RSC Advances
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2016
·Vol. 6
·期 31
·26374-26379
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IF 3.289
Chao Sun,Mengya Liu,Yu Zou,Jiandong Wei,Jiang Jiang
Plasmonic Au–copper sulfides hybrid nanocrystals are of great interest for both fundamental research and application in optoelectronics, catalysis, and biomedicine, in which a precise and high-yield synthesis of the hybrid nanocrystals is required. Herein, we investigated colloidal synthesis of Au–CuS hybrid nanocrystals based on a seed-mediated method. Different from previously reported deposition of Cu-rich Cu chalcogenides, we found that decreasing the Cu–S reaction rate is critical for the deposition of relatively S-rich CuS on Au seeds in high yield, which can be achieved by using a chlorobenzene solution containing a small amount of oleylamine as the solvent. The influence of the S/Cu feed molar ratio and reaction temperature on the formation of Au–CuS hybrid nanocrystals has also been investigated. The obtained Au–CuS hybrids showed better photothermal transduction efficiency over CuS nanocrystals prepared under identical conditions. In addition, Au–CuS hybrids could be used as templates to synthesize Au–CuInS2 and Au–Cu2ZnSnS4 hybrid nanocrystals via subsequent reactions with In or Zn/Sn precursors at high temperature. These results provide insight into the critical parameters governing the growth of Au–copper sulfides hybrid nanostructures, which can be useful for the design of other noble metal–semiconductor hybrid nanostructures.
研究领域:
材料科学
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纳米技术
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催化
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生物医学
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2022
·
IF 4.831
Ciyang Zhang,Xingen Xie,Shasha Feng,Wu Lei,Mingzhu Xia,Fengyun Wang,Hualai Wang
The novel CuMnS nanoflower fluorescent probe based on Mn-doped CuS was developed to achieve the fluorescence detection of oxytetracycline hydrochloride (OTC), the fluorescent sensor has good selectivity and stability. The doping of Mn significantly increased the fluorescence intensity of CuS, which was above 10 times that of CuS. When the predominant species of OTC molecule was zwitterionic OTC +/− at the solution pH of about 5.00, the fluorescence quenching efficiency of CuMnS by OTC reached the highest. Through fluorescence lifetime and UV absorption, the sensing mechanism between CuMnS and OTC was found to be static quenching. Moreover, Multiwfn wavefunction analysis program based on density function theory (DFT) calculation was applied to compare the interactions between different OTC species and CuMnS at different pH, to reveal the micromechanism of fluorescence quenching of CuMnS by OTC from the views of atoms. The molecular surface quantitative analysis and basin analysis of different OTC species demonstrated that the N atom and O atoms of tricarbonylamide moiety of zwitterionic OTC +/− can provide lone pair electrons to form a non-fluorescent ground state complex with CuMnS. Meanwhile, the electrostatic attraction of OTC +/− with negatively charged CuMnS was also beneficial to the interaction, resulting in the effective fluorescence quenching of CuMnS. This work offers a convenient method for sensitively detecting OTC and broadens the application of CuMnS in the field of fluorescence detection.
研究领域:
分析化学
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环境科学
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药物检测
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PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 12
·期 1
·2201746
·
IF 11.092
Zhihao Zhang,Jinghong Wen,Jie Zhang,Donggang Guo,Quanxi Zhang
Cu-based nanomaterials have been developed to alleviate the problem of antibiotic resistance due to their superior properties and good biocompatibility. Defects in nanomaterials have a major role in improving photocatalytic performance. Herein, two CuS nanospheres with predominant V CuSCu and V CuSS vacancy (abbreviated as CuS and CuS-T150, respectively) characterized by positron annihilation spectra are synthesized. The combination of experimental and theoretical calculation results demonstrates that CuS-T150 exhibits excellent antibacterial, achieving bactericidal rates of 99.9% against to Escherichia coli ( E. coli ) under 808 nm laser irradiation. Compared with CuS, the superior antimicrobial activity of CuS-T150 is mainly attributed to its stronger ability to adsorb oxygen molecules, more easily bind with surface of E. coli , and higher photothermal conversion efficiency (PTCE). This work provides a deeper understanding of nanomaterials with vacancy modulated the antibacterial efficiency by synergistic effect of photodynamic and photothermal therapy.
