38 kW kg −1 , and it still retains the specific energy of 100.91 Wh kg −1 under the higher specific power of 7.76 kW kg −1 . And it also displayed high rate performance and cycling durability with keeps 72% of the initial capacity after 3000 cycles (at 3 A g −1 ).
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Nanoscale
·
2019
·Vol. 11
·期 30
·14400-14409
·
IF 6.97
Lei Xia,Xiaoyi Guo,Teli Liu,Xiaoxia Xu,Jinquan Jiang,Feng Wang,Zhen Cheng,Hua Zhu,Zhi Yang
Somatostatin receptor subtype 2 (SSTR2) is highly expressed in pulmonary neuroendocrine tumors, which account for approximately 25% of all lung cancers including small-cell lung cancer (SCLC). It is possible to establish SCLC-specific imaging agents for multimodal imaging to obtain tumor integrity information. Herein, we constructed novel multifunctional organic melanin nanoparticles (MNPs) as a carrier and surface-loaded somatostatin analog octreotide to produce a human small-cell lung cancer-targeted nanoprobe OCT-PEG-MNPs. MNPs have an excellent photoacoustic imaging (PAI) function and can be directly chelated with the magnetic resonance contrast agent Mn2+, and N-bromo succinimide (NBS) can be used as an oxidant to label the nanoparticles with the long half-life radionuclide 124I by an electrophilic substitution reaction. Therefore, (124I, Mn) OCT-PEG-MNPs can not only be used for PAI but also be used for positron emission tomography (PET) and magnetic resonance imaging (MRI). The NCI-H69 SCLC tumor xenograft model with high SSTR2 expression was constructed to evaluate the multimodal imaging ability of (124I, Mn) OCT-PEG-MNPs. This nanoprobe showed good imaging abilities in PAI, MRI and PET. The PA images showed that the photoacoustic signal in the NCI-H69 tumor site gradually increased with time, and the NCI-H69 xenograft showed a clear increase in the T1-weighted signal intensity after injection of Mn-OCT-PEG-MNPs at 24 h compared to that in the prescan. MicroPET and biodistribution studies showed that the uptake of NCI-H69 tumors (8.03 ± 0.37% ID g−1) was significantly higher than that in the control A549 model (3.35 ± 0.54% ID g−1) after injection of (124I, Mn) OCT-PEG-MNPs at 24 h. The (124I, Mn) OCT-PEG-MNPs were successfully applied to multimodal imaging in a small-cell lung cancer model with high SSTR2 expression. This nanoprobe may be considered for clinical trials since it combines the numerous advantages of organic nanoparticles.
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Materials Science & Engineering C-Materials for Biological Applications
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2019
·
IF 4.959
Yuehuang Wu,Pengjin Ge,Weixia Xu,Mingyu Li,Qi Kang,Xiaokun Zhang,Jingjing Xie
Therapeutic peptide, NuBCP-9 (N9) as a Bcl-2 functional converter, has been demonstrated to have the remarkable anticancer efficiency in Bcl-2-abundant cancer. However, it faced technical challenges in clinical use, such as the low bioavailability, the easily-destroyed bio-stability, and the insusceptibility to cellular interior. With the potential of mesoporous silica nanoparticles (MSNs) as the promising delivery vehicle of therapeutic macromolecules, we developed a kind of MSNs with the surface coating of folic acid (FA) for cancer cell targeting and with the macropore loading of N9 peptide for cancer therapy. Our results showed that the functional MSNs had the relatively greater biosafety than the naked MSNs in zebrafish models, leading to less than 30% embryo of death at 200 μg/ml, which could further specifically target the folate receptor (FR)-overexpressed cervical cancer HeLa cells instead of FR-negative normal embryonic kidney HEK 293T cells in a FA-competitive manner. N9 peptide with the delivery of functional MSNs could be internalized by HeLa cells, and co-localized with mitochondria in a Bcl-2-dependent manner. Moreover, N9 peptide delivered by FA-modified MSNs displayed the excellent anticancer efficiency with great selectivity, inducing approximately 52% HeLa cells into apoptosis. In summary, our results illustrated the potential of functional MSNs with large pore size as an efficient nanocarrier for the intracellular delivery of peptide drugs with targeting proteins to realize cancer therapy.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2019
