INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Deyi Peng,Dafeng Deng,Jianhua Lv,Wenchang Zhang,Huaqin Tian,Xia Zhang,Mi Wu,Yan Zhao
Carboxymethyl chitosan (CMCS) and sodium alginate (SA), which are excellent polysaccharide-based hemostatic agents, are capable of forming polyelectrolyte complexes (PEC) through electrostatic interactions. However, CMCS/SA PEC sponges prepared by the conventional sol-gel process exhibited slow liquid absorption rate and poor mechanical properties post-swelling. In this work, a novel strategy involving freeze casting followed by acetic acid vapor treatment to induce electrostatic interactions was developed to fabricate novel PEC sponges with varying CMCS/SA mass ratios. Compared to sol-gel process sponge, the novel sponge exhibited a higher density of electrostatic interactions, resulting in denser pore walls that resist re-gelation and swelling according to FTIR, XRD, and SEM analyses. Additionally, the liquid absorption kinetics, as well as compression and tension tests, demonstrated that the novel sponge had significantly improved rapid blood absorption capacity and mechanical properties. Furthermore, in vitro coagulation and drug release studies showed that the novel sponge had a lower blood clotting index and clotting time, along with a slower drug release rate after loading with berberine hydrochloride, showcasing its potential as a rapid hemostatic dressing with controlled drug release capabilities.
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高影响因子
BIOSENSORS & BIOELECTRONICS
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2017
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IF 7.78
Hui-Fang Cui,Wen-Wen Wu,Meng-Meng Li,Xiaojie Song,Yuanxu Lv,Ting-Ting Zhang
A highly stable electrochemical acetylcholinesterase (AChE) biosensor for detection of organophosphorus pesticides (OPs) was developed simply by adsorption of AChE on chitosan (CS), TiO 2 sol-gel, and reduced graphene oxide (rGO) based multi-layered immobilization matrix (denoted as CS @ TiO 2 -CS/rGO). The biosensor fabrication conditions were optimized, and the fabrication process was probed and confirmed by scanning electron microscopy and electrochemical techniques . The matrix has a mesoporous nanostructure . Incorporation of CS and electrodeposition of a CS layer into/on the TiO 2 sol-gel makes the gel become mechanically strong. The catalytic activity of the AChE immobilized CS @ TiO 2 -CS/rGO/glassy carbon electrode to acetylthiocholine is significantly higher than those missing any one of the component in the matrix. The detection linear range of the biosensor to dichlorvos , a model OP compound, is from 0.036 μM (7.9 ppb) to 22.6 μM, with a limit of detection of 29 nM (6.4 ppb) and a total detection time of about 25 min. The biosensor is very reproducibly and stable both in detection and in storage, and can accurately detect the dichlorvos levels in cabbage juice samples, providing an efficient platform for immobilization of AChE, and a promisingly applicable OPs biosensor with high reliability, simplicity, and rapidness.
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Journal of Materials Chemistry B
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2017
·Vol. 5
·期 21
·3898-3906
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IF 4.543
Yong-Gang Zhang,Ying-Jie Zhu,Feng Chen,Tuan-Wei Sun
In this work, a novel ultralong hydroxyapatite microtube (HMT)–chitosan (CHS) composite scaffold has been successfully prepared. The mechanical properties of the HMT–CHS composite scaffold is greatly improved compared with the CHS–hydroxyapatite nanorod scaffold and the pure chitosan scaffold. By using gentamicin sulfate (GS) as the model drug, the GS-loaded HMT–CHS composite scaffold has a high drug loading capacity, sustained drug release behavior and high antibacterial activity. The as-prepared HMT–CHS composite scaffold has promising applications in various fields such as drug delivery and bone defect repair.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Huayong Luo,Juexi Zeng,Mingqi Xu,Qiongfang Tang,Tao Liu,Shuhan Wu,Shiyin Li,Hongwei Rong
