ChemNanoMat
·
2021
·Vol. 7
·期 5
·553-560
·
IF 3.154
Meihua Gao,Zhiyin Yao,Na Du,Quanhua Deng,Lijing Liu,Jianqiang Liu,Wanguo Hou
Graphical Sodium monododecylphosphate can form vesicles in alcohol/water mixtures. The vesicles show remarkable stability but are metastable in thermodynamics. Sodium monododecylphosphate (SDP), a typical single-chain amphiphile (SCA), exhibits extremely low solubility in water, which limits the investigation on its aggregation behavior. In the current work, we introduced short- and medium-chain alcohols into the SDP-water system to improve its solubility. An isotropic phase was found to be formed in the presence of alcohol with a suitable dielectric constant (11–25) or alkyl chain (2–7 carbons). In addition, vesicular, dendritic, and micellar structures were identified in the isotropic phase, depending on the composition of the SDP/alcohol/H 2 O ternary systems. The structure, stability, permeability, and formation mechanism of the vesicles formed in the SDP/ n -pentanol (NPT)/H 2 O system were investigated. The vesicles have a unilamellar structure, with size-selective permeability. They show remarkable stability upon long-term storage, exposure to high temperature, and freeze-thawing cycles, but are metastable in thermodynamics. The hydrogen bonding between SDP molecules plays an important role in the formation of vesicles. Furthermore, the SDP/NPT/H 2 O vesicles were used to construct three spatially segregated enzyme-loaded compartments to support a cascade enzyme reaction. The chemical signal transduction among the enzyme-loaded vesicles was achieved. This study provides a deeper understanding of the features of SDP vesicles and demonstrates their potential applications such as in biomembrane mimicking and micro-reactors.
✓ 已验证
产品关联
DOI
高影响因子
Bioactive Materials
·
2021
·
IF 14.593
Jiani Gu,Qianqian Zhang,Mengru Geng,Weizhong Wang,Jin Yang,Atta ur Rehman Khan,Haibo Du,Zhou Sha,Xiaojun Zhou,Chuanglong He
Vascularization and bone regeneration are two closely related processes during bone reconstruction. A three-dimensional (3D) scaffold with porous architecture provides a suitable microenvironment for vascular growth and bone formation. Here, we present a simple and general strategy to construct a nanofibrous poly( l -lactide)/poly(ε-caprolactone) (PLLA/PCL) scaffold with interconnected perfusable microchannel networks (IPMs) based on 3D printing technology by combining the phase separation and sacrificial template methods. The regular and customizable microchannel patterns within the scaffolds (spacings: 0.4 mm, 0.5 mm, and 0.6 mm; diameters: 0.8 mm, 1 mm, and 1.2 mm) were made to investigate the effect of microchannel structure on angiogenesis and osteogenesis. The results of subcutaneous embedding experiment showed that 0.5/0.8-IPMs (spacing/diameter = 0.5/0.8) and 0.5/1-IPMs (spacing/diameter = 0.5/1) scaffolds exhibited more vascular network formation as compared with other counterparts. After loading with vascular endothelial growth factor (VEGF), [email protected] /0.8 scaffold prompted better human umbilical vein endothelial cells (HUVECs) migration and neo-blood vessel formation, as determined by Transwell migration, scratch wound healing, and chorioallantoic membrane (CAM) assays. Furthermore, the microangiography and rat cranial bone defects experiments demonstrated that [email protected] /0.8 scaffold exhibited better performance in vascular network formation and new bone formation compared to [email protected] /1 scaffold. In summary, our results suggested that the microchannel structure within the scaffolds could be tailored by an adjustable caramel-based template strategy, and the combination of interconnected perfusion microchannel networks and angiogenic factors could significantly enhance vascularization and bone regeneration.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2021
·Vol. 17
·期 25
·2100862
·
IF 13.281
Liang Huang,Yuxing Zhang,Tao Liao,Kui Xu,Chenxing Jiang,Dinglv Zhuo,Yang Wang,Hui-Min Wen,Jing Wang,Lijiao Ao,Jun Hu
Exploring signal amplification strategies to enhance the sensitivity of lateral flow immunoassay (LFIA) is of great significance for point-of-care (POC) testing of low-concentrated targets in the field of in vitro diagnostics. Here, a highly-sensitive LFIA platform using compact and hierarchical magneto–fluorescent assemblies as both target-enrichment substrates and optical sensing labels is demonstrated. The large-pored dendritic templates are utilized for high-density incorporation of both superparamagnetic iron oxide nanoparticles (IOs) and quantum dots (QDs) within the vertical channels. The hierarchical structure is built via affinity-driven assembly of IOs and QDs from organic phase with silica surface and mercapto-organosilica intermediate layer, respectively. The sequential assembly with central–radial channels enables 3D loading of dual components and separately controlling of discrete functionalities. After the alkyl-organosilica encapsulation and silica sealing, the composite spheres exhibit high stabilities and compatibility with LFIA for procalcitonin (PCT) detection. With the assistance of liquid-phase antigen-capturing, magnetic enrichment, and fluorescence-signal amplification, a limit of detection of 0.031 ng mL −1 for PCT is achieved with a linear range from 0.012 to 10 ng mL −1 . The current LFIA is robust and validated for PCT detection in real serum, which holds great diagnostic significance for precise guidance of antibiotic therapy with POC manner.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2021
