JOURNAL OF APPLIED POLYMER SCIENCE
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2024
·
IF 2.7
Yujie Qi,Haoqi Zhai,Xing Huang,Mengquan Shi,Yuxi Zhang,Yuxia Zhao
As the largest renewable source of aromatic feedstock in nature, lignin has good thermal stability, strong ultraviolet (UV) absorption, and mechanical reinforcing property. In this study, a lignin-based Type I macromolecular photoinitiator (macro PI) named DAL-11ene-TPO is designed and synthesized through covalently grafting 10-undecenoyl chloride (11ene) and 2,4,6-trimethylbenzoyl-ethoxy-phenylphosphine oxide (TPO-L, a commercial small molecular PI) into dealkaline lignin (DAL) skeleton. A series of characterizations were performed to prove that DAL-11ene-TPO was synthesized successfully, including 1 H NMR, FTIR, UV–vis, 31 P NMR, GPC (gel permeation chromatography). The formed active free radicals were monitored by electron spin resonance (ESR). DAL-11ene-TPO can high-efficiently initiate the monomers polymerization upon the irradiation of 405 nm LED. The resulting polymer films showed strong UV-blocking performance and good visible light transmittance. Moreover, the elongation at break of the polymer film containing 0.5% DAL-11ene-TPO is improved by 50% compared with that of TPO-L control group. Furthermore, DAL-11ene-TPO has polymerizable groups, which can be bonded into the network of the polymers, resulting in a high biosafety of the end products. The results indicate that DAL-11ene-TPO can be used as a high-efficient bio-based macro PI for preparing high performance UV-blocking films.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2010
·Vol. 117
·期 1
·235-242
·
IF 1.203
Hongtao Liu,Weilin Xu,Sanping Zhao,Jingjing Huang,Hongjun Yang,Yunli Wang,Chenxi Ouyang
Biomedical polyurethane (PU) and silk fibroin have similar molecular architecture in their primary and aggregate structure, both of which have imido bonds and microphase separation, and they have been employed as scaffold materials for biomedical applications. As the featured peptide sequence of silkworm silk protein, GlyAlaGlyAla (GAGA) tetrapeptide was synthesized by using traditional liquid-phase peptide synthesis method with Boc-protected alanine and glycine as starting materials, and was transformed to its derivative with two end-amido groups. The derivative was incorporated into the backbone of the classical synthetic copolyurethane as a chain extender to form a silk-inspired polyurethane. Elemental analysis showed the nitrogen content in the silk-inspired PU was higher than that in the butanediol-extended PU but lower than the theoretical value, indicating the chain extender containing GAGA was partially incorporated into the PU chain. The results from 1 H-nuclear magnetic resonance, Fourier transform infrared spectra, Raman scattering spectra and pyrolysis-gas chromatography/mass spectrometry qualitatively identified the primary structure of the silk-inspired polyurethane. This concept and strategy may allow the fabrication of a new class of thermoplastic polyurethane elastomer to mimic the structure and properties of silk fibers if in fiber form, which combines traditional synthetic polymer chains with peptide sequences. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2010
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高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2011
·Vol. 51
·期 11
·2254-2260
·
IF 1.296
Huiqin Lian,Shuxin Li,Kelong Liu,Liangrui Xu,Kuisheng Wang,Wenli Guo
Butyl rubber, IIR nanocomposites based on modified graphene sheets, were fabricated by solution processing followed by compression molding. MG was prepared from natural graphite, NG through graphite oxide route. X-ray diffraction showed that the exfoliated MG was homogeneously dispersed in the IIR matrix with doping levels of 1-10 wt% as evidenced by the lack of the characteristic graphite reflection in the composites. In contrast, the graphite retained its stacking order and showed the sharp characteristic peak in the NG-IIR composites. Scanning electron microscope images of the fracture surfaces of the IIR matrix showed that MG nanofillers exhibited better compatibility than NG did. The mechanical properties of the MG-IIR nanocomposites were significantly improved due to the efficient distribution of the large surface area MG sheet. The tensile modulus of nanocomposite with doping level of MG 10 wt% was 16 times that of the pure IIR. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers
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JOURNAL OF MEDICINAL CHEMISTRY
·
2025
·
IF 6.8
Fei Cai,Jinrong Dong,Peng Xie,Hanlong He,Huiyi Yao,Junxian Guo,Zhibo Yan,Li Ma,Tianfeng Chen
Developing structurally well-defined targeted drugs is an effective way to enhance the chemotherapy efficacy. Herein, a target mitochondrial complex I (complex I) inhibitor was developed for the key methylation site ARG-85 in the key subunit NDUFS2. Based on the unique :NH═C– group of guanidyl and the surrounding environment of ARG-85, the macrocyclic and bulky manganese porphyrin complex [MnIII(TTPPC2–)]+ was selected to insert into the gap of NDUFS2. Experimental and computational analyses revealed that the planar π system of the TTPPC2– ligand and the rotatable benzene ring stably bind between the :NH═C– group of ARG-85 and the manganese metal center, a medium-strong Lewis acid. The Mn-specific recognition of guanidine drives the selective inhibition of complex I activity. Further, MnIII(TTPPC2–)]+ was modified into targeted nanoformulation Mn NPs. In vitro and in vivo experiments confirmed the efficient and mechanism inhibition of complex I activity, offering a novel strategy for targeted drug development.
