SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Wenwen Li,Tao Wu,Mengyao Xu,Yingrong Zhong,Xiaoyu Wang,Meng Gao,Guanchen Xu,Yuanyuan Tao,Dongwei Li,Xingshuang Zhang
To meet the dual requirements of particulate and iodine vapor removal in iodine-containing aerosol purification during nuclear fuel reprocessing, a series of PI/COF-316 composite nanofiber aerogels were fabricated via an electrospinning-freeze-drying approach. The thermally imidized PAA nanofibers formed a three-dimensional (3D) porous skeleton, while the uniformly dispersed COF-316 particles provided abundant active sites. PI/COF-25 wt% NFAs achieved the best overall performance, delivering 98.12% filtration efficiency for PM 0.3 with a pressure drop of 140 Pa and an iodine vapor adsorption capacity of 361.36 mg/g. The adsorbed iodine was effectively desorbed using ethanol, and 83.09% of the initial capacity was retained after five adsorption-desorption cycles. These results demonstrate that PI/COF composite NFAs provide a robust platform for iodine-containing aerosol purification. Environmental implication This polyimide/COF-316 nanofiber aerogel enables simultaneous purification of submicron particulates and iodine vapor (a hazardous nuclear-related pollutant) in aerosols. Its recyclability reduces material waste, offering a sustainable, efficient solution for hazardous iodine-containing aerosol control to mitigate environmental and health risks.
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CHEMICAL ENGINEERING JOURNAL
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2025
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IF 13.2
Zhen Yu,Yan Zhang,Dongquan Leng,Tingting Wu,Si-Jia Ge,Dawei Fan,Hongmin Ma,Yu Du,Qin Wei
Human papillomavirus (HPV) infection represents a major global health concern due to its strong association with cervical cancer and other malignancies, underscoring the critical need for highly sensitive detection methods. In this study, an advanced photoelectrochemical biosensing platform was developed for ultrasensitive HPV detection. An In 2 S 3 -sensitized SnO 2 heterostructure substrate that dramatically enhances photogenerated charge separation efficiency, generating extremely significant photocurrent enhancement. Furthermore, a CuFe 2 O 4 @T-COF nanosphere serving as a multifunctional signal quencher through synergistic steric hindrance, competitive oxygen consumption and light absorption effects. Notably, an exonuclease III-powered DNA walker system enabling cyclic signal amplification through programmable target recycling. The biosensor demonstrates exceptional analytical performance, achieving a broad dynamic range of 10 −6 to 10 μmol/L with an ultralow detection limit of 1.37 × 10 −7 μmol/L. This breakthrough sensing platform not only provides a powerful tool for early HPV diagnosis but also opens new possibilities for developing next-generation biosensors with clinical-level sensitivity and specificity.
研究领域:
生物传感器
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纳米技术
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分子诊断
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病毒学
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癌症研究
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分析化学
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IONICS
·
2023
·Vol. 29
·期 9
·3795-3803
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IF 2.8
Xiong Qinghao,Wan Haifei,Peng Xia,Zhu Yongmei
N-rich carbon (C) microspheres loaded with Ni nanoparticle (NiNP) microspheres (Ni@N-doped C) were obtained by calcination of covalent organic framework (COF) LZU-1 with abundant N atoms/Ni 2+ . Lots of NiNPs with the size of 4 nm are arrayed uniformly and firmly into N-doped C microspheres derived from COF LZU-1 based on the strong coordination between N atoms on the wall of well-ordered pores and Ni atoms, which is more beneficial to rapid electron and mass transfer. The synergistic effect from N-doped C microspheres and small-sized NiNPs in Ni@N-doped C enhances catalytic activity of Ni@N-doped C microspheres greatly, which provides feasibility for the construction of non-enzymatic electrochemical sensor. The non-enzymatic electrochemical sensor based on Ni@N-doped C microspheres is applied to the detection of dopamine (DA) and shows good detection results with a low detection limit of 0.009 μM and a wide detection range of 0.027–70 μM. What is more, this DA sensor has good anti-interference, reproducibility, and stability, which provides new idea for the construction of non-enzymatic electrochemical sensor.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2022
