Research
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2024
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IF 8.5
Hao Liu,Ke Huang,Hao Zhang,Xiaohui Liu,Hui Jiang,Xuemei Wang
Achieving antitumor immunotherapy based on hybridization of multiple types of inactivated cells has attracted a lot of attention. However, the hybridized cells of disordered structure could result in the shedding of antigens and their transfer to immune cells, which suppresses tumor immunity through trogocytosis. Here, we report a strategy for in situ solidification of tumor whole cell by biomineralization for sustained stimulation of antitumor immunity. The near-infrared light was used to accelerate the breaking of Au=P bonds in auranofin, and the exposed Au atoms biomineralize at the secondary structure (β-corner) of the protein to form Au nanocrystals with in situ protein coronas in tumor cells. Au nanocrystals are anchored to the tumor cells through protein coronas, which fixes the morphology and antigens of whole tumor cells, rendering them physiologically inactive. Interestingly, this solidified tumor cell prevents immune cells from undergoing trogocytosis, which inhibits proximal and distal tumor growth. Thus, this study presents the strategy of solidified cells and its potential application in tumor immunotherapy.
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Xinyu Cao,Xu Guo,Tianyuan Xiao,Wenchao Jia,Xiaodi Liu,Changgeng Li,He Zhang,Pedram Fatehi,Haiqiang Shi
Aerogels are great adsorbents for oil decontamination due to their high porosity and specific surface area. However, the current oil-adsorbing materials for preparing such aerogels are expensive and environmentally unfriendly. This study successfully prepared three superhydrophbic biomass-based aerogels (SBAs) using treating biomass in a green LiBr·3H 2 O system and hydrophobic modification with hexadecyltrimethoxysilane (HDTMS). The time and temperature of hydrophobic modification reaction and biomass components are optimized by orthogonal experiment and investigated by the response surface methodology to improve water contact angle (WCA). The prepared SBAs have low weight, specific surface area (85.12–136.64 m 2 /g), and hierarchical porous structure. The WCA of the SBAs was 157°±5°, exhibiting excellent superhydrophobicity of the SBAs. The high WCA is attributed to the successful grafting of Si in the forms of Si–O and C–Si onto the aerogel, as indicated by FTIR and XPS. Oil adsorption experiments have shown that SBAs had outstanding sorption capacity in the range of 8–37.8 g/g of oil/SBAs. Furthermore, the SBAs exhibited excellent reusability after ten cycles of use. These results demonstrate that the SBAs are practically viable and highly efficient biosorbents for treating oil spills and organic pollutants.
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Science China-Materials
·
2024
·
IF 6.8
Ye Maosheng,Chen Wei,Wang Yixuan,Zhao Ran,Xiao Wuyi,Li Jiexin,Meng Jingxin,Wang Shutao
The use of lubricant-infused surfaces (LIS) presents a highly promising approach to mitigating contamination from various sources, including bacteria, ice, and scale. However, these lubricants’ natural liquid characteristics frequently cause them to run out in adverse environments, which results in a failure to prevent fouling. Here, we report the sustainable anti-scaling performance of a phase-change lubricant-infused surface (PCLIS). The increased resistance is ascribed to a high degree of stability in the solid state at temperatures below PCL’s melting point ( T < T m ). Furthermore, the anti-scaling capability comes from its smooth morphology and reduced scale adhesion in liquid state ( T > T m ). As a result, this work offers a viable method to deal with scaling problems in real-world applications, especially those that involve temperature changes.
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Cell Reports Physical Science
·
2024
·
IF 7.9
Wei-Ming Yin,Ben Dang,Yuanyuan Miao,Shujun Li,Jian Li,Shouxin Liu,Tony D. James,Zhijun Chen
Producing room temperature phosphorescent materials from natural sources is essential for sustainability. However, either toxic chemical reagents or complicated processing is still required to produce such phosphorescent materials derived from natural resources. Here, we produce sustainable room temperature phosphorescence (RTP) materials from wood and sugar. Specifically, sugar is introduced into a wood matrix, which confines the lignin in the wood matrix in situ . As a result, the treated wood (sucrose wood [S-wood]) exhibited RTP emissions with a lifetime of ∼284.4 ms. Life cycle carbon analysis indicates that ∼8.1–11.2 kg CO 2 is produced during the preparation of S-wood, which is lower than for other similar materials. Moreover, the S-wood could be naturally degraded in the soil over 40 days. As a demonstration of the practical potential, S-wood is used for visual decorations and anti-counterfeiting applications.