The development of a sustainable and eco-friendly silver-based hybrid nanocomposite for safe and efficient point-of-use (POU) water disinfection remains a challenge. Herein, a simple and facile approach was proposed for the in situ immobilization of silver nanoparticles (AgNPs) on chitosan-g-poly (sulfobetaine methacrylate) (CS-g-PSBMA) hydrogel beads, which have been achieved via graft copolymerization of sulfobetaine methacrylate along the chitosan chains followed by a drop method. The AgNPs-decorated CS-g-PSBMA hydrogel beads were characterized and their bactericidal efficacy towards Escherichia coli was evaluated concurrently with their anti-biofouling behaviors. The results indicated that the grafted PSBMA hydrogels on CS would not only enhance the immobilization of more AgNPs (122.63 mg/g material), but also restricted the silver release (only 0.015 % after the 14th day of incubation), which surpassed numerous other AgNPs-based nanocomposites for water disinfection. Moreover, the release of silver can be modulated by altering the temperature due to the thermosensitivity of PSBMA, and the maximum concentration of silver leaching in the effluent was 33.1–52.3 μg/L at 25–60 °C. Importantly, the synthesized AgNPs-based CS-g-PSBMA can exert both exceptional bactericidal and superior anti-biofouling capabilities as well as reusability features, indicating sustained antibacterial effectiveness and significant potential for practical applications in water disinfection.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Yimu Qiao,Xue Han,Yijia Ren,Feiyong Chen,Cuizhen Sun,Jin Wang,Zhigang Yang,Linxu Xu,Xue Shen,Rupeng Liu
The extensive use of ibuprofen (IBU) and acetaminophen (APAP) has led to their accumulation in surface water, resulting in combined pollution with natural organic matter (NOM). In this study, a novel modified chitosan-based coagulant (CTS-DMDAAC) was successfully synthesized by adding ceric ammonium nitrate (CAN) to make chitosan (CTS) and dimethyldiallylammonium chloride (DMDAAC) produce free radicals for graft copolymerization. The study investigated the effects of pH, initial NOM concentration, and suspended particulates on the performance of contaminant removal and the characteristics of flocs. Through analysis of the Zeta potential and floc characteristics, the primary flocculation mechanisms were identified as: net capture and sweep, charge neutralization, and bridging effect. CTS-DMDAAC demonstrated effective removal of NOM, particularly humus, but encountered challenges in removing small-molecule pharmaceuticals such as IBU and APAP, with removal rates below 15%. To enhance the removal rate of small organic molecules, powdered activated carbon (PAC) was incorporated into the coagulation system, resulting in increased removal rates of IBU and APAP to 71.44% and 79.9%, respectively. Additionally, PAC improved the bridging capacity during coagulation, resulting in a 1.25-fold increase in the strength factor and a 2.34-fold increase in the recovery factor of the flocs. These findings suggest that the combined use of PAC and CTS-DMDAAC presents a novel approach for treating water bodies contaminated with NOM and pharmaceutical complexes.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Lei Liu,Lei He,Liping Jin,Haojie Shi,Shuhan Ye,Lingxin He,Wei Wang,Wenwen Guo
To obtain cotton fabrics with high-efficiency flame retardancy, a novel nanohybrid MXene modified with phosphorylated chitosan (CS) was successfully prepared through a simple chemical modification strategy. It was subsequently employed in the fabrication of PC@T-MXene-functionalized cotton fabric (PC@T-MXene-C) through an impregnation process. The thermal stability and flame retardancy of the pure and treated cotton textiles were analyzed via TGA, LOI, VBT flammability tests and cone calorimetry. Compared with those of the original cotton textile and PCS-decorated cotton fabric (PC-C), the thermal and flame-retardant performance of PC@T-MXene-C was significantly enhanced. When the weight gain of the treated cotton fabric was 12 % (PC@T-MXene-C3), the LOI of PC@T-MXene-C3 significantly reached 35 %, and the peak heat release rate (PHRR) and total heat release (THR) decreased by 80.7 % and 43.7 %, respectively, compared with those of the original cotton textile. Additionally, PC@T-MXene-C3 retained 39.1 % of the char residual at high temperature under a nitrogen atmosphere in the TGA analysis. This eco-friendly biomass-based flame-retardant coating provides a new strategy for fabricating green flame-retardant systems without the use of hazardous compounds.
