RSC Advances
·
2018
·Vol. 8
·期 8
·4119-4124
·
IF 2.936
Pengpeng Zhang,Qing Yu,Xue Min,Linbao Guo,Jiangjian Shi,Xiangyun Zhao,Dongmei Li,Yanhong Luo,Huijue Wu,Qingbo Meng,Sixin Wu
The annealing temperature of solution-processed Cu2ZnSn(S,Se)4 (CZTSSe) precursor films has been carefully optimized for favorable selenization. At higher temperature, more solvent will be removed, and the crystallinity of the precursor films can be improved. It is found that, although the crystallinity of selenized film is continuously enhanced by increasing the temperature, a dense CZTSSe film with round and large grains can only be achieved at medium high temperature ranging from 350 to 400 °C. Further investigation reveals that, in this regime, the carrier and defect densities are obviously reduced, leading to average photoelectric conversion efficiency (PCE) improved from 5.1% to 9.4%. An optimal annealing temperature of 380 °C is obtained and up to 10.04% of photoelectric conversion efficiency has been achieved.
研究领域:
材料科学
·
光伏技术
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DOI
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2020
·
IF 6.984
Bin Xu,Chuanhe Ma,Xiaoshuang Lu,Yulin Liu,Qiao Zhang,Ye Chen,Pingxiong Yang,Junhao Chu,Lin Sun
Cu 2 ZnSn(S,Se) 4 (CZTSSe) has received considerable attention as the promising absorber for thin-film solar cells. For traditional selenization process, the issues of Sn-loss, lower S/(S + Se) ratio, and unsuitable back contact interface extensively exist in CZTSSe solar cells. In present work, SnSe and SnS powder is introduced during selenization process, respectively. The effects of SnSe and SnS powder on CZTSSe films and the Mo/CZTSSe interface have been comprehensively studied. We discover that SnS not only can provide the Sn-contained vapor in selenization process but also offer S-vapor. Due to the presence of Sn-contained vapor, the number of voids in the CZTSSe absorber and Mo/CZTSSe interface decreases remarkably and the Sn-loss is effectively suppressed. The thickness of Mo(S,Se) 2 layer is significantly reduced, and the S/(S + Se) ratio in CZTSSe bulk obviously increases owing to the presence of S-vapor. As a consequence, the open-circuit voltage and fill factor of the solar cell significantly increase and the CZTSSe solar cell with efficiency of 10.07% (total area) is successfully fabricated.
研究领域:
材料科学
·
能源技术
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DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 11
·2068
·
IF 3.06
Wugang Zhang,Mulan Li,Wendi Du,Wuliang Yang,Guofeng Li,Chen Zhang,Xinli Liang,Haifang Chen
10-Hydroxycamptothecin (HCPT) is a broad-spectrum chemotherapeutic drug, although its side effects and multidrug resistance (MDR) limit its clinical application. A range of drug delivery systems have been utilized to overcome its shortcomings and maintain its therapeutic efficacy, however the use of the transport effect of traditional Chinese medicines (TCMs) to improve the distribution of chemotherapeutic drugs has not been widely reported. Platycodonis Radix (JG) and Glycyrrhizae Radix ET Rhizoma (GC) are common TCMs in clinics and are often combined as drug pairs to act as “transport agents”. In the present study, the effect of JG and GC (JGGC) on the distribution of HCPT in tissues and its antitumor efficacy after being combined as a therapy were investigated, for which ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was used. Furthermore, the effect on the protein expression of multidrug resistance proteins (P-gp and LRP), and the immunomodulatory and synergistic antiapoptotic effect on Lewis lung cancer-bearing C57BL/6J mice were also evaluated. The results demonstrate that JGGC significantly increased the area under the concentration time curve (AUC) and mean residence time (MRT) and reduced the clearance rate (CL) of HCPT. In addition, the combined use of JGGC decreased the levels of LRP, P-gp and Bcl-2/Bax when treated with HCPT. JGGC also significantly elevated the levels of RBCs, PLTs, HGB, IL-2, and IFN-γ, and decreased IL-10 levels. In summary, an increased concentration of HCPT in tissues was observed when it was combined with JGGC through inhibition of efflux protein, with a synergistic enhancement of the anticancer effect observed through promotion of apoptosis and immunity due to a reversion of the Th1/Th2 shift. Our findings provide a reference for the feasibility of combining JGGC with chemotherapy drugs in clinical applications.Keywords:10-hydroxycamptothecin;Platycodonis Radix;Glycyrrhizae Radix ET Rhizoma;tissue distribution;anti-lung cancer efficacy
研究领域:
药理学
·
肿瘤学
·
中药
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DOI
PubMed
高影响因子
Polymers
·
2026
·Vol. 18
·期 7
·782
·
IF 5.8
