ACS Nano
·
2022
·
IF 18.027
Yingying Li,Peisen Zhang,Wen Tang,Kevin J. McHugh,Stephen V. Kershaw,Mingxia Jiao,Xiaodan Huang,Sergii Kalytchuk,Collin F. Perkinson,Saisai Yue,Yuanyuan Qiao,Lichong Zhu,Lihong Jing,Mingyuan Gao,Buxing Han
Improving the effectiveness of cancer therapy will require tools that enable more specific cancer targeting and improved tumor visualization. Theranostics have the potential for improving cancer care because of their ability to serve as both diagnostics and therapeutics; however, their diagnostic potential is often limited by tissue-associated light absorption and scattering. Herein, we develop CuInSe2@ZnS:Mn quantum dots (QDs) with intrinsic multifunctionality that both enable the accurate localization of small metastases and act as potent tumor ablation agents. By leveraging the growth kinetics of a ZnS shell on a biocompatible CuInSe2 core, Mn doping, and folic acid functionalization, we produce biocompatible QDs with high near-infrared (NIR)-II fluorescence efficiency up to 31.2%, high contrast on magnetic resonance imaging (MRI), and preferential distribution in 4T1 breast cancer tumors. MRI-enabled contrast of these nanoprobes is sufficient to timely identify small metastases in the lungs, which is critically important for preventing cancer spreading and recurrence. Further, exciting tumor-resident QDs with NIR light produces both fluorescence for tumor visualization through radiative recombination pathways as well as heat and radicals through nonradiative recombination pathways that kill cancer cells and initiate an anticancer immune response, which eliminates tumor and prevents tumor regrowth in 80% of mice.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2022
·
IF 14.903
Lujing Geng,Tong Lu,Huaqing Jing,Yue Zhou,Xiaoyang Liang,Jiao Li,Nan Li
Ferroptosis (FPT), a novel form of programmed cell death, is characterized by overwhelming iron/reactive oxygen species (ROS)-dependent accumulation of lipid peroxidation (LPO). However, the insufficiency of endogenous iron and ROS level limited the FPT therapeutic efficacy to a large extent. To overcome this obstacle, the bromodomain-containing protein 4 (BRD 4 )-inhibitor (+)-JQ1 (JQ1) and iron-supplement ferric ammonium citrate (FAC)-loaded gold nanorods (GNRs) are encapsulated into the zeolitic imidazolate framework-8 (ZIF-8) to form matchbox-like [email protected] /ZIF-8 for the amplified FPT therapy. The existence of matchbox (ZIF-8) is stable in physiologically neutral conditions but degradable in acidic environment, which could prevent the loaded agents from prematurely reacting. Moreover, GNRs as the drug-carriers induce the photothermal therapy (PTT) effect under the irradiation of near-infrared II (NIR-II) light owing to the absorption by localized surface plasmon resonance (LSPR), while the hyperthermia also boosts the JQ1 and FAC releasing in the tumor microenvironment (TME). On one hand, the FAC-induced Fenton/Fenton-like reactions in TME can simultaneously generate iron (Fe 3+ /Fe 2+ ) and ROS to initiate the FPT treatment by LPO elevation. On the other hand, JQ1 as a small molecule inhibitor of BRD 4 protein can amplify FPT through downregulating the expression of glutathione peroxidase 4 (GPX4), thus inhibiting the ROS elimination and leading to the LPO accumulation. Both in vitro and in vivo studies reveal that this pH-sensitive nano-matchbox achieves obvious suppression of tumor growth with good biosafety and biocompatibility. As a result, our study points out a PTT combined iron-based/BRD 4 -downregulated strategy for amplified ferrotherapy which also opens the door of future exploitation of ferrotherapy systems.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2021
·
IF 5.097
Leilei Sun,Sisi Shi,Hongchao Geng,Yao Huang,Yan Qiao,Jie Song,Lan Yang,Craig A. Grimes,Xinxin Feng,Qingyun Cai
Bacterial infections are a serious ongoing threat to human health. As such, within the context of modern technology, there is an urgent need to develop fluorescent probes suitable for diagnosing bacterial infections in vivo. Herein, we synthesize NaGdF4:Nd@NaGdF4 core-shell down-conversion nanoparticles (DCNPs) demonstrating excellent emission intensity in the second near-infrared (NIR-II) window for use as fluorescent probes to enable high-quality imaging of pathogenic infections. The fluorescent probe is covalently linked with vancomycin (Van), which specifically binds to Gram-positive bacteria such as S. aureus. Both in vitro detection and in vivo imaging results show that the Van-modified NIR-II fluorescent probe can distinguish Gram-positive from Gram-negative bacteria with a high degree of selectivity. Biocompatibility is verified by MTT assay and histological analyses.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2021
·Vol. 17
·期 31
·2100794
·
IF 13.281
