JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2026
·Vol. 37
·期 20
·1565
·
IF 3.2
Yang Bowen,Zhang Siqi,Guan Mengxiang,Liu Lei,Yan Ziyu,Liang Yongri,Peng Guirong,Zhou Zhe
Owing to the outstanding ferroelectric properties, PVDF and its copolymers have emerged as the most promising piezoelectric polymer materials to date. To enhance the dielectric constant of P(VDF-HFP) while reducing its dielectric loss, BT@C@SiO 2 with a double-layer shell structure was synthesized and blended with P(VDF-HFP) to fabricate a piezoelectric film. Under mild conditions, PDA was synthesized as the precursor of the conductive carbon inner shell, which was carried out in a weakly alkaline Tris buffer system at room temperature, only involving stirring, centrifugation, water washing, and low-temperature drying, without any drastic reaction procedures. The results demonstrated that the incorporation of BT increased the dielectric constant of the film, whereas the introduction of the C layer formed micro-capacitors within the matrix, further enhancing the dielectric constant. Simultaneously, the C layer with high defect density captured freely mobile carriers in the film, thereby reducing AC conductivity and dielectric loss, which improved the energy harvesting efficiency of the piezoelectric film. The dielectric constant of the BT@C@SiO 2 /P(VDF-HFP) film could reach up to 15.8 (100 Hz), while the dielectric loss and conductivity were as low as 0.042 and 3.77 × 10 –9 S/m (100 Hz), respectively. The BT@C@SiO 2 acted as a nucleating agent in the P(VDF-HFP) matrix, and consequently induced the increase of the crystallization temperature and the formation of β phase in P(VDF-HFP). When the BT@C@SiO 2 content reached 5%, under a pressure of 40 N and a loaded resistance of 10 6 Ω, the composite film achieved its highest piezoelectric output with the output voltage of 1.1 V. Under a pressure of 40 N and a loaded resistance of 10 11 Ω, the piezoelectric output power reached its maximum value of 8.76 μW. A 5% BT@C@SiO 2 /P(VDF-HFP) film was fabricated into a piezoelectric sensor for practical applications. The output voltages of the film during finger bending, finger tapping and foot stepping were 0.40 V, 0.75 V, and 2.65 V, respectively. These results indicated that BT@C@SiO 2 /P(VDF-HFP) piezoelectric film exhibited potential application in motion monitoring.
✓ 已验证
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Ding Qian,Liu Shijie,Lin Kai,Zhao Lijun,Lee Jong-Hoon,Li Miaoyun,Liang Dong,Zhu Yaodi,Ma Yangyang
In this study, chicken was used as the base material, and a combination of fermentation regulation and whole egg incorporation was applied to systematically investigate the effects of protein degradation degree and whole egg synergism on the quality of chicken mince gels. First, chicken mince models with different degrees of protein degradation were constructed by controlling fermentation time. The degradation characteristics were evaluated by measuring pH, trichloroacetic acid (TCA)-soluble peptides, total volatile basic nitrogen (TVB-N), and SDS-PAGE, together with sensory evaluation to assess structural and flavor changes. Subsequently, composite gels were prepared by adding 10%, 20%, and 30% whole egg to the fermented chicken mince. The texture profile analysis (TPA), water-holding capacity (WHC), and cooking loss were systematically determined. The results showed that moderate protein degradation reduced gel hardness while generating a protein matrix suitable for subsequent gel modification. Whole egg incorporation subsequently improved gel texture, enhanced water-holding capacity, and reduced cooking loss, with the 30% addition level exhibiting the best overall quality. The addition of whole egg further optimized the gel network structure, increased gel strength, and reduced cooking loss, with the 30% addition level exhibiting the best overall quality. Finally, the swallowing properties were evaluated based on the International Dysphagia Diet Standardization Initiative (IDDSI). The results indicated that the optimized composite gels met the dietary requirements for individuals with dysphagia. Overall, this study elucidates the synergistic mechanism of protein degradation and whole egg incorporation in regulating the quality of chicken mince gels, providing a theoretical basis and technical support for the development of high-protein, animal-based gel foods tailored for dysphagia patients and the elderly population.