Qing Peng,Wenxiang Zhang,Qiwei Pan,Shumei Liu,Jianqing Zhao
The development of high-performance polymers exhibiting both low dielectric constant (Dk) and low dielectric loss (Df) at high frequencies is highly desirable yet challenging for applications in microelectronics and wireless communication technologies. In this work, a series of siloxane-containing poly(ester imide)s (SiPEIs) are designed and synthesized via a two-step polymerization route, using 1,4-phenylene bis(1,3-dioxo-1,3-dihydroisobenzofuran-5-carboxylate) (TAHQ) as the dianhydride monomer, and 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (DMS) together with 4,4′-diaminodiphenyl ether (ODA) as the diamine comonomers. Although the introduction of short siloxane segments lowers the glass transition temperature (Tg) and the tensile strength of the resulting PEIs, they still remain at a relatively high level. Liquid crystalline phase behavior is observed at lower temperature for the siloxane-containing PEIs. Meanwhile, the hydrophobicity and the high-frequency dielectric performance is effectively improved with increasing siloxane content. Notably, SiPEI-20, prepared with 20 mol% DMS, displays an outstanding integrated performance. It exhibits aTgof 200 °C, a Dkof 2.87 and a Dfof 0.00155 at 10 GHz, as well as an adhesive strength of 0.85 N·mm−1on copper foil. Overall, this work provides a feasible strategy by incorporating siloxane into the PEI backbone, enabling the synergistic enhancement of high-frequency dielectric properties (simultaneous reduction in Dkand Df) and adhesion to copper foil.
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产品关联
DOI
PubMed
高影响因子
Drug Delivery and Translational Research
·
2026
·
IF 6.9
Rao Qing,Pan Binbin,Peng Zheng,Yu Qimin,Yu Yulong,Wang Huijun
Dysregulated immune responses and excessive inflammation are central drivers of early sepsis progression. Interleukin-10 (IL-10) is a key anti-inflammatory cytokine. However, the therapeutic potential and mechanistic basis of IL-10 mRNA delivery in correcting early immune dysfunction during sepsis remain poorly defined. In this study, we developed a mannose-modified mesoporous silica nanoparticle system (MMP/IL-10 mRNA) to stabilize IL-10 mRNA and enable sustained release for the immunoregulatory treatment of sepsis. The nanoparticles exhibited uniform size, structural stability, efficient mRNA protection, and sustained IL-10 expression. In LPS-stimulated macrophages, MMP/IL-10 mRNA enhanced cell viability, promoted M2 polarization, suppressed pro-inflammatory cytokine production (TNF-α, IL-1β, IL-6, and IL-17A), and restored the IL-10/IL-17A balance. In a cecal ligation and puncture–induced murine sepsis model, MMP/IL-10 mRNA improved 7-day survival, enhanced bacterial clearance, alleviated lung and liver injury, and ameliorated systemic inflammatory imbalance. Mechanistically, treatment reduced TLR4 expression, prevented IκBα degradation, inhibited NF-κB p65 phosphorylation, and upregulated endogenous IL-10 and DEL-1. Importantly, no detectable toxicity or organ damage was observed. These findings demonstrate that MMP/IL-10 mRNA enables efficient, sustained, and safe delivery of IL-10 mRNA, attenuates early hyper-inflammation, and improves immune dysregulation in sepsis, highlighting its potential as a promising immunoregulatory therapeutic strategy. Graphical abstract
The alternative text for this image may have been generated using AI.
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DOI
PubMed
高影响因子
Nature Communications
·
2026
·
IF 18.1
Wang Xinghuo,Huang Yaru,Wang Hui,Yin Shiheng,Xu Chuanhui,Wang Zuankai,Chen Yukun
Constrained by materials, structures, and interface, achieving high sensitivity, wide strain range, and linearity simultaneously remains an impossible triangle for flexible sensors. Herein, we propose 3D super-interface strategy based on patterned rubber substrate-conductive crack layer, successfully developing a microcrack super-interface flexible sensor (MSFS) with ultra-sensitivity (0–10% strain, GF 1.1 × 10⁸ and linearity 0.98). The 3D super-interface relies on the synergistic micro/nano level physical anchoring, and hydrogen bonding interfacial interactions between the rubber matrix and conductive crack layer, achieving strong interlayer bonding. During the sensing process, the crack structure endows the sensor ultra-sensitivity within 0–10% strain range; while the 3D super-interface ensures continuous electrical conductivity under >50% strain conditions. MSFS holds potential application value in monitoring expansion in silicon anode batteries. When the battery expansion reaches 2%, its resistance change can be as high as 22-fold. This approach enables the customized design of flexible sensors for ultra-sensitivity applications.
