ULTRASONICS SONOCHEMISTRY
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2025
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IF 9.7
Yuhan Fang,Ping Zhang,Shuang Wang,Lulu Li,Zunlai Sheng
This study innovatively employs ultrasound-assisted extraction (UAE) in conjunction with supramolecular solvents (SUPRAS) for the extraction of luteolin from peanut shells, while also investigating the potential mechanism underlying this extraction process. Initially, the formation mechanism of SUPRAS was characterized using Fourier-transform infrared spectroscopy (FTIR). Based on the results of single-factor experiments, the extraction process was optimized using response surface methodology (RSM), resulting in the determination of optimal conditions: an ultrasound temperature of 67 °C, a SUPRAS/equilibrium solution (EqS) volume ratio of 5:1, and a solid-to-liquid ratio of 1:36 g/mL. Under these conditions, the maximum luteolin yield reached 1.645 mg/g. Furthermore, through independent gradient model (IGMH) calculations, molecular orbital theory, interaction energy analysis, and molecular dynamics simulations, it was revealed that the predominant interaction force between the supramolecular solvent and the target compound is hydrogen bonding. Notably, this study also compares the SUPRAS-UAE extraction method with the traditional extraction in terms of efficiency, economic costs, and environmental impact. The results indicate that the SUPRAS-UAE technique demonstrates significant advantages in terms of its green and high-efficiency characteristics. It provides a new sustainable strategy for the efficient recovery of natural active ingredients in chemical engineering and related fields.
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JOURNAL OF SEPARATION SCIENCE
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2020
·Vol. 43
·期 15
·3129-3135
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IF 2.878
Xin Di,Xiaojun Zhao,Xiaoli Guo
A green extractant, hydrophobic deep eutectic solvent was first introduced for extraction of tetracycline, oxytetracycline, and chlortetracycline from environmental water samples prior to high-performance liquid chromatography determination. Deep eutectic solvents consist of methyltrioctylammonium chloride and various medium-chain alcohols/acids, and are easy in preparation, low cost and toxicity, desirably biodegradable, and biocompatible. The overall time required for sample preparation was 6 min and the volume of organic solvent used for extraction was only 400 µL. Under the optimized extraction condition, the present method yielded low limit of detection (0.5–2.0 ng/mL), acceptable precision (relative standard deviations < 9.7%), good linearity from 2.0 to 500 ng/mL ( r 2 ≥ 0.9991). This optimized procedure was applied for determination of tetracyclines in different water samples with desirable spiked recovery ranged from 77.5 to 87.6%. There is, therefore, a great potential to further expand application of the method for investigation of other ultra-trace analyte(s) in environmental matrixes.
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ACS Earth and Space Chemistry
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2025
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IF 2.9
Yaru Song,Minglan Xu,Jianlong Li,Narcisse Tsona Tchinda,Kun Li,Lin Du
Atmospheric release of nuclear wastewater results in the introduction of radionuclides into seawater. These radionuclides can be transported back to the atmosphere by interacting with organic matter at the surface of marine aerosol. Organic molecules, such as organic acids (OAs) and alcohols, the primary components of the organic coating on marine aerosol, play a crucial role in this process. However, the discriminated mechanisms of the interactions of these OAs and organic alcohols at the marine aerosol surface urgently need to be explored. This study uses a Langmuir trough to mimic the marine aerosol surface and investigates the interactions of several OAs (formic acid, hexanoic acid, heptanoic acid, octanoic acid, and nonanoic acid) and dodecanol at seawater-relevant ratios. It was found that upon their addition, metal ions (Ba2+, Co2+, Mn2+, Cs+, Sb3+, Sr2+, Rh3+, Ru3+, and La3+) acting as proxies of radionuclides effectively interacted with the carboxyl headgroups of OAs, which was manifested as a significant increase in the carboxylate asymmetric stretch. This asymmetric stretching vibration is significantly increased with the metal ion concentration and enrichment. Furthermore, the apparent surface binding affinity of metal ions with hexanoic acid is significantly higher than that with nonanoic acid, by a factor of ∼1.95. These findings are significant for understanding how metal ion enrichment at the air-sea interface influences the behavior and fate of radionuclides in the marine atmosphere. Additionally, this study provides new insights into the complex interactions between organic compounds and metal ions, offering valuable perspectives and methodologies for advancing research in marine chemistry and environmental science.
