Food Bioscience
·
2025
·
IF 5.9
Xing Chen,Menglin Jiang,Jie Liu,Genyi Zhang
Whole grain food is a type of healthy food with many beneficial effects, but the fundamental mechanism is still illusive. In the current study, a whole grain component (WGC), as a whole grain model, was prepared by mimicking the endosperm cellular structure through encapsulating glucomannan (dietary fiber) and starch in a matrix formed by polysaccharide gelation. A high level of slowly digestible starch (SDS) (>50 %) in WGC was observed from an in vitro digestion experiment. When the in vivo test of WGC was conducted, a reduced postprandial glycemia and an increased GLP-1 response were observed, which confirmed the stimulation effect of WGC on the secretion GLP-1, an incretin hormone with numerous health benefits. Further study showed that the blood glucose level (from 29.2 to 9.5 mmol/L) and the biomarker HbA1c (from 10.5 to 6.4 %) in diabetic mice were significantly reduced under the condition of WGC-containing diet (WGC-diet). The β-cell function and insulin sensitivity were also significantly improved. Furthermore, the WGC-diet reversed the dysbiosis with increased production of healthy short-chain fatty acids, which are likely the basis to the secretion of GLP-1. Gene expression revealed that WGC-diet activated the GLP-1 signaling pathway, leading to an increased secretion of insulin and improved β-cell function, which all contribute to the glycemic control in diabetic mice. Thus, GLP-1, as pleotropic incretin hormone, could be an important mechanism to the various health benefits of whole grain foods.
研究领域:
营养学
·
分子生物学
·
医学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Dan Zhao,Xianfa Zhang,Wenjing Wang,Lili Sui,Xiaojing Bai,Haixiang Song,Chuanyu Guo,Yingming Xu,Xiaoli Cheng,Shan Gao,Lihua Huo
Early and painless detection of type-I diabetic patients by detecting acetone concentration in their exhaled breath would be a rapid and effective means. TiO 2 materials with exposed active (0 0 1) facet were synthesized mostly with HF as raw material, and the particle size was relatively large. In this work, (0 0 1) and (1 0 1) facets co-doped TiO 2 nanocubes with particle size < 50 nm were successfully prepared by a simple one-step hydrothermal process assisted by the ionic liquid ([Bmim][BF 4 ]) as the fluorine source and morphology modifier. Due to the exposure of the active (0 0 1) facets, the sensor exhibited good gas response to acetone gas at a low operating working temperature (OWT) of 170 °C with a detection limit as low as 30 ppb and a response time of only 2.2 s for 100 ppm acetone gas, and also relatively excellent selectivity, reproducibility, moisture resistance and long-term stability. It is worthy to point that, the changes of acetone concentration were compared in exhaled gas from healthy people and type-I diabetic patients, and the responses to exhaled gas of type-I diabetic patients were also tracked at different time in the same day. This provides significant convenience for early and painless diagnosis of type-I diabetic patients.
研究领域:
材料科学
·
医学
·
传感器技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Lichen Zhang,Xing Su,Shuo Wang,Xiaodong Li,Meishuai Zou
Fluoride coating can reduce the ignition temperature, enhance the burning rate and inhibit the agglomeration of aluminum powder. However, the addition of non-energetic fluoride can reduce the energy of aluminum powder. In this study, for the first time, 3-Perfluorohexyl-1,2-epoxypropane (PFHP) was coated on the surface of aluminum powder, which reacted with glycidyl azide polymer (GAP) in situ to form core–shell Al@PFHP@GAP. Compared with raw aluminum powder, Al@PFHP@GAP not only significantly reduced ignition temperature (about 150 °C), but also greatly improved the combustion efficiency (from 87.7% to 97.6%). Besides, the heat of combustion was also greatly increased by 6.3%, compared with that of raw aluminum powder. Such performances were outstanding among the existing coated Al. In addition, the formation of coating shell effectively improved the hydrophobicity and corrosion resistance of the aluminum powder. In a word, our derived Al@PFHP@GAP provided a novel rationale for aluminum powder with greatly enhanced combustion performance.