✓ 已验证
产品关联
DOI
高影响因子
APOPTOSIS
·
2026
·Vol. 31
·期 9
·210
·
IF 9
Xie Jingyi,Wang Simeng,Liu Juan,Zhang Yan,Zhu Haixiao,Cui Rongrong,Yao Yao,Yu Wei,Hou Peng
KRAS mutations are among the most common genetic alterations in colorectal cancer (CRC) and are strongly linked to poor prognosis and therapeutic resistance. However, current treatments targeting KRAS-mutated CRC have shown limited clinical efficacy. Argonaute 2 (AGO2) is a critical component in microRNA (miRNA)-mediated gene silencing complex, which is involved in the maturation of miRNAs and the regulation of target genes. It has been reported that mutated KRAS can interact with AGO2 and impair its function, thereby amplifying the oncogenic potency of mutant KRAS and accelerating tumor progression. To explore the therapeutic implications of this interaction, we developed a peptide inhibitor and engineered peptide-gold nanoparticles (Au-pep) that specifically disrupted KRAS-AGO2 interaction, which dramatically attenuated the malignant phenotype of KRAS-mutated CRC cells. Mechanistically, Au-pep-mediated disruption of the KRAS-AGO2 complex led to partial restoration of the miRNA expression landscape, with let‑7c‑5p emerging as the most significantly up‑regulated effector. As a result, restored let-7c-5p caused a significant down-regulation of key oncogenic drivers (KRAS, c-Myc and Bcl2) to suppress the growth of KRAS-mutated CRC cells and induce their apoptosis. Furthermore, this miRNA restoration conferred dual therapeutic benefits by sensitizing KRAS-mutated CRC cells to 5-fluorouracil (5-FU) via ABCC5 repression and augmenting immunotherapy responsiveness via PD-L1 down-regulation. Our findings, taken together, delineate a new therapeutic paradigm with significant translational potential for improving clinical outcomes in this recalcitrant patient population.
✓ 已验证
产品关联
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2026
·
IF 2.1
Lin Daifeng,Gong Wanyu,Lu Zeyang,Zhuo Qian,Yang Wenqing
Herein, Ru-doped V 2 O 5 -WO 3 /TiO 2 (VWTi) catalysts were prepared to study the impact of Ru doping on chlorobenzene (CB) oxidation activity. The introduction of Ru weakens the V–O bond strength, resulting in neutralizing the Lewis acid effect and optimizing the overall acid balance of the VWTi catalyst. Moreover, the presence of RuO 2 can significantly enhance the redox capability and surface lattice oxygen mobility. Hence, a significant improvement in both low-temperature activity and CO 2 selectivity has been achieved with the Ru-doped VWTi catalyst, reaching a CB conversion of 50% at 205 °C and a CO 2 selectivity of 73% at 400 °C for 0.50Ru-VWTi catalyst.
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Xiaobo Wang,Ming Ren,Yuxuan Liu,Lizhong Dong,Guang Yang,Yuxin Li,Jiaxi Wang,Mingyang Gao,Xiaona Wang,Jiangtao Di
Skeletal muscle operates through a mechanism in which calcium ions act as a trigger at low electric potentials, followed by contraction powered by adenosine triphosphate hydrolysis. Inspired by this process, we have developed an electrochemical artificial muscle with low-voltage redox triggering and spontaneous contraction. Triggering is achieved by electrochemically charging the muscles at voltages below 0.4 V, which enables I 3 ⁻ injection and subsequent oxidation to I 2 . Spontaneous muscle contraction then occurs via the reaction I 2 + I⁻ → I 3 ⁻, analogous to the role of adenosine triphosphate in skeletal muscle contraction, yet fundamentally distinct from conventional electrochemical artificial muscles. Following this mechanism, pristine carbon nanotube yarn muscles and carbon nanotube yarn muscles modified by quaternary ammonium cations generated contractile strokes of 5.2% and 15.5%, respectively. Moreover, the contracted state can be stably maintained without electrical energy input, and full recovery to the original length is achieved by applying a reverse voltage. Such mechanisms present a promising strategy for the development of energy-efficient artificial muscles. An electrochemical artificial muscle that features low-voltage triggering and spontaneous contraction was developed by utilizing triiodide/iodide redox reactions, mimicking skeletal muscle contraction.
✓ 已验证
DOI
PubMed
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2026
·
IF 10.4
Liu An,Zhang Ming-jun,Guo Jin-rong,Chu Han,Liu Song-bin,Chen Dan-yang,Kai Yuan-zhong,Cao Peng,Zhang Zhi
Although pain sensitization is among the most common conditions affecting the elderly, its underlying neural mechanisms remain unclear. Here, we found that mechanical hypersensitivity arises from enhanced glutamatergic excitability in primary somatosensory cortex due to bradykinin receptor B2 (BDKRB2) upregulation by dystrophic microglia during aging. Specifically, in vivo fiber photometry in aged mice revealed hyperactivity of glutamatergic neurons in primary somatosensory cortex of hindlimb (S1HL Glu ), while chemogenetic inhibition of these neurons reverses pain hypersensitivity in aged mice. BDKRB2 expression on S1HL Glu neurons is significantly increased in aged mice, whereas its conditional knockdown restores pain sensitization, and its overexpression leads to nociceptive hypersensitivity in young mice. Moreover, chemogenetic or pharmacological inhibition of dystrophic microglia in aged mice reduces BDKRB2 levels, alleviating pain hypersensitivity. The present study thus demonstrates that microglia-mediated S1HL Glu hyperactivity drives development of aging-related pain via BDKRB2 signaling, suggesting several potentially effective therapeutic targets for treating geriatric pain.