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高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Qingrui Li,Chenyong Chen,Xiaoqin Li,Yajing Huang,Weizhen Liu,Zhang Lin,Liyuan Chai
Thallium (Tl) is a trace metal with high toxicity and exists in the aquatic environment as Tl(III) and Tl(I). Tl(I) is a major species in industrial wastewater and natural water, which has high solubility, stability, and mobility and is difficult to remove. In this study, Prussian blue–zerovalent iron nanoparticles (PB-nZVI) were successfully prepared at room temperature. The performance of PB-nZVI in removing Tl(I) was studied and compared with PB and nZVI. The experimental results showed that PB-nZVI can remove Tl(I) efficiently (>97%) in a pH range of 3–9, while the highest removal rates of PB and nZVI for Tl(I) were only 83.8% and 53.1% (pH = 9), respectively. Additionally, the variation of Tl(I) removal efficiency in different relative parameters has been studied, such as Tl(I) initial concentration, dosage of absorbent materials, and coexisting cations (K+, Ni2+, Pb2+, Zn2+, Ca2+, Mg2+, Cd2+, and Cu2+). PB-nZVI showed extremely high selectivity for Tl(I), and the efficiency of Tl(I) removal was slightly affected by the coexisting cations with 100 and 1000 mg/L. However, the Tl(I) removal by PB and nZVI was significantly inhibited under identical conditions. The involved mechanisms are as follows: adsorption, precipitation, and ion exchange. The synergistic effect of PB and nZVI enables PB-nZVI to efficiently remove thallium from wastewater.
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MOLECULES
·
2024
·Vol. 29
·期 8
·1721
·
IF 4.2
Shoudong Wang,Lei Zhou,Hongyun Qin,Zixu Dong,Haoyuan Li,Bo Liu,Zhilu Wang,Lina Zhang,Qiang Fu,Xia Chen
Hydrofluorocarbons (HFCs) have important applications in different industries; however, they are environmentally unfriendly due to their high global warming potential (GWP). Hence, reclamation of used hydrofluorocarbons via energy-efficient adsorption-based separation will greatly contribute to reducing their impact on the environment. In particular, the separation of azeotropic refrigerants remains challenging, such as typical mixtures of CH2F2(HFC-23) and CHF3(HFC-32), due to a lack of adsorptive mechanisms. Metal–organic frameworks (MOFs) can provide a promising solution for the separation of CHF3–CH2F2mixtures. In this study, the adsorption mechanism of CHF3–CH2F2mixtures in TIFSIX-2-Cu-i was revealed at the microscopic level by combining static pure-component adsorption experiments, molecular simulations, and density-functional theory (DFT) calculations. The adsorption separation selectivity of CH2F2/CHF3in TIFSIX-2-Cu-i is 3.17 at 3 bar under 308 K. The existence of similar TiF62−binding sites for CH2F2or CHF3was revealed in TIFSIX-2-Cu-i. Interactions between the fluorine atom of the framework and the hydrogen atom of the guest molecule were found to be responsible for determining the high adsorption separation selectivity of CH2F2/CHF3. This exploration is important for the design of highly selective adsorbents for the separation of azeotropic refrigerants.
