MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-16
·
IF 5.3
Yan Ruixue,Guo Hao,Yang Zeyun,Niu Wenting,Yan Yu,Ma Jianpeng,Wang Mingyue,Yang Wu
A sensitive electrochemical sensor was constructed for tyrosine detection by collaborating a highly conductivity, excellent electrocatalysis and large surface of nitrogen-rich porous covalent organic framework in situ grown on three-dimensional conductive carboxylated multi-walled carbon nanotubes network and catalytic activity of triangular silver nanosheets. The prepared electrochemical sensing platform exhibited satisfactory results for detection of tyrosine with a wide linear range of 0.6–280 μM and a low detection limit of 0.017 μM, which were significantly superior to those of most existing electrochemical methods. At the same time, the developed sensor was successfully applied to the detection of tyrosine in real samples including human serum and urine and displayed high recoveries, good stability, reproducibility, and anti-interference ability. This study not only provides a novel sensing platform for tyrosine monitoring but also offers an innovative design concept for leveraging multifunctional nanocomposites in biosensing applications. Graphical
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-11
·
IF 5.3
Bao Mingqiu,Huang Xinyu,Hao Yakai,Chen Huijin,Yue Ruirui,Xu Jingkun,Duan Xuemin
Ractopamine (RAC), illegally used in swine feed to promote lean muscle growth, seriously endangers human health (particularly children’s development), necessitating rapid and accurate monitoring of its residues in pork and derived products. In this work, the well-structured gold/poly(3,4-ethylenedioxythiophene) nanowires (Au/PEDOT NWs) were facilely synthesized via interfacial polymerization, which enabled the uniform loading of Au nanoparticles (Au NPs) on/in cross-linked PEDOT NWs. The component, structure, and morphology of Au/PEDOT NWs were confirmed by series of physical characterization. The Au/PEDOT NWs were used to modify the electrode to fabricate a concise RAC sensing platform, which provides outstanding sensing properties featuring a low detection limit (LOD) of 1.67 μM, wide linear response spanning from 10~200 μM, and a high sensitivity of 1.33 μA μM −1 cm −2 . Furthermore, by comparison with the detecting results of high-performance liquid chromatography (HPLC), this sensing platform achieved satisfactory recoveries for RAC detection in pork samples. The sensor represents a groundbreaking advancement for food safety by enabling rapid, ultrasensitive, and highly selective detection, providing technical support for on-site food safety detection, and promoting the widespread application of electrochemical sensing technique. Graphical
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-9
·
IF 5.3
Yang Yufan,Zhao Bo,Hu Xiaopeng,Gu Huiwen,Yan Xiu-Fang,Yin Xiaoli
A dual-mode fluorescent/colorimetric sensor is presented utilizing Au/ZIF-67 nanocomposites for an ultrasensitive ochratoxin A (OTA) detection. The system employs polydopamine-coated Fe 3 O 4 nanoparticles (Fe 3 O 4 @MIP) as magnetic recognition elements and aptamer/3,3′,5,5′-tetramethylbenzidine (TMB)-functionalized Au/ZIF-67 nanocomposites (Apt/TMB/Au/ZIF-67) as dual-signal probes for both fluorescence and colorimetric detection. Through molecular imprinting-aptamer synergistic recognition, OTA binding induces the formation of sandwich-structured particles (Fe 3 O 4 @MIP-OTA-Apt/TMB/Au/ZIF-67). Magnetic separation of these particles facilitates fluorescence measurements, while residual Apt/TMB/Au/ZIF-67 in solution permits simultaneous colorimetric detection. Crucially, fluorescence intensity increases while colorimetric absorption decreases proportionally with OTA concentration (0.5–25 ng mL⁻ 1 ), enabling self-validating dual-mode detection without requiring reagent replacement. The platform achieves detection limits of 0.15 ng mL⁻ 1 (fluorescence) and 0.13 ng mL⁻ 1 (colorimetry). The sensor was successfully validated for OTA quantification in real food samples, demonstrating significant potential for food safety applications. Graphical
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Discover Food
·
2025
·Vol. 5
·期 1
·1-15
·
IF 3.7
Tian Zhen,Jin Huaizhou,Shang Xiaoxiao,Ma Qifei,Wang Weihong,Jin Shangzhong
The long-term stability of Pickering emulsions is crucial for their application in food systems. This study aimed to evaluate the stability degradation of oil-in-water (O/W) Pickering emulsions stabilized by whey protein isolate (WPI) and chitosan (CS), and to assess their applicability in reduced-fat mayonnaise formulations. Optical tweezers were employed to quantify the interaction forces between emulsion droplets during storage, in combination with microstructural observation and ζ-potential analysis. It was found that the O/W emulsion prepared with a 50% aqueous phase volume fraction maintained a stable droplet size over the storage period without significant changes. The ζ-potential decreased from 79.16 mV to 53.62 mV, while the maximum droplet contact force gradually decreased from 69 pN to 37 pN by day 45. By day 60, droplet coalescence was observed. Compared with traditional rice bran oil mayonnaise, the mayonnaise formulated using this Pickering emulsion exhibited superior mechanical stability and resistance to destabilization. In particular, the formulation with a Pickering emulsion-to-egg yolk volume ratio of 4:1 showed the best mechanical performance, with the droplet contact force gradually decreasing from 68 pN on day 0 to 62 pN on day 20. This study provides a rapid method for evaluating the stability of food systems, offering potential applications in the food industry.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 10