研究领域:
材料科学
·
高能材料
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DOI
高影响因子
Nano Research
·
2023
·Vol. 16
·期 12
·13366-13374
·
IF 9.9
Lin Chaoxin,Kim Kumchol,Wang Zuochao,Yan Zhuang,Tang Zhiyong,Liu Yaling
Integration and synergy of the unique functions of different components have been developed into one of the most convenient and effective ways to construct the composite advanced materials with collective properties and improved performances. In this work, the mace-like tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ)/HKUST-1 composite structures with single single-crystalline TTF-TCNQ submicrorods covered by ordered HKUST-1 nanosheet arrays were successfully constructed by an efficient TTF-TCNQ seed-mediated growth approach. Impressively, thanks to the synergetic and complementary effects between TTF-TCNQ and HKUST-1, the sensors based on such mace-like TTF-TCNQ/HKUST-1 composite structures not only displayed an experimental detection limit of 10 part per billion (ppb) for NO 2 detection, but also exhibited outstanding selectivity even if the concentration of the interfering gases was 10 times that of NO 2 . Meanwhile, good reproducibility and rapid response were also achieved. This work opens the avenue for creation of novel high-performance sensing materials for application in gas sensing.
研究领域:
材料科学
·
化学传感
·
纳米技术
·
气体传感器
✓ 已验证
DOI
高影响因子
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
·
2025
·
IF 1.9
Yu-cheng Jiang,Bao-guang Zhu,Xiang-li Long
The oxidation of 1-(4-chlorophenyl)-pyrazolidin-3-one to 1-(4-chlorophenyl)-1H- pyrazol-3-ol by air can be accelerated by the Co(II)@AC catalyst prepared by loading Co(II) on activated carbon with wet impregnation method. ZnCl 2 solution has been used to treat activated carbon to ameliorate the catalytic ability of Co(II)@AC catalyst. The experiments indicate that the optimal catalyst is made by immersing activated carbon in 0.7 mol/L ZnCl 2 solution at 50°C for 6 h with a liquid/solid ratio of 30/1 (mL/g) followed being calcined at 700°C for 5 h at a heating rate of 5°C/min under N 2 protection. The 1-(4-chlorophenyl)-1H-pyrazol-3-ol concentration catalyzed by the catalyst loaded on the best carbon reaches 0.01953 kg/L, which is 27.56% higher than that catalyzed by the catalyst loaded on the original carbon. The characterization results manifest that the modification with ZnCl 2 enriches the porous structure and increases the acidic groups on the surface of activated carbon. The conversion of 1-(4-chlorophenyl)-pyrazolidin-3-one is mainly determined by the physical structure of the activated carbon while the selectivity to 1-(4-chlorophenyl)-1H- pyrazol-3-ol is largely affected by the chemical characteristics of the activated carbon.
研究领域:
化学
·
催化材料科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Zhen Jiao,Mengnan Zhang,Lixia Yang,Yuxuan Wang,Jiajie Fu
To evaluate the feasibility of extraction of 1-methylimidazole from its low-concentration aqueous solution by ionic liquids, the liquid–liquid equilibrium of the ternary system of water + 1-methylimidazole + ionic liquid ([Hmim][PF6], [Omim][PF6], or [Omim][BF4]) was determined at 303.15 K and atmospheric pressure. The distribution coefficient and selectivity were calculated in accordance with the experimental results. The effects of the anion and cation of ionic liquids on the separation ability were discussed. The results indicated that the extraction capacity increased with increasing cationic carbon chain length, and the change of anions significantly affected the distribution coefficient and selectivity. As expected, the three ionic liquids were feasible as extractants for separating 1-methylimidazole from water. It also indicated that [Omim][PF6] was a more suitable extractant than [Hmim][PF6] and [Omim][BF4] for the extraction. The highest distribution coefficient and selectivity of [Omim][PF6] could reach 1.71 and 111.92, respectively, indicating [Omim][PF6] as a good choice for extracting 1-methylimidazole from water. In addition, the non-random two-liquid model was employed to successfully correlate the experimental data with a root-mean-square deviation of less than 0.0188. Moreover, a GUI-MATLAB tool was used to verify the consistency of the correlated parameters.