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ACS Nano
·
2025
·
IF 16
Cuicui Li,Haocheng Li,Xiuyun Ren,Liang Hu,Jiaojiao Deng,Jinhan Mo,Xiaoqi Sun,Guohua Chen,Xiaoliang Yu
The multielectron conversion electrochemistry of I–/I0/I+ enables high specific capacity and voltage in zinc–iodine batteries. Unfortunately, the I+ ions are thermodynamically unstable and are highly susceptible to hydrolysis. Current endeavors primarily focus on exploring interhalogen chemistry to activate the I0/I+ couple. However, the practical working voltage is below the theoretical level. In this study, the I0/I+ redox couple is fully activated, and I+ is efficiently stabilized by a chelation agent of cost-effective urea in the conventional aqueous electrolyte. A record-high plateau voltage of 1.8 V vs Zn/Zn2+ has been realized. Theoretical calculations combined with spectroscopy studies and electrochemical tests reveal that the coordination between the electron-deficient I+ and the electron-rich O and N atoms in urea molecules is thermodynamically favorable for I0/I+ conversion and inhibits the self-disproportionation of I+, which in turn promotes rapid kinetics and excellent reversibility of I0/I+. Moreover, urea decreases the water activity in the electrolyte by forming hydrogen bonds to further suppress the hydrolysis of I+. Accordingly, a high specific capacity of 419 mAh g–1 is delivered at 1C, and 147 mAh g–1 capacity is retained after 10,000 cycles at 5C. This work offers effective insights into formulating halogen-free electrolytes for high-performance aqueous zinc–iodine batteries.
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ADVANCED MATERIALS
·
2025
·
IF 26.8
Yinghao Ding,Xueying Zhu,Jian Wen,Junchao Xiong,Shengyi Zhang,Zhimou Yang,Zhi-Wen Hu
Antigen presentation deficiency restricted by class I major histocompatibility complex (MHC-I) causes low antigenicity and antigen escape in tumors, thereby limiting T-cell immunotherapy outcomes. Here, a combined tumor immunotherapy is developed, in which tumors can present exogenous non-tumor antigens, and adoptively transferred CD8 + T cells specific for these antigens are re-targeted to attack tumors. The approach leverages a cascade-responsive peptide self-assembly to co-deliver suitable antigens and the chemotherapeutic drug camptothecin (CPT) to tumors. As a proof-of-concept, to re-target ovalbumin (OVA)-specific OT-I CD8 + T cells against tumors, PSA (Nap-GFFpYE-ss-Ag) and CPSA (CPT-GFFpYE-ss-Ag) are constructed, containing an OVA-derived epitope OVA 257-264 and/or CPT. The design enables the release of a unique N-terminal extended OVA 257-264 and CPT into the cytosol. As a result, the extended antigen is efficiently presented on the tumor surface by MHC-I, and CPT further enhances this presentation. When combined with adoptively transferred OT-I CD8 + T cells, the approach effectively facilitates CD8 + T cell infiltration and tumor inhibition. Additionally, CPSA treatment sensitizes immune responses to programmed cell death-ligand 1 (PD-L1) blockade, allowing the approach to synergize with an anti-PD-L1 antibody for improved tumor eradication.
研究领域:
肿瘤免疫学
·
纳米医学
·
药物递送系统
·
免疫治疗
·
分子自组装
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高影响因子
AQUACULTURE
·
2025
·
IF 3.9
Shuai Zhang,Siying Li,Huili Tian,Ming'ao Wang,Mingsheng Lyu,Shujun Wang
Decapod Iridescent Virus 1 (DIV1) leads to high mortality rates in shrimp farming, significantly impacting the aquaculture industry economically. Currently, there are no effective treatments for controlling DIV1 infections, and management primarily relies on preventative measures. Rapid and precise diagnosis of DIV1 is crucial. In this study, we identified two DNA enzymes, MCP-1 and MCP-8, that can specifically recognize DIV1 via in vitro selection. The detection limit of MCP-1 was 6.89 copies/μL of DIV1. We developed a DNAzyme-based “turn off” biosensor for quick detection of DIV1, which is both highly specific and sensitive, by integrating SYBR Green I to enhance the signal. The detection limit of biosensor could reach 2.01 copies/μL of DIV1. Compared to conventional detection methods, this sensor delivers results in 5 min without the need for complex procedures, greatly streamlining the detection process.