·
IF 2.931
Bo-Hui Huang,San-San Shen,Na Wei,Xiao-Feng Guo,Hong Wang
An efficient and stable fluorescent sensor is described for the detection and imaging of thiols. It is making use of silicon quantum dots (SiQDs) which can be rapidly prepared. They were characterized by transmission electron microscopy , X-ray power diffraction, Fourier transform infrared spectroscopy, X-ray photoelectron spectrometry . The SiQDs have an absorption maximum at 300 nm and displayed blue-green fluorescence with excitation/emission maxima at 410/480 nm. A mixture of SiQDs and 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) exhibits strong fluorescence emission which however is quenched within 30 s of incubation with thiols. This is assumed to be due to an inner filter effect caused by the reaction of DTNB and thiols. The following thiols were tested: cysteine, homocysteine , and glutathione . The sensor has a linear response in the 3–100 μM thiol concentration range, and the LODs are between 0.80 and 0.96 μM. The sensor displays low cytotoxicity and was applied to fluorescence imaging of MCF-7 cells and Hela cells where it demonstrated excellent biocompatibility.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Xingang Li,Rui Wang,Yutao Yan,Runnan Zhao,Hong Li,Xin Gao
EG is an important industrial raw material, and the hydrolysis of 2-ethyl-1,3-dioxolane (2ED) to re-obtain EG is a very important step to recover EG from an EG and 1,2-BDO azeotropic mixture via a reversible-reaction-assisted intensification process. The applicability of reactive distillation for 2ED hydrolysis in the presence of KRD-002 ion exchange is studied by experiments and simulations. The reaction kinetics were investigated, and the kinetic parameters were derived. Thermodynamic aspects of the reaction system were discussed, and the NRTL model was built. Pilot-plant reactive distillation experiments were performed using the structured catalytic packing unit (SCPI) with several operating condition variations (reflux ratio (RR), feed mole ratio (FMR), and feed-in style). The experimental results are in good agreement with the simulation results, which prove that the equilibrium stage model can describe the hydrolysis experiments quantitatively. The simulation was subsequently used to determine the influence of important design factors and laid the foundation for industrial application.
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BIOMEDICINE & PHARMACOTHERAPY
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2018
·
IF 3.457
YingHui Zhang,Bing Wang,Feng Guo,ZhiZhen Li,GuiJun Qin
Diabetic nephropathy is one of the manifestations of systemic microangiopathy in diabetes. Hesperetin , a natural flavanone glycoside compound in citrus fruits, has been demonstrated to exert hypoglycemic effects and protect kidney in experimental diabetic animals. The current study was aimed to investigate the mechanisms underlying the hypoglycemic effects of hesperetin in high-fat/streptozocin (STZ)–induced diabetic nephropathy. The results showed that mice in whom hesperetin was administered for 4 weeks attenuated the increased fasting blood glucose and impaired glucose tolerance ability that was observed in high-fat/STZ mice. In addition, we found that hesperetin ameliorated the abnormalities of biochemical parameters in serum, liver, and kidney of mice with diabetic nephropathy. Hesperetin also rescued the irregular distortions in glomerular basement membrane and expanded mesangial regions. Moreover, hesperetin repaired the function of podocyte by increasing renal nephrin expression and decreasing renal alpha-smooth muscle actin expression. Furthermore, hesperetin inhibited the expression of transforming growth factor-β1 (TGF-β1) and its downstream effectors integrin-linked kinase (ILK) and Akt. In conclusion, our study implies that hesperetin produced protective effects in diabetic nephropathy possibly by suppressing TGF-β1-ILK-Akt signaling.