研究领域:
生物医学工程
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材料科学
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微生物学
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PubMed
高影响因子
Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy
·
2024
·
IF 1.4
Xie Huilong,Fu Yunrong,Lin Zhisheng,Wang Jiayi,Wu Jingyu,You Xiuhua,Xie Jieming
This study explores the synergistic effect of T-CUS 245C combined with cyclosporin A, and its possible mechanism. T-CUS 245C is an immunotoxin conjugated with tastuzumab and recombinant cucurmosin 245C (CUS 245C ). Cyclosporin A is a calcium antagonist mainly used as an immune-suppressive agent, which enhances the cytotoxicity of immunotoxins through an unknown mechanism. The sulforhodamine B assay, flow cytometry, DNA fragmentation apoptosis assay, and western blot analysis were used to evaluate the synergistic effects of cyclosporin A combined with T-CUS 245C on proliferation inhibition and apoptosis induction in SK-OV-3 ovarian cancer cells with HER-2-overexpressing. Meanwhile, using confocal microscopy and flow cytometry, the effect of cyclosporin A on the intracellular distribution of T-CUS 245C was observed and quantified. The results of this study showed that the combination index of cyclosporin A combined with T-CUS 245C is less than 0.7, indicating that cyclosporin A significantly enhances the proliferation inhibition and apoptosis induction induced by T-CUS 245C in SK-OV-3 cells. The confocal microscopy and flow cytometry results show that cyclosporin A effectively increases the dispersion of T-CUS 245C in the cytoplasm by promoting the endolysosomal escape. This study demonstrates that cyclosporin A combined with T-CUS 245C has a synergistic anticancer effect, by facilitating the release of T-CUS 245C in the intracellular space. Graphical Abstract
研究领域:
肿瘤学
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细胞生物学
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药理学
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DOI
高影响因子
Journal of Physical Chemistry C
·
2025
·
IF 3.2
Dan Wang,Yunhong Xie,Lingfan Xu,Yixuan Zhou,Kai Li,Zhongfeng Li
The development of bifunctional nanoplatform-based theranostics has garnered considerable attention in cancer therapy research. In this study, we engineer Gd2O3@SiO2-CuS nanorods as an integrated diagnostic-therapeutic system, simultaneously harnessing photothermal conversion and paramagnetic properties for MRI-assisted photothermal intervention. Hydrothermally synthesized Gd2O3 nanorods demonstrate superior T1-weighted contrast performance, achieving a longitudinal relaxivity (r1) of 4.2 mM–1·s–1, which compares favorably with that of commercial contrast agents. Furthermore, the strategically integrated CuS component exhibits remarkable photothermal conversion efficiency (19.6%) and sustained therapeutic stability. These attributes pave the way for achieving the application objective of magnetic resonance imaging-assisted photothermal therapy. Critically, comprehensive biosafety evaluations, including hemocompatibility assays and cytotoxicity profiling, confirm the nanocomposite’s favorable biocompatibility. The findings underscore the substantial potential of Gd2O3@SiO2-CuS nanorods for image-guided photothermal therapy applications.
研究领域:
医学影像学
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纳米医学
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癌症治疗
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高影响因子
MACROMOLECULAR MATERIALS AND ENGINEERING
·
2017
·Vol. 302
·期 11
·1700213
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IF 2.863
Kai Hou,Weijie Wu,Mengge Xia,Meifang Zhu
Thermosensitive nanocomposite (NC) hydrogels are considered as a significant kind of intelligent material to be utilized as sensor, biomaterial, drug carrier, etc. Recently, preparation of remotely controlled NC hydrogel with high-performance attracts more and more concern. To produce facile remote-stimuli thermosensitive NC hydrogel, a novel near-infrared (NIR) laser switched CuS/clay/poly(OEGMA- co -MEO 2 MA) hydrogel is demonstrated, which can be precisely remote-stimulated by NIR irradiation based on the excellent NIR photothermal conversion property of CuS nanoparticle. The temperature change of hydrogel is related to the NIR intensity, CuS content, and crosslinking density. Moreover, the influences on dimensional variation of hydrogel on macroscale are systematically studied, and the hydrogel as smart liquid valve is further utilized which can be remotely controlled by NIR switch on/off successfully. Cyclic test illustrates that this novel CuS/clay/poly(OEGMA- co -MEO 2 MA) hydrogel exhibits stable cyclic volume transition property which has promising applications in the areas of sensors, valves, and intelligent switches.
