Communications Biology
·
2023
·Vol. 6
·期 1
·1-13
·
IF 5.9
Sun Weijia,Li Yuheng,Li Jianwei,Tan Yingjun,Yuan Xinxin,Meng Haoye,Ye Jianting,Zhong Guohui,Jin XiaoYan,Liu Zizhong,Du Ruikai,Xing Wenjuan,Zhao Dingsheng,Song Jinping,Li Youyou,Pan Junjie,Zhao Yunzhang,Li Qi,Wang Aiyuan,Ling Shukuan,Dai Rongji,Li Yingxian
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical stimulation-induced changes in osteoclast function remain to be fully elucidated. Our previous research found Ca 2+ -activated Cl − channel Anoctamin 1 (Ano1) was an essential regulator for osteoclast function. Here, we report that Ano1 mediates osteoclast responses to mechanical stimulation. In vitro, osteoclast activities are obviously affected by mechanical stress, which is accompanied by the changes of Ano1 levels, intracellular Cl − concentration and Ca 2+ downstream signaling. Ano1 knockout or calcium binding mutants blunts the response of osteoclast to mechanical stimulation. In vivo, Ano1 knockout in osteoclast blunts loading induced osteoclast inhibition and unloading induced bone loss and. These results demonstrate that Ano1 plays an important role in mechanical stimulation induced osteoclast activity changes.
研究领域:
生物学
·
生物力学
·
细胞生物学
·
骨生理学
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产品关联
DOI
PubMed
高影响因子
Journal of Material Cycles and Waste Management
·
2023
·Vol. 25
·期 4
·2326-2337
·
IF 3.1
Dou Guolan,Zhang Liying
In the present work, mango pit was used to study the feasibility of converting ionic liquid-pretreated biomass into biofuel and activated biochar by using pyrolysis temperature as a key variable. Ionic liquid 1-butyl-3-methylimidazolium chloride ([Bmim]Cl) was used as a green solvent to dissolve mango pit. The impact of [Bmim]Cl on the pyrolysis properties at peak DTG temperature was investigated. Pretreatment with [Bmim]Cl was observed to slightly enhance biochar yield, while somewhat decreasing bio-oil and biogas yields. The yield of hydrogen and methane, as well as the generation of phenolic and alcoholic bio-oils, are increased by [Bmim]Cl pretreatment. [Bmim]Cl pretreatment was determined to promote the formation of pore structure, a greater number of pores were opened, and the BET surface areas increased 24 times. The pyrolysis kinetics were calculated using the DAEM model. The results showed that [Bmim]Cl pretreatment resulted in lower activation energy and a high amount of fraction mass conversion at low temperatures. As a result, the results showed that pyrolysis of [Bmim]Cl-pretreated biomass did not require high temperatures, and that it is possible to convert ionic liquid pretreatment biomass into high-quality biofuel and active biochar by controlling the pyrolysis temperature. Graphical abstract
研究领域:
能源与环境科学
·
化学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Yunhuan Chen,Xinyue Liu,Rui Zhang,Weier Wang,Hailong Wang,Yongsheng Ren,Xiaoxiao Duan
High permselectivity and antifouling/self-cleaning nanofiltration (NF) membranes are ideal materials for water treatment, and this vision is expected to be reached through the design of multifunctional self-cleaning interfaces. In this study, we employed metal - polyphenol network (MPN) to mediate in situ mineralization of porous substrates, enabling simultaneous modulation of interfacial polymerization (IP) and catalytic self-cleaning. The findings demonstrate that the mineralized layers employ an interlayer modulation strategy to produce a polyamide (PA) layer that is more hydrophilic, thinner, and structurally denser. As a result, the resulting PA-Fe 3 O 4 -PSF membrane exhibited a 2.5-fold increase in permeance (19.2 L m −2 h −1 bar −1 ) and a 7.3-fold enhancement in Cl − /SO 4 2− selectivity (66.4), compared to the control membrane (PA-PSF). Additionally, its highly polarized membrane surface significantly improved its antifouling performance. Compared to membranes with mineralized layers on the surface (Fe 3 O 4 -PA-PSF), PA-Fe 3 O 4 -PSF constructs a confined space that facilitates more efficient regeneration through in situ catalytic self-cleaning and ensures greater stability during multiple fouling-regeneration cycle operations. This study paves the way for fabricating multifunctional NF membranes with sustainable applications in material concentration, wastewater treatment, and environmental remediation.