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Journal of Cleaner Production
·
2018
·
IF 5.651
Guo Lin,Shixing Wang,Libo Zhang,Tu Hu,Jinhui Peng,Song Cheng,Likang Fu,C. Srinivasakannan
A bioadsorbent was synthesized by modifying corn bract with 2-aminothiazole for the selective recovery of gold. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS) were used to characterize the bioadsorbent with the aim of understanding the mechanism of adsorption. Adsorption isotherms and kinetics data were determined and modeled. The adsorption capacity of Au(III) was 1668 mg/g, much higher than the values reported in the literature due to the ion exchange and chelation between the amino/thiol groups and Au(III). Additionally, the effect of pH and other ions on the Au(III) adsorption capacity were assessed. The adsorption isotherm was found to be consistent with the Langmuir isotherm model, and the kinetic was consistent with the pseudo-second-order kinetic model . Further regeneration and cyclic adsorption tests were performed to ensure the effectiveness of the bioadsorbent in commercial applications.
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RSC Advances
·
2018
·Vol. 8
·期 27
·14967-14974
·
IF 2.936
Lei Zhang,Shi-Tao Zhang,Yan-Chun Yin,Shu Xing,Wan-Nan Li,Xue-Qi Fu
Glucagon-like peptide (GLP)-1 is a potent glucose-dependent insulinotropic gut hormone released from intestinal L cells. The aim of this study was to investigate isoquercitrin as an inhibitor of dipeptidyl peptidase IV (DPP-IV) and determine whether it affects GLP-1 release in normal mice and NCI-H716 cells. In vitro, we used chromogenic substrate method detection methods to measure DPP-IV. We found that isoquercitrin was a competitive inhibitor, with IC50 and Ki values of 96.8 and 236 μM, respectively. Isoquercitrin and sitagliptin also stimulated GLP-1 release in NCI-H716 cells. In vivo, a type 2 diabetic mouse model was established, and oral treatment with different concentration of isoquercitrin and sitagliptin for 8 weeks significantly decreased the fasting blood glucose level. The weight and the levels of serum GLP-1 and insulin of the mice in the isoquercitrin group were higher than those in the model group (P < 0.001). An oral glucose tolerance test showed that the isoquercitrin significantly inhibited postprandial blood glucose changes in a dose-dependent manner. These findings demonstrated the hypoglycemic effects of isoquercitrin and indicated that isoquercitrin improved insulin sensitivity by targeting DPP-IV.
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TALANTA
·
2018
·
IF 4.244
Junxing Hao,Kangbing Wu,Chidan Wan,Yong Tang
Developing reliable and feasible electrochemical sensors for the detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) is important because the urinary level of 8-OHdG is related to cancer disease. Moreover, the co-existed uric acid (UA) as an interference severe affects the sensitive detection of 8-OHdG. Herein, sensitive monitoring of 8-OHdG was conducted using a nanocomposite of reduced graphene oxide (rGO) and ZnO nanoparticles (ZnO@rGO) as the sensing material. This nanocomposite was prepared via in-situ reduction of GO with Zn powders. Compared with those obtained on the unmodified glassy carbon electrode (GCE) and GO modified GCE (GO/GCE) the oxidation signals of 8-OHdG are significantly enhanced on the ZnO@rGO nanocomposite coated GCE (ZnO@rGO/GCE). Moreover, uricase has been employed successfully to eliminate the interferences of UA. A large amount of UA did not affect the oxidation signals of trace level of 8-OHdG. The linear range for the detection of 8-OHdG using ZnO@rGO/GCE was from 5.0 to 5000.0 nM. The detection limit was 1.25 nM calculated from a three-signal-to-noise ratio. The developed monitoring system is sensitive and selective for the determination of 8-OHdG and thus useful in practical applications, such as for the monitoring of 8-OHdG in the clinic urine samples.
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