Xingyu Wang,Changwei Li,Junchao Qian,Xiaotong Lv,Hong Li,Jinglu Zou,Jiahui Zhang,Xiangfu Meng,Hongji Liu,Yong Qian,Wenchu Lin,Hui Wang
Phototherapy in the second near-IR (1000–1700 nm, NIR-II) window has achieved much progress because of its high efficiency and relatively minor side effects. In this paper, a new NIR-II responsive hollow magnetite nanocluster (HMNC) for targeted and imaging-guided cancer therapy is reported. The HMNC not only provides a hollow cavity for drug loading but also serves as a contrast agent for tumor-targeted magnetic resonance imaging. The acid-induced dissolution of the HMNCs can trigger a pH-responsive drug release for chemotherapy and catalyze the hydroxyl radical (·OH) formation from the decomposition of hydrogen peroxide for chemodynamic therapy. Moreover, the HMNCs can adsorb and convert NIR-II light into local heat (photothermal conversion efficacy: 36.3%), which can accelerate drug release and enhance the synergistic effect of chemo-photothermal therapy. The HMNCs show great potential as a versatile nanoplatform for targeted imaging-guided trimodal cancer therapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 9
·期 8
·2042-2053
·
IF 6.331
Xiaolu Guo,Changchun Wen,Qianxin Xu,Changping Ruan,Xing-Can Shen,Hong Liang
The second near-infrared (NIR-II) window (1000–1350 nm) usually offers further improved light penetration, a higher maximum permissible exposure (MPE), and a lower background signal. Development of NIR-II optical diagnosis and phototherapy technologies is of great significance for precise, efficient tumor therapy. In this work, a new type of Ti-based targeting agent (B-TiO2@SiO2–HA) nanotheranostic system with strong NIR-II absorption was designed and fabricated for the first time. Oxygen vacancies were formed in B-TiO2 and its band gap was narrowed, resulting in nanotheranostic systems with full-spectrum responses to stimulation with light. The experimental results showed that B-TiO2@SiO2–HA not only can enable high NIR-II photothermal conversion and provide excellent reactive oxygen species (ROS) production capacity, but also can enable high-resolution photoacoustic imaging (PAI) under NIR-II laser irradiation. Moreover, HA modification gives the nanotheranostic systems the useful ability to target high-CD44-expression tumor cells and tissues. In vitro and in vivo experiments demonstrated that B-TiO2@SiO2–HA exhibited a targeted photothermal/photodynamic (PTT/PDT) effect that produced tumor-cell ablation and apoptosis under the guidance of real-time NIR-II PA imaging. B-TiO2@SiO2–HA exhibits precise nanotheranostic potential for PAI-guided tumor-targeting phototherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Nano
·
2026
·
IF 7.6
Houlin Li,Jiaxin Sun,Peng Yan,Aikelaimu Aihemaiti,Abdukader Abdukayum
Near-infrared II (NIR-II) luminescence imaging, with its significant advantages of deep tissue penetration and high spatial resolution, has become a promising technology for cancer diagnosis. The integration of NIR-II imaging with multifunctional therapeutic modalities has been widely explored in biomedicine, offering valuable development opportunities. Persistent luminescent nanoparticles (PLNPs) are of great interest in biomedical applications due to their ability to emit afterglow without the need for in situ excitation. However, single PLNPs exhibit limited performance in processes related to photothermal therapy (PTT) and photodynamic therapy (PDT), and there remains a lack of PLNPs-based multifunctional nanocomposites that simultaneously possess NIR-II afterglow luminescence, as well as PDT, PTT and photocatalytic therapy (PCT) properties. Herein, we report a novel multifunctional nanocomposite, ZGO@IR-820, which is composed of PLNPs (ZnGa 1.97 O 4 :Cr 0.01 ,Bi 0.02 , ZGO) and the near-infrared fluorescent dye IR-820. This nanocomposite not only exhibits NIR-II afterglow emission, but also integrates PDT, PTT and PCT properties. The NIR-II afterglow performance is achieved through the persistent luminescence resonance energy transfer between the PLNPs and IR-820. This multifunctional design expands the photophysical and photochemical properties of PLNPs-based nanocomposites, providing an innovative material design strategy for the development of precise disease diagnosis and efficient therapy.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2023
·
IF 6.2
Jiajia Meng,Yanyan Cui,Yaling Wang