研究领域:
分子生物学
·
水产养殖学
·
病毒学
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高影响因子
CRYSTENGCOMM
·
2016
·Vol. 18
·期 40
·7737-7744
·
IF 3.849
Ming Zhao,Xinyue Niu,Liao Guan,Haolei Qian,Wei Wang,Jian Sha,Yewu Wang
The growth of high-quality black phosphorus crystals is very important to further study the physical properties of two-dimensional black phosphorus exfoliated from bulk crystals. Herein, we designed a series of experiments to fully understand the growth of black phosphorus crystals and then explore the roles of metals (or alloys) and I elements in its growth process. Finally, we developed a general approach to grow black phosphorus in high yield with high quality and low cost. The work introduced here sheds light on the growth mechanism of black phosphorus crystals and opens up the possibility of the growth of black phosphorus thin film.
研究领域:
材料科学
·
物理化学
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高影响因子
Animal Nutrition
·
2026
·
IF 8.3
Wang F,Bao Y,Zhao Y,Lai J,Yu E,Jiang F,Xu J.
The physiological impacts of bile acids (BA) conjugation states remain underexplored in aquatic species. This study investigated the effects of supplementing conjugated BA (bile salts [BS]) or non-conjugated BA (free bile acids [FBA]) on the intestinal health of pearl gentian grouper ( Epinephelus fuscoguttatus ♂ × Epinephelus lanceolatus ♀) fed a high plant-protein diet for 8 weeks. A total of 300 healthy juveniles (approximately 90-d-old; initial body weight 15.21 ± 0.04 g) were randomly distributed into four dietary groups in triplicate (25 fish per tank): CD group (a fishmeal-based control diet [CD]), PD group (a plant protein-based diet [PD], with 50% fishmeal replaced by cottonseed protein concentrate), BS group (PD supplemented with 0.09% BS), and FBA group (PD supplemented with 0.09% FBA). Compared to the CD group, the PD group significantly impaired growth performance (final body weight and weight gain rate), gut morphology (muscle thickness, plica height, and width), and induced inflammatory response, oxidative stress, endoplasmic reticulum stress, cell apoptosis, and dysregulated amino acid metabolism ( P P P < 0.05). In conclusion, BS, but not FBA, effectively attenuates intestinal damage and promotes health in groupers fed high plant-protein diets, highlighting the critical importance of BA conjugation in nutritional interventions.
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高影响因子
Marine Drugs
·
2020
·Vol. 18
·期 11
·526
·
IF 4.073
Bihong Hong,Jianlin He,Chaochun Fan,Chao Tang,Qingqing Le,Kaikai Bai,Siwen Niu,Meitian Xiao
In recent years, a large number of pharmacologically active compounds containing a butenolide functional group have been isolated from secondary metabolites of marine microorganisms. Butyrolactone I was found to be produced byAspergillus terreusisolated from several marine-derived samples. The hypoglycemic activity of butyrolactone I has aroused our great interest. In this study, we synthesized six racemic butenolide derivatives (namely BL-1–BL-6) by modifying the C-4 side chain of butyrolactone I. Among them, BL-3 and BL-5 improved the insulin resistance of HepG2 cells and did not affect the proliferation of RIN-m5f cell line, which indicated the efficacy and safety of BL-3 and BL-5. Furthermore, BL-3, BL-4, BL-5, and BL-6 displayed a significant protein tyrosine phosphatase 1B (PTP1B) inhibitory effect, while the enantiomers of BL-3 displayed different 50% percentage inhibition concentration (IC50) values against PTP1B. The results of molecular docking simulation of the BLs and PTP1B explained the differences of biological consequences observed between the enantiomers of BL-3, which supported BLs as PTP1B inhibitors, and also indicated that the chirality of C-4 might influence the inhibitory effect of the BLs. Our findings provide a novel strategy for the development of butyrolactone derivatives as potential PTP1B inhibitors for the treatment of type 2 diabetes mellitus.Keywords:butenolide;insulin resistance;secondary metabolites;chirality
研究领域:
药理学
·
生物化学
·
药物化学
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高影响因子
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