BIOMATERIALS
·
2014
·
IF 8.312
Zhaolu Xie,Zhonghua Ji,Zhirong Zhang,Tao Gong,Xun Sun
Mucus layer coating the vaginal epithelium represents a barrier for intravaginally delivered recombined adenoviral (rAd) vectors, but it could be overcome by proper polyethylene glycol (PEG) modification. Here we synthesized two cationic PEG derivatives, amino-(EO) n /(AGE) m -Cyss (APCs). The polymers contained neutral linear PEG (2–5 kDa) to provide a hydrophilic surface and amine pendants to provide positive charge for coating negatively charged rAd by physical adsorption. Given proper molecular composition, the polymer (5k-APC) could coat rAd without causing aggregation, facilitating its mucus penetrating ability and enhancing gene expression both in vitro and in vivo . With HIVgag as the model antigen, the polymer-rAd complexes were administered intravaginally to elicit both systemic and mucosal immune responses. 5k-APC-rAd immunization elicited robust HIVgag-specific cellular responses and also induced higher antigen-specific serum IgG. More importantly, mice immunized with 5k-APC-rAd showed higher level of IgA in vaginal lavage fluid. These findings suggest that 5k-APC-rAd is a promising system for intravaginal immunization against infectious diseases such as HIV within the vaginal tract.
研究领域:
病毒学
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药剂学
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免疫学
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生物技术
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DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
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2017
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IF 3.386
Haipeng Wang,Dejin Tong,Lei Wang,Lei Chen,Na Yu,Zhanxiong Li
Poly(ω-caprolactone) (PCL) has been the focus in many research initiatives, especially regarding various ways though which to introduce reactive sites to the polyester chains. In this work, hydroxyl groups were covalently introduced into the chain of PCL by reacting ester groups with 6-amino-1-hexanol. Poly(ethylene glycol) (PEG) was crosslinked to the PCL chain through esterification , by using N,N’-carbonyldiimidazole (CDI) as catalyst. The prepared PCL-PEG copolymers were characterized by various analytical techniques such as Fourier transform infrared spectroscopy (FT-IR), 1 H NMR and X-ray photoelectron spectroscopy (XPS). Static water contact angles measurement indicated that hydrophilicity of the copolymer films modified by PEG has improved considerably. The copolymer films were prepared by casting the polymer solution onto a stainless plate. The degradation of the copolymer samples, in a phosphate buffer solution containing a type of Lipase (Aspergillus Oryzae), was observed at different time intervals. The results of weight loss ratio, during the degradation process, indicated that blocking PEG chains onto the PCL chains can effectively accelerate the process of enzymatic degradation of the resulting copolymer. The changes in molecular weight of the copolymer films were investigated by Gel Permeation Chromatography (GPC) and the copolymers were characterized by 1 H NMR during degradation. Surface morphology of PCL and PCL-PEG polymers, before and after degradation, was observed by Scanning electron microscopy (SEM), and emphasized that the enzymatic degradation of PCL-PEG copolymers occurred faster by comparison with PCL, starting from the surface layer of the films.
研究领域:
材料科学
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聚合物化学
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生物可降解高分子
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酶降解
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Xiaojian Xu,Yuhe Shen,Ruizhe Xing,Jie Kong,Rongxin Su,Renliang Huang,Wei Qi
The development of high-performance biosensors is a key focus in the nanozyme field, but the current limitations in biocompatibility and recyclability hinder their broader applications. Herein, we address these challenges by constructing core–shell nanohybrids with biocompatible poly(ethylene glycol) (PEG) modification using a galvanic replacement reaction between orthovanadate ions and liquid metal (LM) (VOx@EGaIn-PEG). By leveraging the excellent charge transfer properties and the low band gap of the LM surface oxide, the VOx@EGaIn-PEG heterojunction can effectively convert hydrogen peroxide into hydroxyl radicals, demonstrating excellent peroxidase-like activity and stability (Km = 490 μM, vmax = 1.206 μM/s). The unique self-healing characteristics of LM further enable the recovery and regeneration of VOx@EGaIn-PEG nanozymes, thereby significantly reducing the cost of biological detection. Building upon this, we developed a nanozyme colorimetric sensor suitable for biological systems and integrated it with a smartphone to create an efficient quantitative detection platform. This platform allows for the convenient and sensitive detection of glucose in serum samples, exhibiting a good linear relationship in the range of 10–500 μM and a detection limit of 2.35 μM. The remarkable catalytic potential of LM, combined with its biocompatibility and regenerative properties, offers valuable insights for applications in catalysis and biomedical fields.