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ULTRASONICS SONOCHEMISTRY
·
2025
·
IF 9.7
Han Yuan,Xiangzhou Li,Jun Zhou,Yanhong Yang,Wensheng Li,Peng Zhou
To address potential issues such as low efficiency, prolonged processing time, the environmental friendliness deficiency of traditional extraction processes of ginkgo flavonol glycosides, this study adopted an ultrasonic-assisted extraction of Ginkgo Flavonol Glycosides with natural deep eutectic solvent-based supramolecular solvent/equilibrium solution (NADES-SUPRAS/EqS). With the assistance of ultrasound, this method achieved an efficient and green extraction process, especially demonstrating significant advantages in reducing extraction time. Through experimental optimization, the optimal conditions were determined as follows: ultrasonic power 160 W, treatment duration 15 min, solid-to-liquid ratio 40 mg/mL, and extraction temperature 30 ℃. Under these conditions, the yield of Ginkgo Flavonol Glycosides reached 8.025 mg/g. Recovery experiments confirmed excellent recyclability of the NADES-SUPRAS/EqS solvent, achieving a flavonol glycoside recovery rate of 91.3 %. This approach holds significant potential for industrial-scale production of Ginkgo Flavonol Glycosides. Microstructural analysis revealed that the NADES-SUPRAS/EqS solvent formed normal micellar vesicles with a hydrophobic core and hydrophilic corona, and the combination of ultrasonic action could effectively disrupt the cell walls of Ginkgo leaves. Density functional theory (DFT)-based molecular modeling elucidated the extraction mechanism, demonstrating strong hydrogen bonding and van der Waals interactions between the NADES-SUPRAS/EqS solvent and rutin. The significance of this research lies in offering a reference framework for green and efficient ultrasonic-assisted extraction studies of natural bioactive compounds, which may provide a feasible technical solution for production of ginkgo flavonol glycosides.
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JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Xinmeng Wang,Yanwen Liu,Su Li,Weiyan Wang,Juan Wang
Monitoring biofluids involved in the circulation of pollutants after entering the body is crucial for determining their physical burden and investigating metabolic processes and health risks associated with exposure to these pollutants. Considering the complexity and high viscosity of biofluids, we herein developed magnetically boosted light-driven hydrogel microrobots (HMRs) that exhibit excellent antifouling ability and satisfactory motion speeds of 204, 176, and 92.5 μm/s in unprocessed urine, bile, and whole blood for overcoming sensor passivation and facilitating the mass transfer and target perfluorooctane sulfonic acid (PFOS) recognition. PFOS is an emerging persistent organic pollutant that is ubiquitous worldwide and may lead to many serious diseases. The HMRs-based electrochemical sensor enables fast (5 min) and ultrasensitive detection of PFOS in urine, bile, and whole blood with detection limits of 0.0147, 0.0155, and 0.0179 fg/mL, respectively. Through the detection of biofluids at different stages after PFOS ingestion, it is found that PFOS mainly circulates in blood and small amounts are excreted through bile and urine, which intuitively confirms that PFOS in the body is difficult to eliminate and helpful for understanding its health threat. Finally, the initial attempt at in-situ detection of intravascular PFOS demonstrates HMRs' future potential in the in-vivo monitoring field.