·Vol. 414
·期 27
·7885-7895
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IF 4.478
Zhang Xiaoya,Feng Quanshou,Xie Zehu,Xu Fuxing,Yan Yinghua,Ding Chuanfan
In this work, on the basis of an immobilized metal ion affinity chromatography enrichment strategy, a new kind of covalent organic framework (COF) material for enrichment of phosphorylated peptides and exosomes was successfully prepared in a facile method, and Ti 4+ and Nb 5+ were used as dual-functional ions (denoted as COF-S–S-COOH-Ti 4+ /Nb 5+ ). With the advantage of unbiased enrichment towards phosphopeptides, COF-S–S-COOH-Ti 4+ /Nb 5+ shows ultra-high selectivity (maximum molar ratio of β -casein: BSA is 1:20,000) and low limit of detection (0.2 fmol). In addition, the material has an excellent phosphopeptide loading capacity (100 μg/mg) and reusability (at least seven times). Furthermore, applying the material to the actual sample, 4 phosphopeptides were selectively extracted from the serum of renal carcinoma patients. At the same time, exosomes with an intact structure in the serum of renal carcinoma patients were successfully isolated rapidly using this strategy. All experiments have shown that COF-S–S-COOH-Ti 4+ /Nb 5+ exhibits exciting potential in practical applications. Graphical abstract
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CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Wei Lai,Linglong Shan,Ju Bai,Luqi Xiao,Lu Liu,Shunli Wang,Lili Gong,Yang Jiao,Wei Xie,Hongyan Liu,Shuangjiang Luo,Suojiang Zhang
The fabrication of nanofiltration (NF) membranes with excellent acid resistance and high separation performance remains a tremendous challenge due to the lack of precise membrane structure manipulation. Herein, covalent organic frameworks (COFs), due to their abundant porosity and highly ordered structures, are employed to synthesize high-permeation nanofiltration membranes. An acid-stable COF layer and a polysulfonamide (PSA) layer were fabricated by in-situ interfacial polymerization (IP) upon the polyethersulfone (PES) ultrafiltration substrate in turns. The acquired COF-based composite membrane exhibited sub-nanometer pore size and excellent rare-earth ions separation performance due to the interlaced stacking between the COF and PSA layers, as well as the COF interlayer regulated IP process. Additionally, the composite membrane showed high rejection of >92.2% for trivalent rare-earth ions (RE 3+ ) and high water permeance of >43.3 L h −1 m −2 bar −1 at both pH = 6.8 and pH = 1, the superior separation performance can be ascribed to the high porosity and abundant transportation pathway provided by the COF layer and the interlaced stacking structure between the COF layer and the PSA layer. The facile membrane fabrication procedure, along with the excellent water permeation performance and acid resistance, render the composite membrane in this study applicable for a broad range of critical industrial and environmental processes.
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Analytical Methods
·
2021
·Vol. 13
·期 42
·4994-5002
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IF 2.896
Hao Guo,Lei Sun,Meng Yang,Mingyue Wang,Ning Wu,Tingting Zhang,Junye Zhang,Fan Yang,Wu Yang
In this work, a covalent organic framework (COF) TAPT-TFP-COF containing a triazine ring was prepared by a typical Schiff base condensation reaction of 1,3,5-tris-(4-aminophenyl)triazine (TAPT) and 1,3,5-triformyl phloroglucinol (TFP). The TAPT-TFP-COF and carboxyl-functionalized multi-wall carbon nanotubes (COOH-MWCNTs) were drip-coated on glassy carbon electrode respectively to develop a novel and simple electrochemical sensor in order to simultaneously detect dopamine (DA) and paracetamol (PA). COOH-MWCNTs interconnected the TAPT-TFP-COF and acted as bridges between the COF particles, which had a good synergistic effect and accelerated electron transfer. Under optimal conditions, linear responses were obtained over the concentration range 1–190 μM for DA and PA with limits of detection (LOD) of 0.14 μM and 0.19 μM, respectively. Furthermore, the fabricated sensor possesses outstanding repeatability and high selectivity, and can be applied for the determination of DA and PA in dopamine injection and acetaminophen drugs with satisfactory recoveries.