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APPLIED CLAY SCIENCE
·
2024
·
IF 5.3
Chao Li,Tie Geng,Ju Huang,Cheng Zhang,Ming Duan,Shenwen Fang,Xinliang Li,Shuai Liu
With the large-scale development of shale gas , oil-based drilling fluids have found widespread application. However, a significant challenge arises in removing small harmful solids of oil-based drilling fluids after multiple uses. Investigating the stable mechanism of harmful solids in nonpolar solvents is crucial for their removal. Here, kaolin is chosen as the harmful solid phase. Various surfactants sodium bis(2-ethylhexyl) sulfosuccinate (AOT), sorbitan monooleate (Span 80), sorbitan trioleate (Span 85), cetyltrimethylammonium bromide (CTAB), oleic acid (OA), and stearic acid (SA) are used as dispersants to explore the dispersibility and stability mechanisms of kaolin in the oil phase. Results reveal that the Span 80 and Span 85 exhibit the best dispersibility and rheological performance for kaolin, followed by AOT, while SA shows the poorest dispersibility and rheological performance. Except for SA and CTAB, the other dispersants significantly improve the wettability of kaolin particles. X-ray diffraction (XRD) results indicate that all dispersants adsorb on the surface of kaolin. FT-IR and XPS confirm that nonionic surfactants Span 80 and Span 85 adsorb on the surface of kaolin through hydrogen bonding . Strong Zeta potential on the particle surface suggests that Span 80 and Span 85 stabilize the kaolin system through electrostatic repulsion mechanisms.
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Journal of Functional Foods
·
2024
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IF 3.8
Fang Shi,Yong-Sheng Gao,Shu-Mei Han,Huan Shi,Qing-Sheng Hou,Yang Gao,Xiao-Wen Wen,Zhen-Yu Zhu,Kai Liu,Wei-Peng Gong,Ben-Shi Wang,Xin Liu,Lei Zou
There is a growing amount of research that highlights the significant connection between the development of colitis and both metabolic imbalance and the inflammatory response. Tagatose, an inherent sweetening agent and alternative to sugar, plays a crucial role in the biosynthesis of several chemicals and metabolic pathways in living organisms. However, the specific biochemical mechanism via which tagatose hinders colitis is still not understood. According to recent study, tagatose plays a crucial role in safeguarding the integrity of tight junctions inside the intestinal mucosal barrier. Furthermore, it is crucial to acknowledge the presence of a correlation between the severity of inflammatory bowel disease (IBD) and the occurrence of colorectal cancer (CRC), chemically-induced colitis in rodents, and reduced blood levels of tagatose. The treatment of tagatose resulted in a decrease in intestinal mucosal injury in mice with colitis, regardless of whether it was caused by dextran sodium sulfate (DSS) or spontaneous colitis in IL-10 -/- mice and C3H/HeJBir mice. The introduction of tagatose in a colitis model triggers a cascade of events, wherein it hinders the expulsion of cathepsin B and enhances lysosomal cohesiveness. The aforementioned method successfully inhibits the activity of myosin light chain kinase (MLCK) in the context of intestinal epithelial damage, hence impeding the deterioration of tight junction integrity and the initiation of mitochondrial dysfunction. In summary, the outcomes of the study have provided empirical evidence that substantiates the beneficial effects of tagatose in mitigating the progression of colitis. The ability to prevent the disruption of the intestinal barrier is responsible for this achievement. Hence, tagatose has promise as a therapeutic adjunct for the management of colitis.