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Foods
·
2025
·Vol. 14
·期 21
·3781
·
IF 5.1
Yangyang Sun,Heyun Zhang,Huan Zhang,Jihong Huang,Liping Du,Juan Wang
At present, the classification of nongxiangxing baijiu (NXB) predominantly relies on the subjective expertise of distillers and tasters, in the absence of scientifically standardized criteria. This reliance poses challenges for achieving precise classification. Consequently, there is an urgent need to employ flavoromics technology to identify the key characteristic aroma compounds that distinguish different grades of NXB. This study uses sensory evaluation, an electronic nose, and three-dimensional fluorescence spectroscopy to determine the significant differences in aroma profiles among different grades of NXB. Further, 112 compounds were identified by GC-MS, and quantitative analysis was conducted on 33 major volatile compounds. Using odor activity value (OAV) analysis, it found 21, 23, and 26 key aroma compounds (OAV ≥ 1) in Grade 2 (G2), Grade 1 (G1), and prime-grade (GP), respectively. Aroma recombination successfully simulated the aroma distribution of different grades of NXB, and omission experiments identified 11 key aroma compounds as the foundation for NXB. Additionally, each grade exhibited a unique profile of key compounds. G2 was characterized by the presence of octanoic acid, which imparts sweaty and cheesy aromas. G1 contained benzoic acid ethyl ester, phenethyl acetate, pentanoic acid, 2-methyl-1-propanol, and furfural, contributing to sweet, floral, sweaty/cheesy, alcoholic, and roasted aromas. GP demonstrated higher concentrations of aroma compounds compared to G1 and G2, with distinctive compounds such as decanoic acid ethyl ester, dodecanoic acid ethyl ester, 3-methyl-1-butanol, and 1-hexanol, which are associated with sweaty/cheesy, fruity, and alcoholic aromas. This study elucidated the role of these compounds in determining the flavor profiles of various NXB grades, thereby providing a theoretical foundation for the quality grading of NXB.
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Materials
·
2025
·Vol. 18
·期 21
·4885
·
IF 3.2
Zahir Abdalla,Chengqi Liu,Shefiu Kareem,Xiaoqian Wang,Zisheng Tang,Yong Liu
Two-dimensional (2D) colloidal CsPbBr3nanosheets (NSs) possess size-dependent optoelectronic properties; however, conventional hot-injection methods often lack precise growth control and well-ordered superlattice self-assembly. Herein, we introduce a modified ligand-assisted hot-injection strategy that promotes direct precursor–ligand interactions prior to solvent mixing, thereby enabling highly controlled nanosheet superlattice growth. By adjusting the reaction temperature from 130 to 150 °C, we obtained rectangular nanosheets with monodisperse, well-defined thicknesses of 3.35 ± 0.05 nm and 4.05 ± 0.09 nm at 130 and 140 °C, respectively, both below the 7 nm exciton Bohr diameter, consistent with strong quantum confinement. The resulting superlattices exhibited sharp, tunable photoluminescence peaks at 462, 464, and 513 nm, with time-resolved PL revealing a clear size–lifetime correlation, where smaller lateral superlattices at 130 °C showed a short decay time of 8.65 ns, intermediate growth at 140 °C yielded 15.42 ns, and larger lateral superlattices at 150 °C reached 35.49 ns. Importantly, the modified synthesis facilitated the formation of ordered superlattices that preserved their intrinsic emission properties, underscoring their structural stability and scalability. These findings establish a direct link between ligand-mediated synthesis, reaction temperature, nanosheet dimensions, and optical performance, offering a pathway to high-quality perovskite NS superlattices for advanced optoelectronic applications such as light-emitting diodes and sensors.
