CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2019
·Vol. 35
·期 5
·792-798
·
IF 1.071
Dong Lu,Xu Yongkai,Zhang Yun,Sun Aijun,Hu Yunfeng
Bacillus sp. DL-2 was isolated from the deep sea of the Western Pacific and further utilized as novel biocatalysts to efficiently asymmetrically hydrolyze (±)-1-phenylethyl acetate. After the optimization of hydrolytic reactions, chiral chemicals ( R )-1-phenylethanol and ( S )-1-phenylethyl acetate were obtained with high optical purities (96% and 99.8%, respectively). Our research is about the asymmeric hydrolysis of (±)-1-phenylethyl acetate using whole-cell biocatalysts. In addition, the optical purity of ( S )-1-phenylethyl acetate generated through the kinetic resolution of (±)-1-phenylethyl acetate using the whole-cells of Bacillus sp. DL-2 was the highest report so far. Using the whole cells of deep sea bacterium Bacillus sp. DL-2 as the biocatalysts is an environmentally friendly method and will play critical roles in industrial asymmetric synthesis.
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高影响因子
MICROPOROUS AND MESOPOROUS MATERIALS
·
2023
·
IF 5.2
Zilin Wang,Tao Wang,Long Mu,Zhilin Chen,Lishuang Hu,Chao Xiao
Understanding of the main factors affecting the hydrothermal stability of zeolites is vital for the application of zeolites in catalysis and separation. Although incorporation of extra-framework metal cations is an important stagey to improve the hydrothermal stability of Al-rich zeolites, how these metal cations affect the hydrothermal stability of high-silica zeolites is not well understood. In this work, the effects of residual alkali cations on the hydrothermal/thermal stability of silicalite-1, a pure-silica MFI-type zeolite, is explored. We show that the alkali impurities from commercial tetrapropylammonium hydroxide (TPAOH) are not negligible; the concentration and type of residual alkali cations dictate the hydrothermal/thermal stability of silicalite-1. Above a certain concentration (∼0.3–0.5 wt%), the alkali cations can lead to less silanol defects but much poorer hydrothermal/thermal stability. Below this concentration, the degrading effect is negligible. Removal of the alkali cations by proton exchange improves the stability significantly. Steaming (hydrothermal treatment) has two opposite effects on the silicalite-1 crystal structure: destruction by hydrolysis and perfecting by healing the defects. For silicalite-1 with considerable amounts of alkali cations, the destruction effect predominates; while the perfecting effect predominates for silicalite-1 with low alkali contents.
研究领域:
材料科学
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化学工程
·
催化
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高影响因子
Science Advances
·
2025
·Vol. 11
·期 39
·
IF 12.5
Yuyu Guo,Cunliang Li,Yao Liu,Hanyi Mao,Yin Zhang,Pascal Genschik,Lili Wang,Shunping Yan
Plants have evolved sophisticated mechanisms to balance growth and defense. The evolutionarily conserved polymerase-associated factor 1 complex (PAF1C) plays multiple roles in transcription. Here, we show that PAF1C regulates the growth-defense tradeoff by repressing defense genes expression in Arabidopsis . Loss of PAF1C leads to increased expression of defense genes, enhanced disease resistance, but compromised growth. Mechanistically, PAF1C binds to defense genes, where it interacts with histone deacetylases, such as HDA6, to promote histone deacetylation, thereby repressing defense genes expression. The plant immune hormone salicylic acid (SA) promotes the interaction between PAF1 and the SA receptor NPR1, which functions as an E3 ubiquitin ligase to mediate the polyubiquitination and degradation of PAF1. Genetically, loss of PAF1 suppresses the immune defects of the npr1 mutant, supporting the notion that PAF1 functions downstream of NPR1. Collectively, this study identifies the NPR1-PAF1C-HDA6 module that regulates the growth-defense tradeoff.