研究领域:
化学工程
·
材料科学
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2022
·
IF 3.119
Yingmin Yu,Xiaocheng Zhang,Lingxiao Yi,Min Li,Fangyu Zhang,Jiajun Wei
Liquid–liquid equilibrium (LLE) data of ternary systems {2-ethyl-1-hexanol + ethylene glycol + water/n-heptane} were measured at 298.2, 308.2, and 318.2 K under 101.3 kPa. The distribution coefficient (D) and selectivity coefficient (S) of the systems were calculated to analyze the extraction ability of the two extractants that separate 2-ethyl-1-hexanol and ethylene glycol. Meanwhile, the NRTL and UNIQUAC activity coefficient models were used to correlate the experimental data and the different model parameters were obtained by data regression. The root-mean-square deviation (RMSD) between the calculated and experimental values was less than 0.96%, indicating that both models have a reasonable correlation with the experimental data of the ternary system and can accurately predict the experimental data. GUI-MATLAB has validated the binary interaction parameters.
研究领域:
化学工程
·
热力学
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DOI
高影响因子
Food & Function
·
2025
·
IF 5.4
Qi Gu,Litao Wang,Mingyue Xu,Wan-Mei Zhou,Guosheng Liu,Haiting Tian,Thomas Efferth,Chenlu Wang,Yujie Fu
Phloretin is a natural dihydrochalcone with a variety of biological activities. Its potential in modulating lipid metabolism in vitro and in vivo with HepG2 and C. elegans was investigated in this study. Phloretin significantly diminished lipid accumulation and ROS levels, mitigated the degree of lipid peroxidation, and ameliorated mitochondrial dysfunction in HepG2 cells. The expression levels of lipid synthesis genes (SREBP and FASN) were downregulated, while PI3K-AKT related genes (AKT, FOXO, MTOR) were upregulated. Furthermore, phloretin significantly alleviated the detrimental effects of lipid accumulation on growth indices and locomotor ability in C. elegans. It also reduced lipofuscin, ROS level as well as glucose and triglyceride contents, significantly affected amino acid and lipid metabolism pathways based on metabolomics profiles and analysis. Gene expression levels of sbp-1, mdt-15, fat-5, fat-6, and fat-7 were markedly down-regulated following treatment with phloretin, while daf-16, age-1 and skn-1were significantly up-regulated. Tests with mutant C. elegans strains of daf-16, age-1, sbp-1 and nhr-49 further confirmed that the phloretin-induced decrease in lipid accumulation was attributed to the inhibition of lipid biosynthesis pathway by IIS and sbp-1/SREBP. Our study indicated that phloretin exerted hypolipidemic effects in vitro and in vivo, providing a basic foundation for considering phloretin as a phytochemical candidate for regulating lipid metabolism and preventing hyperlipidemia.
研究领域:
代谢生物学
·
分子生物学
·
药理学
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Rui Wang,Xingang Li,Jian Na,Yan Wu,Runnan Zhao,Yutao Yan,Hong Li,Xin Gao
Reversible reaction-assisted technology for ethanediol (EG) and 1, 2-butanediol(1,2-BDO) azotropic mixture separation was proved effective. However, the missing acetalization kinetic parameters hinder the process design and industrialization. This paper addresses the competitive kinetics of EG and 1,2-BDO mixture towards propyl aldehyde. The reaction mechanism was illustrated, and the impacts of feed composition, temperature and solution inhomogeneity were explored. The pseudo-homogeneous model was derived for the system, and the kinetic parameters were obtained. Results demonstrated that the aldehyde and 2-ethyl-1,3-dioxione (2ED) inputs were crucial manipulation variables for reversible reaction-assisted separating (RRAS) process design. The RRAS process was proposed, based on the competitive kinetics, to evaluate the techno-economic performance of RRAS. Two promising processes, which differed in the conversion of EG, were proposed to implement the separation. The economic evaluation revealed that the flowsheet with EG and 1,2-BDO both being converted to acetals and EG then being recovered through 2ED hydrolyzation, has more potential for industrial application.