研究领域:
纳米生物学
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生物医学工程
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催化科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Wenlu He,Jingtong Zhang,Qihao Sun,Ying Hao,Jingjing Yang,Jing Yang,Daming Wu,Jingyao Sun
To meet high-efficiency thermal management demands in agricultural greenhouses, bio-based chitosan (CS) and polyethylene glycol (PEG) composite hydrogel films (P1–P3) were prepared. By incorporating PEG into the chitosan matrix, the limitation of traditional CS hydrogels—which offer passive insulation but lack active energy storage—was effectively addressed. Experimental results demonstrated that the composite hydrogels possess exceptional thermal stability; after being heated at 60°C for 30 min, the PEG remained firmly locked within the CS network without any leakage. In thermal insulation tests, when exposed to a 200°C heat source, the P3 sample (containing 21% PEG) took the longest time (313 s) for its top surface to reach 60°C, significantly outperforming the neat P0 sample (188 s). In greenhouse simulation experiments, after 2 h of light-induced heating, the P3 group achieved an indoor temperature rise of 15.1°C, exhibiting the strongest thermal storage and release capacity. Regarding mechanical properties, P3 showed the highest mean compressive stress of 75.19 ± 1.60 kPa. Additionally, the transparency of the hydrogels increased with higher PEG content, which is beneficial for greenhouse lighting. This study proves that CS/PEG composite hydrogels offer significant advantages in thermal management and structural durability for agricultural greenhouse film applications.
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Hongdong Wang,Ruxue Hou,Xiacong Zhang,Qi Wang,Cheng Zhang,Yuhong Liu,Jianhua Zhang
Prolonged exposure to visible light can disrupt tear-film stability and compromise ocular lubrication, potentially leading to eye fatigue, dryness, and the development of dry-eye disease, thereby highlighting the need for durable and long-lasting ocular lubrication. In this study, we develop a photoresponsive double-network hydrogel (PDNH) for the ocular environment that addresses these issues and achieves superlubricity. The PDNH is composed of a polyvinylpyrrolidone (PVP) hydrogel framework and a responsive supramolecular system of β-cyclodextrins/polyethylene glycol (β-CD/PEG) and competitive guest azobenzene derivative (Azo-C2). Under visible-light irradiation, the competitive host–guest interaction between the β-CD/PEG supramolecule and Azo-C2 lead to the release of the PEG chain ends from the β-CD cavities, allowing the PEG chains to diffuse toward the hydrogel surface. The strong hydrophilicity of PEG promotes water retention at the ocular surface, forming a stable lubricating layer that effectively reduces ocular friction. With continuous visible-light irradiation, the friction coefficient (COF) of the hydrogel gradually decreases and reaches its optimal state after 6 h of exposure, with the COF reduced by 25%, and its mechanical properties can remain at a high level. Its self-regulating lubrication capability minimizes dependence on frequent external lubricant administration. Moreover, its excellent biocompatibility highlights the promise as a smart ophthalmic lubricant, with the photoresponsive mechanism offering broad potential for biomedical systems and a novel route to ocular superlubricity in drug delivery.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2026
·
IF 4.6
Chenyu Fei,Chenchen Zhao,Shubo Li,Zhaohui Wang,Ke Liu,Xian Du,Wenbo Du