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PubMed
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 16
·10523-10541
·
IF 3.9
Delong Wang,Min Li,Jing Li,Yali Fang,Zhijia Zhang
In an effort to exploit the bioactive natural scaffold 3,4-dihydroisoquinolin-1(2H)-one for plant disease management, 59 derivatives of this scaffold were synthesized using the Castagnoli–Cushman reaction. The results of bioassay indicated that their antioomycete activity against Pythium recalcitrans was superior to the antifungal activity against the other 6 phytopathogens. Compound I23 showed the highest in vitro potency against P. recalcitrans with an EC50 value of 14 μM, which was higher than that of the commercial hymexazol (37.7 μM). Moreover, I23 exhibited in vivo preventive efficacy of 75.4% at the dose of 2.0 mg/pot, which did not show significant differences compared with those of hymexazol treatments (63.9%). When the dose was 5.0 mg per pot, I23 achieved a preventive efficacy of 96.5%. The results of the physiological and biochemical analysis, the ultrastructural observation and lipidomics analysis suggested that the mode of action of I23 might be the disruption of the biological membrane systems of P. recalcitrans. In addition, the established CoMFA and CoMSIA models with reasonable statistics in the three-dimensional quantitative structure–activity relationship (3D-QSAR) study revealed the necessity of the C4-carboxyl group and other structural requirements for activity. Overall, the above results would help us to better understand the mode of action and the SAR of these derivatives, and provide crucial information for further design and development of more potent 3,4-dihydroisoquinolin-1(2H)-one derivatives as antioomycete agents against P. recalcitrans.
研究领域:
植物病理学
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药物化学
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分子生物学
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PubMed
高影响因子
3 Biotech
·
2021
·Vol. 11
·期 12
·1-13
·
IF 2.406
Tang Miaolong,Cai Jimin,Wang Yan,Huan Zhirong,Yao Hao,Xu Ce,Ge Xin,Song Sheng
Hemorrhage shock (HS) is a major threat to patients with trauma and spontaneous bleeding, resulting in multi-organ failure including the kidney. Tyrosine kinase nonreceptor 1 (TNK1) has been shown to be upregulated in the kidney of experimental HS and patients with severe trauma . The study aims to investigate the role of TNK1 and the underlying mechanism in HS-induced kidney injury. A model of HS was established with femoral artery bloodletting, followed by resuscitation in Sprague–Dawley rats. Renal expression of TNK1 was abnormally induced by HS in rats. Knockdown of TNK1 alleviated HS-induced cell apoptosis and the level of proinflammatory cytokines (TNF-α, IL-6 and IL-1β) in the kidney. The expression of M1 macrophage markers (CD86 and iNOS) and the activation of STAT1 were inhibited by TNK1 knockdown in HS rats. In vitro, human monocyte THP-1 cells were treated with 20 ng/mL interferon-gamma plus 100 ng/mL lipopolysaccharide to induce M1 polarization. TNK1 knockdown exerted inhibitory effect on macrophage M1 polarization, M1-type inflammatory cytokine production and STAT1 activation in THP-1 cells. In conclusion, downregulation of TNK1 alleviates HS-induced kidney injury by suppressing macrophage M1 polarization, inflammation and kidney cell apoptosis, in which the deactivation of STAT1 signaling may be involved.
研究领域:
医学
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免疫学
·
分子生物学
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PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2019
·
IF 3.375
Changfa Xiao,Long Jiang,Yi Dan
The unsaturated linear (UL) copolymer of methyl acrylate (MA), 1-octene, and allyl glycidyl ether (AGE) and the long-chain branch (LCB) copolymer of MA, 1-octene, and 1,7-octadiene were synthesized, respectively, via AlCl3-catalyzed radical copolymerization, and then both UL and LCB copolymers were vulcanized using dicumyl peroxide (DCP) curing system. For UL copolymer, cross-linking heat first increases with DCP dosages and then decreases when DCP dosages increases further to 2.5, that is quite reasonable to relate with cross-link and degradation reactions during vulcanization. However, the reaction heat flow curves of DCP-LCB curing system with DCP dosages ranging from 1.5 phr to 3.5 phr exhibit a bimodal-like “crosslinking” endotherm, suggesting a two-stage reaction of intramolecular cross-linking and intermolecular cross-linking. Results from dynamic mechanical analysis and tensile tests confirm that LCB copolymers are propitious to form effective networks at low DCP dosages and to keep the vulcanized topological structure with redundant DCP.
