ACS Nano
·
2024
·
IF 15.8
Xiaoyu Chen,Ning Huang,Danyang Wang,Miao Zhang,Xuyang Deng,Fangze Guo,Bingcheng Yi,Changqing Yuan,Qihui Zhou
Periodontitis, a prevalent chronic inflammatory disease worldwide, is triggered by periodontopathogenic bacteria, resulting in the progressive destruction of periodontal tissue, particularly the alveolar bone. To effectively address periodontitis, this study proposed a nanoformulation known as CuS@MSN-SCS. This formulation involves coating citrate-grafted copper sulfide (CuS) nanoparticles with mesoporous silica (MSNs), followed by surface modification using amino groups and sulfated chitosan (SCS) through electrostatic interactions. The objective of this formulation is to achieve efficient bacteria removal by inducing ROS signaling pathways mediated by Cu2+ ions. Additionally, it aims to promote alveolar bone regeneration through Cu2+-induced pro-angiogenesis and SCS-mediated bone regeneration. As anticipated, by regulating the surface charges, the negatively charged CuS nanoparticles capped with sodium citrate were successfully coated with MSNs, and the subsequent introduction of amine groups using (3-aminopropyl)triethoxysilane was followed by the incorporation of SCS through electrostatic interactions, resulting in the formation of CuS@MSN-SCS. The developed nanoformulation was verified to not only significantly exacerbate the oxidative stress of Fusobacterium nucleatum, thereby suppressing bacteria growth and biofilm formation in vitro, but also effectively alleviate the inflammatory response and promote alveolar bone regeneration without evident biotoxicity in an in vivo rat periodontitis model. These findings contribute to the therapeutic effect on periodontitis. Overall, this study successfully developed a nanoformulation for combating bacteria and facilitating alveolar bone regeneration, demonstrating the promising potential for clinical treatment of periodontitis.
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NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 10
·4507-4520
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IF 2.7
Luhua Wang,Yi Ren,Hongfang Zhao,Hongxia Li,Xiaohui Niu,Deyi Zhang,Haiyan Fan,Kunjie Wang
To address the water pollution problem caused by hexavalent chromium, this study took advantage of a multi-defect adsorption mechanism and constructed a multiple defect-containing type-II heterojunction material, CuS/Cv-CNNs. This material has simultaneous sulfur vacancies, copper vacancies, and carbon vacancies, which were used to accelerate the removal of chromium from wastewater. Attributed to the formation of electron-rich structures and free-moving ions by the construction of multiple defect sites, the photogenerated carriers generated by CuS/Cv-CNNs-70 were efficiently separated, and a high amount of physical Cr(VI) adsorption was achieved by electrostatic attraction and ion exchange, consistent with a Freundlich isothermal adsorption model. Studies on the adsorption thermodynamics demonstrate that CuS/Cv-CNNs-70 prefers to adsorb Cr(VI) when temperatures are raised. In addition, the removal of Cr(VI) (120 mg L−1) by CuS/Cv-CNNs-70 reached 97.10% after 60 minutes through the synergistic effect of adsorption and visible-light photocatalysis. This finding indicates that the synergistic effect between the multilocation defects stimulated the combined potential of adsorption and photocatalysis of CuS/Cv-CNNs-70 to realize the full utilization of the defects. In conclusion, this study confirms the prominent role of a multiple defect mechanism in wastewater treatment and environmental protection.
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Journal of Water Process Engineering
·
2024
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IF 6.3
Meng Li,Weiji Sun,Wangkai Hui,Lang Liu
Photocatalytic oxidation technology is a green and low carbon approach for degradation of mineral processing wastewater, which is extensively applied to ecological environment restoration. In this research, coal gangue-ZnS/CuS pyroelectric/photothermal composite photocatalyst is constructed by high temperature calcination method. The temperature difference between heat converted from light energy absorbed by CuS and the circulating condensate water provides the impelling force for the pyroelectric effect. The porous structure of coal gangue acts as a “heat capacitor”, which furnishes greater temperature fluctuation for pyroelectric effect. Furthermore, the hydroxyl groups on the surface of coal gangue can availably adsorb oxygen and facilely form superoxide radicals with electrons. The degradation efficiency of xanthate is as high as 99.5 % within 50 min. This research has significant implications for designing and developing highly efficient photocatalysts for the degradation of mining wastewater.