Lanthanide-doped nanoparticles (LDNPs) are widely used in biophotonics due to their narrow emission band, long lifetime and broad-spectrum tunable luminescence properties. Usually, photosensitizers for biotherapeutic applications need to be triggered by visible light, while bioimaging requires near-infrared (NIR) light with better penetration. However, it is still challenging to achieve efficient luminescence emission in the visible to second near-infrared (NIR-II, 1000–1700 nm) range simultaneously for multifunctional nanoparticles excited at a single NIR wavelength. Here, a simple NaYF 4 :Er/Ce@NaYbF 4 :Er@NaYF 4 :Nd core-shell-shell nanoparticle with interfacial energy transfer by the Yb-sensitized shell and partition doping of Er 3+ under 808 nm excitation, which allows the system to achieve visible and NIR-II luminescence emission from different partitions of Er 3+ . When Ce 3+ is introduced into the core, the Er 3+ in the Yb-sensitized shell is responsible for the emission in the visible region, while the core-doped Er 3+ is mainly responsible for the emission at 1550 nm in the NIR-II. In addition, this core-shell-shell nanostructure has a long luminescence emission lifetime in the visible and NIR-II regions, especially the luminescence lifetime of Er 3+ at 1550 nm is extended to 6.4 ms. More importantly, efficient 1 O 2 generation can be achieved by coupling core-shell-shell nanoparticles with photosensitizer. These results will provide previously unattainable opportunities for LDNPs in biotherapeutic and imaging applications.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Changrui Ying,Xiaolong Zhu,Shuqing Xiang,Mingqian Wang,Xuefeng Jiang,Jian Shen
Single-atom catalysts based on carbon-based materials have a high catalytic activity and excellent photothermal performance. In this article, iron single-atom catalysts loaded on C-MOF-5 carriers have been prepared for the application of photothermal catalytic antimicrobial therapy. Iron single-atom catalysts (Fe SACs) exhibit significant peroxidase-like catalytic activity and catalyze the production of large amounts of hydroxyl radicals (·OH) when hydrogen peroxide is present, which have a killing effect on bacteria. In addition, the excellent photothermal properties of the carbon material allow Fe SACs to rapidly generate a localized high temperature under NIR-II laser light (1064 nm) to kill bacteria and enhance peroxidase-like catalytic activity to produce a large number of hydroxyl radicals. In vitro bacterial assays demonstrated that the synergistic antimicrobial strategy of chemodynamic therapy (CDT) and photothermal therapy (PTT) is nearly 100% effective against E. coli and S. aureus, demonstrating greater antimicrobial efficiency than chemodynamic therapy and photothermal therapy alone. In vivo bacterial assay shows better wound healing in mice treated with CDT, PTT synergistic antimicrobial therapy. In summary, these carbon-based single-atom catalysts could be used as antimicrobial agents through the CDT and PTT synergistic antimicrobial effect.
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Yingxin Zhu,Xianzhu Luo,Zihang Yu,Shihui Wen,Guochen Bao,Le Zhang,Cuiling Zhang,Yuezhong Xian
Methicillin-resistant Staphylococcus aureus (MRSA) is responsible for causing life-threatening infections that result in high morbidity and mortality rates. The development of advanced imaging and therapeutic methods for in vivo diagnosis and treatment of MRSA infections remains challenging. Here, we develop a hybrid nanoplatform based on rare-earth-doped nanoparticles (RENPs) sensitized by a moiety-engineered near-infrared (NIR) TPEO-820 dye and with a ZIF-8 layer that incorporates CysNO, a photochemically triggered nitric oxide donor. We then use the hybrid for both NIR-II bioimaging and photoactivatable treatment of MRSA-infected wounds. We show that the NIR dye sensitization leads to an 8.5-fold enhancement of the downshifting emission and facilitates deep-tissue NIR-II imaging of bacterial infections. Moreover, the sensitization strategy enhances the UV emission of RENPs by two orders of magnitude, leading to the efficiently controllable release of nitric oxide for effective disinfection of MRSA in vitro and in vivo. The hybrid nanoplatform thus offers promising opportunities for simultaneous localization and controllable treatment of MRSA. Statement of Significance Early detection and treatment of MRSA infections are crucial for reducing public health risks. It is a significant challenge that develops sensitive in vivo diagnosis and complete elimination of drug-resistant bacterial infections. Herein, a nanoplatform has been developed for photoactivatable therapy of MRSA infections and deep tissue NIR-II imaging. This platform utilizes lanthanide-doped rare earth nanoparticles (RENPs) that are sensitized by a moiety-engineered near-infrared (NIR) dye TPEO-820. The TPEO-820 sensitized RENPs exhibit 5 times increase in the release of NO concentration for MRSA treatment compared to unsensitized RENPs, enabling precise therapy of MRSA infection both in vitro and in vivo. Moreover, the platform demonstrates NIR-II luminescence in vivo, allowing for sensitive imaging in deep tissue for MRSA infection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Yiyu Chen,Ping Liu,Chunze Zhou,Tao Zhang,Tianxing Zhou,Dandan Men,Guihua Jiang,Lifeng Hang