研究领域:
水处理
·
膜科学
·
材料科学
·
环境工程
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yi-Ying Ma,Ze-Long Lu,Yun-Zhu Xing,Wei-Shi Zheng,Chun-Guang Liu
In this case, various characterization technologies have been employed to probe dissociation mechanism of cellulose in N , N -dimethylacetamide/lithium chloride (DMAc/LiCl) system. These results indicate that coordination of DMAc ligands to the Li + –Cl − ion pair results in the formation of a series of Li x (DMAc) y Cl z (x = 1, 2; y = 1, 2, 3, 4; z = 1, 2) complexes. Analysis of interaction between DMAc ligand and Li center indicate that Li bond plays a major role for the formation of these Li x (DMAc) y Cl z complexes. And the saturation and directionality of Li bond in these Li x (DMAc) y Cl z complexes are found to be a tetrahedral structure. The hydrogen bonds between two cellulose chains could be broken at the nonreduced end of cellulose molecule via combined effects of basicity of Cl − ion and steric hindrance of [Li (DMAc) 4 ] + unit. The unique feature of Li bond in Li x (DMAc) y Cl z complexes is a key factor in determination of the dissociation mechanism.
研究领域:
化学
·
材料科学
·
高分子科学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Zi-Ming Zhou,Zhe Feng,Jun Zhou,Bi-Yun Fang,Zhi-Ya Ma,Bo Liu,Yuan-Di Zhao,Xue-Bin Hu
A new method is proposed for determination of carcino-embryonic antigen (CEA) based on quantum dot (QD)-modified aptamer probe by capillary electrophoresis-chemiluminescence (CE-CL) detection system. An oligonucleotide sequence A contains two parts, one is CEA aptamer and the other is bridging segment. Horseradish peroxidase (HRP) conjugates with sequence A (HRP-DNA A ) and then mixes with QD labeling complementary bridging segment (QD-DNA B ), forming HRP-DNA A-B -QD probe. When CEA exists, the specific combination of the aptamer in sequence A and CEA can form CEA/HRP-DNA A-B -QD complex. After separation of CEA/HRP-DNA A-B -QD complex and HRP-DNA A-B -QD probe by capillary electrophoresis (CE), the chemiluminescence (CL) catalyzed by CEA/HRP-DNA A-B -QD complex can be detected without any interference, and the content of CEA can be estimated by the CL intensity. It has been proved that the separation efficiency of HRP-DNA A-B -QD and CEA/HRP-DNA A-B -QD complex is improved greatly after QD modification, then the interference issue resulted from free HRP-DNA A-B -QD probe is solved well; and the specific combination of HRP-DNA A-B -QD and CEA leads to a closer distance of HRP and QD, then chemiluminescent resonance energy transfer (CRET) occurs, which confirms the validity of the strategy. Results show that the CL intensity has a linear relationship with the concentration of CEA in the range from 0.0654 to 6.54 ng/mL, and the limit of detection is approximately 8 pg/mL ( S / N = 3). This proposed method with high specificity has been applied for the accurate analysis of content of CEA in patient's serum.
研究领域:
分析化学
·
生物技术
·
纳米技术
·
医学诊断
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产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Wenzhi Wang,Liwei Wang,Shuo Song,Xinxin Guo,Hongyu Liu,Guangqiang Liu
All inorganic perovskite quantum dots (PQDs) have been studied extensively because of their excellent photoelectric properties. However, its poor stability and lead toxicity limit its practical application. At the same time, the complex synthesis conditions of the hot injection method also limited the preparation of large quantities. Here, we have successfully synthesized Mn-doped CsPb(Cl/Br) 3 PQDs with excellent thermal stability at room temperature by a simple supersaturation crystallization method. The synthesized Mn-doped CsPb(Cl/Br) 3 PQDs has good homogeneity and crystallinity. Meanwhile, Mn-doped CsPb(Cl/Br) 3 PQDs maintains the same crystal structure as CsPb(Cl/Br) 3 PQDs. Importantly, it was found that the activation energy of CsPb(Cl/Br) 3 PQDs after manganese doping increased from 65.1 meV to 222.8 meV through the high and low temperature PL test of 80 K–500 K. The crystal structure of CsPb(Cl/Br) 3 PQDs is more stable due to the introduction of manganese ion, and the thermal stability is significantly improved. In this study, manganese doped CsPb(Cl/Br) 3 PQDs with good crystallinity and thermal stability was rapidly synthesized by a simple supersaturation crystallization method at room temperature, which opened up a new way to improve the stability of PQDs and explore other non-toxic metal elements to replace Pb 2+ .