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Science China-Materials
·
2024
·Vol. 67
·期 12
·4021-4030
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IF 6.8
Guan Hong-Zhou,Wang Zhan-Zhan,Wang Meng-Qi,Zhai Hua-Zhang,Cao Mao-Sheng
The study of high-performance multifunctional electromagnetic materials is one of the inevitable challenges in the field of electromagnetic wave (EMW) absorption. In order to improve the attenuation ability of EMW and broaden the frequency range of absorbing materials, rational design of material structure and interface is an important way to optimize the effective absorption bandwidth (EAB). Therefore, enhanced-interface and strongly polarized CuS/Ti 3 C 2 T X composites were successfully synthesized by in-situ etching, sacrificial template and freeze-drying techniques. Its EMW absorption performance was improved by optimizing the hybridization ratio and loading content. The maximum reflection loss of CuS@Ti 3 C 2 T X (mass ratio = 5:5) is −54.6 dB and the maximum EAB covering the major of Ku band is 4.72 GHz due to the interface polarization, multiple scattering and dipole polarization. In addition, the electromagnetic interference shielding performance of CuS@Ti 3 C 2 T X (mass ratio = 3:7) is up to 23.9 dB. A new heterodimensional structure was developed by the spherical structure and lamellar, which realizes the broadband EMW absorption and electromagnetic protection.
研究领域:
材料科学
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电磁学
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纳米复合材料
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功能材料
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微波工程
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MICROCHEMICAL JOURNAL
·
2025
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IF 5.1
Jinqiu Xu,Haoyu Chen,Jing Liu,Jianru Tang,Xiaohua Zhu,Sheng Yang,Shu Huang,Youyu Zhang,Meiling Liu
The development of analytical methods capable of simultaneously detecting multiple components in biological samples holds significant potential for advancing disease diagnosis. However, constructing optical platforms for continuous detection remains challenging due to limitations such as insufficient selectivity, specificity, response speed, and sensitivity. Herein, we developed a facile and efficient microwave-assisted method to rapidly synthesize CuS quantum dots (QDs) and constructed a fluorescence-based sensing platform for detecting Ag + and glutathione (GSH). The fluorescence emission of CuS QDs at 500 nm was selectively quenched upon interaction with Ag + , exhibiting a linear correlation with Ag + concentrations ranging from 0.3 to 300 μM. Notably, the quenched fluorescence could be restored by introducing GSH, accompanied by a slight redshift in the emission wavelength. This Ag + -mediated “off-on” fluorescence sensing mechanism significantly enhanced the sensitivity for GSH detection. This platform demonstrated high selectivity towards both Ag + and GSH, enabling their quantitative determination in complex matrices, including tap water, human serum, and cell lysate. This work not only presents a novel synthetic approach for CuS QDs but also achieves successive detection of Ag + and GSH without requiring complex probe modifications or the integration of multiple nanomaterials, representing a simplified yet highly effective design compared to more intricate systems. The proposed platform serves as a versatile measurement tool applicable across various fields, from environmental contaminant monitoring to the detection of key biological thiols, demonstrating a generalizable strategy for diverse analytical scenarios in both environmental and clinical contexts.
研究领域:
分析化学
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纳米生物学
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生物医学工程
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分子诊断
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环境监测
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临床检验
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药物代谢
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Dong Wang,Feng Yuan,Xuliang Deng,Haoyang Li,Siyang Nie,Qingda Liu,Xun Wang
Therapy based on heat and reactive oxygen species (ROS) generation have attracted increasing attention, while the weak photothermal ability and low ROS production have severely limited the efficiency of the tumor treatment. Here, 2D ultrathin CuS-phosphomolybdic acid (PMA) nanosheets are synthesized at sub-nanoscale. Typically, the improved second near-infrared light (NIR-II) light absorption, small bandgap, fast hot carrier response, abundant oxygen vacancies, and the electron delocalization between closely connected PMA and CuS units in sub-nanoscale result in the notably enhanced NIR-II photothermal therapy (PTT) performance of CuS-PMA. The reversible redox of Mo active sites in PMA provides basis for glutathione (GSH) depletion while triggering chemodynamic therapy (CDT) in the tumor microenvironment (TME), and the heat produced by the PTT greatly promotes the CDT and GSH depletion, where CuS-PMA presents sevenfold more ROS generation and fourfold more GSH depletion under PTT. In addition, the ROS generation/GSH depletion can downregulate heat shock proteins, weakening the heat resistance of tumor cells and thereby amplifying the killing effect of PTT. Moreover, the combination of antiprogrammed death-ligand 1 (αPD-L1) with the treatment of CuS-PMA promote the immunotherapy, resulting in the suppression of untreated abscopal tumors.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Qingao Wang,Shang Tang,Fangze Guo,Yunqi Feng,Yabo Li,Mengqing Gong,Yu Zhang,Caiyi Zhang,Li Mei,Youbin Wang,Daishuo Zhang,Wen Su,Changqing Yuan
Periodontitis is a chronic infectious disease caused by bacteria, characterized by progressive destruction of periodontal soft and hard tissues, ultimately leading to tooth loss. To treat periodontitis, this study combined the advantages of nanoparticles and hydrogels, and successfully developed an injectable aldehyde-functionalized PF127, carboxymethyl and sulfonated chitosan hydrogel doped with copper sulfide nanoparticles (CuS/PCS). The CuS/PCS hydrogel was synthesized through a dynamic Schiff base reaction. The injectable hydrogel forms a gel in situ after injection into deep periodontal pockets, achieving high antibacterial activity without causing bacterial resistance. The CuS/PCS hydrogel exhibited good biocompatibility, maintained cell viability, promoted stem cell proliferation, and demonstrated significant antimicrobial activity. In the rat periodontitis model, the CuS/PCS hydrogel effectively reduced inflammation and bone loss, and promoted periodontal tissue regeneration. These results suggest that CuS/PCS hydrogel could be a promising biomaterial for the treatment of periodontitis.