·
IF 4.952
Xi Cao,Yayu Pan,Wei Wei,Tinglan Yuan,Sen Wang,Lingyun Xiang,Yongjun Yuan
Effects of various fermentation conditions on fatty acid composition of single cell oil (SCO) from Trichosporon sp. F1-2 were investigated. Ten carbon sources clustered into two groups using hierarchical clustering algorithm and principal component analysis. Xylose and soluble starch from each group were further studied. SCO using xylose had a high oleic acid content, while the linoleic acid and α-linolenic acid content increased significantly in SCO using soluble starch especially at the sn -2 position. 20 and 31 triacylglycerol (TAG) types were detected, respectively. The increased types were rich in linoleic acid and α-linolenic acid. The effect of C/N ratios was the weakest (distance threshold 3.05), followed by inoculation amounts (3.08), fermentation time (4.30) and nitrogen sources (5.64). The optimum nitrogen source, C/N ratio, inoculation amount and fermentation time for SCO accumulation were ammonium sulfate, 60, 6% and 120 h, respectively. Two different SCOs were produced using xylose and soluble starch under optimum conditions, which were demonstrated to be potential substrates for synthesis of 1,3-distearoyl-2-oleoyl-glycerol (a cocoa butter improver) and MLM-type TAG (the dietary TAG with low caloric value) respectively. Therefore, changing the carbon source can help broaden application fields of SCOs and increase feedstock sources of structured TAG synthesis.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2021
·Vol. 32
·期 10
·13581-13587
·
IF 2.478
Chen Junzhe,Du Haiying,Xu Yifeng,Ma Boyu,Zheng Zhihong,Li Pengchan,Jiang Yuqiu
Carbon quantum dots (CQDs) were synthesized by coffee grounds as the carbon source under hydrothermal carbonization treatment for the first time. The obtained turn-on CQDs showed a strong emission at the wavelength of 460 nm, with an optimum excitation of 370 nm, and enrichment of the surface functional groups (–OH, –NH 2 ). Sodium cyclamate in an aqueous solution and the turn-on CQDs could form a core–shell structure by hydrogen bonding and van der waals bonding to enhance the fluorescent emission. With such a design, turn-on CQD-based fluorescence detection techniques towards sodium cyclamate could be realized. Under optimal conditions, a linear relationship was found in the range of 2.8–56 µmol/L sodium cyclamate with the detection limit (3 δ/k ) of 3.16 µmol/L which is lower than the national standard detection limit of 49.7 µmol/L. The sensitive method has a great application prospect in detection of sodium cyclamate in real samples owing to its low detection limit, simplicity and rapidity.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Zhongbao Ma,Long-Fei Ren,Diwen Ying,Jinping Jia,Jiahui Shao
High-performance thin film composite polyamide (TFC-PA) membranes with controllable structure and transport properties are of great significance. However, TFC-PA membranes prepared by interfacial polymerization are far from ideal due to their quick and uncontrollable reaction process. In this study, we reported a novel strategy to fabricate TFC-PA membranes via an electrospray interface-less polymerization (EILP) technique with a miscible solvent system. The miscible solvent system facilitated both the stable and fine spraying of monomer solutions and the efficient polymerization of monomers, and thus resulting in the formation of a smooth and defect-free PA skin layer. Moreover, the crosslinking degree and thickness of the EILP membrane skin layer could be controlled easily by regulating the concentration and dose of sprayed monomers. Attenuated total reflectance-Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, zeta potential and mean effective pore size were employed to characterize the EILP membrane and clarify the separation mechanism. The optimum EILP membrane showed excellent filtration performance with a high water flux of up to 17.7 L m −2 h −1 bar −1 , high salt rejection (98.2% of Na 2 SO 4 ) and complete dye rejection for Congo red. This study provides new insights into the understanding of electrospray procedures and enlightens the design and manufacture of advanced membrane materials through electrospray.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Wen Zhang,Xuan Zhang