·1-13
·
IF 3
Li Yuan,Fan Jun,Huang Bingyao,Li Hongyan,Zhao Jie,Li Kai,Wang Fei
Removal of PH 3 from industrial gases have attracted extensive attention due to its high toxicity and catalyst poisoning characteristics. In this study, a series of copper-based support-free catalysts were synthesized by a facile method using different nitrogen and carbon sources. The 100% removal of PH 3 could reach 540 min in micro-oxygen environment by using the obtained catalyst. The X-ray diffractometer (XRD) and X-ray photoelectron spectroscopy (XPS) results exhibited that the formation of Cu 3 P was contributed to the deactivation of the catalysts, which was considered as active component for the decomposition of PH 3 . The PH 3 decomposition performance could achieve 99% under 450 ℃ with 90% yield of H 2 using the exhausted catalysts. This strategy is beneficial for the development of dephosphorization catalyst and provides a new route for the secondary use of exhausted catalysts. Graphical A facile strategy was employed for synthesize support-free catalysts for PH3 oxidation by using Cu(NO3)2 and different nitrogen resources or carbon resource. The performance were thoroughly compared. The exhausted catalyst was conducted in the PH3 catalytic dissociation reaction, where the conversion rate of PH3 could reach 99% with 90% hydrogen production under 450 ℃.
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WATER AIR AND SOIL POLLUTION
·
2025
·Vol. 236
·期 11
·1-17
·
IF 3
Yang Yangyang,Chen Qi,Wang Xiao,Hou Jun,Ren Lingxiao,Fan Xiulei,Liu Qiang,Liu Jiaqiang,Xu Ke,You Guoxiang
Microplastics (MPs) act as vectors for antibiotics in aquatic environments; however, their adsorption capacities, influenced by their color and the concentration of algal organic matter (AOM) in water, remain poorly understood. Herein, black tire wear particles (B-TWPs) and white polyethylene (W-PE) MPs were selected as model MPs. To accurately compare property differences between the two MP types in water environments, MPs particles subjected to ultraviolet aging (30 w) in ultrapure water, water with 5 mg/L AOM, and freshwater were analyzed. Further, changes in the structure, functional groups, and adsorption–desorption behaviors of tetracycline hydrochloride (TCH) on these MPs were studied. Results revealed that the hydrophilic properties of both the MPs developed with oxygen-containing functional groups, which enhanced their adsorption capacity after aging. AOM inhibited the aging extent of B-TWPs and W-PE MPs, with B-TWPs exhibiting a greater degree of aging than W-PE. These alterations substantially influenced the adsorption–desorption behavior of TCH, as confirmed by adsorption and desorption kinetic studies. The adsorption process of aged B-TWPs and W-PE MPs in the presence of AOM was best described by a second-order kinetic model (R 2 > 0.97). The isothermal adsorption results confirmed that the Freundlich model better described the adsorption of antibiotics on the MPs with and without AOM present (R 2 > 0.98). This study is the first to underscore the critical role of AOM in the aging of MPs with different colors. AOM modifies the adsorption and desorption behaviors of co-occurring antibiotics in the environment.
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JOURNAL OF ELECTRONIC MATERIALS
·
2025
·
IF 2.5
Lu Y.,Tian Y.,Hong B.,Xu J. C.,Song Y. M.,Peng X. L.,Chen H. W.,Qiu S.,Wang X. Q.
This study employed in situ polymerization to achieve polyaniline (PANI)-encapsulated hollow cobalt ferrite (CoFe 2 O 4 ) nanospheres, resulting in the formation of CoFe 2 O 4 @PANI nanocomposites. By combining the hollow CoFe 2 O 4 nanospheres with the conductive PANI, the components, microstructures, and microwave absorption (MA) performance versus PANI content was investigated in detail. The synergistic interaction between these two components not only optimized the impedance matching characteristics but also substantially improved the overall microwave attenuation capability. Notably, S6 (with a mass ratio of PANI to CoFe 2 O 4 of 6:1) exhibited superior MA properties at a matching thickness of 5.5 mm, with a minimum reflection loss (RL min ) of −43.20 dB at 5.28 GHz and an effective absorption bandwidth (EAB) of 2.0 GHz. Meanwhile, when the thickness of S4 was 5.0 mm, the RL min and EAB were −28.87 dB and 1.54 GHz, and when the thickness of S8 was 4.0 mm, the RL min and EAB were −34.62 dB and 2.02 GHz. The highly improved MA performance is attributed to the optimal impedance matching, hollow structure-enhanced scattering, enhanced conductive loss, natural resonance, eddy current loss, and interface/dipolar effects from the synergistic effects of magnetic CoFe 2 O 4 nanospheres and conductive PANI.