✓ 已验证
DOI
高影响因子
Neuroscience Bulletin
·
2026
·
IF 6.8
Cheng Shuai,Zhao Qi,Rong Guiyuan,Sun Shichu,Wang Hongjie,Tan Zhiyong,Ji Yonghua,Zhou You
Tinnitus is a common refractory disorder with complex mechanisms. Emerging evidence suggests that inflammation plays key roles in tinnitus pathogenesis; however, its overall inflammatory signatures remain underinvestigated. This study integrates transcriptomic data from patients with tinnitus and a noise-induced mouse model to identify conserved neuroinflammatory pathways. RNA sequencing of blood samples from patients with tinnitus and concurrent hearing loss revealed significant enrichment of immune-related pathways. Similar inflammatory signatures were detected through transcriptomic and cytokine profiling of the peripheral blood samples obtained from mice with noise-induced hearing loss. Microglial activation and elevated pro-inflammatory cytokines were observed in the cochlear nucleus and auditory cortex during the onset of noise-induced tinnitus. Pharmacological inhibition of microglial activation or tumor necrosis factor-α signaling alleviated tinnitus-like behaviors in mice. These findings reveal a dynamic peripheral-to-central inflammatory axis in tinnitus as well as identify blood-based biomarkers and auditory-center inflammation as potential therapeutic targets.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL PAPERS
·
2026
·
IF 2.7
Feng Shimiao,Chai Hongliang,Zhang Zhe,Zhang Yu,Li Fengrui,Liu Yanyan,Gao Shuang
Naringenin (NAR), a natural flavonoid, possesses potent antibacterial and antioxidant properties. However, its therapeutic potential is severely limited by poor water solubility. Therefore, there is an urgent need to explore efficient drug delivery formulations to improve the physicochemical properties of NAR. In the present work, NAR was successfully encapsulated into methyl- β -cyclodextrin (M β CD) to form inclusion complex, which were further processed into nanofibers (NAR/M β CD-IC-NF) via electrospinning technology. SEM results indicated that the nanofibers were uniform and bead-free, with the NAR/M β CD-IC-NF displaying a remarkably large surface area per unit mass together with a highly developed porous framework. Multiple complementary characterization techniques including Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), proton nuclear magnetic resonance ( 1 H NMR), carbon nuclear magnetic resonance ( 13 C NMR), and X-ray diffraction (XRD) were adopted to verify the successful formation of NAR/M β CD inclusion complex within nanofibers. Molecular docking simulation was further performed to illuminate the host–guest interaction and binding conformation between NAR and M β CD at the molecular level. Additionally, there was a marked increase in the water solubility of NAR, with NAR/M β CD-IC-NF capable of complete dissolution in water within 3 s. Free radical scavenging and antibacterial assays confirmed that NAR/M β CD-IC-NF significantly enhanced the biological activity of NAR. In summary, NAR/M β CD-IC-NF served as an effective carrier system to significantly improve the solubility of NAR, thereby expanding its application prospects and bioavailability in biopharmaceuticals. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2026
·
IF 18.1
Zhi-Hui Zha,Yakun Peng,Dong-Liang Huang,Zhi-Peng Chen,Fang-Fang Wang,Bo-Rui Li,Bo Wang,Linfeng Sun,Ji-Shen Zheng,Shutang Tan,Cong-Zhao Zhou,Wen-Tao Hou,Yuxing Chen
In plants, peroxisomal β oxidation is essential for energy production, sugar metabolism and the regulation of hormonal signaling. The Arabidopsis COMATOSE (CTS) gene, which encodes the peroxisomal ATP-binding cassette transporter ABCD1 (also known as CTS or PAX1), mediates the import of various fatty acyls and hormones into peroxisomes for β oxidation. Although physiological evidence has demonstrated that defects in CTS impair plant development and growth, the underlying molecular mechanisms remain poorly understood. In this study, biochemical assays confirm that CTS transports a broad range of fatty acyl-CoAs, as well as indole-3-butyric acid (IBA), an auxin and precursor to indole-3-aceditc acid, and auxin herbicide 2,4-dichlorophenoxy butyric acid (2,4-DB). We further solve five cryo-EM structures of CTS: the apo form, ATP-bound, and three substrate-bound states (C12:0-, IBA- and 2,4-DB-CoA) at near-atom resolutions. These structures reveal that CTS binds a single substrate molecule in a characteristic U-shaped conformation. Moreover, physiological studies using point mutations of key substrate-binding residues identify critical residues essential for its function. Our findings reveal the molecular principles by which CTS integrates lipid metabolism, hormone regulation, and xenobiotic activation throughout the plant life cycle, as well as underscore its potential as a target for crop improvement and herbicide development. Researchers report five cryo-EM structures of the Arabidopsis peroxisomal transporter CTS, revealing how it imports fatty acids, hormone precursors, and herbicides into peroxisomes for β oxidation.
