POLYMER
·
2024
·
IF 4.1
Jinqi Chen,Cong Luo,Yanhua Niu,Guangxian Li
Gel polymer electrolyte (GPE) is one of the promising candidates to overcome the defects of liquid and solid electrolyte for lithium metal batteries (LMBs). The obstacle for the practical application of GPEs lies in achieving a balance between ion transport, mechanical properties and interface stability. In this work, a star shaped polymer matrix polyhedral oligomeric silsesquioxane-polymethyl methacrylate (POSS-PMMA) is successfully synthesized with POSS as the core via atom transfer radical polymerization (ATRP) method. 1-ethyl-3-methylimidazole bis(trifluoromethanesulfon)imide ([EMIM][TFSI]) and bistrifluoromethanesulfonimide lithium salt (LiTFSI) are blended with the matrix to increase ionic conductivity. Attributed to the star structure and the lithium ion migration channel provided by POSS, the synthesized GPE possesses excellent balanced mechanical and electrochemical properties. To further stabilize the Li/GPE interface, a polymer and plastic crystalline electrolyte (PPCE) is coated as interface modification layer on both sides of GPE. Benefitting from the design, the synthesized GPE reaches a highly stable Li striping/plating cycling for 1000 h at 0.1 mA cm −2 with ionic conductivity of 3.5 × 10 −4 S cm −1 , Li + transference number of 0.35, and electrochemical stability window of 4.9 V. Furthermore, the Li||POSS-PMMA-PPCE||LiFePO 4 (LFP) full cell shows a high capacity retention of 99.5 % after 100 cycles at 0.2 C under room temperature (RT), and the high voltage Li||POSS-PMMA-PPCE||LiNi 1-x-y MnxCo y O 2 (NCM811) cell shows a high capacity retention of 88.3 % after 50 cycles at 0.1 C under RT. This work opens up a new frontier to stabilize the Li/GPE interface and enables safe operation of room temperature lithium metal batteries.
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DOI
高影响因子
Polymer Chemistry
·
2024
·
IF 4.1
Quan Yan,Bailiang Xue,Tonghe Zhang,Wenliang Wang,Xinping Li,Xiaojun Shen,Lulu Ning,Xianzhi Meng,Wei Zhao
The star–star coupling is often regarded as an undesirable side reaction in in the synthesis of star polymers. To mitigate this issue, strategies such as operating at low temperatures, maintaining low monomer concentrations, and limiting monomer conversion are typically employed, albeit at the cost of reduced synthetic efficiency in producing the desired polymer materials. In this study, we propose a novel approach to harness this side reaction for the creation of a lignin-containing, sustainable, and solvent-resistant dynamic dual network using a one-pot synthesis strategy. Initially, a lignin-based macroinitiator with low polydispersity index (PDI) was synthesized to facilitate the precise formation of well-defined star polymers functionalized with epoxy groups. Subsequent to this, the first network, composed of star-shaped lignin-grafted copolymers, was successfully established through the utilization of the free radical bimolecular termination reaction. Following this, the second dynamic crosslinked network was formed via vitrimer chemistry between epoxy and carboxylic acid. The resulting dynamic dual network, accessible through a straightforward one-pot method, exhibited excellent reprocessability and solvent resistance, rendering it suitable for applications as high-performance adhesives. This study introduces a novel strategy for the synthesis of dynamic dual networks based on star-shaped lignin-grafted copolymers, offering promising prospects for the advancement of sustainable biomaterial synthesis.
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DOI
高影响因子
LANGMUIR
·
2020
·
IF 3.557
Shaoqiao Li,Zhuliu Xiao,Kairui Guo,Huihui Gan,Jirong Wang,Yong Zhang,Liping Yu,Zhigang Xue
Porous membranes fabricated from poly(vinylidene fluoride) (PVDF) and a star polymer with linear poly(ethylene glycol) (PEG) arms and cycloPEG cores were fabricated via the phase-separation method. The porous gel polymer electrolytes (PGPEs) were obtained by immersing the porous membranes in the electrolyte solution. When the additive amount of star polymer was up to 20 wt %, the prepared membrane had the largest porosity and the pores were uniformly distributed in the membrane. The star polymer can not only decrease the crystallization of PVDF and enhance the absorption of liquid electrolyte but also offer ion conduction channels (cycloPEG cores). Therefore, the PGPE with 20 wt % star polymers exhibited competitive ionic conductivities of 1.27 mS cm–1 at 30 °C and 2.89 mS cm–1 at 80 °C. To stabilize the liquid electrolyte in the holes of porous membranes, a gelator was introduced in the liquid electrolyte to form gelled porous gel polymer electrolytes (GPGPEs), and the leakage of liquid electrolytes was thus remarkably reduced. The ionic conductivity of GPGPEs with 20 wt % star polymer and 1.5 wt % gelator was importantly improved at high temperatures (6.02 mS cm–1 at 80 °C). We systematically investigated the electrochemical performances of PGPEs without star polymer, PGPEs with star polymer, and GPGPEs with star polymer. The incorporation of star polymers with linear PEG arms and cycloPEG cores into the PGPEs and GPGPEs significantly improved the electrochemical performances of the lithium metal/LiFePO4 cell assembled with the PGPEs or GPGPEs.