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CHEMICAL PAPERS
·
2025
·
IF 2.5
Kong Weizhen,Mao Jiaming,Peng Qianqian,Qin Shucan,Shi Longmei,Wu Anshuang,Xu Shengyun,Shi Jianming,Liu Yanrong,Ma Yunqian
High-value-added sulfur products as well as hydrogen (H 2 ) can be obtained by electrolytic oxidation of hydrogen sulfide (H 2 S), which is a promising energy conversion technology that contributes to the resource utilization of the pollutants. In conventional sulfide oxidation reaction (SOR), the recovery of the anodic product typically requires additional acidification treatment, resulting in the unsustainable use of electrolyte. Here, a novel H 2 S direct electrolysis system with ionic liquid (IL)-based electrolyte, consisting of acetate-based ILs and NaOH aqueous solution, was investigated. Compared to single NaOH aqueous solution, [Hmim]Ac-based electrolyte showed high H₂S absorption capacity and best electrochemical performance for SOR. Significantly, the anodic sulfur product was proved to be α-sulfur, which could be self-precipitated from the electrolyte without extra acid. The [Hmim]Ac-based electrolyte has the highest equilibrium solubility of sulfur (30.8 g L −1 ), which was 2–3 times that of the conventional electrolyte of NaOH aqueous solution. It is mainly attributed to the synergistic coupling of ILs and NaOH for H 2 S absorption and the modulating effect of ILs. Under constant potential electrolysis at 1.2 V vs RHE in [Hmim]Ac-based electrolyte, the maximum current density reached 194.4 mA cm −2 , the maximum hydrogen production rate reached 3945 μmol h −1 , the Faraday efficiency reached 97.9%, and the sulfur recovery of 82.6%. The IL-based electrolyte can be reused for at least three cycles of absorption-electrolysis, holding promise for efficient and continuous electrolysis of H 2 S. Graphical abstract
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 9
·1-12
·
IF 2.4
Zhong Yuhang,Xu Hui,Li Zhiguo,Zhang Yuqi,Hou Jianyuan,Yuan Yuan,Liu Xingang,Zhang Renxi
This study demonstrates an innovative approach for green and efficient hydrogen production from seawater, utilizing Cu–Fe/Al 2 O 3 catalysts coupled with a dielectric barrier discharge (DBD) system. The catalytic performance was systematically evaluated under varying voltages and Cu/Fe ratios in a DBD reactor to optimize hydrogen production efficiency. Subsequent investigations focused on humidity and gas flow rate effects using the optimal catalyst (Cu/Fe/Al 2 O 3 = 2:1:9). Multimodal characterization (XRD, XPS, FTIR, OES) combined with DFT calculations revealed the mechanistic role of Cu–Fe/Al 2 O 3 in plasma-driven hydrogen generation. The synergistic interaction between Fe and Cu enhanced hydroxyl/hydrogen radical generation through improved adsorption, thereby boosting hydrogen evolution efficiency and yield. The optimized system achieved a maximum hydrogen yield of 7.4 g/kWh at 3 kV operating voltage, 3 L/min argon flow, and 100% relative humidity, establishing an energy-efficient pathway for sustainable hydrogen production from seawater. Graphical
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CATALYSIS LETTERS
·
2025
·Vol. 155
·期 9
·1-12
·
IF 2.4
Peng Zhou-Xin,Wu Yu-chen,Xiao Shi-Yun,Zhou Hua-Lan,Wang Sheng-Kang,Wang Xue-Song
Low-cost nickel catalyst (Ni@C/C) derived from a metal organic framework (MOF) was synthetized for the hydrodeoxygenation (HDO) of biomass-derived vanillin. Unlike expensive noble-metal catalysts, Ni@C/C achieves full conversion of vanillin to 2-methoxy-4-methylphenol (MMP)—a key biofuel precursor—under mild conditions (180 °C, 2 MPa H₂). Ni@C/C exhibited excellent catalytic activity for the HDO of vanillin in isopropanol. Moreover, the main product of vanillyl alcohol (VA) under N 2 was 4-(isopropoxymethyl)-2-methoxyphenol (iPMP). The possible mechanism of vanillin by using Ni@C/C catalyst was that Vanillin was hydrogenated to generate VA, and VA was hydrogenated on Ni@C/C to generate MMP by two HDO paths: (1) VA was directly HDO to generate MMP; (2) VA was hydrogenated with isopropanol to generate iPMP by dehydration, then iPMP was hydrogenated to produce MMP. The Ni-based catalyst is relatively cheap and the preparation method is facile, green, and easy to scale up, thus achieving a low-cost transformation of biomass to bio-oils and chemicals. Graphical
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Journal of Analytical Science and Technology