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JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
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2021
·
IF 6.064
Tengfei Liu,Wen Li,Chenyang Zhang,Wei Wang,Wenwen Dou,Shougang Chen
In this work, multi-layer stacked two-dimensional (2D) covalent organic framework of TpPa-1 was synthesized as nanocontainer to fabricate self-healing epoxy coating. The corrosion inhibitor of benzotriazole (BTA) was loaded into porous TpPa-1 (Tp: 1,3,5-Triformylphrogroglucinol, Pa-1: 1,4-phenylenediamine), and the load capacity was further improved by electrostatic adsorption. Then, 0.5 wt.% BTA/TpPa-1 and 0.5 wt.% TpPa-1 were added to the epoxy coating, respectively. The electrochemical Impedance Spectroscopy (EIS) test shown that after 60 days of immersion, the impedance of the BTA/TpPa-1/EP in low-frequency region was 6.45 × 10 8 Ω cm 2 , while the impedance corresponding to the TpPa-1/EP coating was 9.04 × 10 7 Ω cm 2 . In addition, in the localized electrochemical impedance spectroscopy (LEIS) test, as the immersion time was extended, the impedance of TpPa-1/EP coating at the defect continued to decrease, while the impedance at the defect of the BTA/TpPa-1/EP coating shown an upward trend, showing self-healing performance. This was due to the pH change when the metal at the defect is corroded, which caused the BTA to be released from the nanocontainer and adhered to the metal surface to form a protective film. The improvement of the anti-corrosion performance of BTA/TpPa-1/EP coating mainly comes from two aspects: (1) The good dispersion of TpPa-1 in EP coating improves the physical shielding effect of the coating; (2) The controlled release of BTA can Realize the continuous formation of the bare metal surface protective layer.
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JOURNAL OF MEMBRANE SCIENCE
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2020
·
IF 7.183
Yi-Yi Su,Xi Yan,Yan Chen,Xiao-Jing Guo,Xing-Fan Chen,Wan-Zhong Lang
Covalent organic frameworks (COFs) have attracted great interest as advanced membrane materials due to their uniform channel structure and high porosity. In this work, COF-LZU1/PES composite membranes were prepared via interfacial polymerization (IP) process, and the thin and defectless COFs active layers were successfully grown on poly (ether sulfone) (PES) microfiltration substrates with 1,3,5-triformylbenzene (TFB) and p-phenylenediamine (PDA) as precursors. The prepared COF-LZU1/PES composite membranes exhibit a high rejection rate (>99.0%) for the dyes with molecular size above 1.5 nm and nonselective permeation for inorganic salts (<12.0%). At the same time, a water permeance above 80.0 L m -2 h -1 ·bar -1 is achieved, which is much higher than many other membranes with similar rejections. Long-term filtration demonstrates that COF-LZU1/PES membranes have good water stability. The excellent water permeance, high dyes separation performance and great stability endow COF-LZU1/PES membranes the performance of removing dyes from saline wastewater.
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LANGMUIR
·
2020
·
IF 3.557
Jun Zhao,Bo Jin,Rufang Peng
Nitroaromatic explosives in wastewater are hardly degraded, which seriously endangers the ecological environment and human safety. We report a core–shell structure hybrid material (IR-MOF3@COF-LZU1) with high crystallinity and graded porosity. It is an effective visible-light-driven photocatalyst that degrades p-nitrophenol (PNP). After 3.5 h, PNP was degraded well under visible light, and it is proven that the photocatalytic degradation is efficient. In addition, this photocatalytic activity adhered to pseudo-first-order kinetics, and a possible photocatalytic mechanism was discussed in detail.