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2025
·
IF 14.1
Wenwei Li,Yang Liu,Ming Wei,Zhichao Yang,Zhaoyu Li,Zezhong Guo,Liang Yan,Yang Lu,Hao Tang,Bofeng Li,Wei Huang
Osteoarthritis (OA) is a low-grade inflammatory disease that is highly associated with severe hyperplasia of the synovial membrane and the degeneration of cartilage. Interleukin-10 (IL-10), has been extensively studied, while its receptor, IL-10Rα, has not been widely mentioned in the context of OA. A significant difference is found in the expression of IL-10Rα in synovial macrophages from normal and OA patients, along with a marked increase in the glycolytic activity of synovial macrophages. In IL-10Rα Lysm OA mice, the specific deficiency of IL-10Rα exacerbated the progression of OA. Mechanistically, hypoxia-inducible factor-1α (HIF-1α) is identified as a key transcription factor, and its inhibition significantly weakened the glycolytic process. Additionally, differences in ferroptosis of chondrocytes are observed. After co-culturing the two types of cells in vitro, a significant connection is found between the glycolytic state of synovial macrophages and the ferroptosis of chondrocytes. To achieve targeted therapy, MI@UN, a biomimetic nanoparticle encapsulating NO-prednisolone in UIO-66-NH 2 , surface-modified with IL-10, and coated with macrophage membranes (MM), is developed. It significantly slows osteoarthritis progression in mice. This offers new insights into OA pathogenesis, highlighting IL-10Rα as a therapeutic target and supporting MI@UN's translational use for OA treatment.
研究领域:
免疫学
·
骨科
·
纳米医学
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产品关联
DOI
PubMed
高影响因子
CELL BIOLOGY AND TOXICOLOGY
·
2025
·Vol. 41
·期 1
·1-17
·
IF 5.9
Mao Shitao,Yu Na,Wang Wei,Mao Yikai,Du Ying,Zhao Qihe,Gu Xiu,Kang Jian
Idiopathic pulmonary fibrosis (IPF), characterized by fibroblast activation and collagen deposition, is a progressive lung disease that lacks effective interventions. Ubiquitin-specific peptidase 10 (USP10) acts as a multifunctional player in inflammatory response and progression of cancers, the effect on pulmonary fibrosis is unknown. Here, we demonstrated downregulated expression of USP10 in fibrotic lung tissues of IPF patients. In the current study, lung tissues were collected at the end of weeks 1, 2, or 3 post bleomycin (BLM)-intratracheal delivery. Consistently, USP10 expression levels were reduced after BLM challenge in a time-dependent manner. Mice treated with lentivirus overexpressing USP10 exhibited mitigative lung injury and reduced collagen deposition. USP10 overexpression enhanced autophagy in BLM-treated mouse lungs. Interestingly, the protective effect of USP10 was attenuated as the pulmonary autophagy flux was blocked by autophagy inhibitor 3-methyladenine (3-MA). Primary human and mouse lung fibroblasts were treated with pro-fibrotic TGF-β1 to verify the role of USP10 in vitro. Mechanically, the deubiquitinating enzyme USP10 interacted with Sirtuin 6 (Sirt6) and inhibited its degradation. Furthermore, USP10 overexpression inhibited the activation of Sirt6-mediated AKT/mTOR pathway in both lung tissues and fibroblasts. Our findings suggest that USP10 might attenuate pulmonary fibrosis through the promotion of Sirt6/AKT/mTOR-mediated autophagy. These data prioritize USP10 as a therapeutic target for treating IPF. Graphical
研究领域:
医学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Zhe Kong,Yucai Lu,Jinyu Dai,Yunlan Sun,Jiuyu Chen,Baozhong Zhu
Hydrocarbon fuels doped with aluminum nanoparticles (ANPs) can enhance their combustion and energy output characteristics. However, there is an unknown impact of its oxidation degree on the stability and ignition and combustion performance (IACP) of nanofluid fuels. The experimental and molecular dynamics (MD) simulations were combined to explore the impact of ANPs with varying degrees of oxidation on the stability and IACP of aluminum/JP-10 (Al/JP-10)-based nanofluid fuels. The unoxidized ANPs are better dispersed in JP-10 fuel. However, as the oxidation degree of the ANPs increases, their agglomeration in JP-10 increases, reducing the stability of Al/JP-10 fuels. Especially, the activation energy of the Al/JP-10 (ANPs) system also increases, leading to a 36.8 % longer ignition delay for JP-10 fuel. In addition, the oxidation of ANPs partially inhibits the reaction of the core Al, which delays the peak of the formation of Al cluster, and thus hindering the combustion behavior of the nanofluid fuel. At 2000 K, the oxidation of ANPs suppresses the thermal decomposition of JP-10, while at 3000 K, Al 2 O 3 exhibits the most pronounced catalytic influence on JP-10 combustion.