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Jingxian Niu,Qianzhu Lin,Xiaojing Li,David Julian McClements,Hangyan Ji,Zhengyu Jin,Chao Qiu
In this study, four different types of essential oil monomer and tannic acid were used to prepare different kinds of essential oil-tannin particles. As well as encapsulating the chemically labile essential oils, these particles could also be used as Pickering emulsifiers to prepare oil-in-water emulsions. These emulsions were co-stabilized using the essential oil-tannin particles in combination with chitosan. The resulting Pickering emulsions were shown to have good storage stability, viscoelastic properties, antioxidant activity , and antibacterial activity. The emulsions co-stabilized by cinnamaldehyde-tannin and chitosan had the smallest particle size and largest shear viscosity, shear modulus, and physical stability. An in vitro digestion study showed that the cinnamaldehyde encapsulated within these emulsions also had a relatively high bioaccessibility. Considerable differences were observed in the stabilities of emulsions prepared with different oil phase volume fractions. The more concentrated emulsions did not exhibit phase separation after 30 days storage, which was attributed to the fact that the close packing of the oil droplets prevented their movement. This study shows that essential oil-polyphenol particles can be used as multifunctional ingredients, such as antioxidants, antimicrobial agents, and emulsifiers.
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ULTRASONICS SONOCHEMISTRY
·
2025
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IF 9.7
Ruihua Zhang,Shuting Li,Mingyan Ai,Shenghuizi Chen,Chunlan Zhang,Zhiqiang Zhou,Lili Huang,Xiang Li,Jiankang Lu
Cantaloupe seed protein isolate (CSPI) has attracted the attention of its low cost, easy digestion and balanced composition of essential amino acids. However, due to the low solubility of CSPI, its application in the food industry is limited. Therefore, the present study investigated the effect of ultrasound-assisted phosphorylation on the solubility of CSPI and the structural properties were characterized. The solubility of cantaloupe seed protein increased from 9.17 % to 63.27 % by ultrasound assisted phosphorylation, and resulting in an increase in the absolute value of CSPI potential, a decrease in particle size, and a stable structure, which could be used for the construction of the food emulsification system. The modified CSPI was combined with chitosan (CS) to prepare stabilized Pickering emulsion for subsequent stability study. The results showed that stable Pickering emulsions could be prepared with CSPI at pH 7, CS 0.5 % and oil phase fraction 55 %. Ultrasound-assisted phosphorylation enhanced electrostatic interaction between CS’s –NH 3 groups and CSPI’s –COO−groups which improved the storability of stabilized Pickering emulsion. This will help to broaden the application range of CSPI and provide a theoretical basis for CPI stable Pickering emulsion.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Wensheng He,Ping Ma,Zutai Zhang,Benxiang Hou
Low cross-linking degree, weak mechanical strength, and poor osteoinductivity are significant obstacles in the development of bone repair materials. In this study, chitosan/gelatin/supersaturated calcium citrate scaffolds were prepared with the dehydrogenation heat treatment method. The results confirmed that citric acid significantly improved the cross-linking degree and efficiency of the chitosan/gelatin scaffolds. But the addition of Ca 2+ reduced the cross-linking degree, water absorption, and resistance to enzymatic degradation of the scaffolds. While, the supersaturated calcium citrate formed inside the scaffold increased its mechanical strength. The biocompatibility and osteogenic activity of scaffolds were measured by inoculation with MC3T3-E1 cells. The rapid and efficient release of Ca 2+ from the scaffolds could significantly promote cell adhesion, proliferation, and differentiation, while cell activities were inhibited by excessive Ca 2+ . The results of repairing skull defects in SD rats demonstrated that the chitosan/gelatin/supersaturated calcium citrate scaffolds with 25 mM Ca 2+ added had a stronger osteogenic effect compared to the chitosan/gelatin scaffolds. Hence, the chitosan/gelatin/ supersaturated calcium citrate scaffolds prepared in this study are promising materials for treating bone defects. The appropriate amount of calcium salt added to the scaffold in order to optimize its biocompatibility and osteogenic activity deserves further investigation.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shuai Zhang,Fuxiong Ren,Kailei Wang,Yuan Gao,Yujia Lu,Junping Han,Li Chen,Haoyun Wang,Yiping Zhao