Sulfolane plasticizes PEG-based electrolyte for aqueous Mg-ion batteries. • Sulfolane modulates solvent microenvironment and relieves PEG chain entanglement. • Balanced electrolyte presents wide ESW, low viscosity and high ionic conductivity. • V 2 O 5 //PTCDI full cell delivers improved capacity and superior cycling stability. Aqueous magnesium-ion batteries offer a safe, low-cost, and sustainable energy storage solution, yet their development is impeded by the narrow electrochemical stability window (ESW) of conventional aqueous electrolytes. Although polyethylene glycol (PEG)-based electrolytes provide an expanded ESW, their high viscosity and low ionic conductivity severely limit ionic transport. Herein, sulfolane is introduced as a plasticizer to regulate the physicochemical properties of PEG400-based electrolytes. Across the tested PEG/SUL compositions, sulfolane incorporation substantially reduces electrolyte viscosity and enhances ionic conductivity, with the conductivity increasing from 480 μS cm −1 to 3390 μS cm −1 , while the selected PEG/SUL-11@20%H 2 O electrolyte retains a broad ESW of approximately 3.570 V . Raman and 1 H NMR analyses suggest that the sulfonyl groups in sulfolane interact with PEG400 chains, thereby modifying the local PEG chain environment and mitigating chain entanglement. Considering the trade-off among ESW, viscosity, ionic conductivity, and electrode compatibility, PEG/SUL-11@20%H 2 O was selected as a balanced formulation. The V 2 O 5 //PTCDI full cell assembled with the selected electrolyte delivers a discharge specific capacity of 147.7 mAh g −1 at 100 mA g −1 and retains 85% of its capacity after 600 cycles, demonstrating promising capacity and stable cycling performance. This sulfolane plasticization strategy effectively addresses the conductivity limitation of PEG-based aqueous electrolytes and provides a promising route toward advanced electrolytes for aqueous magnesium-ion batteries. Download: Download high-res image (545KB) Download: Download full-size image
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DOI
高影响因子
Drug Delivery and Translational Research
·
2019
·Vol. 10
·期 1
·122-135
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IF 3.111
Lu Xiaoyu,Fang Min,Yang Yue,Dai Yu,Xu Jiaqiu,Zhao Di,Lu Yang,Chen Xijing,Lu Shan,Li Ning
PEGylated triacontanol (mPEG 2k -b-TRIA) was developed as a dual-functional polymer with remarkable biocompatibility. The polymer could self-assemble to micelles with critical micelle concentration (CMC) 17.62 μg mL −1 . Docetaxel-loaded mPEG 2k -b-TRIA micelles (DTX PMs) were fabricated to evaluate the feasibility of mPEG 2k -b-TRIA as drug delivery system. DTX PMs achieved desirable particle size of 93.7 nm, drug loading of 6.66%, and drug encapsulation efficiency of 89.87%. The drug release was based on first-order kinetics model, thus enabling prolonged release. Meanwhile, pharmacokinetic study also revealed that DTX PMs could improve the exposure level of DTX and prolong its systemic circulation time. Furthermore, DTX PMs demonstrated significantly enhanced cytotoxicity and cellular uptake in vitro compared with DTX solution. The in vivo tumor inhibition study carried out on MCF-7 bearing BALB/c mice model also validated that DTX PMs exhibited stronger anti-tumor activity but low toxicity. Notably, mPEG 2k -b-TRIA made some contribution to inhibit the growth of breast cancer cells in vitro and in vivo, indicating the potential as anti-tumor complementary agents. All the results suggested that mPEG 2k -b-TRIA polymer as a vehicle in the formulation of anti-cancer drugs may provide an effective way to improve their therapeutic efficacy. Consequently, the mPEG 2k -b-TRIA polymers would be another promising carrier for hydrophobic anti-cancer drugs delivery.