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Biosensors-Basel
·
2024
·Vol. 14
·期 10
·505
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IF 4.9
Zhenzhen Li,Lei Wang,Mengjie Tang,Yulong Sun,Li Zhang,Zhongxiu Chen
Triton X-100 (TX-100) is a commonly used surfactant in the manufacture of biosensors. The factors limiting the use of TX-100 in biosensors are environmental concerns. In this study, the binary system of sodium dodecyl benzene sulfonate (SDBS) and fatty alcohol-polyoxyethlene ether (AEO) was investigated from the physicochemical principle of surfactant interaction and its application in biosensors. The results demonstrated that a mixture of SDBS and AEO at an appropriate molar ratio had a comparable activity to TX-100 in terms of surface activity, micelle formation, dynamic adsorption, foaming, emulsifying, and cell permeability. Theory and experimentation support the idea that SDBS-AEO might take the place of TX-100 in the manufacturing of biosensors. This study contributes to the development of alternatives to TX-100 and provides a new perspective for an in-depth study of the interaction mechanism of additives in biosensor design.
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高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2024
·Vol. 25
·期 17
·9177
·
IF 4.9
Shuoye Yang,Jiaxin Liu,Huajian Yuan,Qianqian Cheng,Weiwei Shen,Yanteng Lv,Yongmei Xiao,Lu Zhang,Peng Li
As a novel therapeutic approach, photothermal therapy (PTT) combined with chemotherapy can synergistically produce antitumor effects. Herein, dithiodipropionic acid (DTDP) was used as a donor of disulfide bonds sensitive to the tumor microenvironment for establishing chemical bonding between the photosensitizer indocyanine green amino (ICG-NH 2 ) and acidified single-walled carbon nanotubes (CNTs). The CNT surface was then coated with conjugates (HD) formed by the targeted modifier hyaluronic acid (HA) and 1,2-tetragacylphosphatidyl ethanolamine (DMPE). After doxorubicin hydrochloride (DOX), used as the model drug, was loaded by CNT carriers, functional nano-delivery systems (HD/CNTs-SS-ICG@DOX) were developed. Nanosystems can effectively induce tumor cell (MCF-7) death in vitro by accelerating cell apoptosis, affecting cell cycle distribution and reactive oxygen species (ROS) production. The in vivo antitumor activity results in tumor-bearing model mice, further verifying that HD/CNTs-SS-ICG@DOX inhibited tumor growth most significantly by mediating a synergistic effect between chemotherapy and PTT, while various functional nanosystems have shown good biological tissue safety. In conclusion, the composite CNT delivery systems developed in this study possess the features of high biocompatibility, targeted delivery, and responsive drug release, and can achieve the efficient coordination of chemotherapy and PTT, with broad application prospects in cancer treatment.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 23
·1-16
·
IF 2.8
Lin Jiayang,Liu Han,Ding Jiangtao,Xu Lelin,Cheng Zhenzhi,Gao Fei,Luo Guangsheng,Zhou Weiping
The integration of magnetic materials with dielectric carbon architectures is promising for enhancing microwave absorption properties due to their inherent resonance properties. In this paper, magnetic composites constituted by high-entropy spinel oxides/conductive heterogeneous FeCo phase were obtained through solid-phase sintering and hydrogen reduction process, which show excellent wave-absorbing properties by modulating the elemental Cr content. Further coating with carbon nanotubes via chemical surface modification dramatically improves the composite’s microwave absorption capability across multiple frequency bands, achieving a reflection loss of − 43.10 dB at 3.1 mm thickness in the C-band and an exceptional minimum reflection loss of − 44.20 dB at 1.5 mm thickness in the Ku-band. This tri-phase composite demonstrates a wide effective absorption bandwidth of 4.77 GHz at a remarkably thin matched thickness of just 1.3 mm. The obtained superior microwave-absorbing properties were ascribed to excellent impedance matching and attenuation properties contributed by natural resonance, interfacial polarization, conductive loss, multiple reflections, and scattering in the multi-component system with abundant heterogeneous interfaces. This unique absorption behavior highlights its potential for next-generation compact microwave absorption applications.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Aolong Li,Hao-Yu Zhao,Xiaohang Lu,Zhiyue Yang,Ji Liu,Zhong-Zhen Yu,Xiaofeng Li