研究领域:
化学工程
·
工业催化
✓ 已验证
DOI
高影响因子
Cancer Nanotechnology
·
2024
·Vol. 15
·期 1
·1-16
·
IF 4.5
Jiang Qiping,Yao Fengjiao,An Yacong,Lai Xialian,Li Xundou,Yu Zhen,Yang Xian-Da
Background PD-1/PD-L1 blockade plays a crucial role in cancer immunotherapy. Exploration of new technologies to further enhance the efficacy of PD-1/PD-L1 blockade is therefore of potential medical importance. Nanotherapeutics can accumulate in tumor tissues due to enhanced permeability and retention (EPR) effects. In this study, a novel nanotherapeutic for cancer immunotherapy was implemented with albumin nanoparticles functionalized by both PD-1 and PD-L1 aptamers.Results Albumin nanoparticles (NP) were functionalized with either PD-1 aptamers (PD1-NP), PD-L1 aptamers (PDL1-NP), or both types of aptamers (PD1-NP-PDL1). Average sizes of PD1-NP, PDL1-NP, and PD1-NP-PDL1 were 141.8 nm, 141.8 nm, and 164.2 nm, respectively. PD1-NP had good affinity for activated T cells that expresses PD-1. Similarly, PDL1-NP could bind with MDA-MB-231 or CT26 tumor cells that express PD-L1. Moreover, the bispecific PD1-NP-PDL1 could bind with both the activated T cells and the PD-L1-expressing tumor cells, and tether the two type of cells together. Functionally, aptamer-modified nanoparticles exhibited stronger immune-stimulating effects vs. free aptamers. Specifically, PD1-NP or PDL1-NP induced stronger lymphocyte-mediated cytotoxicity against PD-L1-expressing tumor cells in vitro vs. free PD-1 or PD-L1 aptamers. Animal studies also showed that PD1-NP or PDL1-NP significantly improved antitumor efficacy against CT26 colon cancer in vivo vs. free PD-1 or PD-L1 aptamers. Importantly, the bispecific PD1-NP-PDL1 further boosted the in vivo antitumor efficacy compared with PD1-NP or PDL1-NP, without raising systemic toxicity.Conclusion The results suggest that the bispecific PD1-NP-PDL1 is a promising nanotherapeutic to improve the efficacy of PD-1/PD-L1 blockade, and may have application potential in colon cancer treatment.
研究领域:
肿瘤学
·
纳米医学
·
免疫学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 30
·25427-25434
·
IF 3.289
Zulin Hua,Qin Qin,Xue Bai,Xin Huang,Qi Zhang
A highly efficient enzyme-based screen printed electrode (SPE) was developed based on the covalent immobilization of tyrosinase (Tyr) on 1-formylpyrene (1-FP) functionalized reduced graphene oxide (rGO). Here, the bifunctional molecule 1-FP was assembled onto rGO sheets. Subsequently, a Tyr molecule was immobilized on the 1-FP forming a biocompatible nanocomposite, which was further coated onto the working electrode surface of the SPE. The performance of as-prepared biosensor was investigated by the detection of phenol in the presence of molecular oxygen. Wide linear range, low detection limit and high sensitivity were obtained with this biosensor due to the good conductivity of rGO as well as the high bioactivity of Tyr well retained by the 1-FP/rGO platform. Finally, the proposed biosensor was successfully employed for the detection of phenol in real water samples with satisfactory results. These findings suggest that this novel biosensor could offer great potential for rapid, cost-effective and on-field analysis of phenolic compounds.
研究领域:
分析化学
·
环境科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Zheng Xing,Wenhao Yang,Chen Zhao,Yuhui Wang,Xiaolian Jiang,Song Qian,Yun Chu,Jiang Xia,Cheng Wang,Jianhao Wang
Androgenetic alopecia (AGA), the preeminent form of clinical hair loss, poses a significant challenge to patients. Growth factors (GFs) have been investigated for the treatment of hair loss. However, the issue of their optimal intra-dermal delivery remains a formidable obstacle. Type XVII collagen (COL17), which plays a crucial role in regulating the hair follicle aging process, has emerged as a highly promising candidate for hair loss treatment. Considering these constraints, we developed an I GF-1 loaded borate- m odified rh C OL 17 MN platform (I-mCOL17 MNs) for the treatment of AGA. The mCOL17 MNs are engineered to precisely control the release of bioactive payloads in response to dynamic changes in the microenvironment. A comprehensive investigation was conducted to verify the physicochemical characteristics, as well as the in vitro and in vivo biological activities of the MNs. Our findings demonstrate that, when contrasted with the clinically utilized drug minoxidil, our MN exhibits a remarkable capacity to enhance neovascularization, alleviate tissue-based inflammatory responses, and promote hair regeneration in murine models of AGA. Overall, this MN represents a novel, safer, and more efficient strategy for the treatment of AGA, offering new hope for patients suffering from this prevalent condition.
研究领域:
生物医学工程
·
皮肤病学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）