Photothermal therapy (PTT), photodynamic therapy (PDT), and chemodynamic therapy (CDT) can cause cancer cell death through an immunogenic process. However, the study of second near-infrared window (NIR-II)-triggered PTT and PDT combined with CDT to induce an immune response has not been recently reported. Here, we integrated gold nanobipyramids and copper sulfide in a core/shell architecture (AuNBP@CuS). The material displays both photodynamic and photothermal properties under irradiation with a NIR-II laser. The released Cu 2+ from CuS under an acidic tumor microenvironment can be converted to Cu + by glutathione following a Fenton-like reaction with hydrogen peroxide to generate highly toxic hydroxyl radicals in the tumor region. Both in vitro and in vivo results demonstrated that such multifunctional nanoplatforms could achieve enhanced efficiency for image-guided tumor suppression based on the NIR-II photo/chemodynamic therapy. We found that damage-associated molecular pattern molecules such as adenosine triphosphate, pre-apoptotic calreticulin , and high mobility group box-1 in dying cells induced by the NIR-II photo/chemodynamic therapy could simultaneously trigger adaptive immune responses. This is the first report revealing that NIR-II photo/chemodynamic therapy based on AuNBP@CuS had promising performance on tumor suppressor with an effective immunogenic cell death process. Statement of significance 1. AuNBP@CuS displays both NIR-II photodynamic and photothermal properties. 2. Cu + following a Fenton-like reaction to generate highly toxic hydroxyl radicals. 3. The NIR-II photo/chemodynamic therapy can trigger adaptive immune responses. 4. Such multifunctional nanoplatforms could achieve enhanced efficiency for tumor suppression.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2019
·Vol. 8
·期 14
·1900341
·
IF 6.27
Jing-Jing Zhang,Yi Lin,Hui Zhou,He He,Jiao-Jiao Ma,Meng-Yao Luo,Zhi-Ling Zhang,Dai-Wen Pang
The advantages of fluorescence bioimaging in the second near-infrared (NIR II, 1000–1700 nm) window are well known; however, current NIR II fluorescent probes for in vivo tumor imaging still have many shortcomings, such as low fluorescence efficiency, unstable performance under in vivo environments, and inefficient enrichment at tumor sites. In this study, Ag 2 Te quantum dots (QDs) that emit light at a wavelength of 1300 nm are assembled with poly(lactic- co -glycolic acid) and further encapsulated within cancer cell membranes to overcome the shortcomings mentioned above. The as-prepared ≈100 nm biomimetic nanobioprobes exhibit ultrabright (≈60 times greater than that of free Ag 2 Te QDs) and highly stable (≈97% maintenance after laser radiation for 1 h) fluorescence in the NIR II window. By combining the active homotypic tumor targeting capability derived from the source cell membrane with the passive enhanced permeation and retention effect, improved accumulation at tumor sites ((31 ± 2)% injection dose per gram of tumor) and a high tumor-to-normal tissue ratio (13.3 ± 0.7) are achieved. In summary, a new biomimetic NIR II fluorescent nanobioprobe with ultrabright and stable fluorescence, homotypic targeting and good biocompatibility for enhanced in vivo tumor imaging is developed in this study.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jianhao Zheng,Pengye Du,Ran An,Yuan Liang,Yi Wei,Shuyu Liu,Xinyu Wang,Pengpeng Lei,Shuyan Song,Hongjie Zhang
Fluorescence thermometry based on metal halide perovskites is increasingly becoming a hotspot due to its advantages of high detection sensitivity, noninvasiveness, and fast response time. However, it still presents certain technical challenges in practical applications, such as complex synthesis methods, the use of toxic solvents, and being currently mainly based on the visible/first near-infrared light with poor penetration and severe autofluorescence. In this study, we synthesize the second near-infrared (NIR-II) luminescent crystals based on Yb3+/Nd3+-doped zero-dimensional Cs2ScCl5·H2O by a simple “dissolve–dry” method. The whole synthesized process does not involve high temperatures or high pressures. Cs2ScCl5·H2O/Yb3+,Nd3+ has an optimum fluorescence performance when the Yb3+/Nd3+ doping amount is 15%/20%. The emission intensity ratio attributed to Yb3+ and Nd3+ varies with temperature, and this variation is exacerbated due to the fact that the 2F5/2 energy level of Yb3+ can be effectively aligned with the O–H bond stretching vibration energy of coordinating water molecules to facilitate energy transfer. Ultimately, the crystals can act as self-referenced ratiometric NIR-II luminescent thermometers with a maximum relative sensitivity of 1.66% K–1 at 323 K. This work highlights the advantages of NIR-II luminescent materials for temperature sensing, which is significant for advancement in the field of noncontact thermometers.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）