研究领域:
材料科学
·
纳米技术
·
化学
·
物理学
✓ 已验证
DOI
高影响因子
Matter
·
2024
·
IF 17.3
Pei Li,Shuo Yang,Jiaxiong Zhu,Shengnan Wang,Yue Hou,Huilin Cui,Ze Chen,Rong Zhang,Zhuoxi Wu,Yiqiao Wang,Zhiquan Wei,Xinghui Liu,Shaoce Zhang,Xinliang Li,Chunyi Zhi
Chlorine-based electrochemical energy storage is a promising candidate for sustainable battery technology. The anionic redox reaction of Cl 0/−1 is of interest due to its superior redox potential (1.36 V vs . standard hydrogen electrode [SHE]), capacity (756 mAh g −1 ), high power, and low cost. Although Cl chemistry has been used in aqueous batteries for a long time, its deployment in organic lithium batteries has been significantly impeded due to the insolubility of Cl − ions (<0.1 M). Scarce oxidizable Cl − blocks redox reactions and the inevitable lithium chloride (LiCl) film passivates electrodes on discharge. We report a eutectic effect to improve the Cl − solubility in organic electrolytes (2 M or higher) by mixing a series of N-/P-centered chloride salts with lithium bis(trifluoromethanesulfonyl)imide at specific ratios. Based on an optimized Cl − concentration, a Li-Cl 2 cell using I as a chemical fixation can achieve a three-electron transfer with a specific capacity of 702 mAh g −1 and an energy density of 1,116 Wh kg −1 .
研究领域:
电化学
·
能源材料科学
✓ 已验证
产品关联
DOI
高影响因子
OPTICAL MATERIALS
·
2024
·
IF 3.8
Lin Chen,Xiong Shen,Jinhe Wei,Zhongming Wang,Fei Hu,Limin Bian,Qiuyun Ouyang
CsPb(Cl/Br) 3 perovskite nanocrystals (NCs) materials were synthesized by a hot injection method. To enhance the stability of the perovskite , CsPb(Cl/Br) 3 - multiwalled carbon nanotubes (CNTs) composites were synthesized by the insitu growth method. First, the successful composite of CNTs and perovskite has been proved by X-ray photoelectron spectroscopy (XPS). After CsPb(Cl/Br) 3 NCs have grew on CNTs, the exciton lifetime decays from 8.2 ns to 4.5 ns, suggesting the presence of an additional electron transfer pathway between CNTs and CsPb(Cl/Br) 3 NCs. The photoluminescence (PL) properties of perovskite NCs and CsPb(Cl/Br) 3 -CNTs were evaluated using temperature-dependent PL spectroscopy . The exciton binding energy of the CsPb(Cl/Br) 3 -CNTs composites (59.28 meV) is higher than that of the CsPb(Cl/Br) 3 NCs (51.79 meV), indicating a more stable exciton state within the CsPb(Cl/Br) 3 -CNTs structure. The PL stability experimental results reveal a notable enhancement in the stability of CsPb(Cl/Br) 3 -CNTs composites compared to CsPb(Cl/Br) 3 NCs. In addition, electrochemical tests of CsPb(Cl/Br) 3 -CNTs show a low resistance to charge transfer ( R ct ) alongside a favorable photocurrent response. This work has proved that the novel CsPb(Cl/Br) 3 -CNTs composites not only exhibit outstanding moisture and UV resistance but also demonstrate remarkable potential optoelectronic device applications.
研究领域:
材料科学
·
光电化学
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产品关联
DOI
高影响因子
Small
·
2024
·Vol. 20
·期 37
·2400549
·
IF 13
Yaoguo Shen,Mingliang Ding,Gang Chen,Yingjie Luo,Sangen Zhao,Junhua Luo
A large optical anisotropy is the most important parameter of birefringent crystals. Integrating π-conjugated groups with large polarizable anisotropy into target compounds is a common strategy for constructing brilliant birefringent crystals. However, the key problem is to enhance the density of the birefringence-active units and further arrange them parallelly. In this study, three novel birefringent crystals, C 9 H 7 NBrX (X = Cl, Br, NO 3 ), are successfully synthesized by introducing a new birefringence-active [C 9 H 7 NBr] + unit. Interestingly, these compounds feature similar layered structures but exhibit different optical anisotropies at 550 nm (0.277 for C 9 H 7 NBrCl, 0.328 for C 9 H 7 NBrBr, and 0.401 for C 9 H 7 NBrNO 3 ) owing to the different anions in them. Particularly, the small trigonal planar NO 3 anions perfectly fill the interstices of the π-conjugated [C 9 H 7 NBr] + groups with large optical anisotropy, with the resulting compound C 9 H 7 NBrNO 3 showing superior optical properties compared to the others. The above findings provide strategies for designing new optical materials with large birefringence by matching birefringence-active groups of different sizes. Additionally, a new theory for predicting and comparing the polarizability anisotropy of compounds is proposed, which would guide in exploring large birefringent crystals.