研究领域:
生物材料学
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口腔医学
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纳米医学
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Cell Reports Physical Science
·
2022
·
IF 7.832
Han Man,Jingjing Feng,Shaofei Wang,Shuyang Li,Peng Li,Huiwen He,Wioletta Raróg-Pilecka,Jie Zhao,Jichao Zhang,Fang Fang,Dalin Sun,Yongtao Li,Yun Song
Transition-metal chalcogenides (TMCs) show great potential as highly efficient and cost-effective electrocatalysts for oxygen evolution reaction (OER). Yet the electrochemical conversion into oxides/hydroxides remains poorly understood. In this work, we develop a built-in, electric-field-induced surface reconstruction strategy for ultra-fast self-activation of transition metal sites in self-supporting CoS 2 /CuS heterostructures. The activated CoS 2 /CuS grown on carbon cloth with oxygenated surface species displays an outstanding OER electrocatalytic activity with ultra-low overpotentials of only 136 mV at the current density of 10 mA cm −2 and 266 mV at 100 mA cm −2 in 1.0 M KOH. Comparative studies via synchrotron radiation X-ray absorption spectroscopy and theoretical calculations are employed to elucidate that the built-in electric field within heterointerfaces significantly promotes the reconstruction efficiency by decreasing the formation energy of (oxy)hydroxide species. We believe this work provides new perspectives to conceive catalysts with ultra-low overpotentials and complements the fundamental comprehension of TMCs’ self-reconstruction mechanism.
研究领域:
材料科学
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电化学
·
催化科学
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高影响因子
CERAMICS INTERNATIONAL
·
2021
·Vol. 47
·期 21
·30860-30868
·
IF 4.527
Junwei Hou,Bingxuan Huang,Lingcong Kong,Yu Xie,Yansheng Liu,Mengmeng Chen,Qingyao Wang
TiO 2 nanotube arrays (TiO 2 NTs) were regarded as the outstanding semiconductors for the photocatalytic application in waste water treatment and H 2 generation, and CdS nanoparticles as the visible light sensitizers were traditionally used to enhance the photocatalytic performance. In this paper, CdS–CuS co-sensitizers were deposited on TiO 2 NTs by one-pot hydrothermal method , and the Cu/Cd ratio was changed to adjust the hybrid photocatalyst composition and electron transfer . The photocatalytic data indicated that suitable CdS–CuS composition could effectively enhance the photocatalytic pollutant removal and photocurrent/H 2 evolution and the hybrid photocatalyst also exhibited the high stability by the inhibition of CdS photocorrosion. The p-n heterojunction construction of TiO 2 NTs/CdS–CuS benefited the solar response, photoelectron separation and photocatalytic reaction, and the photocatalytic mechanism and photoelectron transfer were investigated. The p-n heterojunctional photocatalyst is supposed to apply in environmental remediation and new energy development.