·
2025
·Vol. 16
·期 1
·1-7
·
IF 2.8
Zhang Zhe,Xie Qiaoyi,Zhu Chenbo,Shao Huali,Wu Boying
Alterations in microRNA (miRNA) expression profiles play a pivotal role in the initiation and progression of various diseases, including pediatric pneumonia. Consequently, the development of sensitive, specific, and precise methodologies for miRNA detection represents a promising tool for clinical diagnosis and therapeutic intervention. This study proposes a highly sensitive miRNA detection approach utilizing catalytic hairpin assembly (CHA)-mediated probe release through chain extension and cascade signal amplification. The method enables precise discrimination of target miRNAs from other RNA species via a dual-target recognition mechanism. Furthermore, the incorporation of four signal amplification cycles confers substantial amplification efficiency, permitting accurate detection of low-abundance miRNAs. This system employs cascade isothermal amplification, demonstrating a linear response across concentrations from 1 fM to 100 pM and achieving a detection limit of 0.54 fM. The methodology exhibits significant potential for practical application in complex biological samples, providing a novel platform for profiling miRNA expression patterns and elucidating their mechanistic roles in disease pathogenesis.
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BMC Pharmacology & Toxicology
·
2025
·Vol. 26
·期 1
·1-12
·
IF 2.7
Yang Lili,Liu Xiaotian
Section
Background
To evaluate the effects of tyrosine kinase inhibitors (TKIs) Dovitinib, Lapatinib, and Telatinib on angiogenesis in zebrafish, and to explore the regulatory mechanism of PI3K/AKT pathway activator SC79 on these inhibitory effects.
Section
Methods
Transgenic Fli-1:EGFP zebrafish embryos were used to observe the development and morphological changes of intersegmental vessels (ISVs) by fluorescence microscopy. Real-time fluorescence quantitative PCR was employed to detect the expression of angiogenesis-related genes including kdrl, flt1, vegfaa, akt2, and pik3r1. After determining the maximum tolerated concentration (MTC) of each compound, the effects of single-drug treatment and SC79 co-treatment on vascular development and gene expression were observed.
Section
Results
Dovitinib (0.488 µM) and Telatinib (0.031 µM) significantly reduced the number (by 16.9% and 33.8%, respectively, P < 0.001) and length (by 14.9% and 23.3%, respectively, P < 0.001) of complete ISVs, while Lapatinib (1.95 µM) showed no significant inhibitory effect. Gene expression analysis revealed that Dovitinib mainly downregulated flt1 expression ( P < 0.01), whereas Telatinib more broadly downregulated kdrl ( P < 0.05), flt1 ( P < 0.001), and akt2 ( P < 0.01) expression. SC79 (2.44 nM) promoted angiogenesis, increasing ISV number ( P < 0.01) and length ( P < 0.05), while upregulating kdrl (2.03-fold, P < 0.001), flt1 (1.31-fold, P < 0.05), vegfaa (1.45-fold, P < 0.01), akt2 (1.64-fold, P < 0.01), and pik3r1 (1.48-fold, P < 0.05) expression. Co-treatment experiments showed that all three TKIs could counteract SC79’s pro-angiogenic effects to varying degrees, with Telatinib showing the strongest effect. Under SC79 co-treatment conditions, all TKIs significantly downregulated kdrl expression ( P < 0.001), but had differential effects on other genes: Dovitinib mainly downregulated flt1 ( P < 0.05), Lapatinib specifically downregulated vegfaa ( P < 0.01), akt2 ( P < 0.05), and pik3r1 ( P < 0.05), while Telatinib simultaneously downregulated flt1 ( P < 0.01), akt2 ( P < 0.05), and pik3r1 ( P < 0.01).
Section
Conclusions
Dovitinib and Telatinib exhibit significant anti-angiogenic effects, while Lapatinib is less effective. Different TKIs inhibit angiogenesis by regulating different signaling molecules: Dovitinib primarily targets VEGF receptors, Telatinib targets both receptors and the downstream PI3K/AKT pathway, and Lapatinib shows inhibitory effects on VEGF ligand expression in the SC79 background. SC79 promotes angiogenesis by activating the PI3K/AKT pathway and partially reverses the inhibitory effects of TKIs. These findings provide new insights for targeted therapy of abnormal angiogenesis in ophthalmic diseases, suggesting that precise regulation of angiogenesis may be achieved by modulating the balance between TKIs and the PI3K/AKT signaling pathway.
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