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FOOD CHEMISTRY
·
2021
·
IF 7.514
Quanbin Fu,Bingbing Sun,Jun Fan,Minglin Wang,Xin Sun,Geoffrey I.N. Waterhouse,Peng Wu,Shiyun Ai
A novel mixed matrix of MOF@COF hybrid was firstly formed by coating of hexahedral cage structure MOF with lightweight porous COF, and applied in dispersive solid-phase extraction of the phenoxy carboxylic acids (PCAs) from water and vegetable samples. Combined with liquid chromatography-tandem mass spectrometry, an excellent method with low limits of detection (0.69–1.79 ng·L −1 /0.002–0.006 ng·g −1 ), good reproducibility (1.32%–7.02%/1.81%–6.71%), and excellent linearities (10–1000 ng·L −1 , R ≥ 0.9955/0.04–50 ng·g −1 , R ≥ 0.9966) was established. The adsorption mechanisms deduced that the π-π interaction, hydrophobic effects, hydrogen bond, and halogen bond may promote the excellent adsorption of the PCAs. Finally, the applicability of the method was verified by spiking four kinds of water and vegetable samples with PCAs, and satisfying recoveries were obtained (between 83.3% and 104.9%).
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2019
·
IF 2.931
Lulu Guo,Yonghai Song,Keying Cai,Li Wang
Covalent-organic frameworks (COFs) are new porous crystalline materials owning outstanding stability, adsorbability and hypotoxicity. The assembly of fluorescence probes into porous COF provides a good method for ratiometric fluorescence detection avoiding the toxic effects of fluorescence probes to the samples. Herein, a two-dimensional COF (TAPT-DHTA-COF) was employed as a host to encapsulate N-doped carbon dots (NCDs) and Rhodamine B (RhB) (NCDs-RhB@COF). NCDs and RhB were uniformly assembled into the pores of TAPT-DHTA- COF based on the hydrogen bond . The as-prepared NCDs-RhB@COF nanocomposites exhibited blue emission of NCDs at 440 nm and red emission of RhB at 570 nm at excitation of 340 nm. After the addition of Hg 2+ , the blue emission became weaker while the red emission was enhanced due to the strong coordination between NCDs-RhB@COF and Hg 2+ . This “on-off” fluorescence probe was applied in detection of trace Hg 2+ with linear range of 0.048–10 μM and detection limit of 15.9 nM together with appropriate selectivity, acceptable sensitivity and stability. The work shreds some light for COF as platform to construct ratiometric fluorescent sensor for industrial and biological application.
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TALANTA
·
2025
·
IF 6.1
Yingfei Hui,Hao Guo,Mingyue Wang,Liping Peng,Borong Ren,Yanyan Ma,Wu Yang
Glutathione (GSH) levels have been linked to aging and the pathogenesis of various diseases, highlighting the necessity for the development of sensitive analytical methods for GSH to facilitate disease diagnosis and treatment. In this study, we synthesized a novel core-shell material, UiO@TBTA, by in-situ growing TFPB-TAPA COF on UiO-66-NH 2 through a Schiff base reaction. The resulting composite capitalize on the advantages of both materials, demonstrating excellent stability, large specific surface area, and abundant active functional groups while preserving superior crystallinity. Notably, this strategy effectively reduces the occurrence of aggregation-caused quenching (ACQ) in COFs. Due to the inner filter effect and hydrogen bonding interactions between UiO@TBTA and GSH, a specific ratiometric fluorescence detection of GSH was achieved in the range of 0.1–7 μM, with a limit of detection (LOD) of 0.0685 μM. In addition, due to the sensitive color change of the sensing material from orange to black caused by GSH, a proportional colorimetric sensing strategy has also been proposed, enabling the detection of GSH within the range of 1–200 μM. What's more, two intelligent artificial neural networks models were constructed with the help of machine learning that can quickly, accurately, and sensitively determine the concentration of GSH based on fluorescence images and color photographs respectively. Our work represents the first study utilizing MOF@COF composite for the multimodal detection of GSH, thus providing a novel strategy for the multimodal detection of the target analyte. Prospectively, the construction of the fluorescence/colorimetric dual-mode intelligent ratiometric sensing platform using deep machine learning holds great promise for real-time monitoring.
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