研究领域:
药学
·
肿瘤学
·
药物递送系统
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Yinglan Li,Jianshuo Su,Shufan Liu,Shuangfeng Li,Sisi Liu,Huaizhen Zhang,Zhuang Ding,Zhengping Wang,Min Liu,Yanna Zhao
In this study, novel surface-modified lycopene liposomes were prepared for functional food applications, with systematic comparison of their physicochemical characteristics and biological evaluation. In contrast to whey protein isolate/polyethylene glycol layer-by-layer assembled lycopene liposomes (Lips-LYC/WPI) and PEGylated lycopene liposomes (LYC Lips), sodium caseinate/polyethylene glycol layer-by-layer assembled lycopene liposomes (Lips-LYC/SC) exhibited significantly reduced particle size and improved stability. Besides, Lips-LYC/SC highlighted enhanced encapsulation efficiency and minimized lycopene leakage attributed to sodium caseinate modification. DSC and PXRD confirmed effective reduction of lycopene crystallinity through excipient interaction, which was conducive to its water solubility improvement. FT-IR and fluorescence analysis revealed intermolecular hydrogen bonding between lycopene and the excipients. Furthermore, DPPH antioxidant and ROS scavenging experiments showed that the encapsulation of lycopene effectively improved its antioxidant activity. Cytotoxicity test revealed that Lips-LYC/SC had minimal cytotoxicity towards LO2 cells and Caco-2 cells, achieving cell survival rates >90 %, while the cell scratch results confirmed that LYC Lips induced significantly slower migration rates towards these cells. Moreover, Lips-LYC/SC significantly ameliorated metabolic disorders, oxidative stress, and hepatotoxicity in HFD-induced liver injury model. The above results highlighted the strategic advantage of sodium caseinate and PEG co-decorated liposomes, establishing Lips-LYC/SC as a promising delivery platform for the hydrophobic bioactive ingredient.
研究领域:
食品科学
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生物化学
·
营养学
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产品关联
DOI
PubMed
高影响因子
DRUG DELIVERY
·
2018
·
IF 3.095
Yimeng Zhou,Ning Li,Zhixia Qiu,Xiaoyu Lu,Min Fang,Xijing Chen,Lili Ren,Guangji Wang,Pingkai Ouyang
Triacontanol (TA, C30H62O), abundantly present in plant cuticle waxes and bee waxes, has been found to display promising anti-neoplastic potentials. As a long chain fatty alcohol, TA possesses limited aqueous solubility, which hinders its medicinal application. To overcome its solubility barrier, a polymer prodrug was synthesized through attaching TA to poly ethylene glycol (PEG), using succinic acid as a linker with bifunctional amide and ester bonds. Anti-neoplastic effects of PEG-TA were assessed in LoVo and MCF7 cells, anti-proliferative and apoptosis-inducing activities were subsequently confirmed in mouse xenograft model. Encouragingly, PEG-TA possessed selective anti-cancer ability. It did not exhibit significant cytotoxicity on normal cells. Mechanistic examination revealed inhibition of NF-κB nuclear translocation, suppression on matrix degradation enzyme and down-regulation of angiogenic signaling might contribute to its anti-malignant effects. Pharmacokinetics clearly indicated PEGylated TA (named as mPEG2K-SA-TA) substantially enhanced TA delivery with increased plasma exposure (19,791 vs. 336.25 ng·mL−1·h−1, p < .001), mean residence time (8.46 vs. 2.95 h, p < .001) and elimination half-life (7.78 vs. 2.57 h, p < .001) compared to those of original TA. Moreover, mPEG2K-SA-TA appeared to be safe in preliminary toxicological assessment. PEGylated TA also emerged as a functional carrier to deliver hydrophobic chemotherapeutic agents, since it readily self-assembled to micelles in aqueous solution with a low critical micelle concentration (CMC, 19.1 µg·mL−1). Conclusively, PEG-TA conjugate displayed superior anti-neoplastic activities and low toxicity, as well as facilitated the delivery of other hydrophobic agents, which appeared to be an innovative strategy for cancer therapy.