研究领域:
材料科学
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生物医学工程
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高影响因子
Research
·
2025
·
IF 10.7
Yongzhi Xiong,Mengyuan Qiu,Yihan Wang,Qi Liu,Dong Ouyang,Yajun Liu,Changzhou Chen,Jianchun Jiang,Mengmeng Fan,Kui Wang
Efficient utilization of renewable biomass resources is one of the feasible approaches to address the massive consumption of fossil fuels accompanying severe resource crises and environmental pollution. Currently, 2,5-furandicarboxylic acid derived from the oxidation of biomass-based 5-hydroxymethylfurfural (HMF) is a valuable chemical as the alternative to the fossil resource-derived terephthalic acid. However, the development of high-performance and low-cost Cu-based electrocatalysts for the efficient HMF oxidation reaction (HMFOR) remains an enormous challenge. Guided by our theoretical prediction, we proposed a coordination-pyrolysis strategy to fabricate highly dispersed copper sulfide (CuS) nanosheets supported on N-doped porous carbon precatalyst (CuS@NC). The covalent S species trigger the deep reconstruction of CuS nanosheets, and the in situ generated SO 4 2− not only promotes the formation of Cu 2+δ species but also facilitates the cleavage of α–C–H and –O–H bonds in HMF. The optimized CuS@NC achieved a high current density of 335 mA cm −2 at 1.50 V vs. reversible hydrogen electrode, representing a remarkable 628% enhancement over the control catalyst. This study integrates theoretical predictions with experimental investigations to systematically elucidate how S species promote the deep reconstruction of CuS nanosheets to enhance the HMFOR performance and proposes a scalable strategy for preparing ultra-uniform transition metal sulfide precatalysts.
研究领域:
电催化
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材料化学
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可再生能源
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生物质转化
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纳米材料
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DOI
PubMed
高影响因子
Inorganic and Nano-Metal Chemistry
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2022
·
IF 1.514
Haiyan Yu,Haiou Liang,Jie Bai,Chunping Li
SiO2-CNFs composites were prepared by electrospinning and calcination with change of the dosage of SiO2 nanoparticles into electrospinning precursor solution. CuS nanosheets were controllably grown on the surface of SiO2-CNFs through hydrothermal method, which was characterized by SEM, FTIR, TEM, XRD, and XPS techniques. The results showed that multi-hydroxyl on the surface of SiO2 provided active sites to attract Cu2+. Hence, SiO2 modified CNFs had the function of directional anchoring CuS nanosheets. The photocatalytic degradation of tetracycline using CuS-SiO2-CNFs was further investigated. Compared with CuS-CNFs and CuS-2%SiO2-CNFs samples, the CuS-1%SiO2-CNFs had the optimal photocatalytic activity, which was attributed to that CuS nanosheets were homogeneously dispersed on the surface of 1%SiO2-CNFs.
研究领域:
材料科学
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纳米技术
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环境科学
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化学
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高影响因子
MOLECULES
·
2019
·Vol. 24
·期 20
·3776
·
IF 3.06
Yunchang Fan,Yingcun Li,Xiaojiang Han,Xiaojie Wu,Lina Zhang,Qiang Wang
In this work, a two-phase system composed of hydrophobic ionic liquid (IL) and water phases was introduced to prepare copper sulfide (CuS) nanoparticles. It was found that CuS particles generated from the interfaces of carboxyl-functionalized IL and sodium sulfide (Na2S) aqueous solution were prone to aggregate into nanoplates and those produced from the interfaces of carboxyl-functionalized IL and thioacetamide (TAA) aqueous solution tended to aggregate into nanospheres. Both the CuS nanoplates and nanospheres exhibited a good absorption ability for ultraviolet and visible light. Furthermore, the CuS nanoplates and nanospheres showed highly efficient photocatalytic activity in degrading rhodamine B (RhB). Compared with the reported CuS nanostructures, the CuS nanoparticles prepared in this work could degrade RhB under natural sunlight irradiation. Finally, the production of CuS from the interfaces of hydrophobic IL and water phases had the advantages of mild reaction conditions and ease of operation.Keywords:ionic liquids (ILs);copper sulfide (CuS);nanoparticles;photocatalytic activity
研究领域:
材料科学
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环境科学
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DOI
PubMed
高影响因子
Nano-Micro Letters
·
2026
·Vol. 18
·期 1
·428
·
IF 38.5
Feng Yuhao,Zhao Jindi,Chen Keke,Li Yang,Liu Jiao,Yu Huitao,Qin Mulin,Jia Kaihang,Han Haiwei,Shen Zhenghui,Ma Mingliang,Chen Xiao