研究领域:
高分子化学
·
材料科学
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高影响因子
JOURNAL OF CELLULAR PHYSIOLOGY
·
2018
·Vol. 234
·期 5
·6136-6146
·
IF 3.923
Yucang He,Xiaofang Yu,Zhuojie Chen,Liqun Li
Autologous fat transplantation is increasingly applied in plastic and reconstructive surgery. Stromal vascular fraction cells (SVFs) combined with angiogenic factors, such as VEGF (vascular endothelial growth factor A) and Ang-1 (angiogenin-1), can improve angiogenesis, which is a critical factor for graft survival. However, direct transplant with such a mixture is insufficient owing to the short half-life of angiogenic factors. In this study, we evaluated whether a double sustained release system of VEGF/ANG-1-PLGA (poly (lactic-co-glycolic acid)) microspheres plus SVFs can improve angiogenesis and graft survival after autologous fat transplantation. VEGF/ANG-1-PLGA-sustained release microspheres were fabricated by a modified double emulsion–solvent evaporation technique. Human aspirated fat was mixed with SVF suspension plus VEGF/ANG-1 sustained release microspheres (Group C), SVF suspension (Group B) alone, or Dulbecco’s modified Eagle’s medium as the control (Group A). Eighteen immunocompromised nude mice were injected with these three mixtures subcutaneously at random positions. After 8 weeks, the mean volume of grafts was greater in the SVFs plus VEGF/ANG-1-PLGA group than in the control and SVFs groups (1.08 ± 0.069 ml vs. 0.62 ± 0.036 ml, and 0.83 ± 0.059 ml, respectively). Histological assessments showed that lower fibrosis, but greater microvascular density in the SVFs plus VEGF/ANG-1-PLGA group than in the other groups, though the SVFs group also had an appropriate capillary density and reduced fibrosis. Our findings indicate that SVFs plus VEGF/ANG-1-PLGA-sustained release microspheres can improve angiogenesis and graft survival after autologous fat transplantation.
研究领域:
整形与重建外科
·
生物医学工程
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组织工程
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PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 7
·3177-3190
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IF 3.5
Lu Xiaohui,Yu Shouwu,Gao Tian,Chen Yifu,Zhao Xiang,Xiao Shujuan
The wettability of the membrane surface is very important for the separation of oil-in-water emulsion. In this paper, the hydrophilic NH 2 -CAU-1 was added to the membrane surface by interfacial polymerization, which greatly improved the separation efficiency of oil-in-water emulsion. The effect of the amount of NH 2 -CAU-1 on the separation efficiency of TFN membrane was studied, and it was determined that TFN-1 membrane had ultra-high separation efficiency of oil-in-water emulsion (> 97.60%). TFN-1 membrane has a high underwater oil contact angle (higher than 139.53°), resulting in excellent oil adhesion resistance on the membrane surface. The universality and cycling performance of TFN-1 membrane were tested, and UWOCA had good stability under strong acid, strong base and different NaCl concentrations, and the separation efficiency did not change significantly after 8 cycles. The results show that TFN-1 membrane has excellent performance in separating oil-in-water emulsions and has broad application prospects in separating oil-in-water emulsions stabilized by surfactants. Graphical abstract
研究领域:
膜科学
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化学工程
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材料科学
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环境工程
·
分离技术
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高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 9
·期 7
·4066-4074
·
IF 11.301
Hanzhuo Zhang,Yaseen Muhammad,Xinfang Cui,Zhengsheng Zhang,Long Liu,Zhe Chu,Jing Li,Yanjuan Zhang,Syed Jalil Shah,Zhenxia Zhao
Carboxymethyl cellulose-foam-supported HKUST-1@graphdiyne (HK@GDY/CMC-B) was constructed with high thermal conductivity and directional channels to enhance the ad-/de-sorption efficiency of acetaldehyde. Characterization results showed that (1) HKUST-1 grew within CMC and GDY via an in situ tri-phase cross-linking strategy, forming a special “alkynyl|Cu|COOH” interface, which maintained the high BET surface area (945.1 m2 g−1) of the HK@GDY/CMC-B foam and established a tight connection among the different components of the composite; (2) the π-conjugated carbon structure of GDY and the unique “alkynyl|Cu|COOH” interface within HK@GDY/CMC-B accelerated the phonon conduction and significantly enhanced the thermal conductivity of HK@GDY/CMC-B (336 mW m−1 K−1); (3) the directional channels and the hierarchical pore structure with a unique interface in the HK@GDY/CMC-B foam facilitated the diffusion and adsorption of VOCs; (4) the compact “alkynyl|Cu|COOH” interface generated more unsaturated Cu(II) and Cu(I) sites and increased adsorbent surface polarity to capture acetaldehyde. Consequently, the obtained HK@GDY/CMC-B exhibited an excellent acetaldehyde adsorption capacity of up to 11.0 mmol g−1, which was 1.3–3.4 times higher than that of many state-of-the-art adsorbents. Kinetics performance data revealed that the diffusivity of acetaldehyde on the HK@GDY/CMC-B foam increased by 60% compared to that of the pristine HKUST-1. Similarly, the desorption rate of HK@GDY/CMC-B was 2.2–6.5 times faster than that of several state-of-the-art adsorbents under similar temperature programmed desorption. This greatly realized an energy-conserving approach for adsorbent regeneration. Based on these findings, the current tri-phase cross-linking strategy can be deemed as an efficient tactic to further improve the adsorption efficiency of MOFs for fast adsorption of VOCs on the commercial level.