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Journal of the Taiwan Institute of Chemical Engineers
·
2026
·
IF 6.9
Liu Yang,Yao Ge,Qian Zhou,Xinlei Wang,Yu Xue,Chenglong Xu,Shengqiong Fang
Background This study focuses on the dual issues of catalyst metal agglomeration and metal ion leaching in heterogeneous Fenton reactions, which lead to catalyst inefficiency and secondary metal ion pollution, particularly resulting in significantly insufficient degradation efficiency for persistent antibiotics such as sulfisoxazole (SIZ). Methods The catalyst of copper sulfide-loaded peanut shell biochar catalyst (CCS) was synthesized using a low-temperature hydrothermal method with biochar as the substrate, which was then assessed for its ability to activate hydrogen peroxide system. Advanced characterizations (XRD, SEM, BET, FTIR, EIS, and XPS) were combined with EPR analysis, and DFT calculations to elucidate the structure–property–activity relationship. Additionally, degradation pathways and the toxicity of transformation products were identified by LC-MS and ECOSAR. Significant Findings The CCS catalyst achieved exceptional sulfisoxazole (SIZ) removal (98.4%) under optimal conditions. This high efficiency persisted across a wide pH range and through five reuse cycles, accompanied by consistently negligible copper leaching, confirming superior activity and stability. Mechanistic analysis identified ·OH and O₂·⁻ as the dominant reactive species driving degradation. Furthermore, identified degradation pathways yielded transformation products exhibiting reduced acute and chronic toxicity. Critically, the carbon substrate effectively mitigates metal agglomeration and leaching, underpinning the catalyst's robust performance.
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ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Pengpeng Jia,Yu Zou,Jiang Jiang
Developing antibacterial hydrogels, with good mechanical strength and self-healing ability to resist bacterial invasion and accelerate skin regeneration, is critical for infected full-thickness skin wound treatment. Herein, we report a gelatin-assisted synthesis and direct incorporation strategy to construct a CuS hybrid hydrogel for infected wound healing applications. CuS nanodots (NDs) were synthesized directly inside a gelatin host matrix (Gel-CuS), and these tightly confined and evenly distributed CuS NDs displayed superb dispersibility and stability against oxidation. Gel-CuS was then used to crosslink with oxidized dextran (ODex) to form a Gel-CuS-8/ODex hydrogel (8 stands for the concentration of CuS, in mM) via a facile Schiff-base reaction, which exhibited improved mechanical properties, excellent adhesion and self-healing ability, suitable swelling and degradation behavior, and good biocompatibility. The Gel-CuS-8/ODex hydrogel can act as an efficient antibacterial agent due to its photothermal and photodynamic properties under a 1064 nm laser irradiation. Furthermore, in animal experiments, when being applied as wound dressing, the Gel-CuS-8/ODex hydrogel significantly promoted infected full-thickness cutaneous wound healing through improved epidermis and granulation tissue formation and accelerated generation of new blood vessels, hair follicles, and collagen deposition after proper near-infrared irradiation treatment. This work provides a promising strategy to synthesize functional inorganic nanomaterials tightly and evenly embedded inside modified natural hydrogel networks for wound healing applications.
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International Journal of Nanomedicine
·
2023
·
IF 8
Xiangyang Cheng,Dejian Li,Aiqi Lin,Jun Xu,Liang Wu,Huijie Gu,Zhongyue Huang,Jiangyi Liu,Yiming Zhang,Xiaofan Yin
Introduction For an ideal drug delivery system, the outstanding drug-loading capacity and specific control of the release of therapeutics at the desired lesions are crucial. In this work, we developed a triple-responsive nanoplatform based on copper sulfide (CuS)-capped yolk−shell-structured periodic mesoporous organosilica nanoparticles (YSPMOs) for synergetic chemo-photothermal therapy.Methods Herein, the YSPMOs were employed as a drug carrier, which exhibited a high doxorubicin (DOX) loading capacity of 386 mg/g. In this controlled-release drug delivery system, CuS serves as a gatekeeper to modify YSPMOs with reduction-cleavable disulfide bond (YSPMOs@CuS). CuS could not only avoid premature leakage in the delivery process, but also endowed the excellent photothermal therapy (PTT) ability.Results Upon entering into cancer cells, the CuS gatekeeper was opened with the breaking of disulfide bonds and the DOX release from YSPMOs(DOX)@CuS in response to the intracellular acidic environment and external laser irradiation. Such a precise control over drug release, combined with the photothermal effect of CuS nanoparticles, is possessed by synergistic chemo-photothermal therapy for cancer treatment. Both in vitro and in vivo experimental data indicated that the synergistic effect of YSPMOs(DOX)@CuS showed efficient antitumor effect. In addition, low systemic toxicity was observed in the pathologic examinations of liver, spleen, lungs, and kidneys.Conclusion This versatile nanoplatform combination of PTT, chemotherapeutics, and gating components shows general potential for designing multifunctional drug delivery systems.
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