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Xu Wenlong,Guo Yongchang,Fan Haohan,Liu Yuanfeng,Ma Zhibiao,Bai Linghan,Fan Ruyu,Zhang Tiannan,Zhang Guoguo,Chen Yuhang,Zhang Shijiao,Liu Chuanbao,Ge Binghui,Sun Jingbo,Dong Yanhao,Li Jianqiang
Nanoceramics from sintering routes are challenging to process due to difficulties in deagglomerating nanopowders, suppressing grain growth, and eliminating macroscopic defects. Glass crystallization offers new possibilities by first densifying materials to optical transparency in amorphous form and then fully crystallizing into ceramic form. However, refining the grain size within the nanocrystalline regime is again challenging, due to rapid grain growth under large crystallization driving force and nucleation-controlled kinetics. Here we tackle the problem by decomposing the homogeneous glass precursors into ternary phase composite ceramics, thus coupling the coarsening kinetics to slow cation diffusion required for phase partitioning and hetero-phase boundary motion required for grain growth. The design allows precise adjustment of the evolving microstructure and yields a fine grain size down to ~16 nm in fully crystallized ceramics. We demonstrate that the obtained nanoceramics can deliver high optical transparency, despite the different refractive indices of the cubic La(Al 1/3 Ti 2/3 )O 3 , Y 2 (Zr 0.6 Ti 0.4 ) 2 O 7 and transitional Al 2 O 3 phases, and improved mechanical properties. Our work unlocks the hidden opportunities of designing and producing phase-complex nanoceramics in high-dimensional compositional space beyond the traditional phase-pure solubility constraint.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Food Measurement and Characterization
·
2026
·
IF 3.6
Zhang Shiping,Luo Shu,Huang Zhaoning,Zhao Siyuan,Luo Xia
Bitterness is a major sensory barrier limiting the application of Ganoderma species, yet the metabolic basis underlying interspecific bitterness differences remains poorly understood. This study integrated sensory evaluation, untargeted LC-MS-based metabolomics, weighted gene co-expression network analysis (WGCNA), and quantitative compositional analysis to systematically compare Ganoderma lucidum ( GL ), Ganoderma sinense ( GS ), and Ganoderma leucocontextum ( GLE ). Sensory evaluation revealed that bitterness serves as a key distinguishing attribute among the three species, with GS exhibiting significantly lower bitterness intensity. A total of 27 core bitter-related metabolites were identified, including ganoderic acids, bitter dipeptides, flavonoids, and alkaloids. WGCNA further confirmed the close association of these metabolites with bitterness. Quantitative analysis demonstrated that bitterness intensity was strongly correlated with the selective accumulation of specific ganoderic acid monomers rather than total triterpenoid content. KEGG pathway enrichment indicated that these bitter metabolites were primarily involved in amino acid metabolism, terpenoid backbone biosynthesis, and secondary metabolite biosynthesis pathways. Notably, the identified bitter-related ganoderic acids are also known to possess anti-inflammatory, immunomodulatory, and antitumor activities. These findings provide a metabolic framework for understanding bitterness differences among Ganoderma species and offer potential targets for quality control and flavor-oriented breeding strategies.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE
·
2026
·
IF 2.6
Wan Shuchang,Shao Rongdan,Liu Hao,Wang Zhoufu,Liu Wenyuan,Liu Xuhao,Ma Yan,Zhou Qian,Wang Xitang
In this study, ZrB 2 -SiC-based ceramic composites were fabricated via hot pressing by incorporating Y 2 O 3 and YF 3 additives, respectively, to optimize their microstructure and comprehensive performances. The results indicate that both additives promoted sintering densification and mechanical reinforcement through the in situ formation of YBO 3 phases at the grain boundaries. Notably, the addition of YF 3 yielded superior overall performance compared to Y 2 O 3 . The composites with added YF 3 achieved relative density of 99.82%, with hardness of 14.55 GPa, flexural strength of 366.3 MPa, and fracture toughness of 5.72 MPa·m 1/2 . Crucially for electrode applications, the high densification facilitated the formation of a robust conductive network, resulting in a high electrical conductivity of 6.12 × 10 6 S/m. Regarding oxidation resistance, F − effectively reduced the viscosity of the glass phase protective layer. This enhanced flowability facilitated rapid self-healing of surface defects, resulting in significantly superior oxidation resistance compared to the Y 2 O 3 added composites. This work demonstrates that YF 3 is a highly effective sintering additive for tailoring ZrB 2 -SiC-based ceramic composites to fabricate high-performance ceramic electrodes.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）