研究领域:
药理学
·
肿瘤学
·
药物递送系统
·
生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2016
·
IF 2.74
Guoyong Wang,Yanyun Bai,Xiaoyuan Ma,Wanxu Wang,Qiwen Yin,Zhiping Du
Polycarboxylate-based terpolymers with different PEG length, PAE-Na, were synthesized by free radical emulsion polymerization . The monomers are Poly(ethylene glycol) monomethyl ether monomethacrylate (PMEM, Mn = 950 g/mol, 500 g/mol and 300 g/mol), 2-ethylhexyl acrylate (2-EHA) and acrylic acid (AA), respectively. The structures of terpolymers were characterized by 1 H NMR and FT-IR. This particular molecular structure of terpolymers guarantees its good dispersibility . Here, PAE-Na terpolymers were used as dispersant and CaCO 3 as solid suspension to calculate the dispersion amounts (DAs) by means of titration method. PAE-Na terpolymers with different PEG length show great differences in DAs. Furthermore, the particle size distribution (PSD) and transmission electron microscopy (TEM) were carried out to evaluate the particle size of CaCO 3 suspensions. The experiment results show that the dispersibility of terpolymers has an increasing trend while increasing the PEG side chain length. Based on the theory of Flatt and Scaling law, the molecule size of terpolymers with different length of PEG side chain was calculated. The Flory energy as a function H was calculated when two particles approach. Finally, the anti-redepositing power of 3# terpolymer was investigated. The result shows that 3# terpolymer has strong anti-redepositing power. This study may help elucidate the mechanism of dispersion and develop structure-property relationships which could provide theoretical guidance in the design of molecular structure in the practical application.
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DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Qingxia Zhou,Yanrong Cheng,Delan Ge,Xia Guo
PEG/salt aqueous two-phase systems (ATPSs) are the most common ATPSs because they are nontoxic, biocompatible, and inexpensive; however, the limited polarity difference between the two phases hinders their application. Although increasing the molecular weight of PEG can increase the polarity difference between the two phases, the significant viscosity of the PEG phase makes mass transfer difficult once the PEG molecular weight is too high. In the present study, we focus on enhancing the performance of low-molecular-weight PEG (PEG 400)/salt ATPS by using different ionic surfactants as adjuvants; the surfactants include anionic surfactants sodium dodecyl sulfate and sodium dodecyl benzenesulfonate, cationic surfactant dodecyl trimethylammonium bromide, and zwitterionic surfactant N-dodecyl-N, N-dimethyl-3-ammonio-1-propanesulfonate. It is found that all of these surfactants can promote the PEG 400/salt ATPS formation, but their effects on the ATPS extraction performance are different. By using tryptophan and vanillin as model extracts, it is found that the anionic and zwitterionic surfactants significantly enhance the extraction performance of PEG 400/salt ATPS, while the cationic surfactant significantly reduces the ATPS extraction performance. These results illustrate the potential of anionic and zwitterionic surfactants as adjuvants in enhancing the performance of low-molecular-weight PEG/salt ATPS.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2020
·
IF 3.99
Xiaona Lin,Xinxin Wang,Hongqi Tian
When a burst of reactive oxygen species (ROS) is induced after radiation exposure, a sufficient radioprotector drug must be quickly released to neutralize the ROS . An oral polymeric carrier of poly(ε-caprolactone)-b-poly(ethylene glycol)-b-poly(ε-caprolactone) was synthesized via the ROS-response linker thioketal (TK-linked PCEC) and used for delivery of the drug WR-1065. The drug-loaded nanoparticles (PCEC/WR-1065 NPs) had high WR-1065 content (19.7 % w/w) in the core and a particle size of 183 nm. The PCEC/WR-1065 NPs could protect the drug from degradation at gastric pH. More than 70 % of the TK-linked PCEC copolymer could be cleaved in 1 h. Therefore, a sufficient amount of WR-1065 could be quickly released from the PCEC/WR-1065 NPs to neutralize the burst of free radicals generated under irradiation. The in vitro cell uptake results of TK-linked PCEC NPs indicated that the NPs could be efficiently endocytosized by Caco-2 cells. Oral administration of the PCEC/WR-1065 led to survival benefit as well as protective effects on hematopoiesis and main organs with respect to the irradiation and oral free WR-1065 groups after 7.2 and 8.0 Gy total body irradiation, respectively. In vivo biodistribution studies indicated that the PCEC/WR-1065 NPs accumulated mainly in intestinal tissue. These results suggest that the design presented here provides a promising oral ROS-sensitive platform for acute radiation syndrome.
研究领域:
药剂学
·
放射生物学
·
纳米医学
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DOI
高影响因子
危险品化学品经营许可证（带存储）