Commercial reverse osmosis (RO) membranes experience severe inorganic scaling when treated with seawater. This results in a rapid flux decline that considerably compromises the energy efficiency of the desalination process. To address this issue fundamentally, we proposed an effective pretreatment process for seawater desalination using an ion–ion selective nanofiltration (NF) membrane. Such membranes were fabricated by a conventional interfacial polymerization method, solely using 2,2′-benzidinedisulfonic acid as the aqueous reactant, and trimesoyl chloride in the organic phase, respectively. Under the influence of size and Donnan exclusion, the custom-made membranes could effectively differentiate the ion transport behaviors of calcium and sulfate ions, demonstrating their ability to fractionate the ions that cause scaling. In brief, an ultralow rejection of Ca 2+ ( ca . 5.7%) was obtained by the most optimal membrane (BM-0.7) with a mean pore radius of 0.523 nm. Meanwhile, a large proportion of SO 4 2- was retained at the concentrate side owing to the strong surface negativity of the membrane, and the ion composition varied significantly in the permeate stream of the BM-0.7 membrane. Thus, scaling induced by gypsum in the hybrid NF-RO desalination process was significantly alleviated both on the surface of the BM-0.7 membrane, owing to the lack of Ca 2+ and on the surface of the RO membrane, owing to the insufficient amount of SO 4 2- . In contrast, severe scaling was observed for the NF270 membrane (a commercial loose NF membrane procured from Dupont Company), owing to the high rejection of both ions, suggesting a simple fouling transfer from the RO membrane to NF one. Overall, this study provides a promising strategy of an NF pretreatment to modify the inherent water chemistry of seawater for inhibiting gypsum scaling in the seawater RO industry.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2021
·
IF 8.128
Pei Liu,Weiquan Cai,Junwu Chen,Zhichao Yang,Jinpeng Zhou,Zhijun Cai,Jiajie Fan
Mn-doped activated carbon microspheres (MnO x /ACS) with super-high adsorption capacities and deep removal capability for hexavalent chromium (Cr(VI)) were successfully prepared via an ammonium persulfate-assisted hydrothermal method followed by potassium oxalate activation using KMnO 4 and sucrose as raw materials. Their -physical and chemical properties, as well as those of Mn-doped non-activated carbon spheres (MnO x /CS), were characterized by XRD, SEM, TEM, EDS-mapping, XPS, N 2 adsorption–desorption, ICP-AES, and elemental analysis. It was found that the manganese oxide (MnO x ) particles were uniformly embedded within the carbon spheres via layer-by-layer capture, and the MnO x /ACS exhibited strong redox activity because of the multivalent nature of MnO x , resulting in excellent adsorption performance via reduction. In particular, MnO x /ACS-4 with a Mn content of 1.06 wt% and a specific surface area of 1405.7 m 2 g −1 achieved a maximum adsorption capacity of 660.7 mg g −1 ; this can reduce Cr(VI) content to less than 0.05 mg L -1 , which meets the corresponding Chinese drinking water quality standard when the initial concentration of Cr(VI) is less than 400 mg L -1 . Furthermore, this highly efficient method can be extended to prepare V-, Mo-, or W-doped carbon microspheres with significantly enhanced adsorption performance for Cr(VI) compared to bare activated carbon sphere, indicating their good application prospect for the deep removal for heavy metal ions from wastewater.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Mingyue Shen,Lichun Liu,Fan Zhang,Yujie Jiang,Zhengbo Huang,Jianhua Xie,Yadong Zhong,Shaoping Nie,Mingyong Xie
The formation mechanism of furan has been studied extensively in model systems, however, furan formation in real foods are complex and far from being fully understood. In this study, the effects of acid-regulating agent (citric acid), sugar addition (glucose, fructose and sucrose) and thickening agents (xanthan gum, κ-carrageenan and pectin) on furan levels in strawberry jams were studied; meanwhile the formation pathway of furan in canned strawberry jam was proposed by carbon module labeling (CAMOLA) technique. Our results suggested low pH promoted furan formation in strawberry jam. Besides, fructose produces more furans than sucrose and glucose, and the addition of xanthan gum reduced furan levels significantly. The kinetic data showed that ascorbic and dehydroascorbic acid degradation followed first-order kinetics while rate of furan formation followed zero-order kinetics. This study presented the possibility of mitigating furan formation in canned strawberry jams by optimization of processing parameters and addition of xanthan gum.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Ginseng Research
·
2021
·
IF 6.06
Na Zhang,Xin Huang,Yun-Long Guo,Hao Yue,Chang-Bao Chen,Shu-Ying Liu