The accelerating depletion of fossil fuels and escalating global energy demands have driven an urgent need for sustainable and clean energy solutions. Solar–thermal–electric systems are highly promising but are inherently limited by their real-time dependence on sunlight. Phase-change materials (PCMs) provide a potential pathway for overcoming this constraint by enabling thermal storage and delayed utilization, but conventional PCMs suffer from low thermal conductivity and poor photothermal efficiency. In this work, we develop a high-performance PCM composite by constructing a hybrid thermal conduction filler network combining sodium alginate-stabilized liquid metal nanoparticles and cellulose nanofiber-modified graphene nanoplatelets. Upon vacuum-assisted paraffin impregnation, the resulting PCM composite achieves excellent photothermal conversion efficiency of 92.7%, exceptional thermal conductivity of 24.02 W m–1 K–1 at low filler loadings of 8.35 wt %, and high latent heat retention of 98% after 100 thermal cycles. When integrated into solar–thermal–electric systems, the fabricated PCM composite ensures not only efficient solar energy harvesting and heat generation but also gradual, stable heat release and transfer, enabling sustained power outputs up to 694.3 mV and 74.7 mA. This study provides an innovative and scalable materials design strategy for overcoming the key limitations of traditional PCMs, offering broad potential for next-generation solar energy harvesting, thermal management, and sustainable energy conversion technologies.
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Applied Materials Today
·
2025
·
IF 6.9
Zerong Wang,Ge Yan,Yi Ning,Xiaoli Zhou,Xin Lu,Qianqian Zhou,Qiwei Tian
Transarterial embolization (TAE) is a primary clinical treatment for hepatocellular carcinoma (HCC); however, its therapeutic efficacy is limited by its functional constraints. To enhance treatment outcomes, this study aims to develop a multifunctional embolic microsphere, LUT-Fe@PVA, for the combined treatment of HCC. This approach leverages a synergistic strategy that integrates TAE, sonodynamic therapy (SDT), and chemodynamic therapy (CDT) to improve the therapeutic efficacy. The LUT-Fe@PVA microspheres were synthesized via a microemulsion crosslinking method and loaded with luteolin-iron complexes to enable ultrasound-triggered reactive oxygen species (ROS) generation and Fenton reaction for enhanced tumor destruction. In vitro results demonstrated that the combination therapy significantly kills the tumor cells. In vivo, 18 F-FDG microPET/CT imaging revealed significantly reduced uptake values, while histological analysis confirmed extensive tumor cell necrosis and apoptosis in the combined therapy group. This study presents a promising multifunctional approach for HCC treatment by integrating embolization, SDT, and CDT, offering a novel strategy for effective and selective tumor treatment with minimal side effects.
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CELLULOSE
·
2025
·
IF 4.8
Ke Weikang,Shi Xiaolong,Wang Hailong,Wu Tianyu,Zhang Yutao,Zhao Ruirui,Qi Zhigang,Geng Shuo,Yuan Liang,Yan Youxian
Dimensionally stable paraffin-chitin nanofibers bifunctional composite foams with excellent thermal energy storage performance and promising thermal insulation properties were successfully constructed. Pickering emulsions of paraffin stabilized by chitin nanofibers were first prepared and then assembled with chitin nanofibers to form porous structures after freeze-drying. As a result, the maximum paraffin content in the product can reach 95.3%. Correspondingly, a maximum latent enthalpy value of 197.5 and 197.2 J/g for melting enthalpy and crystallization enthalpy (approximately 91.7 and 92.2% of that of pure paraffin), with the relative retention of 96.2 and 96.7% are achieved, demonstrating its excellent energy storage capacity. The foam can withstand 232 times its weight at a temperature of 180 °C without leakage, proving its excellent high-temperature dimensional stability. The composite foam also exhibits low thermal conductivity (65 mW/m . K) for heat shielding applications. The sustainability, reproducibility, and excellent thermal regulation performances of composite foam give it great application prospects in the field of energy collection and storage.
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