Designing multifunctional materials integrating efficient photoresponsive thermoelectric cogeneration with microwave absorption remains challenging for clean solar energy utilization and electromagnetic interference mitigation. Herein, this study proposes an innovative design strategy combining interfacial bridging engineering and physical encapsulation to construct advanced multifunctional composite phase change materials (PCMs). A nanoparticle-bridged 3D interpenetrating phonon network is constructed via in-situ growth of CuS nanoparticles on layered MXene, creating abundant interfacial sites for polyethylene glycol (PEG) adsorption and efficient electron transport channels for electromagnetic loss. The resulting PEG-MXene@CuS composite PCMs achieve an exceptional photothermal conversion efficiency of 94.5% (100 mW cm −2 ), enabled by broadband absorption of MXene nanosheets and plasmonic effect of CuS nanoparticles. In photoresponsive thermoelectric cogeneration system, PEG-MXene@CuS serves as a heat source to drive thermoelectric module through the Seebeck effect, yielding a stable power output of 21.7 W m −2 (100 mW cm −2 ), with PEG effectively buffering thermal fluctuations. Moreover, MXene@CuS heterointerface and 3D conductive network endow PEG-MXene@CuS with superior microwave absorption, a minimum reflection loss of − 55.5 dB and an effective bandwidth of 5.27 GHz. This design concept provides important insights into designing next‑generation multifunctional PCMs with promising applications in intelligent thermal management, thermoelectric cogeneration, and electromagnetic protection.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jiawei Dai,Dongdong Zhao,Deyu Zhu,Zijian Xin,Guichan Xu,Xueqi Hu,Zhuo Huang,Hongfang Liu,Guangfang Li
An electrochemical sensor for rapid and sensitive detection of methanogenic archaea has been developed through coenzyme M identification. • Synthesis of layered self-assembled CuS nanostructures with multiple hierarchical levels by simply adjusting the molecular weight of structural directing agents. • In situ techniques have revealed detailed information about the oxidation process of coenzyme M on the surface of CuS. Atmospheric greenhouse gas methane (CH 4 ) emission in lakes, strongly related to an anaerobic process mediated by methanogenic archaea, significantly influences carbon cycling and ecosystem stability. A real time monitoring of methanogenic abundance is essential for predicting climate change dynamics and evaluating ecosystem health. The detection of archaea characteristic coenzyme is an effective method for quantifying microbial populations. In this study, we synthesized layered self-assembly copper sulfide nanostructures (nanostar) with multiple hierarchical and rich active sites for the electrochemical identification of 2-mercaptoethanesulfonate (coenzyme M), a unique biomarker participating the final step of CH 4 production during methanogenic archaea's metabolism. The constructed CuS electrochemical sensor enables quantitative detection of methanogenic archaea through catalytic oxidation of coenzymes. In situ infrared spectroscopy and time-dependent Raman spectroscopy reveal detailed insights into the oxidation process of coenzyme M on the CuS surface. The peak current of the CuS electrochemical sensor exhibits a good linear relationship with the concentration of coenzyme M, demonstrating excellent resistance to interference and stability. Furthermore, a linear correlation was established between coenzyme M (Co M) concentration and methanogenic abundance. The developed CuS biosensor enabled rapid quantification of methanogens within a range of 10 3 –10 8 CFU/mL, and realized the detection of methanogenic archaea in the bottom water samples of Donghu lake as 2*10 7 CFU/mL. This work provides a scientific foundation for lake ecosystem assessments and global carbon cycle modeling. Download: Download high-res image (112KB) Download: Download full-size image
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高影响因子
APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Qin Huang,Chunling Xie,Xiufeng Xiao
Two primary obstacles impede the longevity of implants: bacterial infection and fixation loosening. This research introduces an innovative near-infrared (NIR) light-activated drug delivery system tailored to enhance the antimicrobial efficacy and bone integration of titanium-based implants. Titanium dioxide nanotube arrays (TNTs) were modified with epoxy for covalent bonding of therapeutic agents, and copper sulfide nanoparticles (CuS NPs) were added for regulated drug release. Alendronate sodium (ALN), an osteoporosis medication, was successfully bonded to the nanotubes. In vitro experiments showed that the release rate of ALN from TNTs-ALN reached 94 % within 36 h. In contrast, minimal release was observed in TNTs-ECH-ALN-CuS, which effectively addresses the prevalent issue of abrupt drug discharge typical in conventional delivery systems. In the context of NIR light exposure, the TNTs-ECH-ALN-CuS exhibited a notable ALN release efficacy of 48 %, demonstrating effective control over drug delivery. Additionally, the generation of ROS, coupled with temperature elevation under NIR exposure, endowed the modified TNTs with exceptional antibacterial efficacy, exceeding 99 % inhibition against E.coli and S.aureus . We observed a pronounced enhancement in the drug delivery mechanism, characterized by a reduction in the initial burst release and a sustained, controlled release, coupled with robust antibacterial action and notable biological performance.
研究领域:
生物医学工程
·
材料科学
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微生物学
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高影响因子
危险品化学品经营许可证（带存储）