The rapid development of industries has intensified the issue of oily wastewater pollution, necessitating sustainable solutions. Biomass aerogels, known for their environmental friendliness and biocompatibility, offer promising prospects for oil–water separation. This study fabricated a polyamidoamine (PAMAM)-modified chitosan/cellulose interpenetrating polymer network aerogel via sequential cross-linking and directional freeze-drying. This method endowed the aerogel with excellent mechanical properties, including good strength at a low density (0.06–0.11 g/cm 3 ), high anisotropy at 80 % strain, a high specific surface area (1.93–12.56 m 2 /g), and hydrophobicity (WCA = 139.5°). The aerogel exhibited outstanding separation efficiencies for the carbon tetrachloride/water mixture (5501.85 L·m −2 ·h −1 ) and water-in-oil emulsions (4198.60 L·m −2 ·h −1 , 96.67 %), as well as a removal rate of 61.24 % for the cationic dye RhB. A “demulsification–adsorption synergistic separation” mechanism involving dendritic PAMAM polymers and hydrophobic functional groups was proposed, with performance initially increasing and then decreasing as the PAMAM generation number increased. Despite certain limitations, such as sensitivity to environmental factors, the prepared all-biomass aerogel offered a green, efficient, and mechanically robust solution for the treatment of oily wastewater. This study provided a sustainable strategy for fabricating multifunctional hydrophobic aerogels, paving the way for advanced applications in environmental remediation.
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ACS Applied Polymer Materials
·
2024
·
IF 4.4
Tong Xue,Dunjie Fang,Leilei Si,Yunjie Yin
Textiles with antibacterial and antiultraviolet properties have gained significant attention because of their ability to protect the human body. This study presents the design and synthesis of a Schiff base for chitosan modified with salicylaldehyde and titanium dioxide (SCSB-Si-TiO2). SCSB-Si-TiO2 was coated onto cotton fabrics by using a layer-by-layer self-assembly method, resulting in functional cotton fabrics (SCSB-Si-TiO2/cotton) with excellent antibacterial and antiultraviolet properties. This functional textile demonstrated excellent antibacterial effects with inhibition rates of 95.22% against Escherichia coli and 98.99% against Staphylococcus aureus. Moreover, SCSB-Si-TiO2/cotton exhibited outstanding antiultraviolet characteristics, with a ultraviolet protection factor (UPF) value of 110.9, and maintained a UPF value above 82 even after 25 washing cycles. Additionally, SCSB-Si-TiO2/cotton exhibited good hydrophobicity with a water contact angle of 123.6°. The breathability of SCSB-Si-TiO2/cotton decreased slightly, and its tensile strength increased, which was sufficient to meet daily life requirements. This study presents an approach to the development of multifunctional textiles.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2024
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IF 4.9
Xuan Du,Suraya Abdul Rashid,Luqman Chuah Abdullah,Norizah Abdul Rahman
Guided by efficient utilization of natural abundant cellulose and chitosan as separation materials, it is desired to tailor the composition of electrospun cellulose acetate/chitosan (CL/CS) membranes to achieve their optimal application in the management of aquatic heavy metal pollution. In this work, CL/CS membranes with enhanced surface area of 11.3–38.6 m 2 /g were successfully fabricated via electrospinning technique by dissolving cellulose acetate and chitosan into the environmental-friendly electrospinning solvent of LiOH/thiourea/H 2 O. Electrospun CL/CS membranes allowed the efficient sorption of Cr(VI), Pb(II) and Cu(II) with favorable kinetics (8.0 h), and excellent capacities (127.6 mg/g for Cr(VI), 66.2 mg/g for Pb(II), 46.7 mg/g for Cu(II) at pH 5.0, T 298 K). Meanwhile, they presented favorable efficiencies in the removal of these multiple heavy metals from acid simulated wastewaters. The spectroscopic analysis results indicated that the sorption mechanism should be dominant by the surface complexation of heavy metals with hydroxyl O-/amino N-species, the electrostatic attraction (protonated NH 3 + with negatively charged HCrO 4 - , deprotonated O - with positively charged Pb(II) and Cu(II)), as well as the reduction of Cr(VI) to Cr(III) by surface reductive N-species. This work demonstrated the feasibility of electrospun CL/CS membranes as a promising choice for the remediation of aquatic heavy metals.
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