研究领域:
材料科学
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环境工程
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高影响因子
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
·
2014
·
IF 3.679
Sheng-Jie Chen,Yong-Qi Li,Yong-Yong Wang,Xiao-Li Zhao,Ye Liu
The ionic hybrid P,N-ligands of 1 and 2 have been synthesized as one type of unconventional tertiary phosphines with the advantages of both the π-accepting ligands and the hemilabile ligands. The corresponding ionic Rh(I)-complexes of 1A and 2A proved to be more efficient catalysts for hydroformylation of 1-octene over isomerization than the traditional Rh I (acac)(CO)(PPh 3 ), due to the π-backdonation interaction in Rh → P linkage and the hemilabile ligation of N,P-coordinating sites to Rh-center. The in situ high-pressure FT-IR analysis indicated that: (1) the formation and lifetime of the active Rh H species (2047 cm −1 ) derived from 1A are facilitated by the presence of ligand 1 ; (2) the formation of the active Rh H species is depressed without the aid of the P,N-hemilabile ligation; and (3) the active Rh H species derived from Rh I (acac)(CO)(PPh 3 ) is unstable and susceptible to the formation of the inactive carbonyl-bridged Rh-dimer.
研究领域:
化学
·
催化反应
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高影响因子
Frontiers of Chemical Science and Engineering
·
2023
·Vol. 17
·期 6
·772-783
·
IF 4.5
Gao Xiu,Luo Beining,Hong Yanping,He Peihang,Zhang Zedong,Wu Guoqiang
Development of a titanium silicalite-1 (TS-1) catalyst with good crystallinity and a four-coordinate Ti framework is critical for efficient catalytic oxidation reaction under mild conditions. Herein, a size-controlled TS-1 zeolite (TS-1#0.1ACh (acetylcholine)) was synthesized via steam-assisted crystallization by introducing acetylcholine as a crystal growth modifier in the preparation process, and TS-1#0.1ACh was also employed in epoxidations of different substrates containing C=C double bonds. The crystalline sizes of the as-synthesized TS-1#0.1ACh catalysts were controlled with the acetylcholine content, and characterization results showed that the particle sizes of highly crystalline TS-1#0.1ACh zeolite reached 3.0 µm with a good Ti framework. Throughout the synthetic process, the growth rate of the crystals was accelerated by electrostatic interactions between the connected hydroxyl groups of the acetylcholine modifier and the negatively charged skeleton of the pre-zeolites. Furthermore, the TS-1#0.1ACh catalyst demonstrated maximum catalytic activity, good selectivity and high stability during epoxidation of allyl chloride. Importantly, the TS-1#0.1ACh catalyst was also highly versatile and effective with different unsaturated substrates. These findings may provide novel, easily separable and large TS-1 catalysts for efficient and clean industrial epoxidations of C=C double bonds.
研究领域:
化学工程
·
催化科学
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高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Sana Nazeer,Syed Ejaz Hussain,Junjie Qi
Semiconducting 2H-phase MoS 2 often performs poorly in the hydrogen evolution process and has low conductivity. Se increases stability, electrical conductivity, and catalytic activity when added to MoS 2 . Using carbon cloth as the substrate and several sulfur sources, such as Thioacetamide, L-cysteine, and Thiourea, this study developed an effective hydrothermal synthesis process to produce a MoS 2(1-x) Se 2x ternary alloy. When used as an electrocatalyst for HER, the TAA-MoSSe/CC alloy with an S/Se balance of 1:1 reaches at overpotential of 120 mV at the conventional current density of about 10 mA/cm 2 , whereas the observed Tafel slope value is 41 mV/dec. Furthermore, the strength of the Ternary alloys covered by the present investigation is enhanced by testing for air stability and durability. According to the characteristics of these ternary alloys, the creation of MoS 2(1-x) Se 2x depends critically on the temperature at which the sulfur precursor decomposes. Improved HER catalytic performance results from the rapid release of sulfur ions from sulfur precursors, which decompose at lower temperatures. These sulfur ions replace more Se ions in MoS 2(1-x) Se 2x .
研究领域:
材料科学
·
电化学
·
纳米材料
·
能源催化
·
无机功能材料
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DOI
高影响因子
危险品化学品经营许可证（带存储）