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CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Fuhui Luo,Zhongqiao Zhao,Yong He,Fenfen Zeng,Xia Yang,Fengxiang Zhang,Wei Shi
To enhance polyphenol extraction efficiency and enable rapid solvent separation, an innovative and eco-friendly extraction method using a switchable deep eutectic solvent based on alkaline/acidic electrolyzed water (AA-SDES) was firstly developed. This study also pioneers the application of a hydrophobic deep eutectic solvent (SDES) system, which consists of nonoic acid (RS) and n-octanoic acid (XS), for extracting polyphenol compounds from Taraxaci Herba (PGY). Optimized using the Newton-Raphson-based optimizer-Support vector regression-Sparrow search algorithm (NRBO-SVR-SSA) algorithm, the AA-SDES system achieved a polyphenol content of 7.74 mg/g, demonstrating an extraction efficiency approximately 1.5 times higher than the traditional acid-base method (NH-SDES) and 2.7 times higher than conventional methanol extraction. Over five consecutive cycles, the AA-SDES system demonstrated robust polyphenol extraction efficiency (92.9 %). The enhanced characterization of SDES-7 revealed that RS acts as a hydrogen bond donor (HBD) and XS acts as a hydrogen bond acceptor (HBA), mainly mediated by hydrogen bonding. The switching mechanism of SDES further confirms its effective switching properties. Additionally, the extraction mechanism demonstrates that AA-SDES exhibits superior cell wall disruption capabilities compared to NH-SDES and methanol. Notably, AA-SDES increases intermolecular hydrogen bonds (HB) and promotes van der Waals interactions between AA-SDES and active components. Furthermore, the HB formed with the target components provide a protective effect, contributing to the overall efficiency of the extraction process. The green sustainability of the method was validated using established assessment tools (AGREE/Complex GAPI). Overall, as one of the most environmentally friendly pH-responsive solvents, it demonstrates broad application prospects.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Jian Song,Hai-Long Qian,Shu-Ting Xu,Cheng Yang,Xiu-Ping Yan
Efficient extraction of perfluoroalkyl and polyfluoroalkyl substances (PFAS) poses a significant challenge for water treatment and food safety. Here, we report a multifunctional covalent organic framework (COF) for the selective and efficient extraction of PFAS. A facile room-temperature imine condensation of two monomers, 2,2′-bis(trifluoromethyl)-4,4′-diaminobiphenyl (BTFDA) and 1,3,5-triformylphloroglucinol (Tp), produced a multifunctional COF (TpBTFDA). TpBTFDA was rationally designed to synergistically integrate chemical moieties capable of leveraging both fluorophilic (via trifluoromethyl groups) and hydrogen bonding (via β-ketoenamine linkages) interactions with PFAS molecules. Batch adsorption experiments, coupled with systematic comparative studies against control COFs (lacking either the fluorophilic or hydrogen-bonding sites), revealed that this synergistic interplay is essential for the efficient capture of PFAS, demonstrating that both interaction mechanisms are indispensable. Consequently, the TpBTFDA exhibited exceptionally high adsorption capacities (379–521 mg g–1) for eight PFAS. The fabricated TpBTFDA was applied to develop a selective solid-phase extraction method for UHPLC-MS/MS determination of PFAS. The developed method showed a wide linear range (0.01–200 μg L–1), low detection limits (0.006–0.59 μg L–1), good precision (RSD ≤ 5.2%), and recovery (83.0–112.3%) for the accurate determination of PFAS in real water and food samples. This study underscores the potential of rationally designed COFs for effectively enriching and detecting PFAS in practical applications.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2025
·
IF 3.5
Xinmiao Wang,Qian Wang,Xu Guo,Peiyong Tong,Chuan Li,Dayong Zhou,Fawen Yin
BACKGROUND Phenolic compounds are increasingly recognized for their diverse health benefits, particularly their potent antioxidant capacities. To enhance its lipophilicity, stability and bioavailability, hydroxytyrosol has been successfully esterified with various alkyl chains lengths and different isomers (branched-chain and straight-chain), forming hydroxytyrosol-fatty acid acyl esters (Hty-Es). These synthesized Hty-Es, have garnered significant interest and are widely explored in fields such as food preservation because of their superior antioxidant properties. However, little is known about the digestion, fermentation characteristics and the effects on the intestinal microbiota in vitro . RESULTS This study evaluated the influence of hydroxytyrosol (HTy) esterified with fatty acids of varying chain lengths (C2:0, C3:0, C4:0 n , C4:0 i , C6:0, C8:0, C12:0, C14:0 and C16:0) on polyphenol sustained-release properties and gut microbiota modulation during simulated in vitro digestion, fecal fermentation and Lactobacillus fermentation. The findings demonstrated partial hydrolysis of HTy-Es in both simulated gastric fluid and intestinal fluid to slowly release a small amount of polyphenols, suggesting their potential to reach the colon and cecum. Analysis of fermented fecal samples revealed that HTy-Es supplementation modulated microbiota composition, elevating the diversity of Actinobacteriota, Firmicutes and Bacteroidetes , whereas it decreased the diversity of Desulfobacterota, Actinobacteriota, Chloroflexi and Verrucomicrobiota . At the genus level, the growth of detrimental genera ( Escherichia shigella ) was successfully suppressed. Notably, HTy-Es with distinct acyl chain lengths and isomer configurations exhibited divergent effects on polyphenol bioaccessibility and gut microbiome diversity, underscoring their structure-dependent functional potential for health applications. CONCLUSION Conclusively, the slow release of fatty acids and HTy clearly demonstrated that HTy-Es would be an effective approach for enhancing the beneficial health effects of fatty acids and HTy. © 2025 Society of Chemical Industry.