研究领域:
材料科学
·
电化学
·
储能技术
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DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 12
·6373-6380
·
IF 2.936
Bingbing Wang,Hongming Lou,Hongli Xu,Junpeng Zhao,Qiujun Wang,Qiao Shi,Yonghong Deng
In this work, a novel star-comb copolymer based on poly(d,L-lactide) (PDLLA) macromonomer and poly(ethylene glycol)methyl ether methacrylate (PEGMA) was prepared, and the electrochemical properties were studied, with the aim of using it as a solid polymer electrolyte in lithium ion batteries. The six-arm vinyl functionalized PDLLA macromonomer was synthesized by a ring-opening polymerization (ROP) of D,L-lactide and subsequently an acylation of the hydroxy end-groups. A series of free-standing solid polymer electrolyte membranes from different ratios of PDLLA, PEGMA and LiTFSI were prepared through solvent-free free radical polymerization under UV radiation. The chemical structure of the obtained polymers was confirmed by 1H NMR and FTIR. The as-prepared six-arm star-comb solid polymer electrolytes (PDLLA-SPEs) exhibit good thermal stability with Td5%s of ∼270 °C and low Tgs of −48 to −34 °C. The electrochemical characterization shows that the PDLLA-SPEs possess a wide electrochemical window up to 5.1 V with an optimal ionic conductivity of 9.7 × 10−5 S cm−1 at 60 °C at an EO/Li+ ratio of 16 : 1. Furthermore, the all-solid-state LiFePO4/Li cells display extraordinary cycling and rate performances at 60 °C by curing the PDLLA-SPEs directly on the cathode. These superior properties of the six-arm star-comb PDLLA-SPE make it a promising candidate solid electrolyte for lithium batteries.
研究领域:
材料科学
·
电化学
·
能源存储
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DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2026
·
IF 2.9
Li Xin,Yu Shengming,Zhao Cailing,Song Kun,Jiang Yan,Zhang Hongwen
Owing to the numerous hazards associated with oily wastewater, superhydrophobic materials desirable for oil-water separation have attracted considerable attention. Herein, a double hydrophobic polyhedral oligomeric silsesquioxane-polystyrene (POSS-(PS) 8 ) star-shaped copolymer was synthesized by atom transfer radical polymerization (ATRP). The superhydrophobic coating for oil-water separation was prepared by PDMS anchoring POSS-(PS) 8 on the surface of cotton fabric (CF) through nonsolvent induced assembly. The influence of POSS-(PS) 8 and PDMS solution concentration on the optical properties and durability of result superhydrophobic coating were evaluated. Notably, the optimal PDMS dosage endows the superhydrophobic coating with both high optical transmittance (88.4 ± 0.3%) and high haze (87.6 ± 0.6%). Furthermore, the superhydrophobic cotton fabric (SCF) was investigated revealing it has the ability to efficiently separate various oil-water mixtures due to its superhydrophobicity, and maintain good separation efficiency even after 30 cycles. This work will provide a feasible strategy for potential application of the low cost and environmentally friendly SCF in oil-water separation.
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DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Tao Bo,Chenfei Wang,Dingjin Yao,Qiuyu Jiang,Yitong Zhao,Feifei Wang,Wei He,Weiyi Xu,Hao Zhou,Ming Li,Si Zhang,Ruyi Xue
Gene delivery to macrophages holds great promise for cancer immunotherapy. However, traditional gene delivery methods exhibit low transfection efficiency in macrophages. The star -shaped topological structure of polymers is known to encapsulate genes inside their cores, thereby facilitating sustained release of the genetic material. Herein, combining the structural advantages of star polymers and the transfection advantages of poly (β-amino ester)s (PAEs), we developed a novel linear oligomer grafting-onto strategy to synthesize a library of multi-terminal star structured PAEs (SPAEs), and evaluated their gene delivery efficiency in various tissue cells. The transfection with human hepatocellular carcinoma cells (HepG2, HCC-LM3 cells and MHCC-97H cells), rat normal liver cells (BRL-3 A cells), human ovarian cancer cells (A2780 cells), African green monkey kidney cells (Vero cells), human cervical cancer cells (HeLa cells), human chondrosarcoma cells (SW1353 cells), and difficult-to-transfect human epidermal keratinocytes (HaCaT cells) and normal human fibroblast cells (NHF cells) showed that SPAEs exhibited superior transfection profile. The GFP transfection efficiency of top-performing SPAEs in HeLa cells (96.1%) was 2.1-fold, and 3.2-fold higher compared to jetPEI and Lipo3000, respectively, indicating that the star-shaped topological structure can significantly enhance the transfection efficiency of PAEs. More importantly, the top-performing SPAEs could efficiently deliver Nod2 DNA to difficult-to-transfect RAW264.7 macrophages, with a high transfection efficiency of 33.9%, which could promote macrophage M1 polarization and enhanced CD8+ T cell response in co-incubation experiments. This work advances gene therapy by targeting difficult-to-transfect macrophages and remodeling the tumor immune microenvironment.