Background Dried and red ginseng are well-known types of processed ginseng and are widely used as healthy food. The dried and red ginseng quality may vary with the storage period of raw ginseng. Therefore, herein, the effect of the storage period of fresh ginseng on processed ginseng quality was evaluated through multicomponent quantification with statistical analysis. Methods A method based on ultrahigh performance liquid chromatography coupled to triple quadrupole mass spectrometry in multiple-reaction monitoring mode (UPLC-MRM-MS) was developed for quantitation of ginsenosides and oligosaccharides in dried and red ginseng. Principal component analysis and partial least squares discriminant analysis were conducted to evaluate the dynamic distributions of ginsenosides and oligosaccharides after different storage periods. Results Eighteen PPD, PPT and OLE ginsenosides and nine reducing and nonreducing oligosaccharides were identified and quantified. With storage period extension, the ginsenoside content in the processed ginseng increased slightly in the first 2 weeks and decreased gradually in the following 9 weeks. The content of reducing oligosaccharides decreased continuously as storage time extending, while that of the nonreducing oligosaccharides increased. Chemical conversions occurred during storage, based on which potential chemical markers for the storage period evaluation of fresh ginseng were screened. Conclusion According to ginsenoside and oligosaccharide distributions, it was found that the optimal storage period was 2 weeks and that the storage period of fresh ginseng should not exceed 4 weeks at 0 °C. This study provides deep insights into the quality control of processed ginseng and comprehensive factors for storage of raw ginseng.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2021
·Vol. 146
·期 16
·5115-5123
·
IF 4.616
Haiyang Yao,Difei Jiang,Gaoqiu Dong,Jiamin Sun,Shasha Sun,Lingling Li,Fenfen Zheng,Weiwei Xiong
Dynamically monitoring intracellular glutathione (GSH), a crucial biomarker of oxidative stress, is of significance for the diagnosis and treatment of certain diseases. Although manganese dioxide (MnO2) based GSH fluorescent sensors have exhibited high sensitivity and good selectivity owing to the specific reactivity between GSH and MnO2, near-infrared (NIR) MnO2 based nanoprobes for GSH detection are scarce. Herein, we have developed a NIR activatable fluorescence nanoprobe for the imaging and determination of intracellular GSH based on a core–shell nanoparticle, consisting of NIR emitted gold nanocluster doped silica as the fluorescent core and manganese dioxide as the GSH-responsive shell (named AuNCs@MnO2). Due to the absorption competition mechanism, the outer MnO2 shell rather than the inner AuNCs core preferentially absorbed the excitation light, thus leading to fluorescence quenching of the inner AuNCs core. Upon addition of GSH, the fluorescence of the nanoprobe restored along with the reduction of MnO2 to Mn2+ because of the absorption competition disappearance-induced emission. The activatable fluorescence linearly increased upon changing the GSH concentration in the range of 2 to 5000 μM with a detection limit of 0.67 μM. The cytotoxicity test shows that the AuNCs@MnO2 nanoprobes have a good biocompatibility. After entering the cancer cells, the intracellular GSH degraded the outermost MnO2 shell and initiated the NIR fluorescence restoration of AuNCs, which can be used to monitor the dynamic change of intracellular GSH. This strategy provides an NIR-activatable way to detect GSH levels in living cells and offers a promising platform for the diagnosis and treatment of GSH-related diseases.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2021
·
IF 9.297
Fengjiao Lai,Feng Yan,Yingqing Wang,Chunyan Li,Jianjun Cai,Zuotai Zhang
Biomass-derived carbohydrates exploited toward the synthesis of alkyl levulinates is very promising, but still limited by the applicable catalyst. In this study, novel metal/Si-pillared montmorillonite supported phosphotungstic acid catalysts (SG-HPW-XSiMt-y, where X = La 3+ , Ce 3+ , Er 3+ , Cu 2+ , Al 3+ , Ti 4+ , Zr 4+ ) were synthesized by sol-gel method. The catalytic performance of SG-HPW-XSiMt-y were comprehensively studied for glucose methanolysis to methyl levulinate (ML), focusing on the effects of metal acidity, HPW contents and reaction conditions. The appropriate Lewis acidity of metal ions effectively facilitated the isomerization of glucose/methyl-glucoside to fructose/methyl-fructoside; the strong Brønsted acidity of incorporated HPW was capable of suppressing the side reactions; and the large specific surface area and hierarchical pores of the mesoporous structure allow the reaction to take place both on surface and inside the porous framework. Among these as-synthesized catalysts, the SG-HPW-ZrSiMt-20 showed the most superior activity and achieved 65.8% yield of ML from glucose at 170 °C for 4 h. Alternative biomass-derived carbohydrates, including fructose, sucrose and cellobiose, also gave excellent ML yields under such catalytic system . The SG-HPW-ZrSiMt-20 had impressively stable reusability with merely loss of catalytic activity after eight cycles, owing to the uniform dispersion and stable bonding of HPW with ZrSiMt support. Generally, this catalyst system realizes an efficient and sustainable conversion of biomass-derived carbohydrates to ML production.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）