研究领域:
材料科学
·
光学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2021
·Vol. 21
·期 12
·6073-6081
·
IF 0
Zhang Qian,Wang Bingxin,Hong Jun-Ming
The application of electrochemical catalytic oxidation in wastewater treatment with powerful Cldoped graphene as an anode has been discussed as a novel approach to degrade acetaminophen effectively. The characteristics of Cl-doped graphene that were related to Cl loading content and
microscopic morphology were analyzed by using several instruments, and the defects created by Cl doping were identified. Quenching experiments and electron paramagnetic resonance detection were proposed to clarify the mechanism underlying the production of active free radicals by Cldopedgraphene.
The degradation results indicated that efficiency increased with the percentage of Cl atoms doped into the graphene. The best degradation efficiency of acetaminophen could reach 98% when Cl-GN-12 was used. In the process of electrocatalytic oxidation, O•−
2,
and active chlorine, as the main active species, persistently attacked acetaminophen into open-ring intermediates, such as 4-chlororesorcinol, and finally into CO2 and H2O.
✓ 已验证
DOI
PubMed
ACS Applied Nano Materials
·
2025
·
IF 5.5
Zhifan Wang,Mengmeng Dai,Gang Yang,Xiao Zhang,Pengchao Shen,Chunxiang Zhao,Yongsheng Zhu
Perovskite nanocrystals have gained considerable attention owing to their outstanding photoluminescence and photodetection performance in various applications. However, the rigorous preparation conditions and lead toxicity of most lead halide perovskite nanocrystals still hamper practical application, which achieves efficient deep-red and near-infrared (NIR) emission also meeting the challenge. Herein, sub-25 nm Cl–-doped lead-free CsMnBr3 nanocrystals (NCs) were prepared via a moderate hot-injection method at room temperature and the resulting NCs showcased excellent photoluminescence property with reduced impurities. Furthermore, a substantial enhancement in photoluminescence quantum yield (PLQY) from 54.20% to 78.05% was achieved by manipulating the Cl– doping concentration, which is attributed to the weakened nonradiative recombination pathways induced by Cl–-mediated defect passivation. Consequently, we fabricated photoluminescent light-emitting diodes (LEDs) based on Cl–-doped CsMnBr3 nanocrystals and achieved NIR emissions of Nd3+, Yb3+, and Er3+ ions. These results reveal that Cl–-doped CsMnBr3 perovskites NCs can not only be facilely prepared via a simple room-temperature synthesis, but also demonstrate promising potential in various areas such as photoluminescent LEDs and near-infrared optoelectronic devices.
研究领域:
材料科学
·
纳米技术
·
光电子学
·
光子学
·
半导体物理
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Honglin Xu,Ruilin Wang,Yongsheng Deng,Guofeng Dou,Xinyu Wang
The stable phase equilibrium of the reciprocal quaternary system of Na+, K+//VO3–, Cl––H2O at 298.15 K was investigated by an isothermal solution equilibrium method. The equilibrium liquid phase solubility data and physical property data [density (ρ), refractive index (nD), and pH] were determined, and the composition of the equilibrium solid phase was verified by X-ray diffraction. The phase diagram and physical property–composition diagrams were constructed based on the equilibrium solubility data and physical property data. The phase diagram contains three invariant points, seven isothermal univariant curves, and five crystalline phase regions. The study found that this quaternary system belongs to a complex system with the presence of the double salts. By comparing the experimental results with literature data, it was confirmed that at 298.15 K, the chemical formulas of the complex salt which formed by the quaternary system Na+, K+//VO3–, Cl––H2O were consistent with the complex salt chemical formula (Na2mKn(VO3)2m+n) proposed by the Druzynski group, thus verifying the reliability of this experiment. The results of this study will provide new experimental data for the thermodynamics of vanadium–water systems.
研究领域:
物理化学
·
无机化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）