研究领域:
生物技术
·
药学
·
免疫学
·
癌症研究
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DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2015
·
IF 2.197
Yan-Ling Luo,Yuan Wang,Xuan Wang,Feng Xu,Ya-Shao Chen
Tribrachia star-shaped random copolymers with tunable thermosensitive phase transition temperature were designed and synthesized via a simple one-pot ammonolysis reaction approach with trimesic acid as cores. The self-assembly micellization behavior of the copolymers in aqueous solution was examined by surface tension, UV–vis transmittance, transmission electron microscope, and dynamic light scattering measurements, etc. The results indicated that the resultant copolymers formed thermosensitive micelle aggregates through hydrophobic interactions among the isopropyl groups of poly(N-isopropylacrylamide) PNIPAM chains and inter-star association at a polymer concentration above critical aggregation concentrations from 4.06 to 6.55 mg L−1, with a cloud point range from 36.6℃ to 52.1℃, and homogeneously distributed micelle size below 200 nm. The arm length and the compositional ratios of the two comonomers had effect on physicochemical properties of the polymer micelle aggregates. Particularly, the cloud point values were enhanced as the (N,N-dimethylacrylamide) DMAM monomer was introduced and reached to 36.6℃ and 41.0℃–44.7℃ when the mass ratio of NIPAM to DMAM was 90:10 and 80:20, respectively. The thermo-triggered drug release and cytotoxicity were evaluated to confirm the applicability of the random copolymer micelle aggregates as novel drug targeted release carriers.
研究领域:
材料科学
·
药学
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DOI
高影响因子
MACROMOLECULAR BIOSCIENCE
·
2015
·Vol. 15
·期 10
·1411-1422
·
IF 3.851
Yan-Ling Luo,Mei Han,Feng Xu,Ya-Shao Chen,Yong-Qin Zhang
pH-Responsive H-type poly(methylacrylic acid- block -four hydroxyl terminated poly(butadiene-acrylobitrile)- block -poly(methylacrylic acid (PMAA 2 - b -HTPBN- b -PMAA 2 ) block copolymers were synthesized via atom transfer radical polymerization and the follow-up hydrolysis, and characterized by 1 H NMR, FT-IR and SEC . The block copolymers could self-assemble into nanoscale spherical core-shell micelle aggregates in aqueous solution, and the physicochemical properties depended on the system composition and pH media, with pH phase transition at 5.7–6.1. The copolymer micelle aggregates exhibited pH-triggered drug release and cytotoxicity, and could potentially be used as drug targeting release carriers.
研究领域:
材料科学
·
药学
·
生物医学工程
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2018
·Vol. 219
·期 12
·1800061
·
IF 2.492
Mingqi Wang,Yunfei Wang,Sijie Zhao,Xiaolong Zhang,Hua Wei
Incorporation of the reducible disulfide links into delivery systems has been repeatedly highlighted to realize, elegantly, the tradeoff between extracellular stability and intracellular high therapeutic efficacy. Of all the reported introducing strategies, esterification, seemingly the most extensively-adopted one, suffers from relatively low yield, especially for the esterification coupling between two macromolecules, due to the low condensation efficiency. To improve the coupling efficiency, Cu(I)-catalyzed azide−alkyne cycloaddition (CuAAc) click coupling with high efficiency and high selectivity is used to incorporate disulfide links to the star-shaped amphiphilic block copolymers in this study. Interestingly, besides such synthetic advantages, the click coupling-introduced disulfide joints further endow the resulting star-shaped copolymer-based nanocarriers with higher therapeutic efficacy than the analogues containing esterification-generated disulfide links, in terms of better buffering capacity, greater selective drug release in reducing over nonreducing environments, and higher in vitro cytotoxicity. The disclosed effect of introducing strategy of disulfide link on the delivery efficacy of the drug carriers provides new insights into the structure–property relationship of reduction-sensitive delivery systems, as well as offering new opportunities for the future design and development of intelligent nanocarriers toward enhanced therapeutic efficacy.