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IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION
·
2025
·
IF 3.1
Kaizheng Wang,Hang Ren,Lulu Li,Feipeng Wang,Dihao Lei,Jiran Qin,Zhengdong Zhou,Jian Li
The increasing emphasis on environmental sustainability and efficient resource use drives strong demand for ester-based insulating oils. However, their high production cost limits large-scale application. Low-cost coconut fatty acid distillate (CFAD) is used to synthesize coconut-based trimethylolpropane ester (CTE0). The optimal conditions are 1.2 wt% p-toluenesulfonic acid (TSOH) as the catalyst and a CFAD-to-Trimethylolpropane (TMP) molar ratio of 3.2:1 at 130 °C. CTE0 exhibits a relatively high pour point (–3 °C) and a low fire point (275 °C). To improve its properties, the influence of molecular structures such as branching, carbon–carbon double bonds (C=C), and the odd–even carbon number effect in fatty acid chains on insulating oil properties is investigated. Simulation results indicate that the incorporation of odd-numbered carbon chains and C=C double bonds significantly lowers the pour point due to higher degree of molecular disorder and greater difficulty in forming static packing, while higher molecular weight (MW) enhances the fire point. Therefore, different ratios of nonanoic acid (C9) and oleic acid (C18:1) are added into CFAD to synthesize a high-performance ester insulating oil (CTE3) with pour and fire points of –15 °C and 301 °C, respectively. This study presents a cost-effective synthesis strategy for ester-based insulating oils that reduces production costs by 50–60% compared with commercial natural esters, while also providing key insights into their structure–property relationships.
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JOURNAL OF CONTROLLED RELEASE
·
2025
·
IF 11.5
Haoyang Yuan,Peifu Xiao,Fan Wang,Chen Guo,Shu Pan,Mai Jiang,Shicheng Hou,Yunong Sun,Yibo Wang,Yu Zhang,Tian Yin,Haibing He,Jingxin Gou,Xing Tang
Epithelial cell entrance and trans-epithelial transport are two essential processes that directly affect the efficacy of oral delivery of nanocarriers. Herein, a hydroxyethyl starch-based nanocapsule dual decorated with butyrate and octadecylamine (ODA) was first constructed to enhance transporter-mediated endocytosis and trans-epithelial transport, while reducing exenatide (EXT) loss during absorption. The epithelial barrier was then treated with linoleic acid (LA), which functioned as a cell membrane fluidity regulator. This treatment further improved oral delivery efficiency by lowering the energy cost of endocytosis through fluidizing of the cell membrane and increasing monocarboxylate transporter 1 (MCT1) expression on cell surfaces. The findings revealed that LA upregulated MCT1 expression by 3.26-fold, increased the cellular uptake of nanocapsules co-modified with butyrate and ODA by 4.52-fold, decreased ATP consumption for uptake in LA-pretreated Caco-2 cells to only 18.64 % of that in untreated Caco-2 cells, and increased their transcellular transport by 1.72-fold in a Caco-2/HT29-MTX-E12 co-culture monolayer. Therefore, the oral administration of EXT-loaded Bu-PEG-ODA NCs with LA significantly enhanced the oral bioavailability of EXT (Bu-PEG-ODA NCs group: 10.10 %, Bu-PEG-ODA NCs + LA group: 14.84 %), leading to a significant hypoglycemic effect with a 16.06 % relative pharmacological availability. This dosing strategy exhibited efficacious blood glucose control and pancreatic function recovery capabilities in the type 2 diabetes rat model. This study presents a unique co-optimization strategy based on two key processes in the oral absorption of nanocarriers, yielding significant advancements in the oral bioavailability of nanomedicines and improving their therapeutic efficacy.
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