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高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2018
·
IF 2.196
Ying Zhang,Taotao Zhan,Junshuai Chen,Yutian Chen,Maogang He
1-Methoxy-2-propanol (PGMME) is widely used as an oxygenated additive for diesel fuel. Experimental speed of sound data for PGMME are very scarce. Therefore, the speed of sound in PGMME was measured by the Brillouin light scattering (BLS) method in the temperature range from (306.81 to 648.29) K and pressures up to 10 MPa, including saturated liquid/vapor, liquid, and near-critical and supercritical fluid states. The relative expanded uncertainty (k = 2) of our BLS experimental system is estimated to be less than 1.4%. The variation of the speed of sound with the temperature and pressure is illustrated. Moreover, correlations for experimental speeds of sound in the saturated liquid/vapor and liquid are presented. The correlations represent the experimental data with average absolute deviations of 0.24% for the saturated liquid, 0.19% for the saturated vapor, and 0.36% for the liquid region.
研究领域:
热力学
·
流体物理
·
物理化学
·
化学工程
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DOI
高影响因子
Chinese Physics B
·
2018
·Vol. 27
·期 1
·016402
·
IF 1.321
Xue Min,Jiangjian Shi,Linbao Guo,Qing Yu,Pengpeng Zhang,Qingwen Tian,Dongmei Li,Yanhong Luo,Huijue Wu,Qingbo Meng,Sixin Wu
The Zn/Sn ratio in Cu2ZnSn(S, Se)4 (CZTSSe) films has been regulated to control the composition-related phase, defect, and photoelectric properties for high performance kesterite solar cells. It is found that the increase in the Zn/Sn ratio can slightly narrow the energy band gap to extend the light absorption range and improve the photocurrent. Optimal Zn/Sn ratio of 1.39 in CZTSSe film is obtained with the least secondary phase, the lowest defect density, and the longest charge recombination lifetime. Up to 10.1% photoelectric conversion efficiency has been achieved by this composition regulation.
研究领域:
光伏技术
·
材料科学
·
半导体材料
·
可再生能源
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DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Jing Liu,Jingxin Gou,Yanjiao Wang,Haibing He,Xing Tang
An enzyme/pH dual-responsive HES-10-HCPT prodrug micelle was developed. • The micelles achieved high drug loading (20%) and good stability. • Drug release was accelerated under acidic pH and enzymatic conditions. • HH-2 showed 42.5-fold lower IC50 than free 10-HCPT in 4T1 cells. • HH-2 achieved 52.22% tumor inhibition. Cancer remains a major global public health challenge, posing a substantial threat to human health and socioeconomic development. 10-hydroxycamptothecin (10-HCPT), a potent topoisomerase I inhibitor, exhibits broad antitumor activity; however, its clinical application is limited by poor aqueous solubility, rapid lactone-ring opening under physiological pH, and low bioavailability. To address these limitations, we developed an enzyme- and pH-dual-responsive polymer prodrug nanocarrier based on hydroxyethyl starch (HES). 10-HCPT was conjugated to the HES backbone through a hydrolysable succinate ester linkage, yielding an amphiphilic HES-10-HCPT prodrug capable of self-assembling into micelles. The resulting polymer prodrug micelles exhibited favorable storage and plasma stability. Importantly, drug release was accelerated under acidic and enzymatic conditions, suggesting tumor microenvironment-responsive release behavior. In vitro cytotoxicity assays against 4T1 breast cancer cells showed that the high-drug-loading micelles, HH-2, displayed markedly enhanced potency, with an IC50 value of 0.651 μg/mL, compared with free 10-HCPT, which showed an IC50 value of 27.7 μg/mL. In vivo studies in 4T1 tumor-bearing mice demonstrated that, at an equivalent 10-HCPT dose, HH-2 achieved a tumor inhibition rate of 46.31%, compared with 19.70% for free 10-HCPT. Histological analysis further suggested a favorable preliminary safety profile. Overall, this HES-based polymer prodrug micelle system provides a promising strategy for improving the stability, therapeutic efficacy, and safety of 10-HCPT and may serve as a potential platform for cancer chemotherapy. Download: Download high-res image (67KB) Download: Download full-size image
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PubMed
高影响因子
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