研究领域:
药剂学
·
高分子化学
·
生物医学工程
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 14
·51895
·
IF 3.125
Weihua Su,Yan Qin,Guihua Meng,Jianning Wu,Shengchao Yang,Lin Cui,Wenjuan Li,Zhiyong Liu,Xuhong Guo
Intelligent response carriers have been developed and widely used in agriculture to improve pesticide utilization. However, there are few tailored response carriers that are targeting the cotton aphid pest. Based on the temperature-dependent growth and reproduction of cotton aphids, we constructed a tailored temperature-responsive star-shaped polymer to achieve on-demand controlled release of imidacloprid (IMI) to more effectively kill cotton aphids. In this work, a series of star-shaped polymers based on β -cyclodextrin ( β -CD), 2-(2-methoxyethoxy)ethyl methacrylate (MEO 2 MA), and tert -butyl acrylate ( t BA) were synthesized via atom transfer radical polymerization (ATRP). Next, β -CD-PMEO 2 MA ( β -CD-P0) micelles were developed having different controlled release rates of IMI at different temperatures (14, 21, or 27°C) following the cotton aphid growth and reproduction cycle. At 21°C, the micelle underwent a phase transition from a solution state to a turbidity state. By inducing this structural change, release of IMI was increased to adapt to the reproduction of the cotton aphid population which is highest at 21–27°C. In vitro release experiments showed that 48% of IMI was released from β -CD-P0 after the phase transition temperature (PTT). An aqueous solution of the β -CD-P0 polymer micelle was stable at 4°C for at least 28 days. Therefore, this intelligent response release model has enormous potential as a novel carrier for various pesticides.
研究领域:
农业科学
·
材料科学
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DOI
高影响因子
BIOMATERIALS
·
2021
·
IF 12.479
Chengyuan Huang,Xuan Zhao,Meiling Su,Zongning Yin
As glomerular cells, podocytes are the last line of defense for glomerular filtration barriers (GFB) and play a critical role in chronic kidney disease (CKD). Podocyte-targeted drug delivery is a promising direction in the treatment of CKD. In this study, we constructed four-arm star polymers conjugated with a novel linear RWrNM peptide. And poly ε-caprolactone (PCL) hydrophobic core and brush poly (2-hydroxyethyl methacrylate) (PHEMA) hydrophilic shell were synthesized by ROP and SET LRP polymerization. The PHEMA modified by succinic anhydride was coupled with the novel linear RWrNM peptide, and then the PCL hydrophobic core was loaded with dexamethasone acetate (Dexac) to form micelles with stable dimensions. Our findings showed that the novel micelles had an ultrasmall particle size of 16–30 nm. We, for the first time, showed that the specific affinity of the novel linear RWrNM peptide to primary podocytes (24.9 ± 1.7 times of the free RhB uptake) through the αvβ3 integrin receptor mediation was comparable to that of B16F10 cells (24.4 ± 1.2 times of the free RhB uptake). In vivo studies showed that the novel ultrasmall micelles possessed a significant kidney-targeted effect, excellent podocyte colocalization effect, and GFB permeability at 49%–60 % in normal SD rats . Besides, the novel ultrasmall micelles decreased the plasma elimination half-life of Dexac to 1.62–2.09 h and showed good safety in vitro and in vivo. Both in vitro and in vivo results demonstrated the novel ultrasmall micelles could be used as a promising drug delivery strategy for actively targeted therapy of CKD.
研究领域:
药学
·
纳米技术
·
生物医学工程
·
药理学
·
肾脏生理学
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 22
·8517-8526
·
IF 3.069
Zhiwu Chen,Hui Cao,Tianwei Tan
A well-defined functional star polymer nanoparticle was prepared using an “arm first” approach via RAFT polymerization. In this work, N-adamantylacrylamide and N-succinimidyl acrylate were copolymerized with N-isopropylacrylamide sucessfully. The obtained diblock copolymer regarded as an “arm” endowed the star polymer with multiple conjugate functions. By adjusting the amount of crosslinking agent, the size and polydispersity of the star polymer were controlled. With the star polymer as the scaffold, a sequential multi-enzyme system was constructed, where HRP was placed in the inner layer through covalent conjugation, and β-cyclodextrin-modified GOx was assembled in the outer layer through host–guest recognition. More interestingly, the activity of the enzyme modified by β-cyclodextrin was improved. In addition to the enhanced thermal stability, this multienzyme system also exhibited a reduced Km value (from 2.18 mM to 0.39 mM) and an excellent substrate affinity. The specificity constant (Kcat/Km) for GOx in the star polymer@HRP@GOx system was 1.7-fold higher than that of the free HRP with free GOx system. This strategy will promote the development of biocatalysis reactions and biosensors as a promising method.
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）